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The map label for this gene is hpt

Identifier: 116516681

GI number: 116516681

Start: 11616

End: 12158

Strand: Direct

Name: hpt

Synonym: SPD_0012

Alternate gene names: 116516681

Gene position: 11616-12158 (Clockwise)

Preceding gene: 116516781

Following gene: 116515587

Centisome position: 0.57

GC content: 33.33

Gene sequence:

>543_bases
ATGTTAGAAAACGATATTAAAAAAGTCCTCGTTTCACACGATGAAATTACAGAAGCAGCTAAAAAACTAGGTGCTCAATT
AACTAAAGACTATGCAGGAAAAAATCCAATCTTAGTTGGGATTTTAAAAGGATCTATTCCTTTTATGGCTGAATTGGTCA
AACATATTGATACACATATTGAAATGGACTTCATGATGGTTTCTAGCTACCATGGTGGAACAGCAAGTAGTGGTGTTATC
AATATTAAACAAGATGTGACTCAAGATATCAAAGGAAGACATGTTCTATTTGTAGAAGATATCATTGATACAGGTCAAAC
TTTGAAGAATTTGCGAGATATGTTTAAAGAAAGAGAAGCAGCTTCTGTTAAAATTGCAACCTTGTTGGATAAACCAGAAG
GACGTGTTGTAGAAATTGAGGCAGACTATACCTGCTTTACTATCCCAAATGAGTTTGTAGTAGGTTATGGTTTAGACTAC
AAAGAAAATTATCGTAATCTTCCTTATATTGGAGTATTGAAAGAGGAAGTGTATTCAAATTAG

Upstream 100 bases:

>100_bases
TGTCTCAATTTTGGGAATTGCGACCAATAATTTGAGTAAAAAAACGAAAAATGATATAATGAACACTGTACTTTATATAG
AAAAAATAGATAGGTAAAAA

Downstream 100 bases:

>100_bases
AAAGAATAATCTTTAATGAAAAAACAAAATAATGGTTTAATTAAAAATCCTTTTCTATGGTTATTATTTATCTTTTTCCT
TGTGACAGGATTCCAGTATT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVI
NIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKEREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
KENYRNLPYIGVLKEEVYSN

Sequences:

>Translated_180_residues
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVI
NIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKEREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
KENYRNLPYIGVLKEEVYSN
>Mature_180_residues
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHIEMDFMMVSSYHGGTASSGVI
NIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKEREAASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDY
KENYRNLPYIGVLKEEVYSN

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4504483, Length=180, Percent_Identity=33.8888888888889, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI9910262, Length=180, Percent_Identity=33.8888888888889, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=45.1807228915663, Blast_Score=156, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17510817, Length=178, Percent_Identity=30.3370786516854, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRT_STRPN (Q97TC4)

Other databases:

- EMBL:   AE005672
- PIR:   C97873
- PIR:   D95001
- RefSeq:   NP_344565.1
- ProteinModelPortal:   Q97TC4
- SMR:   Q97TC4
- EnsemblBacteria:   EBSTRT00000025732
- GeneID:   929749
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_0012
- TIGR:   SP_0012
- GeneTree:   EBGT00050000028142
- HOGENOM:   HBG536385
- OMA:   INAHYAD
- ProtClustDB:   CLSK2752071
- BioCyc:   SPNE170187-1:SP_0012-MONOMER
- BRENDA:   2.4.2.8
- GO:   GO:0005737
- InterPro:   IPR005904
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01203

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.8

Molecular weight: Translated: 20213; Mature: 20213

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
EMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKEREA
EEEEEEEECCCCCCCCCCEEEEHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHHHHHHHH
ASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDYKENYRNLPYIGVLKEEVYSN
CCEEEEEEECCCCCCEEEEECCEEEEECCCCEEEECCCCHHHCCCCCCEEEHHHHHHCCC
>Mature Secondary Structure
MLENDIKKVLVSHDEITEAAKKLGAQLTKDYAGKNPILVGILKGSIPFMAELVKHIDTHI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
EMDFMMVSSYHGGTASSGVINIKQDVTQDIKGRHVLFVEDIIDTGQTLKNLRDMFKEREA
EEEEEEEECCCCCCCCCCEEEEHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHHHHHHHH
ASVKIATLLDKPEGRVVEIEADYTCFTIPNEFVVGYGLDYKENYRNLPYIGVLKEEVYSN
CCEEEEEEECCCCCCEEEEECCEEEEECCCCEEEECCCCHHHCCCCCCEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916