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The map label for this gene is ggt [H]

Identifier: 116621922

GI number: 116621922

Start: 3556946

End: 3558607

Strand: Reverse

Name: ggt [H]

Synonym: Acid_2807

Alternate gene names: 116621922

Gene position: 3558607-3556946 (Counterclockwise)

Preceding gene: 116621924

Following gene: 116621921

Centisome position: 35.71

GC content: 63.96

Gene sequence:

>1662_bases
ATGCGCCGCATCCTAGCTCTGCTGCTGATGGCGGCCACCATACCCCTGTGGGCCGCGCAGCCTGTGCGCGCGCGCCACGG
AATGGTGGTCACCCGAGAACGCCACGCCACCCAGGCCGGCCTCCAGGTTCTGAAGAACGGCGGCAATGCCATCGATGCGG
CGGTCGCGGTTGGACTCGCGCTCGCGGTCACTCATCCCAGCGCGGGCAACATAGGCGGGGGCGGATTCATGCTGATTCGC
CTCGCCGACGGCCGCACCACCTTCATTGATTTCCGCGAACATGCTGCGCAGACCGCATCGCGCAACATGTACCTGGACGC
GACCGGCAAGGCTACGCAGGATTCGGTCACCGGCTATCGCGCCGCCGGAGTTCCCGGCACTGTTCGCGGCCTCGAGTACG
CCAATCACAAATACGGTACGCGTCCCTGGGCGGAACTGGTGCATCCCGCCGTGGAGCTCGCCGCTAAGGGATTCCCGGTC
TCTTACGCGCTCGCCCAATCGCTGCGCGGCTCACGCGGCCTCGCCGCATTCCCGGAATCCCAACGCATTTTCCTCAAGGG
AGGCAAGTTCTATGAACCCGGCGAGTTGCTCACCCAACCCGACCTCGCCCGCACCCTCGAGCGCATCGAGAAGCAAGGCT
CCAAGGATTTCTATGAAGGCGAGACCGCCCGCCTGCTGGCGAAAGACATGGCCACGCACGGTGGACTGATCACCGAAGCC
GACATGAAGATGTATGCCGTTCACGAGCGGGCGCCGCTCACCGGCATGTATCACGGCTACACCGTGGTCACCGCACCTCC
GCCGAGTTCCGGCGGCGTCGGCATTCTGCAAATGCTGGGCATGCTCGATGGCACGGGCTACGAAAAAGGCGGCGCCGGCT
CCGCCTCCGTGGTCCACTACATGACCGAAGCCATGCGACGGTTTTTCGCCGATCGCTCCGAACATCTCGGCGACCCCGAC
TTTGTCAAGGTGCCGATGACCTCCCTGCTCGATCCCAAGTACATCGCCCGCCAGCGCGCGTCCATCGATCCCGAACGCGC
CACCCCAAGCGCGCAGATCAAGGCCGCCAATTTCACCGGCCACGAATCCATGGAGACCACGCATTACACCGTCGCCGATG
AAGCCGGCAACGTGGTCGCCGTCACCTACACGTTGAACGGCGGCTTCGGCAGCAAAGTCACCGCGACCGGCCTCGGCTTC
CTGCTCAATAATGAGATGGATGATTTCGCGTCCAAGCCGGGCGAGGCCAACATGTACGGCCTGATTCAGGGTGAGTTCAA
CGCCATCGCGCCCGGCAAGACCCCGCTCTCCGCCATGACACCGACGATCGTTCTCAAAGACGGAAAGCCCGTGCTGGCCG
TCGGGTCGCCCGGCGGACCCACCATCATCAACACGGTTCTCGAAGTCGTCGTCAACGTGCTGGATTTCGGGATGGGCGTG
CAGGACGCCGTGAACTGGCCGCGTTTCCACCATCAGTGGATGCCTGATGAACTCCGCATGGAACCCGGCTATTCGCCGGA
CACGATCGCGCTTCTCGAAAAGCGCGGCTACATAATCAAGCGCACAAACGCGCAGGGCGAAGCCGCCGCCATCCGCTGGA
ACAACGGATGGCTCGAAGGCGCGCCCGATCCCCGTACCGAAGGCACCGCGGAAGGACACTAA

Upstream 100 bases:

>100_bases
GGATGGCGCCACGGGGCCGTCCGCTCGCAGGACGCCTCGTCCCGCTCTTTGGTCCACGCCGAACAGCGTCTCGCCACGCA
CCTCATAGTAGAATCGAGTG

Downstream 100 bases:

>100_bases
AAGGCCTCAATGGATCACGTACTGTCAACTCACTTGTTCGTGAATCACCGCCTGACGTCGGCCCTGCTCGGCAGAATCGA
GCAGGCCGGTATCCGCGCAG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MRRILALLLMAATIPLWAAQPVRARHGMVVTRERHATQAGLQVLKNGGNAIDAAVAVGLALAVTHPSAGNIGGGGFMLIR
LADGRTTFIDFREHAAQTASRNMYLDATGKATQDSVTGYRAAGVPGTVRGLEYANHKYGTRPWAELVHPAVELAAKGFPV
SYALAQSLRGSRGLAAFPESQRIFLKGGKFYEPGELLTQPDLARTLERIEKQGSKDFYEGETARLLAKDMATHGGLITEA
DMKMYAVHERAPLTGMYHGYTVVTAPPPSSGGVGILQMLGMLDGTGYEKGGAGSASVVHYMTEAMRRFFADRSEHLGDPD
FVKVPMTSLLDPKYIARQRASIDPERATPSAQIKAANFTGHESMETTHYTVADEAGNVVAVTYTLNGGFGSKVTATGLGF
LLNNEMDDFASKPGEANMYGLIQGEFNAIAPGKTPLSAMTPTIVLKDGKPVLAVGSPGGPTIINTVLEVVVNVLDFGMGV
QDAVNWPRFHHQWMPDELRMEPGYSPDTIALLEKRGYIIKRTNAQGEAAAIRWNNGWLEGAPDPRTEGTAEGH

Sequences:

>Translated_553_residues
MRRILALLLMAATIPLWAAQPVRARHGMVVTRERHATQAGLQVLKNGGNAIDAAVAVGLALAVTHPSAGNIGGGGFMLIR
LADGRTTFIDFREHAAQTASRNMYLDATGKATQDSVTGYRAAGVPGTVRGLEYANHKYGTRPWAELVHPAVELAAKGFPV
SYALAQSLRGSRGLAAFPESQRIFLKGGKFYEPGELLTQPDLARTLERIEKQGSKDFYEGETARLLAKDMATHGGLITEA
DMKMYAVHERAPLTGMYHGYTVVTAPPPSSGGVGILQMLGMLDGTGYEKGGAGSASVVHYMTEAMRRFFADRSEHLGDPD
FVKVPMTSLLDPKYIARQRASIDPERATPSAQIKAANFTGHESMETTHYTVADEAGNVVAVTYTLNGGFGSKVTATGLGF
LLNNEMDDFASKPGEANMYGLIQGEFNAIAPGKTPLSAMTPTIVLKDGKPVLAVGSPGGPTIINTVLEVVVNVLDFGMGV
QDAVNWPRFHHQWMPDELRMEPGYSPDTIALLEKRGYIIKRTNAQGEAAAIRWNNGWLEGAPDPRTEGTAEGH
>Mature_553_residues
MRRILALLLMAATIPLWAAQPVRARHGMVVTRERHATQAGLQVLKNGGNAIDAAVAVGLALAVTHPSAGNIGGGGFMLIR
LADGRTTFIDFREHAAQTASRNMYLDATGKATQDSVTGYRAAGVPGTVRGLEYANHKYGTRPWAELVHPAVELAAKGFPV
SYALAQSLRGSRGLAAFPESQRIFLKGGKFYEPGELLTQPDLARTLERIEKQGSKDFYEGETARLLAKDMATHGGLITEA
DMKMYAVHERAPLTGMYHGYTVVTAPPPSSGGVGILQMLGMLDGTGYEKGGAGSASVVHYMTEAMRRFFADRSEHLGDPD
FVKVPMTSLLDPKYIARQRASIDPERATPSAQIKAANFTGHESMETTHYTVADEAGNVVAVTYTLNGGFGSKVTATGLGF
LLNNEMDDFASKPGEANMYGLIQGEFNAIAPGKTPLSAMTPTIVLKDGKPVLAVGSPGGPTIINTVLEVVVNVLDFGMGV
QDAVNWPRFHHQWMPDELRMEPGYSPDTIALLEKRGYIIKRTNAQGEAAAIRWNNGWLEGAPDPRTEGTAEGH

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=555, Percent_Identity=31.8918918918919, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI73915090, Length=555, Percent_Identity=31.8918918918919, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI73915096, Length=555, Percent_Identity=31.8918918918919, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI73915094, Length=555, Percent_Identity=31.8918918918919, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI113429324, Length=556, Percent_Identity=30.3956834532374, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI113429326, Length=564, Percent_Identity=29.9645390070922, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI109148539, Length=553, Percent_Identity=29.2947558770344, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI153266885, Length=502, Percent_Identity=26.6932270916335, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI153266901, Length=503, Percent_Identity=26.8389662027833, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI153266907, Length=501, Percent_Identity=25.3493013972056, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI30581157, Length=224, Percent_Identity=37.0535714285714, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI30581155, Length=224, Percent_Identity=37.0535714285714, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI218505805, Length=223, Percent_Identity=33.6322869955157, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI310124095, Length=223, Percent_Identity=31.390134529148, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1789856, Length=531, Percent_Identity=50.8474576271186, Blast_Score=525, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI72000294, Length=520, Percent_Identity=34.8076923076923, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI212646519, Length=520, Percent_Identity=34.8076923076923, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17506189, Length=544, Percent_Identity=32.3529411764706, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17542894, Length=510, Percent_Identity=31.5686274509804, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI193208245, Length=512, Percent_Identity=30.46875, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI193208247, Length=512, Percent_Identity=30.46875, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17564448, Length=425, Percent_Identity=27.5294117647059, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI72001495, Length=243, Percent_Identity=24.2798353909465, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI72001497, Length=243, Percent_Identity=24.2798353909465, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=517, Percent_Identity=29.0135396518375, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI161077880, Length=543, Percent_Identity=32.5966850828729, Blast_Score=243, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24642670, Length=543, Percent_Identity=32.5966850828729, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24642666, Length=543, Percent_Identity=32.5966850828729, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI45551474, Length=543, Percent_Identity=32.5966850828729, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI161077878, Length=543, Percent_Identity=32.5966850828729, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI161077496, Length=509, Percent_Identity=31.8271119842829, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI18859893, Length=509, Percent_Identity=32.2200392927308, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI18859741, Length=518, Percent_Identity=27.2200772200772, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59332; Mature: 59332

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRILALLLMAATIPLWAAQPVRARHGMVVTRERHATQAGLQVLKNGGNAIDAAVAVGLA
CHHHHHHHHHHHHCCHHCCCCHHHHCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LAVTHPSAGNIGGGGFMLIRLADGRTTFIDFREHAAQTASRNMYLDATGKATQDSVTGYR
EEEECCCCCCCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCCEE
AAGVPGTVRGLEYANHKYGTRPWAELVHPAVELAAKGFPVSYALAQSLRGSRGLAAFPES
ECCCCCHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCC
QRIFLKGGKFYEPGELLTQPDLARTLERIEKQGSKDFYEGETARLLAKDMATHGGLITEA
CEEEEECCCEECCCHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEC
DMKMYAVHERAPLTGMYHGYTVVTAPPPSSGGVGILQMLGMLDGTGYEKGGAGSASVVHY
CCEEEEEECCCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHH
MTEAMRRFFADRSEHLGDPDFVKVPMTSLLDPKYIARQRASIDPERATPSAQIKAANFTG
HHHHHHHHHHHHHHHCCCCCEEECCHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEECCCC
HESMETTHYTVADEAGNVVAVTYTLNGGFGSKVTATGLGFLLNNEMDDFASKPGEANMYG
CCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHHEECCCHHHHHCCCCCCCEEE
LIQGEFNAIAPGKTPLSAMTPTIVLKDGKPVLAVGSPGGPTIINTVLEVVVNVLDFGMGV
EEECCCCEECCCCCCHHHCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCH
QDAVNWPRFHHQWMPDELRMEPGYSPDTIALLEKRGYIIKRTNAQGEAAAIRWNNGWLEG
HHHHCCCHHHCCCCCHHHEECCCCCCCHHHEEECCCEEEEECCCCCCEEEEEECCCEECC
APDPRTEGTAEGH
CCCCCCCCCCCCC
>Mature Secondary Structure
MRRILALLLMAATIPLWAAQPVRARHGMVVTRERHATQAGLQVLKNGGNAIDAAVAVGLA
CHHHHHHHHHHHHCCHHCCCCHHHHCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LAVTHPSAGNIGGGGFMLIRLADGRTTFIDFREHAAQTASRNMYLDATGKATQDSVTGYR
EEEECCCCCCCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCEEEEECCCCCCCCCCCEE
AAGVPGTVRGLEYANHKYGTRPWAELVHPAVELAAKGFPVSYALAQSLRGSRGLAAFPES
ECCCCCHHHCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCC
QRIFLKGGKFYEPGELLTQPDLARTLERIEKQGSKDFYEGETARLLAKDMATHGGLITEA
CEEEEECCCEECCCHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEC
DMKMYAVHERAPLTGMYHGYTVVTAPPPSSGGVGILQMLGMLDGTGYEKGGAGSASVVHY
CCEEEEEECCCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHH
MTEAMRRFFADRSEHLGDPDFVKVPMTSLLDPKYIARQRASIDPERATPSAQIKAANFTG
HHHHHHHHHHHHHHHCCCCCEEECCHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEECCCC
HESMETTHYTVADEAGNVVAVTYTLNGGFGSKVTATGLGFLLNNEMDDFASKPGEANMYG
CCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHHEECCCHHHHHCCCCCCCEEE
LIQGEFNAIAPGKTPLSAMTPTIVLKDGKPVLAVGSPGGPTIINTVLEVVVNVLDFGMGV
EEECCCCEECCCCCCHHHCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCH
QDAVNWPRFHHQWMPDELRMEPGYSPDTIALLEKRGYIIKRTNAQGEAAAIRWNNGWLEG
HHHHCCCHHHCCCCCHHHEECCCCCCCHHHEEECCCEEEEECCCCCCEEEEEECCCEECC
APDPRTEGTAEGH
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]