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The map label for this gene is yjcE [H]

Identifier: 116689413

GI number: 116689413

Start: 1535373

End: 1536953

Strand: Reverse

Name: yjcE [H]

Synonym: Bcen2424_1391

Alternate gene names: 116689413

Gene position: 1536953-1535373 (Counterclockwise)

Preceding gene: 116689414

Following gene: 116689412

Centisome position: 44.12

GC content: 71.47

Gene sequence:

>1581_bases
ATGACCAACGTCGAGCTGTTCCATTACCTGTTGCTGTTGATCTGCGGCGCGGGCGCCCTCACCTGGCTCGCCGAGCGCGT
GTCGATTCCGCCGGCCGTCGTGCTGCTGCTCGGCGGCTGCGTGGTCGCCGTCGCCGGCAAGCGCGTGCCCGACATGGACC
CGGCGCTGCTGCTCGCGGCCGTGCTGCCGCCGCTGCTGATGTCGAGCGGGTTCTACACCGCGTGGAAGGAATTCCGGCAG
GAGCTCGCGTCGATCGCGTCGCTCGCGCTCGGGGCCGTGGCGTTCACGACCGTCGCGGTCGCGCTCGCCGTGCATGCGGC
CAATCCGTCGCTGCCGTGGGCCGCGTGCTTCACGCTCGGCGCGATCGTGTCGCCGCCCGACGCGGTCGCCGCAAAGGCGA
TCCTGCAGCGCCACCCGCTGCCCGCGCGGCTCGTCGCGGTGCTCGAAGGCGAAAGCCTCGTCAACGATGCGTCGGGCCTG
CTGCTGTACCAGATGGCCGTATCGGCCGCGCTCGCCGCCACGATCACGACCGCGAGCGCGACCGGCCTGTTCTTCTCGCT
CACGCTGATCGGCATCGCGGTCGGCCTCGCATGCGGCCATGCGATGTGCTGGGTGCTGCAACGCCTGCGCGAACCGATGC
TCGGCATCGTCGTGACGTTCGCGATGGCATGGGGCAGCTACGGGATCGCGGAAGCCGTCGACGGCTCGGGCGTGCTGTCG
GTCGTCACCTGCGGCCTCGTGCTCGGCGTGCGCCAGCATCGCGTGTTCGGCGCCGACATGCGGATCAAGGCGAAGGCGAC
GTGGGAAGCGATCGTGTTCGTACTCGACGCGCTCGTGTTCATCCTGATCGGCCTCGCGCTGCACGCGATTCTCGCGGGCG
TGAACCACGAAGGCGCGGTGCTGATGGCCGGCCTGCGGGTCGCGCTGCCGGCGACGGCCGCCGCGATCGGCGCGCGCGTA
GTGTGGGTGTTCGTCGCGATGTGGCTGCCGGGCCGCCTGCGCGCGCGGCGCGCGGGCCACGCGGCATGGTCGTGGCGCGA
AGCCGTCGTCCTCGGCTGGTCGGGCATGCGCGGCGTCGTGAGCCTCGCGGCCGCGATTGCGCTGCCGGCCAATTTCCCCG
GCCGCGACCTGATCCTGTTCAGCACGTTCCTGCTGATCATCGCGACGCTCGTCGTGCAGGGCGGCACGCTCGCGCCGCTG
ATCCGCGTGCTGAAGCTGCGCCCGGCCGCGCGCCGCACGATGTCCGAACATGCGGTGCGGGCGCACACGTTCGGCGCGGC
GCTCGCCGAGCTCGATGCGCGCGAGCAACGCGGCGCGGGCCTCGAACGCGCGTCGCTCGACCGGCTGCTGACCGAATACC
GGAGCCGCGTCGCGTTCAACGAGCACGCACATCGCGACGGCGCGGAGCCCGCGGACGTGCGCGCGCGGATGCTGCGCGTC
GAGCTCGAGCTGGTCGGCGTGTCGCGCGACGCGTTGCTCGACCTGCATCGCGACGGCCGGGTCGACGACGCGGTGCTGCA
CCGCATAGAATCGGAGCTCGATTTCGAGGAGTTGCGGCTGCAGCGCCTGCTCGAACCTTAA

Upstream 100 bases:

>100_bases
CGCGACGCGCAGTGCAGCCAGCACATGTTCGGCGCGCTGCCGGGCGGCGCCGCGAACGACCGCAAGCCTTCTTGATCCAC
CCCATCGCCGCCGGCCGCGC

Downstream 100 bases:

>100_bases
CGTCTGGCCTGCCGGCCCGCCCCCTTTTCTCCACATGGAATTTCAATGAGCGAACTCACCGTCGAAGCGAGCATCGGCCC
GGTCGATTACCTCGTCCACT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MTNVELFHYLLLLICGAGALTWLAERVSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAAVLPPLLMSSGFYTAWKEFRQ
ELASIASLALGAVAFTTVAVALAVHAANPSLPWAACFTLGAIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGL
LLYQMAVSAALAATITTASATGLFFSLTLIGIAVGLACGHAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEAVDGSGVLS
VVTCGLVLGVRQHRVFGADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNHEGAVLMAGLRVALPATAAAIGARV
VWVFVAMWLPGRLRARRAGHAAWSWREAVVLGWSGMRGVVSLAAAIALPANFPGRDLILFSTFLLIIATLVVQGGTLAPL
IRVLKLRPAARRTMSEHAVRAHTFGAALAELDAREQRGAGLERASLDRLLTEYRSRVAFNEHAHRDGAEPADVRARMLRV
ELELVGVSRDALLDLHRDGRVDDAVLHRIESELDFEELRLQRLLEP

Sequences:

>Translated_526_residues
MTNVELFHYLLLLICGAGALTWLAERVSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAAVLPPLLMSSGFYTAWKEFRQ
ELASIASLALGAVAFTTVAVALAVHAANPSLPWAACFTLGAIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGL
LLYQMAVSAALAATITTASATGLFFSLTLIGIAVGLACGHAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEAVDGSGVLS
VVTCGLVLGVRQHRVFGADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNHEGAVLMAGLRVALPATAAAIGARV
VWVFVAMWLPGRLRARRAGHAAWSWREAVVLGWSGMRGVVSLAAAIALPANFPGRDLILFSTFLLIIATLVVQGGTLAPL
IRVLKLRPAARRTMSEHAVRAHTFGAALAELDAREQRGAGLERASLDRLLTEYRSRVAFNEHAHRDGAEPADVRARMLRV
ELELVGVSRDALLDLHRDGRVDDAVLHRIESELDFEELRLQRLLEP
>Mature_525_residues
TNVELFHYLLLLICGAGALTWLAERVSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAAVLPPLLMSSGFYTAWKEFRQE
LASIASLALGAVAFTTVAVALAVHAANPSLPWAACFTLGAIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGLL
LYQMAVSAALAATITTASATGLFFSLTLIGIAVGLACGHAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEAVDGSGVLSV
VTCGLVLGVRQHRVFGADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNHEGAVLMAGLRVALPATAAAIGARVV
WVFVAMWLPGRLRARRAGHAAWSWREAVVLGWSGMRGVVSLAAAIALPANFPGRDLILFSTFLLIIATLVVQGGTLAPLI
RVLKLRPAARRTMSEHAVRAHTFGAALAELDAREQRGAGLERASLDRLLTEYRSRVAFNEHAHRDGAEPADVRARMLRVE
LELVGVSRDALLDLHRDGRVDDAVLHRIESELDFEELRLQRLLEP

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI27734935, Length=377, Percent_Identity=25.7294429708223, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI14211919, Length=392, Percent_Identity=23.7244897959184, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI15529998, Length=394, Percent_Identity=22.0812182741117, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI148727259, Length=393, Percent_Identity=21.6284987277354, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI294997330, Length=390, Percent_Identity=24.8717948717949, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI110227626, Length=390, Percent_Identity=24.8717948717949, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI5454070, Length=386, Percent_Identity=24.8704663212435, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI41872703, Length=454, Percent_Identity=21.8061674008811, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4759144, Length=457, Percent_Identity=25.164113785558, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI194239733, Length=481, Percent_Identity=20.7900207900208, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI27777632, Length=410, Percent_Identity=22.6829268292683, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790501, Length=497, Percent_Identity=29.3762575452716, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71980847, Length=462, Percent_Identity=22.2943722943723, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71993590, Length=374, Percent_Identity=21.9251336898396, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71993582, Length=374, Percent_Identity=21.9251336898396, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25150332, Length=408, Percent_Identity=22.3039215686275, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71999817, Length=485, Percent_Identity=21.0309278350515, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71999819, Length=485, Percent_Identity=21.0309278350515, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71999821, Length=485, Percent_Identity=21.0309278350515, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI25147678, Length=442, Percent_Identity=23.0769230769231, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71990932, Length=386, Percent_Identity=21.2435233160622, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71987535, Length=391, Percent_Identity=21.9948849104859, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71990924, Length=386, Percent_Identity=20.9844559585492, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987537, Length=391, Percent_Identity=21.9948849104859, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71992107, Length=369, Percent_Identity=20.0542005420054, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71992101, Length=369, Percent_Identity=20.0542005420054, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71987559, Length=425, Percent_Identity=20.4705882352941, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71987545, Length=425, Percent_Identity=20.4705882352941, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=440, Percent_Identity=20.9090909090909, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221473215, Length=420, Percent_Identity=25, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI281364513, Length=378, Percent_Identity=25.9259259259259, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI221473212, Length=378, Percent_Identity=25.9259259259259, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI221473222, Length=378, Percent_Identity=25.9259259259259, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281360447, Length=416, Percent_Identity=22.8365384615385, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI221510734, Length=393, Percent_Identity=23.4096692111959, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221510738, Length=393, Percent_Identity=23.6641221374046, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI221510732, Length=391, Percent_Identity=23.2736572890026, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221510736, Length=391, Percent_Identity=23.2736572890026, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585580, Length=386, Percent_Identity=23.3160621761658, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585578, Length=386, Percent_Identity=23.3160621761658, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221510740, Length=386, Percent_Identity=23.3160621761658, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56012; Mature: 55881

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNVELFHYLLLLICGAGALTWLAERVSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAA
CCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
VLPPLLMSSGFYTAWKEFRQELASIASLALGAVAFTTVAVALAVHAANPSLPWAACFTLG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGLLLYQMAVSAALAATITTASA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLFFSLTLIGIAVGLACGHAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEAVDGSGVLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHH
VVTCGLVLGVRQHRVFGADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNHEGAV
HHHHHHHHHHHHHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
LMAGLRVALPATAAAIGARVVWVFVAMWLPGRLRARRAGHAAWSWREAVVLGWSGMRGVV
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHEECCCCHHHHH
SLAAAIALPANFPGRDLILFSTFLLIIATLVVQGGTLAPLIRVLKLRPAARRTMSEHAVR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHH
AHTFGAALAELDAREQRGAGLERASLDRLLTEYRSRVAFNEHAHRDGAEPADVRARMLRV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ELELVGVSRDALLDLHRDGRVDDAVLHRIESELDFEELRLQRLLEP
HHHHEECCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TNVELFHYLLLLICGAGALTWLAERVSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAA
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
VLPPLLMSSGFYTAWKEFRQELASIASLALGAVAFTTVAVALAVHAANPSLPWAACFTLG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGLLLYQMAVSAALAATITTASA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLFFSLTLIGIAVGLACGHAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEAVDGSGVLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHH
VVTCGLVLGVRQHRVFGADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNHEGAV
HHHHHHHHHHHHHHEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
LMAGLRVALPATAAAIGARVVWVFVAMWLPGRLRARRAGHAAWSWREAVVLGWSGMRGVV
EEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHEECCCCHHHHH
SLAAAIALPANFPGRDLILFSTFLLIIATLVVQGGTLAPLIRVLKLRPAARRTMSEHAVR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHH
AHTFGAALAELDAREQRGAGLERASLDRLLTEYRSRVAFNEHAHRDGAEPADVRARMLRV
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ELELVGVSRDALLDLHRDGRVDDAVLHRIESELDFEELRLQRLLEP
HHHHEECCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]