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The map label for this gene is hemC [H]

Identifier: 116622285

GI number: 116622285

Start: 4027640

End: 4028533

Strand: Direct

Name: hemC [H]

Synonym: Acid_3179

Alternate gene names: 116622285

Gene position: 4027640-4028533 (Clockwise)

Preceding gene: 116622284

Following gene: 116622286

Centisome position: 40.42

GC content: 69.69

Gene sequence:

>894_bases
ATGCTCGTCATCGCATCACGCGGTTCGCAGCTCGCATTGTGGCAGGCCCACTGGGTGGAGGCGCAGTTGCAGGCGGCCGG
CCACGAGTGCCGCATCGAGATCATCAAGACCACGGGCGATAAAATCACCGACGTGCCGCTGGCCAAGGTCGGGACCAAGG
GACTGTTCACCAAGGAGATCGAGGAGGCGCTGTTGGACGGGCGCGCCCAACTGGCGGTGCACAGCCTGAAGGACCTCCCG
ACGGAACTGCCCGAGGGGCTGGTGCTGGGCGCGGTGCCGAAGCGGGAGGATCCGCGGGACGCGGTGATCGGCAAAACGCT
GGCCGAGCTGCCGCTGGGCGCGAAGGTGGGGACGAGCTCACTGCGGCGGTCGGCGCAGTTGAAGCGGCTGCGGCCGGACC
TGGTGGTGGAATCGATCCGCGGGAATCTGGACACGCGGCTGCGCAAGCTGGACGAAGGCCAGTACGACGCGATTCTACTG
GCGGCGGCCGGGATGAAGCGGCTCGGGTGGGGCGCGCGGATCGCGGAGATCCTGCCCCCGGATTTGATGTGTCCCGCGGT
GGGACAAGGCGCTTTGGCGATCGAGACGCGGGCGGGGTTCGTGCTGCCGGCGGTTCTGAATCACGCCGATACCCACACGG
CGGTGCTGGCTGAGCGGGGGCTGTTGGGCGCGTTGGGCGGCGGCTGCCAGGTGCCGATCGGCGCGCACGCTACGGTGGCG
GGCGGGCGGGTGAGGCTGCTCGGATTGGTCGCGGCGCCGGATGGGTCGGAGATCGTGCGGGCGGAAGCGGAAGGCGCGTC
GGGCGAGGCAGCGGAGATCGGGAAACGGCTGGGGGCGGAGTTACTGGCACGCGGCGCGCGCAGGATTCTGGACGGCGTGT
ATGGAGTGGCCTAG

Upstream 100 bases:

>100_bases
GCACGGTCCGATCTCCGAACTGCGGTCGCAGGCGGGCAAGCCGGATGGAGCCCCGGCAATCGCGGCCATACGAAAAGCAT
TCCACTTACAGGACTGATTC

Downstream 100 bases:

>100_bases
CGGCGCGTTGTATTACGGTGCATTCGTGTGCTCGCAGGGCGCGAGGGAGTGCAACGAGCTTTCGATTCCAACCTTCGACC
GCCACCCTGCGGCTCGCCGT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MLVIASRGSQLALWQAHWVEAQLQAAGHECRIEIIKTTGDKITDVPLAKVGTKGLFTKEIEEALLDGRAQLAVHSLKDLP
TELPEGLVLGAVPKREDPRDAVIGKTLAELPLGAKVGTSSLRRSAQLKRLRPDLVVESIRGNLDTRLRKLDEGQYDAILL
AAAGMKRLGWGARIAEILPPDLMCPAVGQGALAIETRAGFVLPAVLNHADTHTAVLAERGLLGALGGGCQVPIGAHATVA
GGRVRLLGLVAAPDGSEIVRAEAEGASGEAAEIGKRLGAELLARGARRILDGVYGVA

Sequences:

