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The map label for this gene is czcD [H]

Identifier: 116516957

GI number: 116516957

Start: 1652152

End: 1653042

Strand: Reverse

Name: czcD [H]

Synonym: SPD_1638

Alternate gene names: 116516957

Gene position: 1653042-1652152 (Counterclockwise)

Preceding gene: 116515309

Following gene: 116515738

Centisome position: 80.79

GC content: 40.85

Gene sequence:

>891_bases
ATGAAGGCAAAATATGCTGTTTGGGTGGCTTTTTTCTTAAATTTGACTTATGCCATTGTTGAGTTTATTGCAGGTGGAGT
ATTTGGTTCTAGCGCTGTTCTTGCTGACTCTGTGCATGACTTGGGAGATGCGATTGCAATTGGAATATCAGCTTTTCTAG
AAACAATCTCCAATCGTGAAGAAGACAATCAGTACACCTTGGGCTATAAGCGGTTTAGCCTGCTAGGAGCCTTGGTAACA
GCTGTGATTCTCGTAACGGGCTCTGTTCTAGTCATTTTGGAAAATGTCACGAAGATTTTGCATCCGCAACCAGTCAATGA
TGAGGGGATTCTCTGGTTAGGAATTATTGCGATTACTATCAATCTGTTAGCGAGTCTGGTGGTTGGTAAGGGAAAGACAA
AGAATGAGTCTATTCTGAGTCTGCATTTTCTGGAAGATACGCTAGGGTGGGTAGCTGTTATCCTGATGGCGATTGTTCTT
CGATTTACGGACTGGTATATCCTAGATCCTCTTTTGTCCCTTGTCATTTCTTTCTTTATTCTTTCAAAAGCCCTTCCACG
TTTTTGGTCTACACTCAAGATTTTCTTGGATGCTGTGCCAGAAGGTCTTGATATCAAGCAAGTAAAGAGTGGCCTGGAGC
GATTGGACAATGTGGCCAGCCTTAATCAGCTTAATCTCTGGACTATGGATGCTTTGGAAAAAAATGCCATTGTCCATGTT
TGTCTAAAAGAAATGGAACATATGGAAACTTGTAAAGAGTCTATTCGAATTTTCCTAAAAGATTGTGGTTTTCAAAATAT
TACCATTGAAATTGATGCTGACCTAGAAACTCACCAAACCCATAAGCGAAAGGTGTGTGACTTGGAACGGAGTTATGAGC
ATCAACATTAG

Upstream 100 bases:

>100_bases
ATAAAGCTGACGTTTTGCTTCTATCCTTTCTTTGAGTTTTAGTGGATAATGATAATGAACAAGGTGTTCATAAATCTATT
ATAACAAAGGAATGAGAAAT

Downstream 100 bases:

>100_bases
AAAAAAGTGAAAAATACTTGGGTACTATCTTATTTGGAATAGAGTAATTTCTTTATTATTTAAATATTTCAAAAATTGGT
AAGAGAAGAGCATTGTATAA

Product: cation efflux system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDAIAIGISAFLETISNREEDNQYTLGYKRFSLLGALVT
AVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
RFTDWYILDPLLSLVISFFILSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH

Sequences:

>Translated_296_residues
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDAIAIGISAFLETISNREEDNQYTLGYKRFSLLGALVT
AVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
RFTDWYILDPLLSLVISFFILSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH
>Mature_296_residues
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDAIAIGISAFLETISNREEDNQYTLGYKRFSLLGALVT
AVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITINLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVL
RFTDWYILDPLLSLVISFFILSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=317, Percent_Identity=23.0283911671924, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI52352805, Length=288, Percent_Identity=25, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI289803013, Length=289, Percent_Identity=23.1833910034602, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI289803009, Length=289, Percent_Identity=23.1833910034602, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI289803007, Length=289, Percent_Identity=23.1833910034602, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI289803003, Length=289, Percent_Identity=23.1833910034602, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI64762489, Length=289, Percent_Identity=23.1833910034602, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786966, Length=269, Percent_Identity=26.7657992565056, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555794, Length=294, Percent_Identity=22.4489795918367, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17555796, Length=294, Percent_Identity=22.4489795918367, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI32564488, Length=302, Percent_Identity=22.1854304635762, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193210990, Length=298, Percent_Identity=25.8389261744966, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33127; Mature: 33127

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDAIAIGISAFLETISNRE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDNQYTLGYKRFSLLGALVTAVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITI
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
NLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVLRFTDWYILDPLLSLVISFFI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKAKYAVWVAFFLNLTYAIVEFIAGGVFGSSAVLADSVHDLGDAIAIGISAFLETISNRE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EDNQYTLGYKRFSLLGALVTAVILVTGSVLVILENVTKILHPQPVNDEGILWLGIIAITI
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
NLLASLVVGKGKTKNESILSLHFLEDTLGWVAVILMAIVLRFTDWYILDPLLSLVISFFI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKALPRFWSTLKIFLDAVPEGLDIKQVKSGLERLDNVASLNQLNLWTMDALEKNAIVHV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
CLKEMEHMETCKESIRIFLKDCGFQNITIEIDADLETHQTHKRKVCDLERSYEHQH
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]