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The map label for this gene is sucD [H]

Identifier: 116622209

GI number: 116622209

Start: 3927065

End: 3928471

Strand: Reverse

Name: sucD [H]

Synonym: Acid_3101

Alternate gene names: 116622209

Gene position: 3928471-3927065 (Counterclockwise)

Preceding gene: 116622210

Following gene: 116622203

Centisome position: 39.42

GC content: 60.91

Gene sequence:

>1407_bases
ATGGCAAGGCTCATCACAGACGAGGAAAAACAGGTCGCGCACGAACTGTTGGAACGCGGGCGCGCCGCCATGCAGTGCAT
CGAGAATTACGACCAGGCGCAGGTCGATCGACTCTGCCAGGCGGTCGGCTGGGCAACCGCCAACGCGGAAACCTTCACTC
GCCTCGCCAACATGAGCGTCGATGAGAGCGGCCTGGGAGATCGCGCCGGACGGCCCAACAAGCGCTTCAAGATCATGGGC
ATTCTCCGCGACGCGCTGCGCCAGAAGAGCATGGGCGTGATCGAAGAGATCCCCGAAAAAGGCATCGTGAAATATGCCAA
GCCGGTGGGCGTGATCGCTTCGCTGGTCCCCGTGACCAACGCAGCGCTGACCGAGTCCGGCAACGGAATCTACTCGCTGA
AGTGCAAGAACGCGATCATCTTCTCGCCGCACCCGGCCAGCAAGAAGACCACATTCGAGACCGTCCGCATTATGCGCGCC
GCGCTCAAGACACAGGCGGCGCCCGAAGACCTCTTCCAGTGCATCGAGAAGCCGAGCATTCCGCTCGCCGAGTACCTGAT
GTCGATCTGCGACCTGACCATCGCGACCGGTGGACCGGCGATGGTGAAAGCCGCGTACAGCTCGGGCAAGCCGGCTTACG
GCGTGGGCGCCGGCAACGCAACCATGGTGATCGACGAGACCGCCGACATCAATGAAGCCGCGCGCAATACCCGCCTGAGC
AAAACATCCGACAACGGATCCGGCTGTTCGGCAGACGGCAACCTGCTGGTGGATTCCGCCATCTACGATAAATTCCTGGC
ACAGCTTCAGACCGAAGGAGGCTACCTGCTCTCCGAGGCCGAAAAGCAGTTGCTGCACAGAGCCTTGTGGGATGACGAAG
GCCACCGGACCAGCAACACGATCGCGCGCCCGGCCGCGGCAATCGCCGGAGTCGCGGGCTTTGCCATTCCCGAGGGCAAG
ACGTTTCTGATCGTGAAGGAATCGCACATCGGAAAATCGCACCGGTTCTCCAGTGAGAAACTCTCTCCGGTGCTGGCCAT
TTTCCGGTATTCCGGTTTCCCTCAAGCCCTGGAGATGGTGCGGCAGATTTACGAGGTCGGCGGCAAGGGCCATTCCTGCG
GCATCTACTCCTTCAATGATGACCACATCCACCAGCTCGCTCTTACCGCCCCCGTCAGCCGCATCATGGTGCGGCAGCCT
CAATCCAAAGCCAACGCGGGCGCGTTCAACAACGGCATGCCGATGACCTCCAGCATGGGCTGCGGCATCTGGGGGGGCAA
TATCACCAACGAGAACGTCGCCCTCAAACACTACATGCAGGTGACCTGGGTCAGCCGCCCGATTCCCGAAGACAAACCCT
CGGAACAGGAACTATTCGGCGAGTTCTACAACACCGCAACGTTCTAA

Upstream 100 bases:

>100_bases
CTCAGCGCCGAAGTCGCCGAGGAGTACGCGCGCGAGAAAGCGATGCGGATCCGCATTCCGGTGACCTATGATGGGCCGCC
TCCACGGGAGATCGAATAAC

Downstream 100 bases:

>100_bases
ACAGTTCGCGGACCGCAGACATCCGCGCCGGAATATTCGCCGCCCCATCAGAGCCGCGACCGTGAGGGAGCGTCCGTTGT
ACAATGTGGGGCGGCCAATC

Product: succinate-semialdehyde dehydrogenase (NAD(P)(+))

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MARLITDEEKQVAHELLERGRAAMQCIENYDQAQVDRLCQAVGWATANAETFTRLANMSVDESGLGDRAGRPNKRFKIMG
ILRDALRQKSMGVIEEIPEKGIVKYAKPVGVIASLVPVTNAALTESGNGIYSLKCKNAIIFSPHPASKKTTFETVRIMRA
ALKTQAAPEDLFQCIEKPSIPLAEYLMSICDLTIATGGPAMVKAAYSSGKPAYGVGAGNATMVIDETADINEAARNTRLS
KTSDNGSGCSADGNLLVDSAIYDKFLAQLQTEGGYLLSEAEKQLLHRALWDDEGHRTSNTIARPAAAIAGVAGFAIPEGK
TFLIVKESHIGKSHRFSSEKLSPVLAIFRYSGFPQALEMVRQIYEVGGKGHSCGIYSFNDDHIHQLALTAPVSRIMVRQP
QSKANAGAFNNGMPMTSSMGCGIWGGNITNENVALKHYMQVTWVSRPIPEDKPSEQELFGEFYNTATF

Sequences:

