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The map label for this gene is pth

Identifier: 116515731

GI number: 116515731

Start: 4186

End: 4755

Strand: Direct

Name: pth

Synonym: SPD_0005

Alternate gene names: 116515731

Gene position: 4186-4755 (Clockwise)

Preceding gene: 116516338

Following gene: 116516151

Centisome position: 0.2

GC content: 33.33

Gene sequence:

>570_bases
ATGACCAAATTACTTGTAGGTTTGGGAAATCCAGGGGATAAATATTTTGAAACAAAACACAATGTTGGTTTTATGTTGAT
TGATCAACTAGCGAAGAAACAGAATGTCACTTTTACACACGATAAGATATTTCAAGCTGACCTAGCATCCTTTTTCCTAA
ATGGAGAAAAAATTTATCTGGTTAAACCAACGACCTTTATGAATGAAAGTGGAAAAGCAGTTCATGCTTTATTAACTTAC
TATGGTTTGGATATTGACGATTTACTTATCATTTACGATGATCTTGACATGGAAGTTGGGAAAATTCGTTTAAGAGCAAA
AGGCTCAGCAGGTGGTCATAATGGTATCAAGTCTATTATTCAACATATAGGAACTCAGGTCTTTAACCGTGTTAAGATTG
GAATTGGAAGACCTAAAAATGGTATGTCAGTTGTTCATCATGTTTTGAGTAAGTTTGACAGGGATGATTATATCGGTATT
TTACAGTCTATTGACAAAGTTGACGATTCTGTAAACTACTATTTACAAGAGAAAAAATTTGAGAAAACAATGCAGAGGTA
TAACGGATAA

Upstream 100 bases:

>100_bases
GATATCATGGAATTCCGCTTTAATGTCTAAAAATTAATAAATGGTGTCAATTAGGTTGGAAAAAAATTCCAACCCTTTTG
GCTTTTGAAAGGAAAAATAA

Downstream 100 bases:

>100_bases
ATGGTGACCTTATTAGATTTATTCTCAGAAAATGATCAGATTAAAAAATGGCATCAAAATTTAACAGATAAGAAAAGACA
ACTAATACTTGGTTTATCAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTY
YGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGI
LQSIDKVDDSVNYYLQEKKFEKTMQRYNG

Sequences:

>Translated_189_residues
MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTY
YGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGI
LQSIDKVDDSVNYYLQEKKFEKTMQRYNG
>Mature_188_residues
TKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYLVKPTTFMNESGKAVHALLTYY
GLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSIIQHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGIL
QSIDKVDDSVNYYLQEKKFEKTMQRYNG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=178, Percent_Identity=32.0224719101124, Blast_Score=116, Evalue=1e-26,
Organism=Escherichia coli, GI1787455, Length=176, Percent_Identity=36.3636363636364, Blast_Score=105, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321983, Length=138, Percent_Identity=30.4347826086957, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_STRP2 (Q04N59)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_815426.1
- ProteinModelPortal:   Q04N59
- SMR:   Q04N59
- STRING:   Q04N59
- EnsemblBacteria:   EBSTRT00000019161
- GeneID:   4441019
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0005
- eggNOG:   COG0193
- GeneTree:   EBGT00050000028314
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21419; Mature: 21288

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYL
CCEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHCCCCEEEE
VKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSII
ECCCCEECCCCHHHHHHHHHHCCCHHHEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
QHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGILQSIDKVDDSVNYYLQEKKF
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKTMQRYNG
HHHHHHHCC
>Mature Secondary Structure 
TKLLVGLGNPGDKYFETKHNVGFMLIDQLAKKQNVTFTHDKIFQADLASFFLNGEKIYL
CEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHHCCCCEEEE
VKPTTFMNESGKAVHALLTYYGLDIDDLLIIYDDLDMEVGKIRLRAKGSAGGHNGIKSII
ECCCCEECCCCHHHHHHHHHHCCCHHHEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHH
QHIGTQVFNRVKIGIGRPKNGMSVVHHVLSKFDRDDYIGILQSIDKVDDSVNYYLQEKKF
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKTMQRYNG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA