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The map label for this gene is hprA [H]

Identifier: 116689712

GI number: 116689712

Start: 1878148

End: 1879182

Strand: Reverse

Name: hprA [H]

Synonym: Bcen2424_1690

Alternate gene names: 116689712

Gene position: 1879182-1878148 (Counterclockwise)

Preceding gene: 116689718

Following gene: 116689704

Centisome position: 53.94

GC content: 70.05

Gene sequence:

>1035_bases
ATGGCGCACGCGCCGCCGGCAGAATCGAAGCCGTTCCGCGCCGCCGGGCGCCTGCCAGCGAGACCCGCCATGTTTTCCGT
TTCCGCTCCCGCGAAGATCGTGTTCCTCGACCGCGCGACGCTGTCGCCGCAGATCGGGCTGAAGCCGTTTCCGTTCCCGC
ACATAGTGCAGACATTCGACCGGACGGCCGCACACGAGGTCGCGGCGCGCATCCGCGACGCGGACATCGTCGTGACCAAC
AAGGTGCGGCTCGACGCGGCGGCCCTCGCCGCCGCGCGGCCGTTGCGGATGATCGCGATCGCCGCGACCGGCACGGACAT
CGTCGATCTCGATACCTGTGCGGCACGCGGGATCGTCGTGAGCAATATTCGCGGCTATGCGGTGCGCACGGTGCCCGAGC
ACACGTTCGCGCTGATCTTCGCGCTGCGGCGCAGCCTCGTCGCTTATCGCGACGCGGTGCGCGCGGGGCGCTGGCTCGAC
AGCGGACAGTTCTGCTTCTTCGATCACCCAATTCGCGACCTGGCCGGTTCGACGCTCGGGATCGTCGGCGACGGCGCGCT
CGGGCGCGCGGTGGCCGCCATCGCACGTGCGCTCGACATGCGGGTGCTGTTCGCGGCGCACGGCGACACATCGGGCGACG
GTCATGCGCCGCTCGACACGCTGCTGCGCGACAGCGACGTGATTACGCTGCACTGCCCGCTCACGCCGGCCACGCGGCAC
CTGATCGACGCACACGCGTTTGCGCGGATGGCGCGCCGGCCGCTGCTGATCAATACCGCGCGCGGCGGGCTCGTGGACGA
ACGCGCGCTCGTCGATGCGTTGCAGTCGGGGCAGATCGCGGGCGCCGGGTTCGACGTGGTCACGCAGGAACCGCTGCCGG
CCGCGCATCCGTTTCACGCGATCCTGTCGCATCCGGCGTTCATCCTGACGCCGCACGTTGCGTGGGCGAGCGACGAGGCG
ATGCAGGCGCTGGCCGATCAGCTCGTCGACAACATCGCCGCGTTCGCCGGTGGTGAACCGCGGCATGTCGTGTGA

Upstream 100 bases:

>100_bases
CCGAAACGGAAAGGCGGCCGCCGATGCGAGCATGGCGTCGGTCACGTAGCGAGCCTCTGCCTTTCCTTGCGGGAAAGCCC
GCTCGCGCAACGATCAAACG

Downstream 100 bases:

>100_bases
CACGCACCAACAGAACGGCCCCGCTCGATTGCTCGAAGCGGGGCCGGCTGAATGCGGGGCTGCTTACGCCAGCGACTCGG
CACGTAACGGGTTCGTGCAT

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: GDH; Glyoxylate reductase; Hydroxypyruvate dehydrogenase; NADH-dependent hydroxypyruvate reductase; HPR; HPR-A [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MAHAPPAESKPFRAAGRLPARPAMFSVSAPAKIVFLDRATLSPQIGLKPFPFPHIVQTFDRTAAHEVAARIRDADIVVTN
KVRLDAAALAAARPLRMIAIAATGTDIVDLDTCAARGIVVSNIRGYAVRTVPEHTFALIFALRRSLVAYRDAVRAGRWLD
SGQFCFFDHPIRDLAGSTLGIVGDGALGRAVAAIARALDMRVLFAAHGDTSGDGHAPLDTLLRDSDVITLHCPLTPATRH
LIDAHAFARMARRPLLINTARGGLVDERALVDALQSGQIAGAGFDVVTQEPLPAAHPFHAILSHPAFILTPHVAWASDEA
MQALADQLVDNIAAFAGGEPRHVV

Sequences:

