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The map label for this gene is zraS [C]

Identifier: 116621995

GI number: 116621995

Start: 3647819

End: 3649816

Strand: Reverse

Name: zraS [C]

Synonym: Acid_2880

Alternate gene names: 116621995

Gene position: 3649816-3647819 (Counterclockwise)

Preceding gene: 116621996

Following gene: 116621994

Centisome position: 36.62

GC content: 62.21

Gene sequence:

>1998_bases
ATGGCGACCGGCCAACTTCACCGCAATCAGGAAAAACGGCGGATCTTGCAGATCGCCCACCAGGTTTCCGCCACCATTGG
AAACGACTTTTTTCGAGCGATGGCAAAGCACCTGGCTCGAGAGCTGGAAGCAGACCACGTCCTGGTCGGGGAATTCTGCG
CCGGCCGTACAGAGCGCATCGCGATCCTCGCGAGCATGGCCGGCGGCGATTCCGAGCATATCGAATGTCCCCTCGAAGGC
ACCGCCTCCGCCCAGATCGCCACCGGCAAGGCCGTGCTTTGCCGCTCCGTTGCCCAACATCGCTTCCCCGCCGACCGGGC
ACTGGCAACCCTGAAAGCCCAGGCCTTCGTCGGTATTCCGTTAATGACCTCCGCCGGCGGCGTCTGTGGTGTGCTCATGG
CGGTTTATCGCAAGCCGGCCGCTACTTTGAGCGTCGCCAAATCACTGCTCGAAGTCTTCGCACCCAGGGCGGCCGCCGAA
CTGGAACGTAAACAGGAAAACGATCGCCTGCGCGAAAGCGAACAGCGCTATCAGGCCTTCGTCATGCTCAACGCCGACGC
CATGTGGCGCATCGAACTCGAGCAGCCCATCCCCATCGATCTGCCCGAGGAGGAACAGATCCAGCAGATCTACCGCTACG
GGTACCTCGCCGAGTGTAACGATGCCATGGCCCGTCAGTACGGCCTCGAAAGGGCCAGCCAGCTCACCGGGTGGCGCGTC
AGCGAACTCTCGCCCCTCACCACCGAAGGCGTTCGCGAAGCCATCATCCAGGGCATTCGTTCCGGCTACCATTCCACCGT
GGAGCTCTCTCCCGTGGATGAGGAGGGCAATCGCCGCCACATCCTGCGCACCCAGTGGGGCATCGTCGAACAGGGCATGC
TGCAGCGCATTTGGGGAACTACCCGCGACGTTACCGAACTCAAATCCATCGAACGCGAACTCGATGCTTCCGAAAGGCAG
ATGTCAGATCTGCTGGAGACTCTGAACCTGCTGGTGGTCATGATGCGGGAGGATGGGGCGATCGTCTTCTGCAACAAACA
CTTTTATCAGTTGACCGGTTGGACCGCGGCCGAAACCAAAGACCGGATCTGGTTCGAGCTCATGCTCCTCCCCGAAGATC
GCAAGCTCGCGCGCGCCGCTTTTCAGGCCGCCAACCTTCAGACCGGCGCACCCACCCATTATGAGAGCGCCCTCTTGGGC
CCCAAAGGCGAGTGCTGGCGCGTAGCCTGGGACAGCACCTGCGTGCGCGACGCGGAGCAAAAAATCGTGATGTCCGCCAA
CGTCGGACGCGATATCAGCGAATTCAAAATGCTCGAAGCCCAGTTTCGCCAGGCCCAGGAACTGGAAAGCCTGGGCAGGC
TGGCCGGAGGCGTGGCCCACGATTTCAACAATCTCCTCACTGTGATCACCGGCTACAGCAGCGTGCTGCTGGAGAAGAAG
AGTCCGGACGACCCCGCCTATCCCGTCCTCTGCGAAATCCGCCGCACCGCCGAAAAGGGCGCCTCACTCACCCGCAGCCT
GCTTGCCTTCAGCCGGCGCCAGGCCCCGCGTCCCGAACCCGTGGACCTGACCGCCTTGATTGCCGTGGATGAACCCCTCC
TCCTGCGCCTGCTCAACGAAAACATTCACCTGGTCACCAACCTCCAACCATCGCTCAATTTCGTGCAGGCCGACCCCGGA
CAGATCCGGCAGGTCCTGTTCAACCTCGTAGTCAATGCCCGCGACGCCATGCCGCACGGCGGCATCCTGACCATTGCGAC
TTCAAGCGATGGCTCCAACGTGCAACTCGTCATCTCCGACACCGGAGTCGGCATGACGGAAGACGTCCGGCGTCACCTCT
TCCGCCCCTTCTTCCGGACCGACGAAGAATGCACCGCGGCCGGCCTCGGTATGGCCACAACCTATCGGATCATCCGCCAA
AACGGAGGTCAGATCGAGGTCGATTCCTCTCCCGGCGGCGGCGCCCGCTTCCGCATCCAACTGCCCGCCCTTCCCTGA

Upstream 100 bases:

>100_bases
GCGGGGTCCTGCTCCTTTGCGGGGCCTCGCGGCGGCGCGTGGTCTCAACATATAATCCATCTCGCTGAGCAAAAACAGCA
TCCTGTACAAAACAGGACTT

Downstream 100 bases:

>100_bases
CCGGCTCCGTTTCACTCCACGCGCTCGCGTTGGCACGGCTCTTGGCATCCGCATTGCCTCCATCATGCGCATGAACCGTC
GAAGTGCTACCCGTTGTCGC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MATGQLHRNQEKRRILQIAHQVSATIGNDFFRAMAKHLARELEADHVLVGEFCAGRTERIAILASMAGGDSEHIECPLEG
TASAQIATGKAVLCRSVAQHRFPADRALATLKAQAFVGIPLMTSAGGVCGVLMAVYRKPAATLSVAKSLLEVFAPRAAAE
LERKQENDRLRESEQRYQAFVMLNADAMWRIELEQPIPIDLPEEEQIQQIYRYGYLAECNDAMARQYGLERASQLTGWRV
SELSPLTTEGVREAIIQGIRSGYHSTVELSPVDEEGNRRHILRTQWGIVEQGMLQRIWGTTRDVTELKSIERELDASERQ
MSDLLETLNLLVVMMREDGAIVFCNKHFYQLTGWTAAETKDRIWFELMLLPEDRKLARAAFQAANLQTGAPTHYESALLG
PKGECWRVAWDSTCVRDAEQKIVMSANVGRDISEFKMLEAQFRQAQELESLGRLAGGVAHDFNNLLTVITGYSSVLLEKK
SPDDPAYPVLCEIRRTAEKGASLTRSLLAFSRRQAPRPEPVDLTALIAVDEPLLLRLLNENIHLVTNLQPSLNFVQADPG
QIRQVLFNLVVNARDAMPHGGILTIATSSDGSNVQLVISDTGVGMTEDVRRHLFRPFFRTDEECTAAGLGMATTYRIIRQ
NGGQIEVDSSPGGGARFRIQLPALP

Sequences:

>Translated_665_residues
MATGQLHRNQEKRRILQIAHQVSATIGNDFFRAMAKHLARELEADHVLVGEFCAGRTERIAILASMAGGDSEHIECPLEG
TASAQIATGKAVLCRSVAQHRFPADRALATLKAQAFVGIPLMTSAGGVCGVLMAVYRKPAATLSVAKSLLEVFAPRAAAE
LERKQENDRLRESEQRYQAFVMLNADAMWRIELEQPIPIDLPEEEQIQQIYRYGYLAECNDAMARQYGLERASQLTGWRV
SELSPLTTEGVREAIIQGIRSGYHSTVELSPVDEEGNRRHILRTQWGIVEQGMLQRIWGTTRDVTELKSIERELDASERQ
MSDLLETLNLLVVMMREDGAIVFCNKHFYQLTGWTAAETKDRIWFELMLLPEDRKLARAAFQAANLQTGAPTHYESALLG
PKGECWRVAWDSTCVRDAEQKIVMSANVGRDISEFKMLEAQFRQAQELESLGRLAGGVAHDFNNLLTVITGYSSVLLEKK
SPDDPAYPVLCEIRRTAEKGASLTRSLLAFSRRQAPRPEPVDLTALIAVDEPLLLRLLNENIHLVTNLQPSLNFVQADPG
QIRQVLFNLVVNARDAMPHGGILTIATSSDGSNVQLVISDTGVGMTEDVRRHLFRPFFRTDEECTAAGLGMATTYRIIRQ
NGGQIEVDSSPGGGARFRIQLPALP
>Mature_664_residues
ATGQLHRNQEKRRILQIAHQVSATIGNDFFRAMAKHLARELEADHVLVGEFCAGRTERIAILASMAGGDSEHIECPLEGT
ASAQIATGKAVLCRSVAQHRFPADRALATLKAQAFVGIPLMTSAGGVCGVLMAVYRKPAATLSVAKSLLEVFAPRAAAEL
ERKQENDRLRESEQRYQAFVMLNADAMWRIELEQPIPIDLPEEEQIQQIYRYGYLAECNDAMARQYGLERASQLTGWRVS
ELSPLTTEGVREAIIQGIRSGYHSTVELSPVDEEGNRRHILRTQWGIVEQGMLQRIWGTTRDVTELKSIERELDASERQM
SDLLETLNLLVVMMREDGAIVFCNKHFYQLTGWTAAETKDRIWFELMLLPEDRKLARAAFQAANLQTGAPTHYESALLGP
KGECWRVAWDSTCVRDAEQKIVMSANVGRDISEFKMLEAQFRQAQELESLGRLAGGVAHDFNNLLTVITGYSSVLLEKKS
PDDPAYPVLCEIRRTAEKGASLTRSLLAFSRRQAPRPEPVDLTALIAVDEPLLLRLLNENIHLVTNLQPSLNFVQADPGQ
IRQVLFNLVVNARDAMPHGGILTIATSSDGSNVQLVISDTGVGMTEDVRRHLFRPFFRTDEECTAAGLGMATTYRIIRQN
GGQIEVDSSPGGGARFRIQLPALP

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=31.140350877193, Blast_Score=116, Evalue=6e-27,
Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=32.9166666666667, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786600, Length=368, Percent_Identity=22.2826086956522, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI48994928, Length=391, Percent_Identity=23.0179028132992, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1786912, Length=232, Percent_Identity=29.3103448275862, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790300, Length=242, Percent_Identity=29.7520661157025, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789808, Length=231, Percent_Identity=26.4069264069264, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI145693157, Length=136, Percent_Identity=30.1470588235294, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=27.8026905829596, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73882; Mature: 73751

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGQLHRNQEKRRILQIAHQVSATIGNDFFRAMAKHLARELEADHVLVGEFCAGRTERI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCEE
AILASMAGGDSEHIECPLEGTASAQIATGKAVLCRSVAQHRFPADRALATLKAQAFVGIP
EEEEEECCCCCCCEECCCCCCCCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
LMTSAGGVCGVLMAVYRKPAATLSVAKSLLEVFAPRAAAELERKQENDRLRESEQRYQAF
HHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEE
VMLNADAMWRIELEQPIPIDLPEEEQIQQIYRYGYLAECNDAMARQYGLERASQLTGWRV
EEECCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
SELSPLTTEGVREAIIQGIRSGYHSTVELSPVDEEGNRRHILRTQWGIVEQGMLQRIWGT
CCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHCCC
TRDVTELKSIERELDASERQMSDLLETLNLLVVMMREDGAIVFCNKHFYQLTGWTAAETK
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCEEEEECCCCCCCC
DRIWFELMLLPEDRKLARAAFQAANLQTGAPTHYESALLGPKGECWRVAWDSTCVRDAEQ
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHHH
KIVMSANVGRDISEFKMLEAQFRQAQELESLGRLAGGVAHDFNNLLTVITGYSSVLLEKK
HEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECC
SPDDPAYPVLCEIRRTAEKGASLTRSLLAFSRRQAPRPEPVDLTALIAVDEPLLLRLLNE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHCC
NIHLVTNLQPSLNFVQADPGQIRQVLFNLVVNARDAMPHGGILTIATSSDGSNVQLVISD
CEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEC
TGVGMTEDVRRHLFRPFFRTDEECTAAGLGMATTYRIIRQNGGQIEVDSSPGGGARFRIQ
CCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEE
LPALP
CCCCC
>Mature Secondary Structure 
ATGQLHRNQEKRRILQIAHQVSATIGNDFFRAMAKHLARELEADHVLVGEFCAGRTERI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCEE
AILASMAGGDSEHIECPLEGTASAQIATGKAVLCRSVAQHRFPADRALATLKAQAFVGIP
EEEEEECCCCCCCEECCCCCCCCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
LMTSAGGVCGVLMAVYRKPAATLSVAKSLLEVFAPRAAAELERKQENDRLRESEQRYQAF
HHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEE
VMLNADAMWRIELEQPIPIDLPEEEQIQQIYRYGYLAECNDAMARQYGLERASQLTGWRV
EEECCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
SELSPLTTEGVREAIIQGIRSGYHSTVELSPVDEEGNRRHILRTQWGIVEQGMLQRIWGT
CCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHCCC
TRDVTELKSIERELDASERQMSDLLETLNLLVVMMREDGAIVFCNKHFYQLTGWTAAETK
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCEEEEECCCCCCCC
DRIWFELMLLPEDRKLARAAFQAANLQTGAPTHYESALLGPKGECWRVAWDSTCVRDAEQ
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHHH
KIVMSANVGRDISEFKMLEAQFRQAQELESLGRLAGGVAHDFNNLLTVITGYSSVLLEKK
HEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECC
SPDDPAYPVLCEIRRTAEKGASLTRSLLAFSRRQAPRPEPVDLTALIAVDEPLLLRLLNE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHCC
NIHLVTNLQPSLNFVQADPGQIRQVLFNLVVNARDAMPHGGILTIATSSDGSNVQLVISD
CEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEC
TGVGMTEDVRRHLFRPFFRTDEECTAAGLGMATTYRIIRQNGGQIEVDSSPGGGARFRIQ
CCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEE
LPALP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA