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The map label for this gene is rnc

Identifier: 116517072

GI number: 116517072

Start: 1138196

End: 1138894

Strand: Reverse

Name: rnc

Synonym: SPD_1105

Alternate gene names: 116517072

Gene position: 1138894-1138196 (Counterclockwise)

Preceding gene: 116516265

Following gene: 116515906

Centisome position: 55.66

GC content: 40.34

Gene sequence:

>699_bases
ATGAAAGAATTACAAACTGTACTAAAGAATCATTTTGAAATCGAATTTGCAGACAAAAAGTTACTGGAAACTGCCTTTAC
TCATACGAGTTATGCCAATGAGCACCGCCTCTTAAAAATTTCACACAATGAACGCTTGGAATTTTTAGGAGACGCTGTTC
TACAGTTATTGATTTCAGAATATCTATATAAAAAATATCCTAAAAAGCCTGAAGGTGACCTATCAAAACTCCGTGCTATG
ATTGTCCGTGAGGAGAGTTTAGCTGGTTTTGCGCGTGATTGCCAGTTTGACCAGTTTATCAAGTTGGGTAAAGGGGAAGA
AAAATCTGGTGGTCGCAATCGTGACACCATTCTTGGTGATGCCTTTGAAGCCTTTCTTGGTGCCCTTCTTTTGGATAAGG
ATGTGGCAAAGGTCAAGGAATTTATCTACCAAGTTATGATTCCTAAGGTAGAAGCAGGCGAATTTGAGATGATTACAGAC
TATAAAACCCATCTCCAAGAGTTGCTTCAGGTCAATGGTGATGTGGCTATTCGTTATCAGGTGATTTCTGAAACAGGGCC
TGCTCACGATAAGGTCTTTGATGTAGAAGTTCTTGTTGAAGGTAAGAGCATCGGTCAAGGCCAAGGTCGTTCTAAGAAAT
TAGCAGAGCAGGAAGCTGCCAAAAATGCCGTTGAGAAAGGGCTGGATTCATGTATTTAA

Upstream 100 bases:

>100_bases
TAAAGAATTCCCAAATGCTTTCCAGTCCCGTTTTAGAGTGACTCAGGGGGCTTTTTTTGATATAATAAAAAGGACTATTA
TCAGTTAGAAAGAAGTTGGT

Downstream 100 bases:

>100_bases
AGGAAATCGAAATTCAGGGGTTCAAGTCTTTTGCTGATAAGACCAAGGTCGTTTTTGACCAAGGTGTGACGGCAGTTGTT
GGACCCAATGGATCTGGAAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKELQTVLKNHFEIEFADKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAM
IVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI

Sequences:

>Translated_232_residues
MKELQTVLKNHFEIEFADKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAM
IVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI
>Mature_232_residues
MKELQTVLKNHFEIEFADKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISEYLYKKYPKKPEGDLSKLRAM
IVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGDAFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITD
YKTHLQELLQVNGDVAIRYQVISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=239, Percent_Identity=32.2175732217573, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI155030236, Length=239, Percent_Identity=32.2175732217573, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788920, Length=203, Percent_Identity=38.9162561576355, Blast_Score=137, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17506883, Length=218, Percent_Identity=31.1926605504587, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193202651, Length=218, Percent_Identity=31.1926605504587, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6323895, Length=198, Percent_Identity=29.2929292929293, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17137682, Length=239, Percent_Identity=33.8912133891213, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_STRP2 (Q04K72)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816576.1
- ProteinModelPortal:   Q04K72
- SMR:   Q04K72
- STRING:   Q04K72
- EnsemblBacteria:   EBSTRT00000019438
- GeneID:   4441922
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1105
- eggNOG:   COG0571
- GeneTree:   EBGT00050000028295
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26226; Mature: 26226

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELQTVLKNHFEIEFADKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISE
CHHHHHHHHHCCEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
YLYKKYPKKPEGDLSKLRAMIVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHH
AFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITDYKTHLQELLQVNGDVAIRYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
VISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI
EECCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKELQTVLKNHFEIEFADKKLLETAFTHTSYANEHRLLKISHNERLEFLGDAVLQLLISE
CHHHHHHHHHCCEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
YLYKKYPKKPEGDLSKLRAMIVREESLAGFARDCQFDQFIKLGKGEEKSGGRNRDTILGD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHHH
AFEAFLGALLLDKDVAKVKEFIYQVMIPKVEAGEFEMITDYKTHLQELLQVNGDVAIRYQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
VISETGPAHDKVFDVEVLVEGKSIGQGQGRSKKLAEQEAAKNAVEKGLDSCI
EECCCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA