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The map label for this gene is hemA

Identifier: 116622284

GI number: 116622284

Start: 4026371

End: 4027636

Strand: Direct

Name: hemA

Synonym: Acid_3178

Alternate gene names: 116622284

Gene position: 4026371-4027636 (Clockwise)

Preceding gene: 116622283

Following gene: 116622285

Centisome position: 40.4

GC content: 64.22

Gene sequence:

>1266_bases
ATGAAACTCCTGATCACAGGCGTAAGCCACAAAACGGCGCCGGTGGAAGTCCGCGAATGCCTGGCATTCCGGGAGGAGAC
GCTGCCCGCGGCGCTGGCCGATCTCAAGGCCTGCGAGGGTGTATCGGAAGCGGTGATTCTTTCGACCTGCAACCGGGTGG
AGATCTCGCTGACCACCGAAGATGCGGTGGATCCGCGCGAGATCGTGGACAACTTCCTTTCGCGGCACAAGGCCGTGAGT
TCGGCGAGCATCGGGCCGCACCTCTACCGGCACGAGGGGCGCGATGCGATCCACCATCTGTTCCGGGTGGCGGCGAGCCT
GGATTCCATGGTGGTGGGCGAGCCGCAGATTCTGGGACAGCTCAAGGTCGCGTATGCCGCGGCGAAGGATTGCGGAGCGC
TCTGCGGCTGGCTGGACGGGCTGATGAGCCGCTCCTTCAGCGTGGCCAAGCGGGTGCGGTCGGAGACCGGCATCGGGCAG
ATGGCGGTCTCGGTGAGCTATGCGGCGGTGGAGCTGGCGCGCAAGATTTTCGGATCGCTGACCAACCGCACGGTGATGAT
CGTGGGCGCGGGCAAGATGAGCGAACTGGCGGCGCGGCACCTGCGGCGCAGCGGCGCGAGCCACGTCTTCGTCACCAACC
GGACGCACGAGCGGGCGGTGGACATGGCGAAGCTCTTCCAGGGAACTCCGGTGGAATACGCGCGCTTTACGGCGATGCTG
CCTGAGGTGGACATCCTGATCGCCAGTTCGGGGGCGCCGCATTACATCCTGCACAAGGACGAGATGCAGCGCGTGATTTC
GGCGCGGCGCAACAAACCGATGTTCCTGATCGATATCGCGGTGCCGCGCAATATCGAGCCGGCGATTAACGACCTGGACA
ACGTCTTCCTCTACGACATCGACGATTTGCAGGAGGTGGTCAACTCCAACTTGCGCGAGCGCATGAAGGAAGCCGACCAC
GCCGAGCTGCTGGTCACCGAGGAAGTGGACCGGATGATGGCGCGGATGAAGGTCGCCGAGGTCACGCCCGTCATCGTGAG
CCTGCAGGAGCAACTCGAACAGATCCGCTCGGGAGAGATGGAAAAGGTCCGGCGGCGCTTCGGGCCGTTCACGGCGCAGC
AGGAAGAGGCGCTGGAGGCGTTGACGCGCGGCATCATCAACAAGGTGGCGCACGGTCCGATCTCCGAACTGCGGTCGCAG
GCGGGCAAGCCGGATGGAGCCCCGGCAATCGCGGCCATACGAAAAGCATTCCACTTACAGGACTGA

Upstream 100 bases:

>100_bases
GGCGCGGGCGCAAGGCCGCCCTTATGACGATCGCGGTAGTCGGGTTCTCGGCGCTGACCTGGGCGGCGCACGCGAGGCTC
GGCAGTTTGCTGCTTAAGCC

Downstream 100 bases:

>100_bases
TTCATGCTCGTCATCGCATCACGCGGTTCGCAGCTCGCATTGTGGCAGGCCCACTGGGTGGAGGCGCAGTTGCAGGCGGC
CGGCCACGAGTGCCGCATCG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKLLITGVSHKTAPVEVRECLAFREETLPAALADLKACEGVSEAVILSTCNRVEISLTTEDAVDPREIVDNFLSRHKAVS
SASIGPHLYRHEGRDAIHHLFRVAASLDSMVVGEPQILGQLKVAYAAAKDCGALCGWLDGLMSRSFSVAKRVRSETGIGQ
MAVSVSYAAVELARKIFGSLTNRTVMIVGAGKMSELAARHLRRSGASHVFVTNRTHERAVDMAKLFQGTPVEYARFTAML
PEVDILIASSGAPHYILHKDEMQRVISARRNKPMFLIDIAVPRNIEPAINDLDNVFLYDIDDLQEVVNSNLRERMKEADH
AELLVTEEVDRMMARMKVAEVTPVIVSLQEQLEQIRSGEMEKVRRRFGPFTAQQEEALEALTRGIINKVAHGPISELRSQ
AGKPDGAPAIAAIRKAFHLQD

Sequences:

>Translated_421_residues
MKLLITGVSHKTAPVEVRECLAFREETLPAALADLKACEGVSEAVILSTCNRVEISLTTEDAVDPREIVDNFLSRHKAVS
SASIGPHLYRHEGRDAIHHLFRVAASLDSMVVGEPQILGQLKVAYAAAKDCGALCGWLDGLMSRSFSVAKRVRSETGIGQ
MAVSVSYAAVELARKIFGSLTNRTVMIVGAGKMSELAARHLRRSGASHVFVTNRTHERAVDMAKLFQGTPVEYARFTAML
PEVDILIASSGAPHYILHKDEMQRVISARRNKPMFLIDIAVPRNIEPAINDLDNVFLYDIDDLQEVVNSNLRERMKEADH
AELLVTEEVDRMMARMKVAEVTPVIVSLQEQLEQIRSGEMEKVRRRFGPFTAQQEEALEALTRGIINKVAHGPISELRSQ
AGKPDGAPAIAAIRKAFHLQD
>Mature_421_residues
MKLLITGVSHKTAPVEVRECLAFREETLPAALADLKACEGVSEAVILSTCNRVEISLTTEDAVDPREIVDNFLSRHKAVS
SASIGPHLYRHEGRDAIHHLFRVAASLDSMVVGEPQILGQLKVAYAAAKDCGALCGWLDGLMSRSFSVAKRVRSETGIGQ
MAVSVSYAAVELARKIFGSLTNRTVMIVGAGKMSELAARHLRRSGASHVFVTNRTHERAVDMAKLFQGTPVEYARFTAML
PEVDILIASSGAPHYILHKDEMQRVISARRNKPMFLIDIAVPRNIEPAINDLDNVFLYDIDDLQEVVNSNLRERMKEADH
AELLVTEEVDRMMARMKVAEVTPVIVSLQEQLEQIRSGEMEKVRRRFGPFTAQQEEALEALTRGIINKVAHGPISELRSQ
AGKPDGAPAIAAIRKAFHLQD

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=416, Percent_Identity=38.9423076923077, Blast_Score=273, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_SOLUE (Q022E5)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_824440.1
- ProteinModelPortal:   Q022E5
- SMR:   Q022E5
- STRING:   Q022E5
- GeneID:   4428635
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_3178
- NMPDR:   fig|234267.9.peg.3016
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q022E5
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46432; Mature: 46432

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00747 GLUTR; PS01037 SBP_BACTERIAL_1

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLITGVSHKTAPVEVRECLAFREETLPAALADLKACEGVSEAVILSTCNRVEISLTTE
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEECC
DAVDPREIVDNFLSRHKAVSSASIGPHLYRHEGRDAIHHLFRVAASLDSMVVGEPQILGQ
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
LKVAYAAAKDCGALCGWLDGLMSRSFSVAKRVRSETGIGQMAVSVSYAAVELARKIFGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TNRTVMIVGAGKMSELAARHLRRSGASHVFVTNRTHERAVDMAKLFQGTPVEYARFTAML
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHC
PEVDILIASSGAPHYILHKDEMQRVISARRNKPMFLIDIAVPRNIEPAINDLDNVFLYDI
CCEEEEEECCCCCEEEECHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCEEEEEH
DDLQEVVNSNLRERMKEADHAELLVTEEVDRMMARMKVAEVTPVIVSLQEQLEQIRSGEM
HHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EKVRRRFGPFTAQQEEALEALTRGIINKVAHGPISELRSQAGKPDGAPAIAAIRKAFHLQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCC
D
C
>Mature Secondary Structure
MKLLITGVSHKTAPVEVRECLAFREETLPAALADLKACEGVSEAVILSTCNRVEISLTTE
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEECC
DAVDPREIVDNFLSRHKAVSSASIGPHLYRHEGRDAIHHLFRVAASLDSMVVGEPQILGQ
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
LKVAYAAAKDCGALCGWLDGLMSRSFSVAKRVRSETGIGQMAVSVSYAAVELARKIFGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TNRTVMIVGAGKMSELAARHLRRSGASHVFVTNRTHERAVDMAKLFQGTPVEYARFTAML
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHC
PEVDILIASSGAPHYILHKDEMQRVISARRNKPMFLIDIAVPRNIEPAINDLDNVFLYDI
CCEEEEEECCCCCEEEECHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHCCCCEEEEEH
DDLQEVVNSNLRERMKEADHAELLVTEEVDRMMARMKVAEVTPVIVSLQEQLEQIRSGEM
HHHHHHHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EKVRRRFGPFTAQQEEALEALTRGIINKVAHGPISELRSQAGKPDGAPAIAAIRKAFHLQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA