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The map label for this gene is glmS [H]

Identifier: 116689349

GI number: 116689349

Start: 1460487

End: 1462304

Strand: Reverse

Name: glmS [H]

Synonym: Bcen2424_1327

Alternate gene names: 116689349

Gene position: 1462304-1460487 (Counterclockwise)

Preceding gene: 116689350

Following gene: 116689348

Centisome position: 41.97

GC content: 66.61

Gene sequence:

>1818_bases
ATGTGTGGCATCGTCGGCGCGGTCGCGCAACGGGATATCGTCCCGATTCTGATCGAAGGTTTGCGCCGCCTCGAATATCG
CGGCTACGATTCATGCGGAGTGGCGACCGTCGTCGACGGCCAGGCACGCCGCGAGCGCAGCATGTCGCGCGTCGCCGATC
TCGACGCCCACGTGCGCAGTGCCGGCCTCGCCGGCAGCACCGGCATCGCGCACACGCGCTGGGCAACCCACGGCGCGCCC
GCGACGTGCAACGCGCATCCGATCTTCTCGCGCGACGAAATCGCGCTGGTGCACAACGGCATCATCGAGAACCATGAAAC
GTTGCGCAAGCAACTGTCCGACGAGCACTACGAATTCGACGGCCAGACCGACACCGAGGTGGTCGCGCATCTGATCCACA
GCAAGTATCGCGGCGACCTGCTCGCCGCCGTGCGCGATGCGACCTCGCAACTGCACGGCGCCTACGCGATCGCGGTGTTC
AGCAAGCACGAGCCGCAGCGGCTGATCGGCGCGCGGGCCGGCTCGCCGCTCGTCGTCGGCGTGAAGGACGGCGAATGCTT
TCTCGCGTCCGACGCGCTCGCGCTCGCCGGCATCACCGACCGCTTCATCTTTCTCGAGGAAGGCGACATCGTCGAGCTGA
CGCCGGGCGGCGTGCGGGTACTCGATCGCACCGGCGCGCCGATCGAACGCGCGATACAAACCATTTCGTCCGCGCAGGGC
GTGGTCGAGCTCGGCCCCTACCGGCACTTCATGCAGAAGGAAATTTTCGAGCAGCCGCAGGCCGTGGCCGCGACGATCCC
CGATGCCGGGCTGTTCGATCCCGCCGTATTCGGCCCGGACGCCGCGCGCGCGTTCGAGCAGATCGACAACGTGCTGATCC
TCGCATGCGGCACGAGCCACTACTCCGGCCTGACCGCACGCCGCTGGCTCGAGACGATCGCACGCATCCCCGCGCAGGTC
GAGATTGCGAGCGAATACCGTTACAGCGACGCGCTTGCGACGCCGAATACGCTGGTGGTCAGCGTGTCGCAATCCGGCGA
GACCGCCGACACGCTCGCCGCCCTCAAGTACGCGCAGGCGCTCGGCCACATCGACACGCTGGCGATCTGCAACGTGCCGA
CCAGCGCGATGATGCGCCAGACCGGACTGCGCTTCCTGACGCGGGCCGGCCCGGAAATCGGCGTCGCGTCGACCAAGGCG
TTCACGACGCAGCTCGTCGCGCTGTTCATTCTCGCGGTGACGCTCGGGCGACTGCGCGGCTACGTCGACGATGCGCAACT
CGCGCGCTATACGACGCAGTTGCGGCGCCTGCCCGGCGCGCTCGAAGACGTGCTGGGGCTGGAGTCGCAGATCGCGCGCT
GGGCGGCGGAATTCTCGCAGCATGAAAACGCGCTGTTTCTCGGGCGCGGGCTGCACTACCCGATCGCGCTCGAAGGCGCG
TTGAAGCTGAAGGAGATTTCGTATATCCACGCGGAAGCGTACCCGGCGGGCGAGCTGAAACACGGGCCGCTCGCGCTCGT
CACGCACACGATGCCCGTTGCGACGATCGCGCCGAACGATGCGCTGCTCGAAAAGCTCAAGTCGAACATGCAGGAAGTGC
GGGCGCGCGGCGGACAGCTTTACGTGTTCGCGGATGCCGATACGCGGATCGACAACGGCGAAGGCGTGTCGGTATTGCGG
ATGCCGGATTACTACGGGTTGCTGTCGCCGATTCTGCACGTCGTGCCGTTGCAGTTGCTCGCGTATCACGCGGCGTGCTT
GCGCGGCGCGGATATCGACAAGCCGAGGAATCTCGCGAAATCGGTGACGGTGGAGTGA

Upstream 100 bases:

>100_bases
GCTCGATGCGGCTTCACGACGGCGGCGACAACGGAGACCGCGTCACGCTGACCCACGCGTGCGCACGGTCCGGGGAAATC
TACAGGGAAGGAGACGTGTC

Downstream 100 bases:

>100_bases
TGCGCTCGCGTAATCCGGGGTGGCCCCGGGAAGATCGCCCAGTGATCAAACTGGCCCGCCCTACACGATTCGAACGTGTG
ACCTACGGCTTAGAAGGCCG

Product: glucosamine--fructose-6-phosphate aminotransferase, isomerizing

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSMSRVADLDAHVRSAGLAGSTGIAHTRWATHGAP
ATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFDGQTDTEVVAHLIHSKYRGDLLAAVRDATSQLHGAYAIAVF
SKHEPQRLIGARAGSPLVVGVKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRTGAPIERAIQTISSAQG
VVELGPYRHFMQKEIFEQPQAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSHYSGLTARRWLETIARIPAQV
EIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQALGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKA
FTTQLVALFILAVTLGRLRGYVDDAQLARYTTQLRRLPGALEDVLGLESQIARWAAEFSQHENALFLGRGLHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQLYVFADADTRIDNGEGVSVLR
MPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAKSVTVE

Sequences:

>Translated_605_residues
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSMSRVADLDAHVRSAGLAGSTGIAHTRWATHGAP
ATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFDGQTDTEVVAHLIHSKYRGDLLAAVRDATSQLHGAYAIAVF
SKHEPQRLIGARAGSPLVVGVKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRTGAPIERAIQTISSAQG
VVELGPYRHFMQKEIFEQPQAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSHYSGLTARRWLETIARIPAQV
EIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQALGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKA
FTTQLVALFILAVTLGRLRGYVDDAQLARYTTQLRRLPGALEDVLGLESQIARWAAEFSQHENALFLGRGLHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQLYVFADADTRIDNGEGVSVLR
MPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAKSVTVE
>Mature_605_residues
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSMSRVADLDAHVRSAGLAGSTGIAHTRWATHGAP
ATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFDGQTDTEVVAHLIHSKYRGDLLAAVRDATSQLHGAYAIAVF
SKHEPQRLIGARAGSPLVVGVKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRTGAPIERAIQTISSAQG
VVELGPYRHFMQKEIFEQPQAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSHYSGLTARRWLETIARIPAQV
EIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQALGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKA
FTTQLVALFILAVTLGRLRGYVDDAQLARYTTQLRRLPGALEDVLGLESQIARWAAEFSQHENALFLGRGLHYPIALEGA
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQLYVFADADTRIDNGEGVSVLR
MPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=692, Percent_Identity=35.8381502890173, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=35.8600583090379, Blast_Score=388, Evalue=1e-108,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=53.1045751633987, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=239, Percent_Identity=26.7782426778243, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082251, Length=316, Percent_Identity=22.7848101265823, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=716, Percent_Identity=33.2402234636872, Blast_Score=333, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17532899, Length=437, Percent_Identity=36.1556064073227, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17532897, Length=437, Percent_Identity=36.1556064073227, Blast_Score=262, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6322745, Length=462, Percent_Identity=37.4458874458874, Blast_Score=271, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=30.8584686774942, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=34.9514563106796, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323958, Length=373, Percent_Identity=25.4691689008043, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=35.4651162790698, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI28573187, Length=257, Percent_Identity=25.6809338521401, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24659598, Length=262, Percent_Identity=24.8091603053435, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65422; Mature: 65422

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSMSRVADLDAHVRS
CCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
AGLAGSTGIAHTRWATHGAPATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHCCHHHHHHHHCCCCEECC
GQTDTEVVAHLIHSKYRGDLLAAVRDATSQLHGAYAIAVFSKHEPQRLIGARAGSPLVVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHCCCCCCEEEE
VKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRTGAPIERAIQTISSAQG
ECCCCEEEECCCHHHHCCCEEEEEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHHCCC
VVELGPYRHFMQKEIFEQPQAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSH
CEEECHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCC
YSGLTARRWLETIARIPAQVEIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQA
CCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
LGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKAFTTQLVALFILAVTLGRLRG
HCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
YVDDAQLARYTTQLRRLPGALEDVLGLESQIARWAAEFSQHENALFLGRGLHYPIALEGA
CCCHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCC
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQL
EEHHHHHEEECCCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCEE
YVFADADTRIDNGEGVSVLRMPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAK
EEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
SVTVE
HCCCC
>Mature Secondary Structure
MCGIVGAVAQRDIVPILIEGLRRLEYRGYDSCGVATVVDGQARRERSMSRVADLDAHVRS
CCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHH
AGLAGSTGIAHTRWATHGAPATCNAHPIFSRDEIALVHNGIIENHETLRKQLSDEHYEFD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHCCHHHHHHHHCCCCEECC
GQTDTEVVAHLIHSKYRGDLLAAVRDATSQLHGAYAIAVFSKHEPQRLIGARAGSPLVVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHCCCCCCEEEE
VKDGECFLASDALALAGITDRFIFLEEGDIVELTPGGVRVLDRTGAPIERAIQTISSAQG
ECCCCEEEECCCHHHHCCCEEEEEEECCCEEEECCCCEEEEECCCCCHHHHHHHHHHCCC
VVELGPYRHFMQKEIFEQPQAVAATIPDAGLFDPAVFGPDAARAFEQIDNVLILACGTSH
CEEECHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCC
YSGLTARRWLETIARIPAQVEIASEYRYSDALATPNTLVVSVSQSGETADTLAALKYAQA
CCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
LGHIDTLAICNVPTSAMMRQTGLRFLTRAGPEIGVASTKAFTTQLVALFILAVTLGRLRG
HCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
YVDDAQLARYTTQLRRLPGALEDVLGLESQIARWAAEFSQHENALFLGRGLHYPIALEGA
CCCHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCC
LKLKEISYIHAEAYPAGELKHGPLALVTHTMPVATIAPNDALLEKLKSNMQEVRARGGQL
EEHHHHHEEECCCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCEE
YVFADADTRIDNGEGVSVLRMPDYYGLLSPILHVVPLQLLAYHAACLRGADIDKPRNLAK
EEEECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
SVTVE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]