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The map label for this gene is glmS [H]

Identifier: 116516194

GI number: 116516194

Start: 240299

End: 242107

Strand: Direct

Name: glmS [H]

Synonym: SPD_0248

Alternate gene names: 116516194

Gene position: 240299-242107 (Clockwise)

Preceding gene: 116516550

Following gene: 116515457

Centisome position: 11.74

GC content: 44.5

Gene sequence:

>1809_bases
ATGTGTGGAATTGTTGGTGTTGTTGGAAACACAAATGCAACTGATATTTTGATTCAAGGGCTTGAAAAGCTTGAATACCG
TGGCTATGATTCTGCGGGAATTTTTGTCCTAGATGGTGCTGATAACCATTTGGTGAAGGCTGTTGGTCGTATCGCAGAAT
TGTCTGCCAAGACAGCTGGTGTTGAGGGAACAACTGGTATCGGACATACTCGTTGGGCAACTCATGGGAAACCAACGGAA
GACAATGCTCACCCACACCGCTCTGAGACAGAACGTTTTGTCTTGGTTCACAATGGGGTGATTGAAAACTACCTTGAAAT
TAAAGAAGAATACCTTGCTGGGCACCACTTCAAAGGGCAAACAGATACGGAAATCGCCGTACATTTGATTGGAAAATTTG
CGGAAGAAGACGGTCTCTCAGTTCTTGAAGCCTTTAAAAAAGCTCTTCATATTATCCGTGGTTCATATGCCTTTGCCTTG
ATTGACTCTGAAAATCCAGATGTCATCTATGTAGCGAAAAACAAATCTCCACTTTTGATTGGTCTTGGGGAAGGCTACAA
TATGGTCTGCTCAGATGCTATGGCTATGATTCGTGAAACCAACCAATACATGGAAATTCATGACCAAGAGTTGGTAATCG
TCAAGGCTGATAGCGTGGAAGTTCAAGACTATGATGGTAACAGTCGTGAACGTGCTAGCTATACTGCGGAACTTGACTTG
TCAGATATCGGTAAGGGAACTTATCCTTACTACATGCTTAAGGAAATTGATGAGCAACCAACTGTTATGCGTAAACTCAT
TCAAGCCTACACGGATGATGCTGGTCAAGTAGTGATTGATCCTGCTATCATTAAGGCTGTTCAAGACGCAGACCGCATCT
ACATCCTTGCAGCTGGAACATCTTACCATGCAGGATTTGCTTCTAAGAAAATGTTGGAAGAATTGACAGATACACCAGTT
GAACTTGGCATCTCATCTGAGTGGGGCTACGGTATGCCACTTCTCAGCAAGAAACCACTCTTCATCTTTATCAGCCAATC
TGGTGAAACAGCGGATAGTCGTCAAGTTTTGGTCAAGGCTAATGAAATGGGAATTCCAAGCTTAACAGTGACAAACGTTC
CAGGTTCAACCCTCTCACGTGAAGCCAACTATACCATGCTCCTTCACGCAGGTCCTGAAATTGCCGTGGCATCAACTAAA
GCCTATACAGCGCAAATCGCAGCCCTTGCCTTCCTTGCAAAAGCAGTCGGAGAAGCAAATGGTAATGCTAAAGCGCAAGC
CTTTGACCTGGTTCATGAATTGTCAATCGTAGCTCAGTCTATCGAATCAACTCTTTCAGAGAAAGAAACCATTGAAGCCA
AGGTTCGTGAACTTCTTGAAACAACTCGTAACGCCTTTTACATCGGACGTGGTCAAGATTACTACGTAGCCATGGAAGCA
AGTCTCAAACTCAAAGAGATTTCTTATATCCAGTGTGAAGGTTTTGCGGCAGGAGAACTCAAGCACGGAACCATTGCCTT
GATTGAAGAAGGAACACCTGTCTTGGCTCTCTTGTCAGATCCAGTCCTTGCCAACCACACTCGTGGAAATATCCAAGAGG
TGGCAGCCCGTGGTGCTAAGGTCCTCACTATCGCAGAAGAAAATGTTGCTAAAGATACCGACGATATCGTCCTTACGACT
GTACACCCTTACCTCTCACCAATTTCAATGGTCGTACCGACGCAATTGGTTGCTTACTTTGCAACCCTCCACCGTGGCCT
CGATGTGGATAAACCACGTAACCTTGCTAAATCAGTAACGGTAGAATAA

Upstream 100 bases:

>100_bases
AAAGAAACAAGTATATACTGTTTTTGCTGATTCTATAAAAGATGAATTAGACTATACCAATTTTAAGGAGAAAGCACAGC
TTGCCTGTGTCGTATATACT

Downstream 100 bases:

>100_bases
GCTAAAAAAGTCTAGTTATCTAGGCTTTTTCTAATGAGCAAATTGGTTGCTTGTACTCAAGATTCGTGTTAGAATAATTT
TTCAAATTGAAGGACAGAGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTE
DNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEDGLSVLEAFKKALHIIRGSYAFAL
IDSENPDVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNSRERASYTAELDL
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDAGQVVIDPAIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPV
ELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTK
AYTAQIAALAFLAKAVGEANGNAKAQAFDLVHELSIVAQSIESTLSEKETIEAKVRELLETTRNAFYIGRGQDYYVAMEA
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTT
VHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE

Sequences:

>Translated_602_residues
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTE
DNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEDGLSVLEAFKKALHIIRGSYAFAL
IDSENPDVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNSRERASYTAELDL
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDAGQVVIDPAIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPV
ELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTK
AYTAQIAALAFLAKAVGEANGNAKAQAFDLVHELSIVAQSIESTLSEKETIEAKVRELLETTRNAFYIGRGQDYYVAMEA
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTT
VHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE
>Mature_602_residues
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTE
DNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEDGLSVLEAFKKALHIIRGSYAFAL
IDSENPDVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNSRERASYTAELDL
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDAGQVVIDPAIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPV
ELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTK
AYTAQIAALAFLAKAVGEANGNAKAQAFDLVHELSIVAQSIESTLSEKETIEAKVRELLETTRNAFYIGRGQDYYVAMEA
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTT
VHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=31.7851959361393, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI205277386, Length=691, Percent_Identity=31.548480463097, Blast_Score=305, Evalue=1e-82,
Organism=Escherichia coli, GI1790167, Length=615, Percent_Identity=40.1626016260163, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=30.0578034682081, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=32.4009324009324, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=31.7865429234339, Blast_Score=218, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=31.7865429234339, Blast_Score=217, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322745, Length=434, Percent_Identity=33.6405529953917, Blast_Score=230, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6323731, Length=414, Percent_Identity=27.2946859903382, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=34.1346153846154, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=32.6530612244898, Blast_Score=331, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65479; Mature: 65479

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAG
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC
VEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCC
TDTEIAVHLIGKFAEEDGLSVLEAFKKALHIIRGSYAFALIDSENPDVIYVAKNKSPLLI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNSRERASYTAELDL
ECCCCCCHHHHHHHHHHHHCCHHHEECCCEEEEEEECCEEEEECCCCCCCCCEEEEEECH
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDAGQVVIDPAIIKAVQDADRIYILAAGT
HHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCEEEEEEECC
SYHAGFASKKMLEELTDTPVELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKA
CCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
NEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTKAYTAQIAALAFLAKAVGEAN
CCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCC
GNAKAQAFDLVHELSIVAQSIESTLSEKETIEAKVRELLETTRNAFYIGRGQDYYVAMEA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEC
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAK
CEEEEEEEEEEECCEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHCCCE
VLTIAEENVAKDTDDIVLTTVHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVT
EEEEECCCCCCCCCCEEEEEECHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
VE
CC
>Mature Secondary Structure
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAG
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC
VEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCC
TDTEIAVHLIGKFAEEDGLSVLEAFKKALHIIRGSYAFALIDSENPDVIYVAKNKSPLLI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNSRERASYTAELDL
ECCCCCCHHHHHHHHHHHHCCHHHEECCCEEEEEEECCEEEEECCCCCCCCCEEEEEECH
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDDAGQVVIDPAIIKAVQDADRIYILAAGT
HHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCEEEEEEECC
SYHAGFASKKMLEELTDTPVELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKA
CCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
NEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTKAYTAQIAALAFLAKAVGEAN
CCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCC
GNAKAQAFDLVHELSIVAQSIESTLSEKETIEAKVRELLETTRNAFYIGRGQDYYVAMEA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEC
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAK
CEEEEEEEEEEECCEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHCCCE
VLTIAEENVAKDTDDIVLTTVHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVT
EEEEECCCCCCCCCCEEEEEECHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
VE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]