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The map label for this gene is pyrDb [H]

Identifier: 116517057

GI number: 116517057

Start: 865521

End: 866459

Strand: Direct

Name: pyrDb [H]

Synonym: SPD_0852

Alternate gene names: 116517057

Gene position: 865521-866459 (Clockwise)

Preceding gene: 116515976

Following gene: 116517112

Centisome position: 42.3

GC content: 43.88

Gene sequence:

>939_bases
ATGACTACAAATCGATTACAAGTGTCTCTACCTGGTTTGGATTTGAAAAATCCGATTATTCCAGCATCAGGCTGTTTTGG
CTTTGGACAAGAGTATGCCAAGTACTATGATTTAAACCTTTTAGGTTCTATTATGATCAAGGCGACAACCCTTGAACCAC
GTTTTGGGAACCCAACTCCAAGAGTAGCAGAGACGCCTGCTGGTATGCTCAATGCAATTGGCTTGCAAAATCCTGGTTTA
GAGGTTGTTTTGGCTGAAAAGCTACCTTGGCTGGAAAGAGAATATCCAAATCTTCCTATTATTGCCAATGTAGCTGGTTT
TTCAAAACAAGAGTATGCAGCTGTTTCTCATGGGATTTCCAAGGCAACTAATGTAAAAGCTATCGAGCTCAATATTTCTT
GTCCCAATGTTGACCACTGTAATCATGGACTTTTGATTGGTCAAGATCCAGATTTGGCTTATGATGTGGTGAAAGCAGCT
GTGGAAGCCTCAGAAGTGCCAGTTTATGTCAAATTAACCCCGAGTGTGACCGATATCGTTACTGTCGCAAAAGCTGCAGA
AGATGCGGGAGCAAGTGGCTTGACCATGATCAATACTCTGGTTGGAATGCGCTTTGACCTCAAAACCAGAAAACCAATCT
TGGCCAATGGAACAGGTGGAATGTCAGGTCCAGCAGTCTTTCCAGTAGCCCTCAAACTCATCCGCCAAGTAGCCCAAACA
ACAGACCTGCCTATCATTGGAATGGGGGGAGTGGATTCGACTGAAGCTGCCCTAGAAATGTATCTGGCTGGGGCATCTGC
TATCGGAGTTGGAACAGCTAACTTTACCAATCCTTATGCCTGCCCTGACATCATCGAAAATTTACCAAAAGTCATGGATA
AATACGGTATTAGCAGTCTGGAAGAACTCCGTCAGGAAGTAAAAGAGTCTCTGAGGTAA

Upstream 100 bases:

>100_bases
TGTGTTCTAAAAGTACCAGAAAGCGAGACGGTCAGCCAACGCGTCTGTGAAGATGGTCCTGTTTTCCGCACAGGAACAGT
TGTATTATAAGGAGAAAATT

Downstream 100 bases:

>100_bases
ACTGCAATCAATCTGTTCTTGATTTTTTATTAGTTTGTAATATGAATTTAGGAGAATTTTGGTACAATAAAATAAATAAG
AACAGAGGAAGAAGGTTGAT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase B; DHOD B; DHODase B; Dihydroorotate oxidase B [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTTNRLQVSLPGLDLKNPIIPASGCFGFGQEYAKYYDLNLLGSIMIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGL
EVVLAEKLPWLEREYPNLPIIANVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGLLIGQDPDLAYDVVKAA
VEASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVGMRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQT
TDLPIIGMGGVDSTEAALEMYLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSLEELRQEVKESLR

Sequences:

>Translated_312_residues
MTTNRLQVSLPGLDLKNPIIPASGCFGFGQEYAKYYDLNLLGSIMIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGL
EVVLAEKLPWLEREYPNLPIIANVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGLLIGQDPDLAYDVVKAA
VEASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVGMRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQT
TDLPIIGMGGVDSTEAALEMYLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSLEELRQEVKESLR
>Mature_311_residues
TTNRLQVSLPGLDLKNPIIPASGCFGFGQEYAKYYDLNLLGSIMIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGLE
VVLAEKLPWLEREYPNLPIIANVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGLLIGQDPDLAYDVVKAAV
EASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVGMRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQTT
DLPIIGMGGVDSTEAALEMYLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSLEELRQEVKESLR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=192, Percent_Identity=34.375, Blast_Score=114, Evalue=9e-26,
Organism=Escherichia coli, GI87082059, Length=327, Percent_Identity=29.9694189602446, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71984108, Length=192, Percent_Identity=32.8125, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322633, Length=298, Percent_Identity=28.5234899328859, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24640763, Length=193, Percent_Identity=35.2331606217617, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI18858217, Length=193, Percent_Identity=35.2331606217617, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI281361352, Length=321, Percent_Identity=28.0373831775701, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137316, Length=321, Percent_Identity=28.0373831775701, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 33168; Mature: 33036

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNRLQVSLPGLDLKNPIIPASGCFGFGQEYAKYYDLNLLGSIMIKATTLEPRFGNPTP
CCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCC
RVAETPAGMLNAIGLQNPGLEVVLAEKLPWLEREYPNLPIIANVAGFSKQEYAAVSHGIS
CCCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHCCH
KATNVKAIELNISCPNVDHCNHGLLIGQDPDLAYDVVKAAVEASEVPVYVKLTPSVTDIV
HCCCEEEEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHH
TVAKAAEDAGASGLTMINTLVGMRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQT
HHHHHHHHCCCCCHHHHHHHHCCEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHH
TDLPIIGMGGVDSTEAALEMYLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSL
CCCCEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHH
EELRQEVKESLR
HHHHHHHHHHCC
>Mature Secondary Structure 
TTNRLQVSLPGLDLKNPIIPASGCFGFGQEYAKYYDLNLLGSIMIKATTLEPRFGNPTP
CCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCC
RVAETPAGMLNAIGLQNPGLEVVLAEKLPWLEREYPNLPIIANVAGFSKQEYAAVSHGIS
CCCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCCCEEEECCCCCHHHHHHHHHCCH
KATNVKAIELNISCPNVDHCNHGLLIGQDPDLAYDVVKAAVEASEVPVYVKLTPSVTDIV
HCCCEEEEEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHH
TVAKAAEDAGASGLTMINTLVGMRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQT
HHHHHHHHCCCCCHHHHHHHHCCEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHH
TDLPIIGMGGVDSTEAALEMYLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSL
CCCCEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHH
EELRQEVKESLR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]