>Translated_344_residues
MAHAPPAESKPFRAAGRLPARPAMFSVSAPAKIVFLDRATLSPQIGLKPFPFPHIVQTFDRTAAHEVAARIRDADIVVTN
KVRLDAAALAAARPLRMIAIAATGTDIVDLDTCAARGIVVSNIRGYAVRTVPEHTFALIFALRRSLVAYRDAVRAGRWLD
SGQFCFFDHPIRDLAGSTLGIVGDGALGRAVAAIARALDMRVLFAAHGDTSGDGHAPLDTLLRDSDVITLHCPLTPATRH
LIDAHAFARMARRPLLINTARGGLVDERALVDALQSGQIAGAGFDVVTQEPLPAAHPFHAILSHPAFILTPHVAWASDEA
MQALADQLVDNIAAFAGGEPRHVV
>Mature_343_residues
AHAPPAESKPFRAAGRLPARPAMFSVSAPAKIVFLDRATLSPQIGLKPFPFPHIVQTFDRTAAHEVAARIRDADIVVTNK
VRLDAAALAAARPLRMIAIAATGTDIVDLDTCAARGIVVSNIRGYAVRTVPEHTFALIFALRRSLVAYRDAVRAGRWLDS
GQFCFFDHPIRDLAGSTLGIVGDGALGRAVAAIARALDMRVLFAAHGDTSGDGHAPLDTLLRDSDVITLHCPLTPATRHL
IDAHAFARMARRPLLINTARGGLVDERALVDALQSGQIAGAGFDVVTQEPLPAAHPFHAILSHPAFILTPHVAWASDEAM
QALADQLVDNIAAFAGGEPRHVV

Specific function: Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=281, Percent_Identity=32.0284697508897, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI4557497, Length=284, Percent_Identity=31.6901408450704, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI61743967, Length=277, Percent_Identity=32.4909747292419, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI145580578, Length=277, Percent_Identity=32.129963898917, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI4557499, Length=277, Percent_Identity=32.129963898917, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI145580575, Length=277, Percent_Identity=32.129963898917, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI6912396, Length=258, Percent_Identity=29.8449612403101, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI87082289, Length=299, Percent_Identity=33.4448160535117, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1789279, Length=280, Percent_Identity=31.4285714285714, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787645, Length=267, Percent_Identity=28.4644194756554, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI87081824, Length=143, Percent_Identity=34.2657342657343, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788660, Length=284, Percent_Identity=29.5774647887324, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=270, Percent_Identity=30.7407407407407, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=278, Percent_Identity=25.8992805755396, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=285, Percent_Identity=31.5789473684211, Blast_Score=129, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=284, Percent_Identity=31.3380281690141, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6324055, Length=265, Percent_Identity=30.5660377358491, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=321, Percent_Identity=28.0373831775701, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=142, Percent_Identity=32.3943661971831, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=289, Percent_Identity=31.8339100346021, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24646446, Length=251, Percent_Identity=34.2629482071713, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646448, Length=251, Percent_Identity=34.2629482071713, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646452, Length=251, Percent_Identity=34.2629482071713, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646450, Length=251, Percent_Identity=34.2629482071713, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI62472511, Length=278, Percent_Identity=32.0143884892086, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585516, Length=264, Percent_Identity=30.3030303030303, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28571528, Length=264, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28574286, Length=285, Percent_Identity=29.4736842105263, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=28.7719298245614, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=28.7719298245614, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=28.7719298245614, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=28.7719298245614, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=28.7719298245614, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.29 [H]

Molecular weight: Translated: 36627; Mature: 36495

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHAPPAESKPFRAAGRLPARPAMFSVSAPAKIVFLDRATLSPQIGLKPFPFPHIVQTFD
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHH
RTAAHEVAARIRDADIVVTNKVRLDAAALAAARPLRMIAIAATGTDIVDLDTCAARGIVV
HHHHHHHHHHHCCCEEEEECCEEHHHHHHHHHCCEEEEEEEECCCCEEECHHHHHCCEEE
SNIRGYAVRTVPEHTFALIFALRRSLVAYRDAVRAGRWLDSGQFCFFDHPIRDLAGSTLG
ECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHCCCEEE
IVGDGALGRAVAAIARALDMRVLFAAHGDTSGDGHAPLDTLLRDSDVITLHCPLTPATRH
EEECCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHCCCCEEEEECCCCHHHHH
LIDAHAFARMARRPLLINTARGGLVDERALVDALQSGQIAGAGFDVVTQEPLPAAHPFHA
HHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHH
ILSHPAFILTPHVAWASDEAMQALADQLVDNIAAFAGGEPRHVV
HHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AHAPPAESKPFRAAGRLPARPAMFSVSAPAKIVFLDRATLSPQIGLKPFPFPHIVQTFD
CCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHH
RTAAHEVAARIRDADIVVTNKVRLDAAALAAARPLRMIAIAATGTDIVDLDTCAARGIVV
HHHHHHHHHHHCCCEEEEECCEEHHHHHHHHHCCEEEEEEEECCCCEEECHHHHHCCEEE
SNIRGYAVRTVPEHTFALIFALRRSLVAYRDAVRAGRWLDSGQFCFFDHPIRDLAGSTLG
ECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHCCCEEE
IVGDGALGRAVAAIARALDMRVLFAAHGDTSGDGHAPLDTLLRDSDVITLHCPLTPATRH
EEECCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHCCCCEEEEECCCCHHHHH
LIDAHAFARMARRPLLINTARGGLVDERALVDALQSGQIAGAGFDVVTQEPLPAAHPFHA
HHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHH
ILSHPAFILTPHVAWASDEAMQALADQLVDNIAAFAGGEPRHVV
HHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144463; 1729225; 1657886 [H]