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The map label for this gene is gdhB [H]

Identifier: 116621980

GI number: 116621980

Start: 3626785

End: 3627543

Strand: Reverse

Name: gdhB [H]

Synonym: Acid_2865

Alternate gene names: 116621980

Gene position: 3627543-3626785 (Counterclockwise)

Preceding gene: 116621983

Following gene: 116621979

Centisome position: 36.4

GC content: 65.35

Gene sequence:

>759_bases
GTGCGCGAAAAAGTCCTGATTATCACCGGGTCCACCGGGATCGGCGCGGAGACCGTGCGGATGACCGCGGCTCGAGGAGC
GCGCATCGTGATCGCCACCGGCGATGAGATCTCCGGCTTCGAACTGGCTGCCGAGACCGGCGCGGAATGCTGGGCTGGCG
ACCTGACGCTGGCCAACTCGGCGGACAGCGTGCTGACGCAGTGCCTCTCGAAATTCGGCCGGGTGGACGGTTTATTCAAT
GTTGCGGGGCTGAGCGGTCGGCGCTTCGGCGACGGGCCGGTGCACGAGATTCAGGATGACGCGTGGCACACCACGCTCTC
CCACAACCTGACGCTGGCCTTTCGCATGTGCCGCGCGGTGACGGGCCGGATGCTCGAACAGGAAGGCGGCGGCGCGATCG
TCAACATGGGCAGCGTGCTGGCTGACTCTCCCGAGCCGCGTCACTTTGCCACCCACGCCTACGCCGCGGCGAAGGGCGCG
GTGGCGGCGATGACGAAATCGATGGCGGCTTACTACGCACCGCACGGTATCCGCATCAACCTGATCGCGCCCGGGCTGGT
CCGCACTCCGGCCGGCGAACGCACTCAGGCCGATCCCGCGTTTCAGGAGTTCGTGCGCAAGAAACAACCGCTCAATAGTG
GGATGATCGAGGTAGCCGAGGTAGCGCGAGCAGCAGTTTTTCTGCTGAGCGAGGAATCGCGCTCTGTCACCGGAGAAGTG
TTCACTATCGATGGCGGCTGGCGCCTGAGCGGCGTCTAA

Upstream 100 bases:

>100_bases
TTGAAGTGCATGAAAGGCCAGTTTCGCAGATGCGCCACCGGCAACGCAATCATACTTCACCTTCGCGGGCTTCAGCCTGG
CGGGATACATTAGAAGGAAG

Downstream 100 bases:

>100_bases
AATCCCTGGGGGTTTGGCTTGGTGGTTCTCGGAATCGATATCGGCGGTAATCAGATCCGCGCCGGCATGGTGGATGCCGA
TGGCGCGATCCTCGCTTCGC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MREKVLIITGSTGIGAETVRMTAARGARIVIATGDEISGFELAAETGAECWAGDLTLANSADSVLTQCLSKFGRVDGLFN
VAGLSGRRFGDGPVHEIQDDAWHTTLSHNLTLAFRMCRAVTGRMLEQEGGGAIVNMGSVLADSPEPRHFATHAYAAAKGA
VAAMTKSMAAYYAPHGIRINLIAPGLVRTPAGERTQADPAFQEFVRKKQPLNSGMIEVAEVARAAVFLLSEESRSVTGEV
FTIDGGWRLSGV

Sequences:

>Translated_252_residues
MREKVLIITGSTGIGAETVRMTAARGARIVIATGDEISGFELAAETGAECWAGDLTLANSADSVLTQCLSKFGRVDGLFN
VAGLSGRRFGDGPVHEIQDDAWHTTLSHNLTLAFRMCRAVTGRMLEQEGGGAIVNMGSVLADSPEPRHFATHAYAAAKGA
VAAMTKSMAAYYAPHGIRINLIAPGLVRTPAGERTQADPAFQEFVRKKQPLNSGMIEVAEVARAAVFLLSEESRSVTGEV
FTIDGGWRLSGV
>Mature_252_residues
MREKVLIITGSTGIGAETVRMTAARGARIVIATGDEISGFELAAETGAECWAGDLTLANSADSVLTQCLSKFGRVDGLFN
VAGLSGRRFGDGPVHEIQDDAWHTTLSHNLTLAFRMCRAVTGRMLEQEGGGAIVNMGSVLADSPEPRHFATHAYAAAKGA
VAAMTKSMAAYYAPHGIRINLIAPGLVRTPAGERTQADPAFQEFVRKKQPLNSGMIEVAEVARAAVFLLSEESRSVTGEV
FTIDGGWRLSGV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI66933014, Length=253, Percent_Identity=32.0158102766798, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI40254992, Length=255, Percent_Identity=31.7647058823529, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=29.7297297297297, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=29.7959183673469, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=28.2352941176471, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=30.5882352941176, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI59889578, Length=236, Percent_Identity=30.9322033898305, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI10190704, Length=260, Percent_Identity=29.2307692307692, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=30.1204819277108, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=31.25, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082100, Length=263, Percent_Identity=33.0798479087452, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788459, Length=255, Percent_Identity=30.9803921568627, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=28.5140562248996, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789208, Length=194, Percent_Identity=28.8659793814433, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=28.0155642023346, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=30.6772908366534, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=28.1124497991968, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789378, Length=260, Percent_Identity=27.3076923076923, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=257, Percent_Identity=29.1828793774319, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=29.7397769516729, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=25.6, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=28.2352941176471, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=28.8389513108614, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=28.7878787878788, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=27.1653543307087, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=30.0751879699248, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=269, Percent_Identity=28.996282527881, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=265, Percent_Identity=27.5471698113208, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=265, Percent_Identity=27.1698113207547, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=27.6679841897233, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=29.2134831460674, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=27.6679841897233, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=26.865671641791, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=25.0996015936255, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=29.5454545454545, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=202, Percent_Identity=30.6930693069307, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=27.8195488721804, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=189, Percent_Identity=26.984126984127, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI23397609, Length=257, Percent_Identity=31.9066147859922, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=30.1204819277108, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=29.3436293436293, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737361, Length=258, Percent_Identity=30.6201550387597, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=28.6852589641434, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28571526, Length=257, Percent_Identity=28.4046692607004, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=27.027027027027, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 26664; Mature: 26664

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREKVLIITGSTGIGAETVRMTAARGARIVIATGDEISGFELAAETGAECWAGDLTLANS
CCCEEEEEECCCCCCHHHEEEEECCCCEEEEEECCCCCCEEEHHHCCCCCEECCEEECCC
ADSVLTQCLSKFGRVDGLFNVAGLSGRRFGDGPVHEIQDDAWHTTLSHNLTLAFRMCRAV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHCCCHHHHHHHCCHHHHHHHHHHH
TGRMLEQEGGGAIVNMGSVLADSPEPRHFATHAYAAAKGAVAAMTKSMAAYYAPHGIRIN
HHHHHHCCCCCEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LIAPGLVRTPAGERTQADPAFQEFVRKKQPLNSGMIEVAEVARAAVFLLSEESRSVTGEV
EECCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCCCCCCCEE
FTIDGGWRLSGV
EEECCCEEECCC
>Mature Secondary Structure
MREKVLIITGSTGIGAETVRMTAARGARIVIATGDEISGFELAAETGAECWAGDLTLANS
CCCEEEEEECCCCCCHHHEEEEECCCCEEEEEECCCCCCEEEHHHCCCCCEECCEEECCC
ADSVLTQCLSKFGRVDGLFNVAGLSGRRFGDGPVHEIQDDAWHTTLSHNLTLAFRMCRAV
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHCCCHHHHHHHCCHHHHHHHHHHH
TGRMLEQEGGGAIVNMGSVLADSPEPRHFATHAYAAAKGAVAAMTKSMAAYYAPHGIRIN
HHHHHHCCCCCEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LIAPGLVRTPAGERTQADPAFQEFVRKKQPLNSGMIEVAEVARAAVFLLSEESRSVTGEV
EECCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCCCCCCCEE
FTIDGGWRLSGV
EEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6420184; 3134196; 6413208; 6432532 [H]