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The map label for this gene is penA [H]

Identifier: 116517156

GI number: 116517156

Start: 1501747

End: 1503804

Strand: Reverse

Name: penA [H]

Synonym: SPD_1486

Alternate gene names: 116517156

Gene position: 1503804-1501747 (Counterclockwise)

Preceding gene: 116515474

Following gene: 116516007

Centisome position: 73.5

GC content: 41.84

Gene sequence:

>2058_bases
ATGAGACTGATTTGTATGAGAAAATTTAACAGCCATTCGATTCCGATTCGGCTTAATTTATTGTTTTCAATCGTCATTTT
ACTCTTTATGACCATTATTGGTCGTTTGTTGTATATGCAGGTTTTGAACAAGGATTTTTACGAAAAAAAGCTAGCCTCAG
CTAGTCAGACCAAGATTACAAGCAGTTCAGCCCGTGGGGAAATTTATGATGCTAGTGGAAAACCTTTGGTAGAAAATACG
TTAAAGCAGGTTGTTTCCTTTACGCGTAGCAATAAAATGACGGCTACAGACTTAAAAGAAACAGCTAAAAAGTTACTGAC
TTATGTGAGCATCAGTTCTCCAAATTTGACAGAACGCCAGCTGGCGGATTACTATTTGGCTGATCCTGAAATCTATAAAA
AAATAGTGGAAGCTCTCCCAAGCGAGAAACGCTTGGATTCAGATGGCAATCGTCTATCCGAATCAGAACTGTATAACAAT
GCGGTCGATAGTGTACAAACGAGTCAACTAAACTATACAGAGGATGAAAAGAAAGAAATCTATCTTTTTAGTCAGTTAAA
TGCTGTTGGAAACTTTGCGACAGGAACCATTGCTACAGATCCTCTAAATGATTCTCAGGTGGCTGTTATTGCCTCTATTT
CAAAGGAGATGCCTGGCATTAGTATTTCTACTTCTTGGGATAGAAAGGTTTTGGAAACTTCCCTTTCTTCTATAGTTGGG
AGTGTATCCAGTGAAAAAGCTGGTCTCCCAGCGGAAGAAGCAGAAGCCTATCTTAAAAAAGGCTATTCTCTAAATGACCG
TGTAGGAACCTCCTATTTGGAAAAGCAATATGAAGAGACCTTACAAGGAAAACGCTCGGTAAAAGAAATCCATCTGGATA
AATATGGCAATATGGAAAGCGTGGATACAATTGAGGAAGGTAGTAAGGGAAACAATATCAAACTGACCATTGATTTGGCT
TTCCAAGATAGCGTGGATGCTTTACTGAAAAGTTATTTCAATTCTGAGCTAGAAAATGGTGGAGCCAAGTATTCTGAAGG
TGTCTATGCAGTCGCCCTTAACCCAAAAACAGGTGCGGTTTTGTCTATGTCAGGGATTAAACATGACTTGAAAACGGGAG
AGTTGACGCCTGATTCCTTGGGAACGGTAACCAATGTCTTTGTTCCAGGTTCGGTTGTCAAGGCGGCGACCATCAGCTCA
GGTTGGGAAAATGGAGTCTTGTCAGGAAACCAGACCTTGACAGACCAGTCCATTGTCTTCCAAGGTTCAGCTCCCATCAA
TTCTTGGTATACTCAGGCTTACGGTTCATTCCCTATCACAGCGGTCCAAGCTCTGGAGTATTCATCAAATACCTATATGG
TCCAAACAGCCTTAGGTCTTATGGGGCAAACCTATCAACCCAATATGTTTGTCGGCACCAGCAATCTAGAGTCTGCTATG
GAGAAACTGCGTTCAACCTTTGGCGAATATGGCTTGGGTACTGCGACAGGAATTGACCTACCAGATGAATCTACTGGATT
TGTTCCCAAAGAGTATAGCTTTGCTAATTACATTACTAATGCCTTTGGGCAGTTTGATAACTATACGCCGATGCAGTTGG
CTCAGTATGTAGCAACTATTGCAAATAATGGTGTTCGTGTGGCTCCTCGTATTGTTGAAGGCATTTATGGTAATAATGAT
AAGGGAGGACTGGGTGACTTGATTCAGCAACTGCAACCGACAGAGATGAATAAGGTCAATATATCCGACTCCGATATGAG
CATCTTGCACCAAGGTTTTTATCAGGTTGCCCATGGTACTAGTGGATTGACAACTGGACGTGCCTTTTCAAATGGTGCCT
TGGTATCCATTAGCGGAAAAACAGGTACAGCCGAAAGCTATGTGGCAGATGGTCAGCAAGCAACCAATACCAATGCGGTG
GCCTATGCCCCATCTGATAATCCCCAAATCGCTGTCGCAGTGGTCTTTCCTCATAATACCAATCTAACAAATGGTGTAGG
ACCTTCCATTGCGCGTGACATTATCAATCTGTATCAAAAATACCATCCAATGAATTAG

Upstream 100 bases:

>100_bases
ATCTCTGTTTTAAAAACGAAAAAATCGAAAAAGCTTCTCTCTTTTCCATAATTTTCTACTCAAATTGTGGTACAATTAAG
AGTAAGATTTTAAGTTAGAA

Downstream 100 bases:

>100_bases
AAAGGAAATTATGCTTTATCCAACACCTATTGCCAAGTTGATTGACAGTTATTCTAAGTTACCAGGTATCGGGATTAAGA
CGGCTACGCGTCTGGCCTTT

Product: penicillin-binding protein 2B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 685; Mature: 685

Protein sequence:

>685_residues
MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSARGEIYDASGKPLVENT
LKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNN
AVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVG
SVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLA
FQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISS
GWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAM
EKLRSTFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNND
KGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAV
AYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN

Sequences:

>Translated_685_residues
MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSARGEIYDASGKPLVENT
LKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNN
AVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVG
SVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLA
FQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISS
GWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAM
EKLRSTFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNND
KGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAV
AYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN
>Mature_685_residues
MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSARGEIYDASGKPLVENT
LKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNN
AVDSVQTSQLNYTEDEKKEIYLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVG
SVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIEEGSKGNNIKLTIDLA
FQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISS
GWENGVLSGNQTLTDQSIVFQGSAPINSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAM
EKLRSTFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGVRVAPRIVEGIYGNND
KGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAV
AYAPSDNPQIAVAVVFPHNTNLTNGVGPSIARDIINLYQKYHPMN

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=628, Percent_Identity=23.8853503184713, Blast_Score=106, Evalue=6e-24,
Organism=Escherichia coli, GI1786272, Length=311, Percent_Identity=26.6881028938907, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 74490; Mature: 74490

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKIT
CEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEE
SSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQ
CCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCHHHH
LADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEI
HHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEE
YLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVG
EEEEHHHHHCCCCCCCEEECCCCCCCEEEEEEHHHCCCCCEEECCHHHHHHHHHHHHHHH
SVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMES
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAV
HHHHHCCCCCCEEEEEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCE
LSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVF
EEECCCCHHCCCCCCCCCHHCCHHEEECCCCHHHHHHHCCCCCCCCCCCCCEECCCEEEE
QGSAPINSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAM
ECCCCCHHHHHHHCCCCCHHHHHHEEECCCCEEEEEHHHHCCCCCCCCEEEECCHHHHHH
EKLRSTFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATI
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ANNGVRVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGT
HCCCEEECHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHCCC
SGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNT
CCCCCCCEECCCEEEEEECCCCCCHHHHCCCCCCCCCCEEEECCCCCCCEEEEEEECCCC
NLTNGVGPSIARDIINLYQKYHPMN
CCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLICMRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKIT
CEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEE
SSSARGEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQ
CCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCCHHHH
LADYYLADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEI
HHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEE
YLFSQLNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVG
EEEEHHHHHCCCCCCCEEECCCCCCCEEEEEEHHHCCCCCEEECCHHHHHHHHHHHHHHH
SVSSEKAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMES
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VDTIEEGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAV
HHHHHCCCCCCEEEEEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCE
LSMSGIKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVF
EEECCCCHHCCCCCCCCCHHCCHHEEECCCCHHHHHHHCCCCCCCCCCCCCEECCCEEEE
QGSAPINSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAM
ECCCCCHHHHHHHCCCCCHHHHHHEEECCCCEEEEEHHHHCCCCCCCCEEEECCHHHHHH
EKLRSTFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATI
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ANNGVRVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGT
HCCCEEECHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHCCC
SGLTTGRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNT
CCCCCCCEECCCEEEEEECCCCCCHHHHCCCCCCCCCCEEEECCCCCCCEEEEEEECCCC
NLTNGVGPSIARDIINLYQKYHPMN
CCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916; 2654541 [H]