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The map label for this gene is 116624214

Identifier: 116624214

GI number: 116624214

Start: 6453456

End: 6454301

Strand: Reverse

Name: 116624214

Synonym: Acid_5130

Alternate gene names: NA

Gene position: 6454301-6453456 (Counterclockwise)

Preceding gene: 116624215

Following gene: 116624213

Centisome position: 64.77

GC content: 61.7

Gene sequence:

>846_bases
ATGAAGATTAGCATTCTAATGGCGGCGATGGTGTTGACCTGCATGGCGGCCGATCCGCCGGAGTGGCGGCAGCCCTTCGC
GGCACATCGCGTGGTGGGAAACATTTACTACGTAGGCACGTACGACCTGGCGAGTTTTCTGATTGTGACGCCCGCGGGCA
ACGTCCTGATCAACGGCGGCATGGGCGATTCGGTGCCACTCATGCGGAAGAGCGTCGCCGACCTGGGCTTTCAGTGGAAG
GACATCCGCTGGATGCTAACCACGCAGGCGCATGCCGATCACGTGGCGGCGTTCGCGGAAATCCAGCGGACCACGGGTGC
GAAGGTAATGGCTACCGAGGCCGACGCGAAGCTGCTGGAAGACGGCGGGAAGAGCGATTTCCATTTCACGGGCGCGGAGT
ATCACTACGCGCCCGTGAAGGTGGTGGAGCGGCTACATGACGGGCAGACGCTGAAGTTCGGCGGCACGGAGATCACGGTC
TACTTGCATCCTGGCCATACGAAGGGTAGCGCCTCTTACGCGATTCCGGTGACGGAAGGCGGGCGGACGTACCGGGTGTT
GATCGCCAACATCGGCACAATCAACCCGGGGGTGAAGCTGCTGGGCGAGAAGAATTATCCGGGGATCGCGGCCGATTACG
CCATGACGTTCGAAAAGCAGAAGGCGCTGAGCTGCGATATTTTCCTTTCTTCGCACGCGGGGCAATACGGCCTGCATAGC
AAGTACAAGCCGGGAGCGCCGTACGATCCCGCGCGGTTTGTGGATCCGGCCGGATACCAGAAGGCGGTAGCGGGCGCGGA
GGCGGCGTACCGGAAACAACTGGCGGAGGAAAAGGCGGCGCATTGA

Upstream 100 bases:

>100_bases
CCGGCGATCCGGCTGTACGAGACAGCGGGCTTCGTGCATGTGCAGAGGACGACGCCATCGGAGTACGACCGCAGCGATGT
TTGCATGGAGATGAGGTTTC

Downstream 100 bases:

>100_bases
CCGGCCCATTTAAGATCGCGCGATCGCTTTGGGCGCCATTGTTGTTTGCCGGGATCGTGCTCGCGCTGAACCCGCACTGG
TTTCAAGCGCCGATTGTGGA

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: Beta-lactamase type II; Penicillinase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKISILMAAMVLTCMAADPPEWRQPFAAHRVVGNIYYVGTYDLASFLIVTPAGNVLINGGMGDSVPLMRKSVADLGFQWK
DIRWMLTTQAHADHVAAFAEIQRTTGAKVMATEADAKLLEDGGKSDFHFTGAEYHYAPVKVVERLHDGQTLKFGGTEITV
YLHPGHTKGSASYAIPVTEGGRTYRVLIANIGTINPGVKLLGEKNYPGIAADYAMTFEKQKALSCDIFLSSHAGQYGLHS
KYKPGAPYDPARFVDPAGYQKAVAGAEAAYRKQLAEEKAAH

Sequences:

>Translated_281_residues
MKISILMAAMVLTCMAADPPEWRQPFAAHRVVGNIYYVGTYDLASFLIVTPAGNVLINGGMGDSVPLMRKSVADLGFQWK
DIRWMLTTQAHADHVAAFAEIQRTTGAKVMATEADAKLLEDGGKSDFHFTGAEYHYAPVKVVERLHDGQTLKFGGTEITV
YLHPGHTKGSASYAIPVTEGGRTYRVLIANIGTINPGVKLLGEKNYPGIAADYAMTFEKQKALSCDIFLSSHAGQYGLHS
KYKPGAPYDPARFVDPAGYQKAVAGAEAAYRKQLAEEKAAH
>Mature_281_residues
MKISILMAAMVLTCMAADPPEWRQPFAAHRVVGNIYYVGTYDLASFLIVTPAGNVLINGGMGDSVPLMRKSVADLGFQWK
DIRWMLTTQAHADHVAAFAEIQRTTGAKVMATEADAKLLEDGGKSDFHFTGAEYHYAPVKVVERLHDGQTLKFGGTEITV
YLHPGHTKGSASYAIPVTEGGRTYRVLIANIGTINPGVKLLGEKNYPGIAADYAMTFEKQKALSCDIFLSSHAGQYGLHS
KYKPGAPYDPARFVDPAGYQKAVAGAEAAYRKQLAEEKAAH

Specific function: Has a high activity against imipenem [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001018
- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 30468; Mature: 30468

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISILMAAMVLTCMAADPPEWRQPFAAHRVVGNIYYVGTYDLASFLIVTPAGNVLINGG
CCHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHCCEEEEEEHHCEEEEEECCCCCEEEECC
MGDSVPLMRKSVADLGFQWKDIRWMLTTQAHADHVAAFAEIQRTTGAKVMATEADAKLLE
CCCCCHHHHHHHHHCCCCEECEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCHHHHHH
DGGKSDFHFTGAEYHYAPVKVVERLHDGQTLKFGGTEITVYLHPGHTKGSASYAIPVTEG
CCCCCCEEECCCEEECHHHHHHHHHCCCCEEEECCEEEEEEECCCCCCCCCEEEEEECCC
GRTYRVLIANIGTINPGVKLLGEKNYPGIAADYAMTFEKQKALSCDIFLSSHAGQYGLHS
CCEEEEEEEECCCCCCCCEEEECCCCCCEEHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
KYKPGAPYDPARFVDPAGYQKAVAGAEAAYRKQLAEEKAAH
CCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKISILMAAMVLTCMAADPPEWRQPFAAHRVVGNIYYVGTYDLASFLIVTPAGNVLINGG
CCHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHCCEEEEEEHHCEEEEEECCCCCEEEECC
MGDSVPLMRKSVADLGFQWKDIRWMLTTQAHADHVAAFAEIQRTTGAKVMATEADAKLLE
CCCCCHHHHHHHHHCCCCEECEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCHHHHHH
DGGKSDFHFTGAEYHYAPVKVVERLHDGQTLKFGGTEITVYLHPGHTKGSASYAIPVTEG
CCCCCCEEECCCEEECHHHHHHHHHCCCCEEEECCEEEEEEECCCCCCCCCEEEEEECCC
GRTYRVLIANIGTINPGVKLLGEKNYPGIAADYAMTFEKQKALSCDIFLSSHAGQYGLHS
CCEEEEEEEECCCCCCCCEEEECCCCCCEEHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
KYKPGAPYDPARFVDPAGYQKAVAGAEAAYRKQLAEEKAAH
CCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8018721; 3931629; 9811546 [H]