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The map label for this gene is sufS [H]

Identifier: 116516952

GI number: 116516952

Start: 774721

End: 775947

Strand: Direct

Name: sufS [H]

Synonym: SPD_0764

Alternate gene names: 116516952

Gene position: 774721-775947 (Clockwise)

Preceding gene: 116516109

Following gene: 116516679

Centisome position: 37.86

GC content: 44.74

Gene sequence:

>1227_bases
ATGTTAGATGTAGAAGCGATTCGCAAGGATTTTCCAATTTTAGATCAGATTGTCAATGATGAACCTCTGGTCTATCTGGA
CAATGCTGCGACGACACAAAAACCACTAGTAGTTCTGAAAGCTATTAACAGCTACTATGAGCAGGACAATGCCAATGTTC
ACCGTGGTGTCCATACCTTAGCGGAACGAGCGACAGCTTCTTATGAAGCTGCTCGTGAAACCATTCGTAAGTTTATTAAT
GCAGGCTCTACAAAGGAAGTTCTCTTTACCAGAGGAACGACAACCAGCCTTAACTGGGTGGCACGCTTTGCTGAGGAAAT
TCTCACTGAGGGAGACCAGGTCTTGATTTCAGTAATGGAACACCATTCTAATATCATTCCATGGCAGGAAGCTTGTCGAA
AGACTGGAGCAGAGCTTGTCTATGTCTATCTTAAAGACGGTGCCTTGGATATGGAGGGTTTGCGAGCTAAATTGACTGAT
AAGGTTAAATTTGTTTCCCTAGCTCATGCCTCCAATGTTCTTGGTGTGGTCAATCCGATCAAGGAAATCACTCAATTAGC
CCACCAAGTTGGGGCAATCATGGTAGTGGATGGTGCTCAATCTACACCTCATATGAAGATTGATGTCCAGGACTTGGATC
TGGACTTTTTCGCCTTTTCGGCTCACAAGATGGCTGGTCCGACTGGTATCGGTGTCCTTTACGGCAAAGAAAAGTATCTT
GAGCAAATGTCTCCAGTAGAATTTGGCGGCGAGATGATTGATTTTGTCTACGAGCAATCTGCTAGTTGGAAGGAATTGCC
TTGGAAATTTGAGGCTGGAACGCCAAATATGGCAGGAGCTATTGGACTTGCGACTGCAGTTGATTATCTGGAAAAGATTG
GTATGGATGCCATTGAAGCTCATGAACAGGAATTGATTGCGTACGTCTATCCAAAACTGCAGGCAATTGAGGGATTGACC
ATTTACGGTTCTCAGGATTTGGCTCAACGTTCGGGTGTTATTGCCTTTAACCTAGGTGATCTCCATCCTCACGATCTTGC
GACGGCTCTGGATTATGAAGGAGTGGCTGTTCGTGCTGGTCACCATTGTGCGCAACCCTTGCTTCAGTATTTGGAAGTCC
CAGCAACAGCTCGTGCAAGTTTTTATATCTACAATACCAAGGCAGATTGCGACAAACTAGTCGATGCCCTACAAAAGACA
AAGGAGTTTTTCAATGGCACTTTCTAA

Upstream 100 bases:

>100_bases
TTCCTTGGATCTGTTATCGTGGAGATTCCAGTCAAGGAAGTTCGTGATGAAATGATTGCAACTATCGAAGAGAAATTGTC
AAAACGCTAAGGGGCAGCCT

Downstream 100 bases:

>100_bases
ACTAGATAGCCTTTATATGGCAGTGGTAGCAGACCATTCGAAAAATCCACATCACCAAGGGAAGTTAGAAGACGCTGAGC
AAATCAGTCTCAACAATCCG

Product: cysteine desulfurases, SufS subfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTLAERATASYEAARETIRKFIN
AGSTKEVLFTRGTTTSLNWVARFAEEILTEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEGLRAKLTD
KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSAHKMAGPTGIGVLYGKEKYL
EQMSPVEFGGEMIDFVYEQSASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAIEAHEQELIAYVYPKLQAIEGLT
IYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKT
KEFFNGTF

Sequences:

>Translated_408_residues
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTLAERATASYEAARETIRKFIN
AGSTKEVLFTRGTTTSLNWVARFAEEILTEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEGLRAKLTD
KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSAHKMAGPTGIGVLYGKEKYL
EQMSPVEFGGEMIDFVYEQSASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAIEAHEQELIAYVYPKLQAIEGLT
IYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKT
KEFFNGTF
>Mature_408_residues
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTLAERATASYEAARETIRKFIN
AGSTKEVLFTRGTTTSLNWVARFAEEILTEGDQVLISVMEHHSNIIPWQEACRKTGAELVYVYLKDGALDMEGLRAKLTD
KVKFVSLAHASNVLGVVNPIKEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSAHKMAGPTGIGVLYGKEKYL
EQMSPVEFGGEMIDFVYEQSASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAIEAHEQELIAYVYPKLQAIEGLT
IYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAGHHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKT
KEFFNGTF

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=231, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156713448, Length=325, Percent_Identity=25.5384615384615, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787970, Length=407, Percent_Identity=46.6830466830467, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1789175, Length=400, Percent_Identity=41.75, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI48994898, Length=218, Percent_Identity=29.3577981651376, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=384, Percent_Identity=28.125, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25143064, Length=223, Percent_Identity=31.8385650224215, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6319831, Length=347, Percent_Identity=26.2247838616715, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI20129463, Length=241, Percent_Identity=28.2157676348548, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45135; Mature: 45135

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTL
CCCHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AERATASYEAARETIRKFINAGSTKEVLFTRGTTTSLNWVARFAEEILTEGDQVLISVME
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
HHSNIIPWQEACRKTGAELVYVYLKDGALDMEGLRAKLTDKVKFVSLAHASNVLGVVNPI
HCCCCCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
KEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSAHKMAGPTGIGVLYGKEKYL
HHHHHHHHHHCEEEEEECCCCCCCEEEEEEECCCCCEEEHHHHCCCCCCEEEEECCHHHH
EQMSPVEFGGEMIDFVYEQSASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAIEA
HHCCCHHHCHHHHHHHHHCCCCHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHH
HEQELIAYVYPKLQAIEGLTIYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAG
HHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCEEEEECCCCCHHHHHHHCCCCCEEEECC
HHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKTKEFFNGTF
HHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDVEAIRKDFPILDQIVNDEPLVYLDNAATTQKPLVVLKAINSYYEQDNANVHRGVHTL
CCCHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AERATASYEAARETIRKFINAGSTKEVLFTRGTTTSLNWVARFAEEILTEGDQVLISVME
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
HHSNIIPWQEACRKTGAELVYVYLKDGALDMEGLRAKLTDKVKFVSLAHASNVLGVVNPI
HCCCCCCHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
KEITQLAHQVGAIMVVDGAQSTPHMKIDVQDLDLDFFAFSAHKMAGPTGIGVLYGKEKYL
HHHHHHHHHHCEEEEEECCCCCCCEEEEEEECCCCCEEEHHHHCCCCCCEEEEECCHHHH
EQMSPVEFGGEMIDFVYEQSASWKELPWKFEAGTPNMAGAIGLATAVDYLEKIGMDAIEA
HHCCCHHHCHHHHHHHHHCCCCHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHH
HEQELIAYVYPKLQAIEGLTIYGSQDLAQRSGVIAFNLGDLHPHDLATALDYEGVAVRAG
HHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCEEEEECCCCCHHHHHHHCCCCCEEEECC
HHCAQPLLQYLEVPATARASFYIYNTKADCDKLVDALQKTKEFFNGTF
HHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]