>Translated_297_residues
MLVIASRGSQLALWQAHWVEAQLQAAGHECRIEIIKTTGDKITDVPLAKVGTKGLFTKEIEEALLDGRAQLAVHSLKDLP
TELPEGLVLGAVPKREDPRDAVIGKTLAELPLGAKVGTSSLRRSAQLKRLRPDLVVESIRGNLDTRLRKLDEGQYDAILL
AAAGMKRLGWGARIAEILPPDLMCPAVGQGALAIETRAGFVLPAVLNHADTHTAVLAERGLLGALGGGCQVPIGAHATVA
GGRVRLLGLVAAPDGSEIVRAEAEGASGEAAEIGKRLGAELLARGARRILDGVYGVA
>Mature_297_residues
MLVIASRGSQLALWQAHWVEAQLQAAGHECRIEIIKTTGDKITDVPLAKVGTKGLFTKEIEEALLDGRAQLAVHSLKDLP
TELPEGLVLGAVPKREDPRDAVIGKTLAELPLGAKVGTSSLRRSAQLKRLRPDLVVESIRGNLDTRLRKLDEGQYDAILL
AAAGMKRLGWGARIAEILPPDLMCPAVGQGALAIETRAGFVLPAVLNHADTHTAVLAERGLLGALGGGCQVPIGAHATVA
GGRVRLLGLVAAPDGSEIVRAEAEGASGEAAEIGKRLGAELLARGARRILDGVYGVA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=330, Percent_Identity=43.9393939393939, Blast_Score=228, Evalue=4e-60,
Organism=Homo sapiens, GI20149500, Length=330, Percent_Identity=43.9393939393939, Blast_Score=228, Evalue=7e-60,
Organism=Escherichia coli, GI48994974, Length=304, Percent_Identity=52.9605263157895, Blast_Score=286, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=40.5063291139241, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI20130425, Length=252, Percent_Identity=45.6349206349206, Blast_Score=205, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 31086; Mature: 31086

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIASRGSQLALWQAHWVEAQLQAAGHECRIEIIKTTGDKITDVPLAKVGTKGLFTKEI
CEEEECCCCEEEEEHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHCCCCCHHHHH
EEALLDGRAQLAVHSLKDLPTELPEGLVLGAVPKREDPRDAVIGKTLAELPLGAKVGTSS
HHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHH
LRRSAQLKRLRPDLVVESIRGNLDTRLRKLDEGQYDAILLAAAGMKRLGWGARIAEILPP
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEHHCHHHHCCCHHHHHHCCC
DLMCPAVGQGALAIETRAGFVLPAVLNHADTHTAVLAERGLLGALGGGCQVPIGAHATVA
CCCCCCCCCCCEEEECCCCEEHHHHHCCCCHHHHHHHHCCCCEECCCCCCCCCCCCEEEC
GGRVRLLGLVAAPDGSEIVRAEAEGASGEAAEIGKRLGAELLARGARRILDGVYGVA
CCEEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVIASRGSQLALWQAHWVEAQLQAAGHECRIEIIKTTGDKITDVPLAKVGTKGLFTKEI
CEEEECCCCEEEEEHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHCCCCCHHHHH
EEALLDGRAQLAVHSLKDLPTELPEGLVLGAVPKREDPRDAVIGKTLAELPLGAKVGTSS
HHHHHCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHH
LRRSAQLKRLRPDLVVESIRGNLDTRLRKLDEGQYDAILLAAAGMKRLGWGARIAEILPP
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEHHCHHHHCCCHHHHHHCCC
DLMCPAVGQGALAIETRAGFVLPAVLNHADTHTAVLAERGLLGALGGGCQVPIGAHATVA
CCCCCCCCCCCEEEECCCCEEHHHHHCCCCHHHHHHHHCCCCEECCCCCCCCCCCCEEEC
GGRVRLLGLVAAPDGSEIVRAEAEGASGEAAEIGKRLGAELLARGARRILDGVYGVA
CCEEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA