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The map label for this gene is coaC [H]

Identifier: 116516321

GI number: 116516321

Start: 1119999

End: 1120550

Strand: Direct

Name: coaC [H]

Synonym: SPD_1089

Alternate gene names: 116516321

Gene position: 1119999-1120550 (Clockwise)

Preceding gene: 116516176

Following gene: 116515509

Centisome position: 54.74

GC content: 41.12

Gene sequence:

>552_bases
ATGGCAAACATTCTCTTGGCTGTAACGGGTTCAATCGCCTCTTATAAGTCGGCAGATTTAGTCAGTTCTCTAAAAAAACA
AGGCCATCAAGTCACTGTCTTAATGACTCAGGCTGCTACAGAGTTTATCCAACCTTTGACACTACAGGTACTCTCACAGA
ATCCTGTCCACTTGGATGTCATGAAGGAACCCTATCCTGATCAGGTCAATCATATCGAACTTGGAAAAAAAGCAGATTTA
TTTATCGTGGTACCTGCAACTGCTAACACTATTGCAAAACTAGCTCACGGATTTGCGGACAACATGGTAACCAGTACAGC
TCTAGCCCTACCAAGTCATATTCCCAAACTAATAGCTCCTGCTATGAATACAAAAATGTATGACCATCCAGTAACTCAGA
ATAATCTGAAAACATTAGAAACCTACGGCTATCAGCTGATTGCTCCTAAGGAATCCCTACTAGCTTGTGGAGACCACGGA
CGAGGAGCTTTAGCTGACCTCACAATTATTTTAGAAAGAATAAAGGAAACTATCGATGAAAAAACGCTCTAA

Upstream 100 bases:

>100_bases
TTGTTGAGAAAAATCAGCTTCAAACAGTCCAGACTAAAGAAGAAATTGCAGAACTCCTCCTTGAAAAAATTCAAGCCTAT
CATTCTTAGAAAGGAAAACT

Downstream 100 bases:

>100_bases
TATTGCACCCATTGCTATCTTTTTTGCTACCATGCTCGTGATACACTTTCTGAGCTCACTTATCTTTAACCTTTTTCCAT
TTCCAATCAAACCGACCATT

Product: phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: PPCDC [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQPLTLQVLSQNPVHLDVMKEPYPDQVNHIELGKKADL
FIVVPATANTIAKLAHGFADNMVTSTALALPSHIPKLIAPAMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHG
RGALADLTIILERIKETIDEKTL

Sequences:

>Translated_183_residues
MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQPLTLQVLSQNPVHLDVMKEPYPDQVNHIELGKKADL
FIVVPATANTIAKLAHGFADNMVTSTALALPSHIPKLIAPAMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHG
RGALADLTIILERIKETIDEKTL
>Mature_182_residues
ANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQPLTLQVLSQNPVHLDVMKEPYPDQVNHIELGKKADLF
IVVPATANTIAKLAHGFADNMVTSTALALPSHIPKLIAPAMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHGR
GALADLTIILERIKETIDEKTL

Specific function: Catalyzes the decarboxylation of 4'- phosphopantothenoylcysteine to 4'-phosphopantetheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=178, Percent_Identity=37.6404494382022, Blast_Score=117, Evalue=6e-27,
Organism=Escherichia coli, GI87082301, Length=168, Percent_Identity=44.047619047619, Blast_Score=134, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17560194, Length=177, Percent_Identity=36.1581920903955, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322762, Length=198, Percent_Identity=33.8383838383838, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322925, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24657262, Length=181, Percent_Identity=37.0165745856354, Blast_Score=123, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011847
- InterPro:   IPR003382 [H]

Pfam domain/function: PF02441 Flavoprotein [H]

EC number: =4.1.1.36 [H]

Molecular weight: Translated: 19866; Mature: 19735

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQPLTLQVLSQNPVHLDV
CCCEEEEECCCHHHCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEE
MKEPYPDQVNHIELGKKADLFIVVPATANTIAKLAHGFADNMVTSTALALPSHIPKLIAP
ECCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHGRGALADLTIILERIKETIDE
HHCCCCCCCCCCCCCCHHHHHCCEEEECCHHHHEECCCCCCCHHHHHHHHHHHHHHHHHH
KTL
CCC
>Mature Secondary Structure 
ANILLAVTGSIASYKSADLVSSLKKQGHQVTVLMTQAATEFIQPLTLQVLSQNPVHLDV
CCEEEEECCCHHHCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEE
MKEPYPDQVNHIELGKKADLFIVVPATANTIAKLAHGFADNMVTSTALALPSHIPKLIAP
ECCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNTKMYDHPVTQNNLKTLETYGYQLIAPKESLLACGDHGRGALADLTIILERIKETIDE
HHCCCCCCCCCCCCCCHHHHHCCEEEECCHHHHEECCCCCCCHHHHHHHHHHHHHHHHHH
KTL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]