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The map label for this gene is glkA [H]

Identifier: 116621979

GI number: 116621979

Start: 3625822

End: 3626763

Strand: Reverse

Name: glkA [H]

Synonym: Acid_2864

Alternate gene names: 116621979

Gene position: 3626763-3625822 (Counterclockwise)

Preceding gene: 116621980

Following gene: 116621975

Centisome position: 36.39

GC content: 66.99

Gene sequence:

>942_bases
GTGGTTCTCGGAATCGATATCGGCGGTAATCAGATCCGCGCCGGCATGGTGGATGCCGATGGCGCGATCCTCGCTTCGCG
CACGCTGCCGACGCCGGGCGACCTGGATACGTTTCTGCCCACCCTGCAGGACGCGATCCGGTGGCTGATGGAGACGACCT
CGCTGCCGGAAGGAGTCGGAGTGGGGTGCAAGGGTATCATCGACCCCGACACTACGCGCATCGAGGCGCTGCCCGGGACC
ATGCACTTCCTGCAGGGACTACGGATCGCGGACCTGGTGGGACTGCCGCTCGAGGTGCCGGTGTTCGCCGACAACGACGC
GCGGGTCGCGCTGGCGGGCGAGATGGTATGGGGCGCGGCGCGAGGGCACGACAATGTCCTGATGTTGACGCTGGGAAATG
GCGTGGGCGGAGCGGCGATTCTGAACGGACGGCTGCTGCGCGGACATTCCGGCGTGGCGGGGCACATGGGGCACATCACG
ATCGAGCCGAACGGGGCGGTGTGCGCGTGCGGCAATCGCGGCTGCCTGGAGACGGTTTTTTCGGCGCGCGCGATCGAGGC
CGAGGCGCAGGCGGCGGTCTTGCGCGGATGCGATTCGGTGCTGACGCGGCTATTCCGCGAGCAGCCGCAGCTGGCCACGT
GCCGGACTATTTTTCAGGCAGCACGGGAAGAGGACGCGGTGGCACGCGCAGTGATCGGACGCGCGATTTTCAAACTCGGT
GCTGCGCTGGCGGGACTGCTGCACCTGTTCGATCCGGAGATCGTGATTCTGGGCGGCAGCGTGGCCGATGCCGGGGAAGA
TTTGATCATCCCACTGCAGGAAGAAGTATGGTCGCGATCGCGCGGGCTGCTGGGGCGGGATGTGCCGATCGTGGAGCAGA
TGGTCGCGGACAAGAGCGGGATTGTGGGGGCGGCGGGATTGGTGATGGCGCCGCGGCCGTGA

Upstream 100 bases:

>100_bases
TCTGCTGAGCGAGGAATCGCGCTCTGTCACCGGAGAAGTGTTCACTATCGATGGCGGCTGGCGCCTGAGCGGCGTCTAAA
ATCCCTGGGGGTTTGGCTTG

Downstream 100 bases:

>100_bases
AAGTTGAGATCGCTCCCTGAGGGTCGCGGTTCGCGGTGACGACGAGCGGTGATGGCGCCGCAGGCGGGGTCAAGGCGATC
GGCTCGTCAGCGGGTGTGGG

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MVLGIDIGGNQIRAGMVDADGAILASRTLPTPGDLDTFLPTLQDAIRWLMETTSLPEGVGVGCKGIIDPDTTRIEALPGT
MHFLQGLRIADLVGLPLEVPVFADNDARVALAGEMVWGAARGHDNVLMLTLGNGVGGAAILNGRLLRGHSGVAGHMGHIT
IEPNGAVCACGNRGCLETVFSARAIEAEAQAAVLRGCDSVLTRLFREQPQLATCRTIFQAAREEDAVARAVIGRAIFKLG
AALAGLLHLFDPEIVILGGSVADAGEDLIIPLQEEVWSRSRGLLGRDVPIVEQMVADKSGIVGAAGLVMAPRP

Sequences:

>Translated_313_residues
MVLGIDIGGNQIRAGMVDADGAILASRTLPTPGDLDTFLPTLQDAIRWLMETTSLPEGVGVGCKGIIDPDTTRIEALPGT
MHFLQGLRIADLVGLPLEVPVFADNDARVALAGEMVWGAARGHDNVLMLTLGNGVGGAAILNGRLLRGHSGVAGHMGHIT
IEPNGAVCACGNRGCLETVFSARAIEAEAQAAVLRGCDSVLTRLFREQPQLATCRTIFQAAREEDAVARAVIGRAIFKLG
AALAGLLHLFDPEIVILGGSVADAGEDLIIPLQEEVWSRSRGLLGRDVPIVEQMVADKSGIVGAAGLVMAPRP
>Mature_313_residues
MVLGIDIGGNQIRAGMVDADGAILASRTLPTPGDLDTFLPTLQDAIRWLMETTSLPEGVGVGCKGIIDPDTTRIEALPGT
MHFLQGLRIADLVGLPLEVPVFADNDARVALAGEMVWGAARGHDNVLMLTLGNGVGGAAILNGRLLRGHSGVAGHMGHIT
IEPNGAVCACGNRGCLETVFSARAIEAEAQAAVLRGCDSVLTRLFREQPQLATCRTIFQAAREEDAVARAVIGRAIFKLG
AALAGLLHLFDPEIVILGGSVADAGEDLIIPLQEEVWSRSRGLLGRDVPIVEQMVADKSGIVGAAGLVMAPRP

Specific function: Required for glucose repression of many different genes [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=268, Percent_Identity=28.3582089552239, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI298566325, Length=268, Percent_Identity=28.3582089552239, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4885285, Length=268, Percent_Identity=28.3582089552239, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI190014632, Length=268, Percent_Identity=28.3582089552239, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1786891, Length=318, Percent_Identity=25.4716981132075, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787878, Length=252, Percent_Identity=26.5873015873016, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082230, Length=268, Percent_Identity=32.089552238806, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787363, Length=274, Percent_Identity=26.2773722627737, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI87081733, Length=323, Percent_Identity=25.6965944272446, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790522, Length=314, Percent_Identity=28.343949044586, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082127, Length=212, Percent_Identity=25.4716981132075, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 32667; Mature: 32667

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLGIDIGGNQIRAGMVDADGAILASRTLPTPGDLDTFLPTLQDAIRWLMETTSLPEGVG
CEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
VGCKGIIDPDTTRIEALPGTMHFLQGLRIADLVGLPLEVPVFADNDARVALAGEMVWGAA
CCCCCCCCCCCCEEEECCCHHHHHCCCCHHHHHCCCEEEEEEECCCCEEEEECCEEEEEC
RGHDNVLMLTLGNGVGGAAILNGRLLRGHSGVAGHMGHITIEPNGAVCACGNRGCLETVF
CCCCCEEEEEECCCCCCEEEECCEEEECCCCCCCCCEEEEECCCCCEEECCCCHHHHHHH
SARAIEAEAQAAVLRGCDSVLTRLFREQPQLATCRTIFQAAREEDAVARAVIGRAIFKLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALAGLLHLFDPEIVILGGSVADAGEDLIIPLQEEVWSRSRGLLGRDVPIVEQMVADKSG
HHHHHHHHHCCCCEEEEECCCCCCCCCEEEECHHHHHHHHCCCCCCCCHHHHHHHHCCCC
IVGAAGLVMAPRP
CEEECCEEECCCC
>Mature Secondary Structure
MVLGIDIGGNQIRAGMVDADGAILASRTLPTPGDLDTFLPTLQDAIRWLMETTSLPEGVG
CEEEEECCCCEEEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
VGCKGIIDPDTTRIEALPGTMHFLQGLRIADLVGLPLEVPVFADNDARVALAGEMVWGAA
CCCCCCCCCCCCEEEECCCHHHHHCCCCHHHHHCCCEEEEEEECCCCEEEEECCEEEEEC
RGHDNVLMLTLGNGVGGAAILNGRLLRGHSGVAGHMGHITIEPNGAVCACGNRGCLETVF
CCCCCEEEEEECCCCCCEEEECCEEEECCCCCCCCCEEEEECCCCCEEECCCCHHHHHHH
SARAIEAEAQAAVLRGCDSVLTRLFREQPQLATCRTIFQAAREEDAVARAVIGRAIFKLG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALAGLLHLFDPEIVILGGSVADAGEDLIIPLQEEVWSRSRGLLGRDVPIVEQMVADKSG
HHHHHHHHHCCCCEEEEECCCCCCCCCEEEECHHHHHHHHCCCCCCCCHHHHHHHHCCCC
IVGAAGLVMAPRP
CEEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1435260; 12000953 [H]