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The map label for this gene is rocF [H]

Identifier: 116621915

GI number: 116621915

Start: 3547855

End: 3548769

Strand: Reverse

Name: rocF [H]

Synonym: Acid_2800

Alternate gene names: 116621915

Gene position: 3548769-3547855 (Counterclockwise)

Preceding gene: 116621917

Following gene: 116621914

Centisome position: 35.61

GC content: 65.36

Gene sequence:

>915_bases
ATGCCTCGCTCGCACATCGCCATTATCGGCGCGCCTCTCGACCTGGGCCAGGACCGCCGCGGCGTCGATATGGGCCCCTC
CGCCCTCCGCGTCGCCTCCCTCAACGCGCGGATCGCCTCCTTGGGCTATGAAGTCGAGGATTGGGGCAACATTCACGTCG
AGCAAAAGGAAGCCCTGCCCGAAGGCCACCCACGCGCCAAGTACCTTGTACAGATCGCCGCCGCCAGCAAGCTCCTGGCC
GCGCGCGTGGATGACGCCCTCACCCAATCCCTGATGCCTCTGGTCCTCGGCGGCGATCACTCCGTCGCCATCGGCACCGT
CACCGGCGTCGCCCGCCACTACCGCGACCGCGGCCAATCCATCGGCCTCATCTGGCTCGACGCCCATGCCGACATGAATA
CTCCGGACAGCAGTCCAAGCGGCAACATCCACGGCATGCCGCTCGCCTGCATTGTCGGCTGTGGTCCCCCGGAACTCGCA
GATCTCGGCGGCTTCCGCCCCAAGGTCGCGCCATGCAACACCGTCATCGTCGGCCTCCGCGATGTCGACGCCGCCGAGAA
GCCCCAGGTTCGCGACTCCGGTGTCCGCGCCTTCACCATGCGCGATATCGATGAGCGCGGCCTCCGCGCCGTAATGGATG
AAGCCATCCGCGCGGCCTCCGATGGGACCGCCGGAATCCACCTTTCGCTCGACATGGATTTCTGCGACCCCGCCGATGCC
CCGGGCGTCGGCACCCCGGTTCGCGGCGGCGCAACGTACCGCGAAGCGCATTTGGCAATGGAAATGATCTGTGATTCGCG
GCGCGTGATGTCGATGGAGGTGGTCGAGGTGAATCCCGTTATCGACGAGAAGAACCGCACTGCCGATTTCGCCGTCGAGC
TCATCATGTCCGGACTAGGAAAACGTATCTTATGA

Upstream 100 bases:

>100_bases
TCTGCGAGAAAAAAGACTCTCTCCCAAACCCGCATAACCCGGGAATGGCGTCAAGAACAACTTAAAGATCTTCCCCCCGC
TCTCTGTATCATGGAATTGG

Downstream 100 bases:

>100_bases
AATTACGAGTAGCCGTAATATACGGCGGCCGCACCGGCGAACATGAAGTGTCCGTGCGTTCCGCCAAGTCAATCCTCGCC
GGACTCGACTGCGAGAAGTA

Product: arginase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MPRSHIAIIGAPLDLGQDRRGVDMGPSALRVASLNARIASLGYEVEDWGNIHVEQKEALPEGHPRAKYLVQIAAASKLLA
ARVDDALTQSLMPLVLGGDHSVAIGTVTGVARHYRDRGQSIGLIWLDAHADMNTPDSSPSGNIHGMPLACIVGCGPPELA
DLGGFRPKVAPCNTVIVGLRDVDAAEKPQVRDSGVRAFTMRDIDERGLRAVMDEAIRAASDGTAGIHLSLDMDFCDPADA
PGVGTPVRGGATYREAHLAMEMICDSRRVMSMEVVEVNPVIDEKNRTADFAVELIMSGLGKRIL

Sequences:

>Translated_304_residues
MPRSHIAIIGAPLDLGQDRRGVDMGPSALRVASLNARIASLGYEVEDWGNIHVEQKEALPEGHPRAKYLVQIAAASKLLA
ARVDDALTQSLMPLVLGGDHSVAIGTVTGVARHYRDRGQSIGLIWLDAHADMNTPDSSPSGNIHGMPLACIVGCGPPELA
DLGGFRPKVAPCNTVIVGLRDVDAAEKPQVRDSGVRAFTMRDIDERGLRAVMDEAIRAASDGTAGIHLSLDMDFCDPADA
PGVGTPVRGGATYREAHLAMEMICDSRRVMSMEVVEVNPVIDEKNRTADFAVELIMSGLGKRIL
>Mature_303_residues
PRSHIAIIGAPLDLGQDRRGVDMGPSALRVASLNARIASLGYEVEDWGNIHVEQKEALPEGHPRAKYLVQIAAASKLLAA
RVDDALTQSLMPLVLGGDHSVAIGTVTGVARHYRDRGQSIGLIWLDAHADMNTPDSSPSGNIHGMPLACIVGCGPPELAD
LGGFRPKVAPCNTVIVGLRDVDAAEKPQVRDSGVRAFTMRDIDERGLRAVMDEAIRAASDGTAGIHLSLDMDFCDPADAP
GVGTPVRGGATYREAHLAMEMICDSRRVMSMEVVEVNPVIDEKNRTADFAVELIMSGLGKRIL

Specific function: Controls arginine catabolism [H]

COG id: COG0010

COG function: function code E; Arginase/agmatinase/formimionoglutamate hydrolase, arginase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arginase family [H]

Homologues:

Organism=Homo sapiens, GI4502215, Length=307, Percent_Identity=37.4592833876222, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI10947139, Length=306, Percent_Identity=36.6013071895425, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI37537722, Length=308, Percent_Identity=28.2467532467532, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71996843, Length=208, Percent_Identity=41.8269230769231, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6325146, Length=295, Percent_Identity=36.271186440678, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24638886, Length=314, Percent_Identity=31.8471337579618, Blast_Score=154, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014033
- InterPro:   IPR006035
- InterPro:   IPR020855 [H]

Pfam domain/function: PF00491 Arginase [H]

EC number: =3.5.3.1 [H]

Molecular weight: Translated: 32410; Mature: 32278

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00147 ARGINASE_1 ; PS00148 ARGINASE_2 ; PS01053 ARGINASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSHIAIIGAPLDLGQDRRGVDMGPSALRVASLNARIASLGYEVEDWGNIHVEQKEALP
CCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEHHCHHHHHCCCEECCCCCEEEEHHHCCC
EGHPRAKYLVQIAAASKLLAARVDDALTQSLMPLVLGGDHSVAIGTVTGVARHYRDRGQS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEHHHHHHHHHHHCCCE
IGLIWLDAHADMNTPDSSPSGNIHGMPLACIVGCGPPELADLGGFRPKVAPCNTVIVGLR
EEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCCEEEEEEE
DVDAAEKPQVRDSGVRAFTMRDIDERGLRAVMDEAIRAASDGTAGIHLSLDMDFCDPADA
CCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
PGVGTPVRGGATYREAHLAMEMICDSRRVMSMEVVEVNPVIDEKNRTADFAVELIMSGLG
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHH
KRIL
HCCC
>Mature Secondary Structure 
PRSHIAIIGAPLDLGQDRRGVDMGPSALRVASLNARIASLGYEVEDWGNIHVEQKEALP
CCCCEEEEECCCCCCCCCCCCCCCCCCEEEEHHCHHHHHCCCEECCCCCEEEEHHHCCC
EGHPRAKYLVQIAAASKLLAARVDDALTQSLMPLVLGGDHSVAIGTVTGVARHYRDRGQS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEHHHHHHHHHHHCCCE
IGLIWLDAHADMNTPDSSPSGNIHGMPLACIVGCGPPELADLGGFRPKVAPCNTVIVGLR
EEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCCEEEEEEE
DVDAAEKPQVRDSGVRAFTMRDIDERGLRAVMDEAIRAASDGTAGIHLSLDMDFCDPADA
CCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
PGVGTPVRGGATYREAHLAMEMICDSRRVMSMEVVEVNPVIDEKNRTADFAVELIMSGLG
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHH
KRIL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8647285; 10196128 [H]