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The map label for this gene is accC [H]

Identifier: 116515928

GI number: 116515928

Start: 390808

End: 392175

Strand: Direct

Name: accC [H]

Synonym: SPD_0388

Alternate gene names: 116515928

Gene position: 390808-392175 (Clockwise)

Preceding gene: 116516802

Following gene: 116515562

Centisome position: 19.1

GC content: 42.84

Gene sequence:

>1368_bases
ATGTTTCGAAAAATTTTAATTGCCAATCGTGGTGAAATTGCGGTTCGTATTATCCGTGCGGCACGTGAATTGGGGATTGC
GACGGTAGCGGTTTATTCAACTGCTGATAAGGAAGCTCTTCATACGCTTTTGGCAGATGAAGCAGTTTGTATTGGTCCTG
GCAAGGCAACAGAGTCTTATCTCAATATTAATGCAGTTCTATCAGCTGCAGTCTTGACTGAGGCAGAAGCTATTCACCCT
GGTTTTGGATTTCTCAGTGAAAATTCCAAATTTGCGACCATGTGTGAAGAAGTAGGTATCAAGTTTATCGGTCCATCTGG
TCATGTTATGGATATGATGGGGGATAAGATCAATGCGCGTGCTCAGATGATTAAAGCAGGTGTGCCTGTTATACCAGGTT
CAGATGGAGAAGTGCATAACTCTGAAGAAGCTTTGATTGTTGCTGAAAAAATTGGCTATCCTGTTATGCTCAAGGCTTCA
GCAGGTGGAGGTGGTAAAGGGATTCGTAAGGTTGAAAAACCAGATGACCTCGTTTCTGCCTTTGAAACTGCCTCTAGTGA
GGCCAAGGCCAATTATGGCAATGGTGCCATGTACATAGAACGGGTTATCTATCCAGCTCGGCACATTGAGGTTCAAATCC
TAGGTGATGAGCATGGACATGTGATTCACTTGGGTGAACGGGATTGTTCTCTTCAAAGGAATAACCAAAAGGTTTTGGAA
GAAAGTCCCTCGATTGCAATCGGAAAAACGCTGCGTCATGAAATAGGTGCTGCTGCTGTTCGAGCGGCAGAGTTTGTTGG
CTATGAGAATGCAGGAACCATTGAATTTCTTCTTGATGAAGCAAGTAGAAATTTCTATTTCATGGAGATGAATACTCGTG
TTCAGGTAGAACATCCAGTAACAGAGTTTGTTTCAGGTGTTGATATCGTTAAGGAACAGATTTGCATTGCGGCAGGTCAG
CCTTTGTCTGTTAAGCAAGAAGATATTGTCCTACGCGGTCATGCCATCGAGTGTCGTATCAATGCAGAAAACCCAGCCTT
TAACTTTGCTCCAAGTCCAGGTAAGATTACTAATCTCTATCTGCCAAGTGGTGGAGTTGGCTTGCGCGTGGATTCAGCAG
TTTATCCAGGTTATACCATTCCGCCTTATTATGATAGTATGATTGCCAAAATCATAGTACACGGCGAAAATCGTTTTGAC
GCCTTGATGAAAATGCAACGTGCCCTCTATGAATTAGAGATTGAAGGAGTGCAGACCAATGCAGATTTCCAGCTTGATCT
CATTTCAGATCGCAATGTCATTGCTGGGGATTATGATACTTCCTTCTTGATGGAAACCTTCTTACCTAAATATCAAGAAA
AAGAATAA

Upstream 100 bases:

>100_bases
GTGGCACCATAGCTGTGGTTGAAGCAAAGGCTGAAGTGGATGGCAAGCTTGCAGCCAGTGGTATCCTTACTTTTGCAATT
GGGAACTAAGGAGGTTCTCC

Downstream 100 bases:

>100_bases
AATGACTTTAAGAGTTTAAACCGAAAAGGGGAATCAATGGCTCTATTTAGTAAAAAAGATAAGTATATTCGAATCAATCC
CAATCGTTCGGTTAGGGAAA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLLADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHP
GFGFLSENSKFATMCEEVGIKFIGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKAS
AGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEHGHVIHLGERDCSLQRNNQKVLE
ESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEFLLDEASRNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQ
PLSVKQEDIVLRGHAIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKIIVHGENRFD
ALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPKYQEKE

Sequences:

>Translated_455_residues
MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLLADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHP
GFGFLSENSKFATMCEEVGIKFIGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKAS
AGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEHGHVIHLGERDCSLQRNNQKVLE
ESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEFLLDEASRNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQ
PLSVKQEDIVLRGHAIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKIIVHGENRFD
ALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPKYQEKE
>Mature_455_residues
MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLLADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHP
GFGFLSENSKFATMCEEVGIKFIGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKAS
AGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEHGHVIHLGERDCSLQRNNQKVLE
ESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEFLLDEASRNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQ
PLSVKQEDIVLRGHAIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKIIVHGENRFD
ALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPKYQEKE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=47.6510067114094, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI65506442, Length=447, Percent_Identity=47.6510067114094, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=47.6510067114094, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=46.3636363636364, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=45.3125, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=45.3125, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=45.3125, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI38679971, Length=516, Percent_Identity=32.1705426356589, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI38679960, Length=516, Percent_Identity=32.1705426356589, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679977, Length=516, Percent_Identity=32.1705426356589, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679967, Length=516, Percent_Identity=32.1705426356589, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI38679974, Length=516, Percent_Identity=32.1705426356589, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=31.496062992126, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=53.3783783783784, Blast_Score=465, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17567343, Length=452, Percent_Identity=45.7964601769911, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=46.1024498886414, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=43.8914027149321, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=485, Percent_Identity=31.5463917525773, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71997168, Length=515, Percent_Identity=30.873786407767, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71997163, Length=515, Percent_Identity=30.873786407767, Blast_Score=229, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6319685, Length=429, Percent_Identity=45.4545454545455, Blast_Score=378, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319695, Length=450, Percent_Identity=45.7777777777778, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321376, Length=450, Percent_Identity=47.1111111111111, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324343, Length=515, Percent_Identity=33.3980582524272, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323863, Length=460, Percent_Identity=33.695652173913, Blast_Score=242, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=47.0720720720721, Blast_Score=423, Evalue=1e-119,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=49.3303571428571, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.5882352941176, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=32.0717131474104, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=32.0717131474104, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=32.0717131474104, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=32.0717131474104, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49609; Mature: 49609

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLLADEAVCIGPGKATESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHCCEEEECCCCCCHHH
LNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGIKFIGPSGHVMDMMGDKINAR
EEHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCEEEECCCCCCHHHCCCCHHHH
AQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKASAGGGGKGIRKVEKPDDLVSA
HHHHHCCCCEECCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHH
FETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEHGHVIHLGERDCSLQRNNQKVLE
HHHCCCCCCCCCCCCCEEEHHHHCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHH
ESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEFLLDEASRNFYFMEMNTRVQVEHPV
CCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECCH
TEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGHAIECRINAENPAFNFAPSPGKITNLY
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECEEEEEEEECCCCCEECCCCCCCEEEEE
LPSGGVGLRVDSAVYPGYTIPPYYDSMIAKIIVHGENRFDALMKMQRALYELEIEGVQTN
ECCCCCCEEECCEECCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHEEEEEEEECC
ADFQLDLISDRNVIAGDYDTSFLMETFLPKYQEKE
CCEEEEEECCCCEEECCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLLADEAVCIGPGKATESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHCCEEEECCCCCCHHH
LNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGIKFIGPSGHVMDMMGDKINAR
EEHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCEEEECCCCCCHHHCCCCHHHH
AQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKASAGGGGKGIRKVEKPDDLVSA
HHHHHCCCCEECCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHH
FETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEHGHVIHLGERDCSLQRNNQKVLE
HHHCCCCCCCCCCCCCEEEHHHHCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHH
ESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEFLLDEASRNFYFMEMNTRVQVEHPV
CCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCEEEEECCH
TEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGHAIECRINAENPAFNFAPSPGKITNLY
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECEEEEEEEECCCCCEECCCCCCCEEEEE
LPSGGVGLRVDSAVYPGYTIPPYYDSMIAKIIVHGENRFDALMKMQRALYELEIEGVQTN
ECCCCCCEEECCEECCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHEEEEEEEECC
ADFQLDLISDRNVIAGDYDTSFLMETFLPKYQEKE
CCEEEEEECCCCEEECCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]