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The map label for this gene is atoC [H]

Identifier: 116621997

GI number: 116621997

Start: 3650947

End: 3652344

Strand: Reverse

Name: atoC [H]

Synonym: Acid_2882

Alternate gene names: 116621997

Gene position: 3652344-3650947 (Counterclockwise)

Preceding gene: 116622001

Following gene: 116621996

Centisome position: 36.65

GC content: 60.09

Gene sequence:

>1398_bases
ATGAGCTCCGGACGAATTCTGATAGTCGAGGACGACGATAGCCTCCGCAAAGTGATGCACGTCCAACTCGAACGCGAAGG
CTACGAAACCAGCTCCGCGTCCACCGCCGAAGAGGCCTTCGCCATCCTCGACAAGGCCTCCCAAAGTCTGGTCATGACCG
ACCTCCACCTGCCCGGTATGTCCGGACTCGAGCTGCTCAAAAAAGTGCGCCTGGACTATCCGGAGACCGCCGTCATCGTC
ATGACCGCTTTTGGAACCATCCAGACCGCCGTCGAGGCGATGAAGGCTGGAGCTTACGACTTTCTCACCAAGCCGATTCA
CCCCTACGAACTCAAAATGCTGGTTCGCAGGTGCCTCGAACACCATCGCCTGATCGAAGAGGTTCAGGTCCTGCGTACTG
CCCTCGACGAGAAATACGGCTTCGAGGCGATCGTCGGCTCTTCGTCGCAGCTCATGCGCGCGCTCGACGTCGCCGCCCGC
GTCGCCTCCACTGACGCCACCATTCTCATCTACGGGGAAACCGGGACTGGTAAGGAGCTCGTCGCCAAAGCCATTCACCT
CCGAAGTTCGCGGCGCGACCGCCCGTTCATCACCATCAACTGCGGCGCCATTCCGAAAGAGCTGCTTGAATCGGAGTTGT
TCGGACACGTCAAAGGCTCCTTCACCGGCGCACTGACACATAAGAAGGGTAAGGTCGAGATGGCGGATGGAGGCACCGTC
CTCCTCGACGAGATCGGCGAGATGCCCTTGGAATTGCAGGTGCGCATTCTGCGCCTGATTCAGGAGCGTGAAATCGAAAA
GGTCGGCGCCACCAGCCCCACCAAGGTCGATGTGCGTATCGTGGCCGCCACCCACCGCGAACTCGCCGGCATGGTCAAAG
CCGGCACTTTCCGCGAAGACCTGTACTACCGCCTGCTCGTTGTGCCCATCAATCTACCACCCCTCCGCGAGCGCACCGGG
GATATCCTGATCCTCGTCCAGCACTTCCTCGAGAAATGCCGGATGAAGCACAGCCGGCCCAATCTCATGATGTCCACCGA
CTTGCTCCCTTACTTCACCAACTACTCGTGGCCCGGCAATGTGCGCCAGTTGGAGAATGCCGTGGAGCGTCTGGTGCTGC
TCGCAAGGGACTCCACAATCAACGCGTCGGACCTCCCGGACTTCCTGTCCGCCGCCCCGGCCCCACCTCCCGAACCCGTG
CCCGTTGCCCTGCCCGAGGGCGGTATCAATCTCGAGGATCTCGAAAAAGACCTCATCCTCCAGGCCCTCAAGAAATATGC
CGGCAACCAGACTCGTGCTGCACAATACCTCAACATGAGCCGCCGCGCGTTTGCTTACCGTCTGGAAAAGTACGACTTCC
ATCCGGACGTCCTCAAAGCCCGCAAACATGACGCCTAG

Upstream 100 bases:

>100_bases
TCACCTACGACCGCATCATGAAAACGTCAGTTTCAGTTGCCATCGGCGGTTTAGGGCCTCGATTCAGATTCGCGTGCACC
GCGAACCCAAGTGACCCAGT

Downstream 100 bases:

>100_bases
TAGTACTGCAAATCTCAATTCACACTAGGATTTGCCCTAATGCAATATAGGGTTTGCCCTCCCACGTGCCTTAACAAATG
TCGAATTTCTAACATTGTGA

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSSGRILIVEDDDSLRKVMHVQLEREGYETSSASTAEEAFAILDKASQSLVMTDLHLPGMSGLELLKKVRLDYPETAVIV
MTAFGTIQTAVEAMKAGAYDFLTKPIHPYELKMLVRRCLEHHRLIEEVQVLRTALDEKYGFEAIVGSSSQLMRALDVAAR
VASTDATILIYGETGTGKELVAKAIHLRSSRRDRPFITINCGAIPKELLESELFGHVKGSFTGALTHKKGKVEMADGGTV
LLDEIGEMPLELQVRILRLIQEREIEKVGATSPTKVDVRIVAATHRELAGMVKAGTFREDLYYRLLVVPINLPPLRERTG
DILILVQHFLEKCRMKHSRPNLMMSTDLLPYFTNYSWPGNVRQLENAVERLVLLARDSTINASDLPDFLSAAPAPPPEPV
PVALPEGGINLEDLEKDLILQALKKYAGNQTRAAQYLNMSRRAFAYRLEKYDFHPDVLKARKHDA

Sequences:

>Translated_465_residues
MSSGRILIVEDDDSLRKVMHVQLEREGYETSSASTAEEAFAILDKASQSLVMTDLHLPGMSGLELLKKVRLDYPETAVIV
MTAFGTIQTAVEAMKAGAYDFLTKPIHPYELKMLVRRCLEHHRLIEEVQVLRTALDEKYGFEAIVGSSSQLMRALDVAAR
VASTDATILIYGETGTGKELVAKAIHLRSSRRDRPFITINCGAIPKELLESELFGHVKGSFTGALTHKKGKVEMADGGTV
LLDEIGEMPLELQVRILRLIQEREIEKVGATSPTKVDVRIVAATHRELAGMVKAGTFREDLYYRLLVVPINLPPLRERTG
DILILVQHFLEKCRMKHSRPNLMMSTDLLPYFTNYSWPGNVRQLENAVERLVLLARDSTINASDLPDFLSAAPAPPPEPV
PVALPEGGINLEDLEKDLILQALKKYAGNQTRAAQYLNMSRRAFAYRLEKYDFHPDVLKARKHDA
>Mature_464_residues
SSGRILIVEDDDSLRKVMHVQLEREGYETSSASTAEEAFAILDKASQSLVMTDLHLPGMSGLELLKKVRLDYPETAVIVM
TAFGTIQTAVEAMKAGAYDFLTKPIHPYELKMLVRRCLEHHRLIEEVQVLRTALDEKYGFEAIVGSSSQLMRALDVAARV
ASTDATILIYGETGTGKELVAKAIHLRSSRRDRPFITINCGAIPKELLESELFGHVKGSFTGALTHKKGKVEMADGGTVL
LDEIGEMPLELQVRILRLIQEREIEKVGATSPTKVDVRIVAATHRELAGMVKAGTFREDLYYRLLVVPINLPPLRERTGD
ILILVQHFLEKCRMKHSRPNLMMSTDLLPYFTNYSWPGNVRQLENAVERLVLLARDSTINASDLPDFLSAAPAPPPEPVP
VALPEGGINLEDLEKDLILQALKKYAGNQTRAAQYLNMSRRAFAYRLEKYDFHPDVLKARKHDA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=42.7631578947368, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=40.6741573033708, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=37.7398720682303, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1788905, Length=454, Percent_Identity=38.5462555066079, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1789087, Length=402, Percent_Identity=40.547263681592, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082117, Length=262, Percent_Identity=49.236641221374, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1789233, Length=333, Percent_Identity=41.7417417417417, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87082152, Length=295, Percent_Identity=44.0677966101695, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1786524, Length=339, Percent_Identity=41.0029498525074, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87081872, Length=331, Percent_Identity=39.2749244712991, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1787583, Length=325, Percent_Identity=36.9230769230769, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI87081858, Length=312, Percent_Identity=28.8461538461538, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789828, Length=247, Percent_Identity=33.1983805668016, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1787375, Length=117, Percent_Identity=35.042735042735, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789809, Length=118, Percent_Identity=31.3559322033898, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790552, Length=118, Percent_Identity=35.5932203389831, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790863, Length=119, Percent_Identity=32.7731092436975, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786599, Length=120, Percent_Identity=31.6666666666667, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082012, Length=127, Percent_Identity=29.9212598425197, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51938; Mature: 51807

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGRILIVEDDDSLRKVMHVQLEREGYETSSASTAEEAFAILDKASQSLVMTDLHLPGM
CCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
SGLELLKKVRLDYPETAVIVMTAFGTIQTAVEAMKAGAYDFLTKPIHPYELKMLVRRCLE
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHH
HHRLIEEVQVLRTALDEKYGFEAIVGSSSQLMRALDVAARVASTDATILIYGETGTGKEL
HHHHHHHHHHHHHHHHHHCCCHHEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VAKAIHLRSSRRDRPFITINCGAIPKELLESELFGHVKGSFTGALTHKKGKVEMADGGTV
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCEE
LLDEIGEMPLELQVRILRLIQEREIEKVGATSPTKVDVRIVAATHRELAGMVKAGTFRED
EEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHCCCHHHH
LYYRLLVVPINLPPLRERTGDILILVQHFLEKCRMKHSRPNLMMSTDLLPYFTNYSWPGN
HEEEEEEEECCCCCCHHCCCCEEHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCC
VRQLENAVERLVLLARDSTINASDLPDFLSAAPAPPPEPVPVALPEGGINLEDLEKDLIL
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHH
QALKKYAGNQTRAAQYLNMSRRAFAYRLEKYDFHPDVLKARKHDA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure 
SSGRILIVEDDDSLRKVMHVQLEREGYETSSASTAEEAFAILDKASQSLVMTDLHLPGM
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
SGLELLKKVRLDYPETAVIVMTAFGTIQTAVEAMKAGAYDFLTKPIHPYELKMLVRRCLE
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHH
HHRLIEEVQVLRTALDEKYGFEAIVGSSSQLMRALDVAARVASTDATILIYGETGTGKEL
HHHHHHHHHHHHHHHHHHCCCHHEECCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VAKAIHLRSSRRDRPFITINCGAIPKELLESELFGHVKGSFTGALTHKKGKVEMADGGTV
HHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCEE
LLDEIGEMPLELQVRILRLIQEREIEKVGATSPTKVDVRIVAATHRELAGMVKAGTFRED
EEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHCCCHHHH
LYYRLLVVPINLPPLRERTGDILILVQHFLEKCRMKHSRPNLMMSTDLLPYFTNYSWPGN
HEEEEEEEECCCCCCHHCCCCEEHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCC
VRQLENAVERLVLLARDSTINASDLPDFLSAAPAPPPEPVPVALPEGGINLEDLEKDLIL
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHH
QALKKYAGNQTRAAQYLNMSRRAFAYRLEKYDFHPDVLKARKHDA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]