>Translated_468_residues
MARLITDEEKQVAHELLERGRAAMQCIENYDQAQVDRLCQAVGWATANAETFTRLANMSVDESGLGDRAGRPNKRFKIMG
ILRDALRQKSMGVIEEIPEKGIVKYAKPVGVIASLVPVTNAALTESGNGIYSLKCKNAIIFSPHPASKKTTFETVRIMRA
ALKTQAAPEDLFQCIEKPSIPLAEYLMSICDLTIATGGPAMVKAAYSSGKPAYGVGAGNATMVIDETADINEAARNTRLS
KTSDNGSGCSADGNLLVDSAIYDKFLAQLQTEGGYLLSEAEKQLLHRALWDDEGHRTSNTIARPAAAIAGVAGFAIPEGK
TFLIVKESHIGKSHRFSSEKLSPVLAIFRYSGFPQALEMVRQIYEVGGKGHSCGIYSFNDDHIHQLALTAPVSRIMVRQP
QSKANAGAFNNGMPMTSSMGCGIWGGNITNENVALKHYMQVTWVSRPIPEDKPSEQELFGEFYNTATF
>Mature_467_residues
ARLITDEEKQVAHELLERGRAAMQCIENYDQAQVDRLCQAVGWATANAETFTRLANMSVDESGLGDRAGRPNKRFKIMGI
LRDALRQKSMGVIEEIPEKGIVKYAKPVGVIASLVPVTNAALTESGNGIYSLKCKNAIIFSPHPASKKTTFETVRIMRAA
LKTQAAPEDLFQCIEKPSIPLAEYLMSICDLTIATGGPAMVKAAYSSGKPAYGVGAGNATMVIDETADINEAARNTRLSK
TSDNGSGCSADGNLLVDSAIYDKFLAQLQTEGGYLLSEAEKQLLHRALWDDEGHRTSNTIARPAAAIAGVAGFAIPEGKT
FLIVKESHIGKSHRFSSEKLSPVLAIFRYSGFPQALEMVRQIYEVGGKGHSCGIYSFNDDHIHQLALTAPVSRIMVRQPQ
SKANAGAFNNGMPMTSSMGCGIWGGNITNENVALKHYMQVTWVSRPIPEDKPSEQELFGEFYNTATF

Specific function: Catalyzes the reduction of succinate semialdehyde to succinyl-CoA. The enzyme is specific for succinate semialdehyde and succinyl-CoA, and only shows low activity with palmitoyl-CoA. There is no activity with NAD(+) as cosubstrate [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787493, Length=438, Percent_Identity=37.2146118721461, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1788797, Length=289, Percent_Identity=29.4117647058824, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.76 [H]

Molecular weight: Translated: 50772; Mature: 50641

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLITDEEKQVAHELLERGRAAMQCIENYDQAQVDRLCQAVGWATANAETFTRLANMSV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
DESGLGDRAGRPNKRFKIMGILRDALRQKSMGVIEEIPEKGIVKYAKPVGVIASLVPVTN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AALTESGNGIYSLKCKNAIIFSPHPASKKTTFETVRIMRAALKTQAAPEDLFQCIEKPSI
HHHCCCCCCEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
PLAEYLMSICDLTIATGGPAMVKAAYSSGKPAYGVGAGNATMVIDETADINEAARNTRLS
CHHHHHHHHHHEEECCCCHHHHHHHHCCCCCCEEECCCCEEEEEECCCCHHHHHHHCCCC
KTSDNGSGCSADGNLLVDSAIYDKFLAQLQTEGGYLLSEAEKQLLHRALWDDEGHRTSNT
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCH
IARPAAAIAGVAGFAIPEGKTFLIVKESHIGKSHRFSSEKLSPVLAIFRYSGFPQALEMV
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
RQIYEVGGKGHSCGIYSFNDDHIHQLALTAPVSRIMVRQPQSKANAGAFNNGMPMTSSMG
HHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
CGIWGGNITNENVALKHYMQVTWVSRPIPEDKPSEQELFGEFYNTATF
CEEECCCCCCCCHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARLITDEEKQVAHELLERGRAAMQCIENYDQAQVDRLCQAVGWATANAETFTRLANMSV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
DESGLGDRAGRPNKRFKIMGILRDALRQKSMGVIEEIPEKGIVKYAKPVGVIASLVPVTN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHH
AALTESGNGIYSLKCKNAIIFSPHPASKKTTFETVRIMRAALKTQAAPEDLFQCIEKPSI
HHHCCCCCCEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
PLAEYLMSICDLTIATGGPAMVKAAYSSGKPAYGVGAGNATMVIDETADINEAARNTRLS
CHHHHHHHHHHEEECCCCHHHHHHHHCCCCCCEEECCCCEEEEEECCCCHHHHHHHCCCC
KTSDNGSGCSADGNLLVDSAIYDKFLAQLQTEGGYLLSEAEKQLLHRALWDDEGHRTSNT
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCH
IARPAAAIAGVAGFAIPEGKTFLIVKESHIGKSHRFSSEKLSPVLAIFRYSGFPQALEMV
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
RQIYEVGGKGHSCGIYSFNDDHIHQLALTAPVSRIMVRQPQSKANAGAFNNGMPMTSSMG
HHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
CGIWGGNITNENVALKHYMQVTWVSRPIPEDKPSEQELFGEFYNTATF
CEEECCCCCCCCHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]