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The map label for this gene is clpL [H]

Identifier: 116515968

GI number: 116515968

Start: 306101

End: 308206

Strand: Direct

Name: clpL [H]

Synonym: SPD_0308

Alternate gene names: 116515968

Gene position: 306101-308206 (Clockwise)

Preceding gene: 116515948

Following gene: 116517011

Centisome position: 14.96

GC content: 43.21

Gene sequence:

>2106_bases
ATGAACAACAATTTTAATAATTTTAACAACATGGATGATTTATTTAACCAATTGATGGGTGGTATGCGAGGATACAGTTC
TGAAAATCGACGTTACTTGATTAATGGACGTGAAGTGACACCTGAGGAATTTGCTTACTATCGTGCAACTGGTCAATTGC
CAGGAAATGCAGAATCTGATGTGCAAATGCAACAACAGGCTTCAGGTATGAAACAAGATGGTGTCCTTGCTAAACTGGGT
CGAAACTTGACAGCAGAAGCGCGTGAGGGCAAGCTGGATCCTGTTATCGGACGAAACAAGGAAATTCAAGAAGCATCTGA
AATCCTCTCACGCCGTACCAAGAACAATCCTGTTTTAGTCGGAGACGCAGGTGTTGGTAAGACAGCCGTTGTCGAAGGCC
TAGCGCAAGCGATTGTGAACGGCGATGTCCCAGCTGCTATTAAGAACAAGGAAATTGTTTCCATTGATATCTCAGGTCTT
GAGGCTGGTACTCAATACCGTGGTAGCTTTGAAGAAAATGTCCAAAACTTAGTCAATGAAGTGAAAGAAGCAGGGAATAT
TATCCTCTTCTTTGATGAAATTCACCAAATTCTTGGTGCTGGTAGCACTGGTGGAGACAGTGGTTCTAAAGGACTTGCGG
ATATTCTCAAGCCAGCTCTCTCTCGTGGAGAATTGACAGTGATTGGGGCAACAACTCAAGACGAATACCGTAACACCATC
TTGAAGAATGCTGCTCTTGCTCGTCGTTTCAACGAAGTGAAGGTCAATGCTCCTTCGGCAGAGAATACTTTTAAAATTCT
TCAAGGAATTCGTGACCTCTATCAACAACACCACAATGTCATCTTGCCAGACGAAGTCTTGAAAGCAGCGGTGGATTATT
CTGTTCAATACATTCCTCAACGTAGCTTGCCAGATAAGGCTATTGACCTTGTCGATGTAACGGCTGCTCACTTGGCGGCT
CAACATCCAGTAACAGATGTGCATGCTGTTGAACGAGAAATCGAAACGGAAAAAGACAAGCAAGAAAAAGCAGTTGAAGC
AGAAGATTTTGAAGCAGCTCTAAACTATAAAACACGCATTGCAGAATTGGAAAGGAAAATCGAAAACCACACAGAAGATA
TGAAAGTGACTGCAAGTGTCAACGATGTGGCTGAATCTGTGGAACGAATGACAGGTATCCCAGTATCGCAAATGGGAGCT
TCAGATATCGAACGTTTGAAAGATATGGCTCATCGCTTGCAAGACAAGGTGATTGGTCAAGATAAGGCCGTAGAAGTTGT
AGCTCGTGCTATCTGTCGTAACCGTGCTGGTTTTGATGAAGGAAATCGCCCAATCGGCAACTTCCTCTTTGTAGGGTCTA
CTGGGGTTGGTAAGACGGAGCTTGCTAAGCAATTGGCACTCGATATGTTTGGAACCCAGGATGCGATTATCCGTTTGGAT
ATGTCTGAATACAGTGACCGCACAGCTGTTTCTAAGTTAATTGGTACAACAGCAGGCTATGTGGGTTATGATGACAATAG
CAATACCTTAACAGAACGTGTTCGTCGCAATCCATACTCTATCATTCTCTTGGATGAAATTGAAAAGGCTGACCCTCAAG
TTATTACCCTTCTCCTCCAAGTTCTAGATGATGGTCGTTTGACAGATGGTCAAGGAAATACAGTAAACTTCAAGAACACT
GTCATTATTGCGACCTCAAATGCTGGATTTGGCTATGAAGCCAACTTGACAGAAGATGCGGATAAACCAGAATTGATGGA
CCGTTTGAAACCCTTCTTCCGTCCAGAATTCCTCAACCGCTTTAATGCAGTCATCGAGTTCTCACACTTGACTAAGGAAG
ACCTTTCTAAGATTGTAGATTTGATGTTGGCTGAAGTTAACCAAACCTTGGCTAAGAAAGACATTGACTTGGTAGTCAGT
CAAGCGGCTAAAGATTATATCACAGAAGAAGGTTACGACGAAGTCATGGGGGTTCGTCCTCTCCGTCGCGTGGTTGAACA
AGAAATTCGTGATAAGGTGACAGACTTCCACTTGGATCATTTAGATGCTAAACATCTGGAAGCAGATATGGAAGATGGCG
TTTTGGTTATTCGTGAGAAAGTCTAA

Upstream 100 bases:

>100_bases
TAGTACATAGAGTAGCGATTTAGCTAGTCTAAATTTTTTAAAGAAAAGGTCAAAGATAGTCAATATCAGTAATAATAAAT
AACAAAAAGAGGTAAAGAAT

Downstream 100 bases:

>100_bases
GACAGAATTTTGAGGATAAAAAAGAAGGAGCCAGCTGAAAAAAACTGGTTCCTTTTTAGGTACGACAGGCATGTCGTATA
GTAGAAGTGTATTATTCTAG

Product: ATP-dependent Clp protease, ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 701; Mature: 701

Protein sequence:

>701_residues
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAYYRATGQLPGNAESDVQMQQQASGMKQDGVLAKLG
RNLTAEAREGKLDPVIGRNKEIQEASEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIVSIDISGL
EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAA
QHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRIAELERKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGA
SDIERLKDMAHRLQDKVIGQDKAVEVVARAICRNRAGFDEGNRPIGNFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNT
VIIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKEDLSKIVDLMLAEVNQTLAKKDIDLVVS
QAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKV

Sequences:

>Translated_701_residues
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAYYRATGQLPGNAESDVQMQQQASGMKQDGVLAKLG
RNLTAEAREGKLDPVIGRNKEIQEASEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIVSIDISGL
EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAA
QHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRIAELERKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGA
SDIERLKDMAHRLQDKVIGQDKAVEVVARAICRNRAGFDEGNRPIGNFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNT
VIIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKEDLSKIVDLMLAEVNQTLAKKDIDLVVS
QAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKV
>Mature_701_residues
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAYYRATGQLPGNAESDVQMQQQASGMKQDGVLAKLG
RNLTAEAREGKLDPVIGRNKEIQEASEILSRRTKNNPVLVGDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIVSIDISGL
EAGTQYRGSFEENVQNLVNEVKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQRSLPDKAIDLVDVTAAHLAA
QHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRIAELERKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGA
SDIERLKDMAHRLQDKVIGQDKAVEVVARAICRNRAGFDEGNRPIGNFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQVLDDGRLTDGQGNTVNFKNT
VIIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNRFNAVIEFSHLTKEDLSKIVDLMLAEVNQTLAKKDIDLVVS
QAAKDYITEEGYDEVMGVRPLRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKV

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family. ClpC subfamily [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=31.8791946308725, Blast_Score=154, Evalue=4e-37,
Organism=Escherichia coli, GI1787109, Length=598, Percent_Identity=39.6321070234114, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1788943, Length=390, Percent_Identity=41.5384615384615, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6320464, Length=707, Percent_Identity=39.1796322489392, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6323002, Length=321, Percent_Identity=40.4984423676012, Blast_Score=247, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR019489 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 77623; Mature: 77623

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50151 UVR ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAYYRATGQLPGNAESD
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHEEEECCCCCCCCCHH
VQMQQQASGMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEIQEASEILSRRTKNNPVLV
HHHHHHHCCCCCCCHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
GDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIVSIDISGLEAGTQYRGSFEENVQNLVNE
ECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHCCCHHHHHHHHHHH
VKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
HHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQ
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHCCCC
RSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRI
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AELERKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGASDIERLKDMAHRLQDKVIGQ
HHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCC
DKAVEVVARAICRNRAGFDEGNRPIGNFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEE
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQ
HHHCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
VLDDGRLTDGQGNTVNFKNTVIIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNR
HHCCCCEECCCCCEEEECCEEEEEECCCCCCEECCCCCCCCCHHHHHHHHHHCCHHHHHH
FNAVIEFSHLTKEDLSKIVDLMLAEVNQTLAKKDIDLVVSQAAKDYITEEGYDEVMGVRP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHH
LRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKV
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MNNNFNNFNNMDDLFNQLMGGMRGYSSENRRYLINGREVTPEEFAYYRATGQLPGNAESD
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHEEEECCCCCCCCCHH
VQMQQQASGMKQDGVLAKLGRNLTAEAREGKLDPVIGRNKEIQEASEILSRRTKNNPVLV
HHHHHHHCCCCCCCHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
GDAGVGKTAVVEGLAQAIVNGDVPAAIKNKEIVSIDISGLEAGTQYRGSFEENVQNLVNE
ECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHCCCHHHHHHHHHHH
VKEAGNIILFFDEIHQILGAGSTGGDSGSKGLADILKPALSRGELTVIGATTQDEYRNTI
HHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
LKNAALARRFNEVKVNAPSAENTFKILQGIRDLYQQHHNVILPDEVLKAAVDYSVQYIPQ
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHCCCC
RSLPDKAIDLVDVTAAHLAAQHPVTDVHAVEREIETEKDKQEKAVEAEDFEAALNYKTRI
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AELERKIENHTEDMKVTASVNDVAESVERMTGIPVSQMGASDIERLKDMAHRLQDKVIGQ
HHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCC
DKAVEVVARAICRNRAGFDEGNRPIGNFLFVGSTGVGKTELAKQLALDMFGTQDAIIRLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEE
MSEYSDRTAVSKLIGTTAGYVGYDDNSNTLTERVRRNPYSIILLDEIEKADPQVITLLLQ
HHHCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
VLDDGRLTDGQGNTVNFKNTVIIATSNAGFGYEANLTEDADKPELMDRLKPFFRPEFLNR
HHCCCCEECCCCCEEEECCEEEEEECCCCCCEECCCCCCCCCHHHHHHHHHHCCHHHHHH
FNAVIEFSHLTKEDLSKIVDLMLAEVNQTLAKKDIDLVVSQAAKDYITEEGYDEVMGVRP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHH
LRRVVEQEIRDKVTDFHLDHLDAKHLEADMEDGVLVIREKV
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA