Click here to switch to the map view.

The map label for this gene is metC [H]

Identifier: 116689800

GI number: 116689800

Start: 1977085

End: 1978266

Strand: Reverse

Name: metC [H]

Synonym: Bcen2424_1779

Alternate gene names: 116689800

Gene position: 1978266-1977085 (Counterclockwise)

Preceding gene: 116689801

Following gene: 116689797

Centisome position: 56.78

GC content: 66.84

Gene sequence:

>1182_bases
ATGACTGCATCCACTTCCAAGCGCGCGCTGCAAACCCGCATCGTTCAACCCGACGACGTCATTCCGGAAGGCTTCCGCTC
GTTCGTGCCGCCGGTCGCGCGCGCATCGACGGTCGTGTTTCCCGATCTCGCGACGATGCGCGCGCTGGTCTGGCACGACG
ACAACCAGTGGCGCTACGGGCTGCATGCGACGCCGACGTCGCTCGCGCTCGCGCAGCGGCTCGCCGAGATCGAGGGCGGC
ACGCACGCGCTGCTGCAGCCGTCGGGTCTCGCGGCGATCATGAACGTCTACTTCGGGATCGTGAAAGCGGGCGACGACGT
GCTGGTTCCGCATAACGTATACGGCCCGAACGCCGATTTCGGCAATTGGCTCGCGAACGATTTCGGCATTACCGTGCGTT
TTTACGATCCATTGATCGGCGCCGGCATCGCCGAGCTGATCCAGCCGAACACGCGGCTGATCTGGCTCGAGGCGCCGGGC
TCGGTGACGATGGAAGTGCCCGACGTGCACGCGATCACGGCGGCCGCGAAGGCGCGCGGCATCGTCACCGCGATCGACAA
CACCTTTTCGGCGGGGCTCGCGTTCAAGCCGTTCGAGCACGGCGTCGACATTTCGGTGCAGGCGCTGACCAAGTATCAGT
CGGGCGGCAGCGACGTGCTGATGGGCGCGACGATCACCGCGAACGCGGAACTGCACGCGAAGCTGAAGCTCGCGCGGATG
CGCTGCGGAATCGGCGTGTCGGTCGACGATTGCTCGCTCGTGCTGCGTAGCCTGCCGAGCATGCAGGTGCGCTTCGATGC
GCACAGCAAGAGCGCGCTCGCGCTCGCGCAATGGCTGAAGGCGCGGCCGGAGATCGCCGCGGTGCTGCATCCGCAGATCG
CCGACTGCCCGGGGCACGCGTCGTTCATGCGCGATTTCAAGGGTGCGGGCGGGCTGTTCTCGGTGGTATTCGACGAACGC
TACAGCGCGGAGCAGGTCGACCGTTTCGTCGAGTCGCTCGAGCTGTTCGCGATCGGCTGGAGCTGGGGCGGCGCGTGCAG
CCTCGCGATGCCTTACGACGTCGCGTCGATGCGTCCGGACTGGCCGCATCGCGGCACGCTGGTGCGTTTCTACGTGGGTC
TGGAAGACGAAGCCGACCTGCGCGCGGACATCGAGCGCGCGATGCAGGCCGCGCTGGGCTGA

Upstream 100 bases:

>100_bases
GGTGTGCGCGGCGCGCATTGTATCGGGCCAACCGCGCCGATTTTGGCTACTCTAACGACATATTCCGCAACCGAACGGCC
TCGTGCCCGGCCTCCAAGTC

Downstream 100 bases:

>100_bases
TCGCGGGCCGGCAACGTCCGGCACAAAAGCAAAACGCCGGCGCGATGCGATATCGCGCCGGCGTTTTTCATTGAGGGTGC
CGCAGGATCAGAACAGTCGC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTASTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHDDNQWRYGLHATPTSLALAQRLAEIEGG
THALLQPSGLAAIMNVYFGIVKAGDDVLVPHNVYGPNADFGNWLANDFGITVRFYDPLIGAGIAELIQPNTRLIWLEAPG
SVTMEVPDVHAITAAAKARGIVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARM
RCGIGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHASFMRDFKGAGGLFSVVFDER
YSAEQVDRFVESLELFAIGWSWGGACSLAMPYDVASMRPDWPHRGTLVRFYVGLEDEADLRADIERAMQAALG

Sequences:

>Translated_393_residues
MTASTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHDDNQWRYGLHATPTSLALAQRLAEIEGG
THALLQPSGLAAIMNVYFGIVKAGDDVLVPHNVYGPNADFGNWLANDFGITVRFYDPLIGAGIAELIQPNTRLIWLEAPG
SVTMEVPDVHAITAAAKARGIVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARM
RCGIGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHASFMRDFKGAGGLFSVVFDER
YSAEQVDRFVESLELFAIGWSWGGACSLAMPYDVASMRPDWPHRGTLVRFYVGLEDEADLRADIERAMQAALG
>Mature_392_residues
TASTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHDDNQWRYGLHATPTSLALAQRLAEIEGGT
HALLQPSGLAAIMNVYFGIVKAGDDVLVPHNVYGPNADFGNWLANDFGITVRFYDPLIGAGIAELIQPNTRLIWLEAPGS
VTMEVPDVHAITAAAKARGIVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARMR
CGIGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHASFMRDFKGAGGLFSVVFDERY
SAEQVDRFVESLELFAIGWSWGGACSLAMPYDVASMRPDWPHRGTLVRFYVGLEDEADLRADIERAMQAALG

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=374, Percent_Identity=30.7486631016043, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI299473759, Length=286, Percent_Identity=32.8671328671329, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI25453487, Length=373, Percent_Identity=28.4182305630027, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1789383, Length=362, Percent_Identity=37.5690607734807, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=29.7872340425532, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560056, Length=379, Percent_Identity=31.6622691292876, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17538055, Length=374, Percent_Identity=31.8181818181818, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71980708, Length=375, Percent_Identity=29.8666666666667, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=325, Percent_Identity=37.5384615384615, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319307, Length=347, Percent_Identity=28.2420749279539, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323333, Length=418, Percent_Identity=24.8803827751196, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321904, Length=368, Percent_Identity=25, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6321254, Length=262, Percent_Identity=29.3893129770992, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922554, Length=390, Percent_Identity=31.7948717948718, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42559; Mature: 42428

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHDDNQWRYG
CCCCCHHHHHHHHCCCCCCCCHHHHHHHCCHHHHCCEEECCCHHHHEEEEEECCCCEEEE
LHATPTSLALAQRLAEIEGGTHALLQPSGLAAIMNVYFGIVKAGDDVLVPHNVYGPNADF
CCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHEECCCCEECCCCCCCCCCCC
GNWLANDFGITVRFYDPLIGAGIAELIQPNTRLIWLEAPGSVTMEVPDVHAITAAAKARG
HHHHHHCCEEEEEEECCHHHCCHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCC
IVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARM
EEEEECCCCCCCCEECCHHCCCCEEEEEEHHHCCCCCCEEEEEEEEECCEEHHHHEEEHH
RCGIGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHA
HCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
SFMRDFKGAGGLFSVVFDERYSAEQVDRFVESLELFAIGWSWGGACSLAMPYDVASMRPD
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCEEEEECCCCHHHCCCC
WPHRGTLVRFYVGLEDEADLRADIERAMQAALG
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TASTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRALVWHDDNQWRYG
CCCCHHHHHHHHCCCCCCCCHHHHHHHCCHHHHCCEEECCCHHHHEEEEEECCCCEEEE
LHATPTSLALAQRLAEIEGGTHALLQPSGLAAIMNVYFGIVKAGDDVLVPHNVYGPNADF
CCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHEECCCCEECCCCCCCCCCCC
GNWLANDFGITVRFYDPLIGAGIAELIQPNTRLIWLEAPGSVTMEVPDVHAITAAAKARG
HHHHHHCCEEEEEEECCHHHCCHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCC
IVTAIDNTFSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITANAELHAKLKLARM
EEEEECCCCCCCCEECCHHCCCCEEEEEEHHHCCCCCCEEEEEEEEECCEEHHHHEEEHH
RCGIGVSVDDCSLVLRSLPSMQVRFDAHSKSALALAQWLKARPEIAAVLHPQIADCPGHA
HCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
SFMRDFKGAGGLFSVVFDERYSAEQVDRFVESLELFAIGWSWGGACSLAMPYDVASMRPD
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCEEEEECCCCHHHCCCC
WPHRGTLVRFYVGLEDEADLRADIERAMQAALG
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]