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The map label for this gene is vncR [H]

Identifier: 116516514

GI number: 116516514

Start: 534860

End: 535516

Strand: Direct

Name: vncR [H]

Synonym: SPD_0524

Alternate gene names: 116516514

Gene position: 534860-535516 (Clockwise)

Preceding gene: 116515629

Following gene: 116515343

Centisome position: 26.14

GC content: 44.44

Gene sequence:

>657_bases
ATGAAAATTTTAATTGTAGAAGATGAAGAGATGATCCGTGAGGGGGTCAGTGATTATTTGACGGATTGTGGCTATGAAAC
TATTGAGGCAGCGGACGGTCAGGAAGCTCTGGAGCAATTTTCTAGCTATGAGGTGGCCCTGGTTTTACTGGATATCCAGA
TGCCCAAGCTTAACGGCTTAGAAGTTCTAGCTGAGATTCGTAAAACCAGTCAGGTTCCTGTCTTGATGTTGACAGCTTTT
CAGGATGAGGAATACAAGATGAGTGCCTTTGCCTCTTTGGCAGATGGCTATCTGGAAAAACCTTTCTCCCTCTCCCTCTT
AAAAGTGAGGGTGGACGCGATTTTCAAGCGCTACTACGATACAGGACGAATCTTTTCTTACAAGGATACCAAGGTGGACT
TTGAAAGCTACAGTGCAAGCCTCGCAGGTCAAGAAGTGCCTATCAATGCCAAAGAGTTGGAAATTCTGGACTATCTAGTG
AAAAATGAAGGCCGGGCCTTGACTCGGTCTCAGATTATCGATGCCGTCTGGAAAGCGACAGATGAGGTTCCCTTTGACCG
TGTTATTGATGTTTATATCAAGGAATTGCGGAAAAAGCTAGACTTGGATTGTATCCTCACTGTGCGCAATGTTGGTTATA
AATTGGAGCGAAAATGA

Upstream 100 bases:

>100_bases
TGATCAGTTACTTACAGACAAAAGGCCAGCAAGAGACTATAATAGAAAATAGAGTAGGTATTTATTCTAAGAAAAATAAA
AAATAGAGAGCAGTTAAAGT

Downstream 100 bases:

>100_bases
AACGAACAGGTTTATTTGCAAAGATATTTATCTATACCTTCTCGATATTTAGTGTTCTGGTTATCTGCCTTCATTTAGCT
ATTTATTTTCTTTTTCCTTC

Product: DNA-binding response regulator VncR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYEVALVLLDIQMPKLNGLEVLAEIRKTSQVPVLMLTAF
QDEEYKMSAFASLADGYLEKPFSLSLLKVRVDAIFKRYYDTGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLV
KNEGRALTRSQIIDAVWKATDEVPFDRVIDVYIKELRKKLDLDCILTVRNVGYKLERK

Sequences:

>Translated_218_residues
MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYEVALVLLDIQMPKLNGLEVLAEIRKTSQVPVLMLTAF
QDEEYKMSAFASLADGYLEKPFSLSLLKVRVDAIFKRYYDTGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLV
KNEGRALTRSQIIDAVWKATDEVPFDRVIDVYIKELRKKLDLDCILTVRNVGYKLERK
>Mature_218_residues
MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYEVALVLLDIQMPKLNGLEVLAEIRKTSQVPVLMLTAF
QDEEYKMSAFASLADGYLEKPFSLSLLKVRVDAIFKRYYDTGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLV
KNEGRALTRSQIIDAVWKATDEVPFDRVIDVYIKELRKKLDLDCILTVRNVGYKLERK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=33.1858407079646, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=30.0448430493274, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=29.7297297297297, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=30.9090909090909, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=30.6306306306306, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=28.3842794759825, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=31.25, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1790552, Length=217, Percent_Identity=30.4147465437788, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=28.3783783783784, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=25.6756756756757, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI2367329, Length=208, Percent_Identity=32.6923076923077, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=27.8761061946903, Blast_Score=80, Evalue=7e-17,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=25.6637168141593, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=34.7107438016529, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=36.036036036036, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787487, Length=148, Percent_Identity=33.1081081081081, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI145693157, Length=109, Percent_Identity=33.9449541284404, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24967; Mature: 24967

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYEVALVLLDIQMPKLNGL
CEEEEECCHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHCCCEEEEEEEEECCCCCCHH
EVLAEIRKTSQVPVLMLTAFQDEEYKMSAFASLADGYLEKPFSLSLLKVRVDAIFKRYYD
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
TGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLVKNEGRALTRSQIIDAVWKAT
CCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
DEVPFDRVIDVYIKELRKKLDLDCILTVRNVGYKLERK
CCCCHHHHHHHHHHHHHHHCCCCEEEEEHHCCEEECCC
>Mature Secondary Structure
MKILIVEDEEMIREGVSDYLTDCGYETIEAADGQEALEQFSSYEVALVLLDIQMPKLNGL
CEEEEECCHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHCCCEEEEEEEEECCCCCCHH
EVLAEIRKTSQVPVLMLTAFQDEEYKMSAFASLADGYLEKPFSLSLLKVRVDAIFKRYYD
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
TGRIFSYKDTKVDFESYSASLAGQEVPINAKELEILDYLVKNEGRALTRSQIIDAVWKAT
CCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
DEVPFDRVIDVYIKELRKKLDLDCILTVRNVGYKLERK
CCCCHHHHHHHHHHHHHHHCCCCEEEEEHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]