Click here to switch to the map view.

The map label for this gene is guaC

Identifier: 116516265

GI number: 116516265

Start: 1139212

End: 1140198

Strand: Reverse

Name: guaC

Synonym: SPD_1107

Alternate gene names: 116516265

Gene position: 1140198-1139212 (Counterclockwise)

Preceding gene: 116516577

Following gene: 116517072

Centisome position: 55.73

GC content: 42.55

Gene sequence:

>987_bases
ATGTTAAATGAATTTCCAATTTTTGATTACGAAGATATTCAATTGATTCCAAATAAATGTGTCATTAAAAGCCGTGCAGA
AGCGGATACAAGTGTCACTTTAGGAAATCACACCTTTAAACTACCTGTTGTGCCAGCGAATATGCAGACGATTTTGGATG
AAAATGTAGCAGAGCAACTGGCTAAAGGTGGTTACTTCTACATTATGCACCGTTTTGATGAGGCAGGACGCATTCCTTTT
ATTAAACGAATGCACGATCAAGGGCTCATTGCTTCCATATCTGTCGGTGTTAAGGATTATGAGTATGATTTTGTTAGCCA
GCTCAAGGCTGATGCTCCTGAGTATATCACTATTGATATTGCTCATGGTCATGCGGATAGCGTGATTTCTATGATTCAAC
ACATCAAGAAAGAATTGCCAGATACCTTTGTCATTGCTGGAAATGTGGGAACACCAGAAGCTGTGCGTGAATTGGAAAAT
GCTGGTGCAGATGCTACTAAGGTCGGAATCGGTCCTGGTAAGGTTTGTATCACCAAGGTTAAGACTGGTTTTGGTACAGG
TGGTTGGCAGTTGGCTGCTCTACGCTGGTGTGCCAAGGCTGCGCGTAAACCGATTATCGCTGATGGAGGAATTCGTACTC
ACGGTGATATTGCCAAGTCTATCCGCTTCGGTGCTAGCATGATCATGATTGGTTCCCTCTTTGCAGGACACATTGAAAGT
CCAGGGAAAACGATTGAAGTCGATGGTGAACAGTTCAAAGAATATTATGGTTCAGCCTCACAATATCAGAAAGGTGCTTA
CAAAAATGTGGAAGGCAAACGTATCTTGCTTCCTGCTAAAGGTCATCTGCAAGACACTTTAACTGAGATGGAACAAGACC
TTCAAAGTGCTATTTCTTATGCAGGTGGACGTCAGGTTGCTGACCTTAAACACGTTGATTATGTGATCGTGAAAAACTCC
ATCTGGAATGGGGATGCTTCCCACTAA

Upstream 100 bases:

>100_bases
AAAACTGTACTTTGGTTTATAATAAATTAAGGAAACGTCGGAAAAGGCGTAGTGATGCGAGAGCATAGGTAGGTCATTAC
AAAAGAAACGAGACATCGAT

Downstream 100 bases:

>100_bases
GACGGGGTCTTTGACCAAAAAACTTGTTATTAGAGCAAATTTCTGTTATAATAAAACAAGTTTCCACCCTTAGTGTAATG
GATATCACGTAAGATTCCGG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPF
IKRMHDQGLIASISVGVKDYEYDFVSQLKADAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNS
IWNGDASH

Sequences:

>Translated_328_residues
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPF
IKRMHDQGLIASISVGVKDYEYDFVSQLKADAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNS
IWNGDASH
>Mature_328_residues
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPF
IKRMHDQGLIASISVGVKDYEYDFVSQLKADAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELEN
AGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNS
IWNGDASH

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily

Homologues:

Organism=Homo sapiens, GI50541954, Length=326, Percent_Identity=34.3558282208589, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI50541952, Length=326, Percent_Identity=34.3558282208589, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI50541948, Length=326, Percent_Identity=34.3558282208589, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI50541956, Length=326, Percent_Identity=34.3558282208589, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI156104880, Length=320, Percent_Identity=30.625, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI217035150, Length=273, Percent_Identity=31.5018315018315, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI217035148, Length=273, Percent_Identity=31.5018315018315, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI217035146, Length=273, Percent_Identity=31.5018315018315, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI217035152, Length=273, Percent_Identity=31.5018315018315, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI156616279, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI34328930, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI34328928, Length=273, Percent_Identity=31.5018315018315, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI66933016, Length=238, Percent_Identity=33.1932773109244, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786293, Length=340, Percent_Identity=31.7647058823529, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788855, Length=223, Percent_Identity=36.322869955157, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17560440, Length=329, Percent_Identity=34.3465045592705, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71994389, Length=169, Percent_Identity=37.2781065088757, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994385, Length=169, Percent_Identity=37.2781065088757, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323464, Length=175, Percent_Identity=33.1428571428571, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322012, Length=256, Percent_Identity=28.125, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323585, Length=175, Percent_Identity=32.5714285714286, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319352, Length=210, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641071, Length=192, Percent_Identity=33.8541666666667, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24641073, Length=192, Percent_Identity=33.8541666666667, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI28571163, Length=192, Percent_Identity=33.8541666666667, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): GUAC_STRP2 (Q04K71)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816577.1
- ProteinModelPortal:   Q04K71
- SMR:   Q04K71
- STRING:   Q04K71
- EnsemblBacteria:   EBSTRT00000020264
- GeneID:   4441775
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1107
- eggNOG:   COG0516
- GeneTree:   EBGT00050000027666
- HOGENOM:   HBG298985
- OMA:   PDYITID
- ProtClustDB:   PRK05458
- HAMAP:   MF_01511
- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF036500
- TIGRFAMs:   TIGR01306

Pfam domain/function: PF00478 IMPDH

EC number: =1.7.1.7

Molecular weight: Translated: 35883; Mature: 35883

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: ACT_SITE 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQL
CCCCCCCCCCCCCEECCCHHEECCCCCCCCEEEECCEEEEEEEECCHHHHHHHHHHHHHH
AKGGYFYIMHRFDEAGRIPFIKRMHDQGLIASISVGVKDYEYDFVSQLKADAPEYITIDI
HCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEE
AHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKV
ECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEE
KTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
ECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCC
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISY
CCCEEEECHHHHHHHCCCHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
AGGRQVADLKHVDYVIVKNSIWNGDASH
CCCCEEEHHHHCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQL
CCCCCCCCCCCCCEECCCHHEECCCCCCCCEEEECCEEEEEEEECCHHHHHHHHHHHHHH
AKGGYFYIMHRFDEAGRIPFIKRMHDQGLIASISVGVKDYEYDFVSQLKADAPEYITIDI
HCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEE
AHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKV
ECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEE
KTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIES
ECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCC
PGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISY
CCCEEEECHHHHHHHCCCHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
AGGRQVADLKHVDYVIVKNSIWNGDASH
CCCCEEEHHHHCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA