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The map label for this gene is coaB [H]

Identifier: 116516176

GI number: 116516176

Start: 1119298

End: 1119987

Strand: Direct

Name: coaB [H]

Synonym: SPD_1088

Alternate gene names: 116516176

Gene position: 1119298-1119987 (Clockwise)

Preceding gene: 116515602

Following gene: 116516321

Centisome position: 54.7

GC content: 40.0

Gene sequence:

>690_bases
ATGAAAATTTTAGTTACATCGGGCGGTACCAGTGAAGCTATCGATAGCGTCCGCTCTATCACTAACCATTCTACAGGTCA
CTTGGGGAAAATTATCACAGAGACTTTGCTTTCTGCAGGGCATGAAGTTTGTTTAATTACGACAAAACGAGCTCTGAAGC
CAGAGCCTCATCCTAACCTAAGTATTCGAGAAGTTACCAATACCAAGGACCTTCTAATAGAAATGCAAGAACGTGTTCAG
GATTATCAGGTCTTGATCCACTCAATGGCTGTTTCTGACTACACTCCTGTTTATATGACAGGGCTTGAGGAAGTTCAGGC
TAGCTCCAATCTAAAAGAATTTTTAAGCAAGCAGAATCATCAGGCCAAGATTTCTTCAACTGATGAGGTTCAGGTTTTGT
TCCTTAAAAAGACACCCAAAATCATATCCCTAGTCAAGGAATGGAATCCCACTATTCATCTGATTGGTTTCAAACTGCTG
GTTGATGTTACCGAAGATCATCTGGTTGACATTGCACGAAAAAGTCTTATCAAGAATCAAGCAGATTTAATCATCGCGAA
TGACCTGACTCAAATTTCAGCAGATCAGCACCGAGCTATATTTGTTGAGAAAAATCAGCTTCAAACAGTCCAGACTAAAG
AAGAAATTGCAGAACTCCTCCTTGAAAAAATTCAAGCCTATCATTCTTAG

Upstream 100 bases:

>100_bases
TATATGGCTTTATAGTTTGAAACTATAGTAAATCTTCGTTTTTACCAAAAATTTATCACTTTCATTTTACTTACCGCTTA
TTTTTGTGTACAATAGTGCT

Downstream 100 bases:

>100_bases
AAAGGAAAACTATGGCAAACATTCTCTTGGCTGTAACGGGTTCAATCGCCTCTTATAAGTCGGCAGATTTAGTCAGTTCT
CTAAAAAAACAAGGCCATCA

Product: phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGHEVCLITTKRALKPEPHPNLSIREVTNTKDLLIEMQERVQ
DYQVLIHSMAVSDYTPVYMTGLEEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLL
VDVTEDHLVDIARKSLIKNQADLIIANDLTQISADQHRAIFVEKNQLQTVQTKEEIAELLLEKIQAYHS

Sequences:

>Translated_229_residues
MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGHEVCLITTKRALKPEPHPNLSIREVTNTKDLLIEMQERVQ
DYQVLIHSMAVSDYTPVYMTGLEEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLL
VDVTEDHLVDIARKSLIKNQADLIIANDLTQISADQHRAIFVEKNQLQTVQTKEEIAELLLEKIQAYHS
>Mature_229_residues
MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGHEVCLITTKRALKPEPHPNLSIREVTNTKDLLIEMQERVQ
DYQVLIHSMAVSDYTPVYMTGLEEVQASSNLKEFLSKQNHQAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLL
VDVTEDHLVDIARKSLIKNQADLIIANDLTQISADQHRAIFVEKNQLQTVQTKEEIAELLLEKIQAYHS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=233, Percent_Identity=27.0386266094421, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 25725; Mature: 25725

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGHEVCLITTKRALKPEPHPNL
CEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCC
SIREVTNTKDLLIEMQERVQDYQVLIHSMAVSDYTPVYMTGLEEVQASSNLKEFLSKQNH
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLLVDVTEDHLVDIARKSLIKNQ
CEECCCCCCEEEEEEECCHHHHHHHHHCCCEEEEEEHHHEEECHHHHHHHHHHHHHHCCC
ADLIIANDLTQISADQHRAIFVEKNQLQTVQTKEEIAELLLEKIQAYHS
CCEEEECCCHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKILVTSGGTSEAIDSVRSITNHSTGHLGKIITETLLSAGHEVCLITTKRALKPEPHPNL
CEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECHHCCCCCCCCC
SIREVTNTKDLLIEMQERVQDYQVLIHSMAVSDYTPVYMTGLEEVQASSNLKEFLSKQNH
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
QAKISSTDEVQVLFLKKTPKIISLVKEWNPTIHLIGFKLLVDVTEDHLVDIARKSLIKNQ
CEECCCCCCEEEEEEECCHHHHHHHHHCCCEEEEEEHHHEEECHHHHHHHHHHHHHHCCC
ADLIIANDLTQISADQHRAIFVEKNQLQTVQTKEEIAELLLEKIQAYHS
CCEEEECCCHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]