Click here to switch to the map view.

The map label for this gene is kgtP [H]

Identifier: 116689638

GI number: 116689638

Start: 1780071

End: 1781375

Strand: Direct

Name: kgtP [H]

Synonym: Bcen2424_1616

Alternate gene names: 116689638

Gene position: 1780071-1781375 (Clockwise)

Preceding gene: 116689637

Following gene: 116689639

Centisome position: 51.09

GC content: 65.98

Gene sequence:

>1305_bases
ATGGACGTCCAGACCGACCAAGCTGCGCTGTCCGCGCAAGACACCCGGCGGCGCGTGTTCGCCATCGTCGGCGCCTCATC
GGGCAACCTCGTCGAGTGGTTCGACTTCTACATCTACTCGTTCTGCGCGCTGTACTTCGCGCCGGCATTCTTCCCGAGCG
GCAACACGACGACGCAGCTGCTGAACACGGCCGGCGTGTTCGCGGCCGGCTTCCTGATGCGTCCGATCGGCGGCTGGCTG
TTCGGCCGCATCGCCGACCGGCACGGCCGTCGCGCGGCGATGATGATCTCGGTGCTGATGATGTGCGGCGGGTCGCTCGT
GATCGCGGTGCTGCCGACCTATGCGCAGATCGGCGCGCTCGCGCCGGCGCTGCTGCTGGTCGCGCGCCTGTTCCAGGGCC
TGTCGGTGGGCGGCGAATACGGGACGAGCGCGACCTACATGAGTGAAGTGGCATTGAAGGGCCGTCGCGGCTTCTTCGCG
TCGTTCCAGTACGTGACGCTGATCGGCGGCCAGCTGTGCGCGCTGCTGGTGCTCGTGATCCTGCAGCAGACGCTGTCGGC
CGGCGAGCTGAAAGCGTGGGGCTGGCGCATTCCGTTCGTGGTCGGCGCGGCGGCCGCGCTGATTTCGCTGTACCTGCGCA
AATCGCTCGACGAGACGTCGACGAGCGCATCGCGCGACAAGAAGGACGCCGGCACGATCCGCGGCGTGTGGCAGCACAAG
GGCGCGTTCTTCACGGTGGTCGGCTTCACGGCCGGCGGCTCGCTGATCTTCTACACGTTCACGACGTACATGCAGAAGTA
CCTCGTGAACACGGCCGGCATGCACGCGAAGACGGCCAGCAACGTGATGACCGTCGCGCTGCTCGTTTACATGCTGATGC
AGCCGGTGTTCGGCGCGCTGTCGGACAAGATCGGCCGCCGCACGTCGATGATCCTGTTCGGTTCGTTCGCGGTGATCGGC
ACGGTGCCGCTGATGCATGCGCTGAAGGGCGTGACGAGCCCGGTGGCCGCGTTCGTGCTGATCACGGTTGCGCTGGCGAT
CGTCAGCTTCTACACGTCGATCAGCGGCCTGATCAAGGCCGAGATGTTTCCGCCGGAAGTGCGCGCGATGGGCGTGGGCC
TGTCGTATGCGGTCGCGAACGCGATCTTCGGCGGTTCGGCCGAGTACGTCGCGCTGTGGTTCAAGTCGATCGGCAGCGAG
GAAACGTTCTACTGGTACGTGACCGTGCTGTGCGCGATCTCGCTGATCGTGTCGTGGCGGATGCGCGATCCGAGCAAGGA
AGGGTACCTGCGCCACGAGCCGTGA

Upstream 100 bases:

>100_bases
AATCCCGTAGCGCCGTGCGCCGGAACCGGTGCCACGTGCGACCGCACGCGGCGGCCCCAGCCGTCTCGCCCAGAAAGCAC
TAAAAGGAACAGACCAACCC

Downstream 100 bases:

>100_bases
TCGGTCGCGCGTGGCGCGTACTCGCATCATGACGAACGTCCCGCCGGTTGGCGGGACGTTTTTTTTGCGGCGTGCGATGA
CGTGCGCGGCGGCATCCACT

Product: major facilitator superfamily metabolite/H(+) symporter

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MDVQTDQAALSAQDTRRRVFAIVGASSGNLVEWFDFYIYSFCALYFAPAFFPSGNTTTQLLNTAGVFAAGFLMRPIGGWL
FGRIADRHGRRAAMMISVLMMCGGSLVIAVLPTYAQIGALAPALLLVARLFQGLSVGGEYGTSATYMSEVALKGRRGFFA
SFQYVTLIGGQLCALLVLVILQQTLSAGELKAWGWRIPFVVGAAAALISLYLRKSLDETSTSASRDKKDAGTIRGVWQHK
GAFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMHAKTASNVMTVALLVYMLMQPVFGALSDKIGRRTSMILFGSFAVIG
TVPLMHALKGVTSPVAAFVLITVALAIVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANAIFGGSAEYVALWFKSIGSE
ETFYWYVTVLCAISLIVSWRMRDPSKEGYLRHEP

Sequences:

>Translated_434_residues
MDVQTDQAALSAQDTRRRVFAIVGASSGNLVEWFDFYIYSFCALYFAPAFFPSGNTTTQLLNTAGVFAAGFLMRPIGGWL
FGRIADRHGRRAAMMISVLMMCGGSLVIAVLPTYAQIGALAPALLLVARLFQGLSVGGEYGTSATYMSEVALKGRRGFFA
SFQYVTLIGGQLCALLVLVILQQTLSAGELKAWGWRIPFVVGAAAALISLYLRKSLDETSTSASRDKKDAGTIRGVWQHK
GAFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMHAKTASNVMTVALLVYMLMQPVFGALSDKIGRRTSMILFGSFAVIG
TVPLMHALKGVTSPVAAFVLITVALAIVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANAIFGGSAEYVALWFKSIGSE
ETFYWYVTVLCAISLIVSWRMRDPSKEGYLRHEP
>Mature_434_residues
MDVQTDQAALSAQDTRRRVFAIVGASSGNLVEWFDFYIYSFCALYFAPAFFPSGNTTTQLLNTAGVFAAGFLMRPIGGWL
FGRIADRHGRRAAMMISVLMMCGGSLVIAVLPTYAQIGALAPALLLVARLFQGLSVGGEYGTSATYMSEVALKGRRGFFA
SFQYVTLIGGQLCALLVLVILQQTLSAGELKAWGWRIPFVVGAAAALISLYLRKSLDETSTSASRDKKDAGTIRGVWQHK
GAFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMHAKTASNVMTVALLVYMLMQPVFGALSDKIGRRTSMILFGSFAVIG
TVPLMHALKGVTSPVAAFVLITVALAIVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANAIFGGSAEYVALWFKSIGSE
ETFYWYVTVLCAISLIVSWRMRDPSKEGYLRHEP

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=422, Percent_Identity=69.9052132701422, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1790550, Length=425, Percent_Identity=29.6470588235294, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1788292, Length=435, Percent_Identity=28.2758620689655, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789941, Length=424, Percent_Identity=31.3679245283019, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082231, Length=325, Percent_Identity=26.1538461538462, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082404, Length=312, Percent_Identity=25.6410256410256, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 46959; Mature: 46959

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVQTDQAALSAQDTRRRVFAIVGASSGNLVEWFDFYIYSFCALYFAPAFFPSGNTTTQL
CCCCCHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LNTAGVFAAGFLMRPIGGWLFGRIADRHGRRAAMMISVLMMCGGSLVIAVLPTYAQIGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHH
APALLLVARLFQGLSVGGEYGTSATYMSEVALKGRRGFFASFQYVTLIGGQLCALLVLVI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LQQTLSAGELKAWGWRIPFVVGAAAALISLYLRKSLDETSTSASRDKKDAGTIRGVWQHK
HHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
GAFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMHAKTASNVMTVALLVYMLMQPVFGAL
CCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SDKIGRRTSMILFGSFAVIGTVPLMHALKGVTSPVAAFVLITVALAIVSFYTSISGLIKA
HHHHCCHHEEHEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMFPPEVRAMGVGLSYAVANAIFGGSAEYVALWFKSIGSEETFYWYVTVLCAISLIVSWR
CCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
MRDPSKEGYLRHEP
CCCCCCCCCCCCCC
>Mature Secondary Structure
MDVQTDQAALSAQDTRRRVFAIVGASSGNLVEWFDFYIYSFCALYFAPAFFPSGNTTTQL
CCCCCHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LNTAGVFAAGFLMRPIGGWLFGRIADRHGRRAAMMISVLMMCGGSLVIAVLPTYAQIGAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHH
APALLLVARLFQGLSVGGEYGTSATYMSEVALKGRRGFFASFQYVTLIGGQLCALLVLVI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LQQTLSAGELKAWGWRIPFVVGAAAALISLYLRKSLDETSTSASRDKKDAGTIRGVWQHK
HHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
GAFFTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMHAKTASNVMTVALLVYMLMQPVFGAL
CCEEEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SDKIGRRTSMILFGSFAVIGTVPLMHALKGVTSPVAAFVLITVALAIVSFYTSISGLIKA
HHHHCCHHEEHEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMFPPEVRAMGVGLSYAVANAIFGGSAEYVALWFKSIGSEETFYWYVTVLCAISLIVSWR
CCCCCHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
MRDPSKEGYLRHEP
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]