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The map label for this gene is rmlA [H]

Identifier: 116622131

GI number: 116622131

Start: 3819056

End: 3819805

Strand: Direct

Name: rmlA [H]

Synonym: Acid_3019

Alternate gene names: 116622131

Gene position: 3819056-3819805 (Clockwise)

Preceding gene: 116622130

Following gene: 116622132

Centisome position: 38.32

GC content: 61.2

Gene sequence:

>750_bases
ATGTGGGGAATTATTCCGGCGGCGGGAAAAGGCAGTCGCATACAGCCCTTGGCATTTTCCAAAGAACTTCTGCCGGTGGC
GGCCCGCAGCGAAGGCGGCGGACAGCGTCCCCGTGCAGTAAGCGACTATCTCATCGAGCGACTTGTGGCCGGCGGAGCAA
CGCGGCTCTGCTTTGTGATTTCGCCGGCAAAATCCGACATCCTGGCGTACTATGGCGGATCCGCGCATGGCGTGCCGATT
TGCTATTGCGTTCAGCCGGAGCCGCGGGGATTGTGCGACGCGATTTTTCGCGCGATACCGGTGATCGATCCCAATGAGCC
GGTGCTGATCGGGCTACCGGATACCGTCTGGTTCCCGGCGGACGGGTTGCGTAGTTTGTCTGACGACGGCCTCTCATTTC
TGCTCTTCCCGGTGGCGCATCCCGAGTTCTTCGACGCTGTCATCGCGGACGAGGAAGGACGCGTGAGCGCGATCCAGGTA
AAGGACCCGGCACCTGCGTCGCACTGGGTCTGGGGAGCGTTTAAAATGCCCGGCACGATATTCCGGTCGCTACACGAATT
GTGGAGAGGGCGGGGCGATGAATATATCGGGACCTTGGTGAATGCCTGGTTGGCGCAGGGAGGCGAGGCGCGGGCCGTTC
GCGCCGGTACGTCGTATCTGGACGTCGGAGCGATGGAGGGCTATGTGGCCGCGATGCAGTCACTGGAAAAACTTGAAATG
GACTCCGCGATGGCAGGAGGCATCCGATGA

Upstream 100 bases:

>100_bases
ATCGCCGACCATTCGGCTGTGGTGCGTGCCGAACAACTGGAAACGATTCTTGATTCGACCCGGGTCCGGGGCACGGCATG
GAGAGAGCAGGCAGTTTGAT

Downstream 100 bases:

>100_bases
AGAGCTCACCTAGTGCCCCCGCGGCACTGCCGAGAGAAGAGATCCGGCGGAGGGTCTCGGAACTCGGGGAGTGGTTTCAC
AATCTCGATCTGGACGGGGT

Product: nucleotidyl transferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MWGIIPAAGKGSRIQPLAFSKELLPVAARSEGGGQRPRAVSDYLIERLVAGGATRLCFVISPAKSDILAYYGGSAHGVPI
CYCVQPEPRGLCDAIFRAIPVIDPNEPVLIGLPDTVWFPADGLRSLSDDGLSFLLFPVAHPEFFDAVIADEEGRVSAIQV
KDPAPASHWVWGAFKMPGTIFRSLHELWRGRGDEYIGTLVNAWLAQGGEARAVRAGTSYLDVGAMEGYVAAMQSLEKLEM
DSAMAGGIR

Sequences:

>Translated_249_residues
MWGIIPAAGKGSRIQPLAFSKELLPVAARSEGGGQRPRAVSDYLIERLVAGGATRLCFVISPAKSDILAYYGGSAHGVPI
CYCVQPEPRGLCDAIFRAIPVIDPNEPVLIGLPDTVWFPADGLRSLSDDGLSFLLFPVAHPEFFDAVIADEEGRVSAIQV
KDPAPASHWVWGAFKMPGTIFRSLHELWRGRGDEYIGTLVNAWLAQGGEARAVRAGTSYLDVGAMEGYVAAMQSLEKLEM
DSAMAGGIR
>Mature_249_residues
MWGIIPAAGKGSRIQPLAFSKELLPVAARSEGGGQRPRAVSDYLIERLVAGGATRLCFVISPAKSDILAYYGGSAHGVPI
CYCVQPEPRGLCDAIFRAIPVIDPNEPVLIGLPDTVWFPADGLRSLSDDGLSFLLFPVAHPEFFDAVIADEEGRVSAIQV
KDPAPASHWVWGAFKMPGTIFRSLHELWRGRGDEYIGTLVNAWLAQGGEARAVRAGTSYLDVGAMEGYVAAMQSLEKLEM
DSAMAGGIR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide,

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 26714; Mature: 26714

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWGIIPAAGKGSRIQPLAFSKELLPVAARSEGGGQRPRAVSDYLIERLVAGGATRLCFVI
CCCCCCCCCCCCCCCCHHHCHHHHCEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEE
SPAKSDILAYYGGSAHGVPICYCVQPEPRGLCDAIFRAIPVIDPNEPVLIGLPDTVWFPA
CCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEECCCCEEECC
DGLRSLSDDGLSFLLFPVAHPEFFDAVIADEEGRVSAIQVKDPAPASHWVWGAFKMPGTI
HHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCHHH
FRSLHELWRGRGDEYIGTLVNAWLAQGGEARAVRAGTSYLDVGAMEGYVAAMQSLEKLEM
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHH
DSAMAGGIR
HHHHCCCCC
>Mature Secondary Structure
MWGIIPAAGKGSRIQPLAFSKELLPVAARSEGGGQRPRAVSDYLIERLVAGGATRLCFVI
CCCCCCCCCCCCCCCCHHHCHHHHCEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEE
SPAKSDILAYYGGSAHGVPICYCVQPEPRGLCDAIFRAIPVIDPNEPVLIGLPDTVWFPA
CCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCEEEECCCCEEECC
DGLRSLSDDGLSFLLFPVAHPEFFDAVIADEEGRVSAIQVKDPAPASHWVWGAFKMPGTI
HHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCHHH
FRSLHELWRGRGDEYIGTLVNAWLAQGGEARAVRAGTSYLDVGAMEGYVAAMQSLEKLEM
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHH
DSAMAGGIR
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9084178 [H]