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The map label for this gene is mutX [H]

Identifier: 116515668

GI number: 116515668

Start: 1057872

End: 1058336

Strand: Reverse

Name: mutX [H]

Synonym: SPD_1031

Alternate gene names: 116515668

Gene position: 1058336-1057872 (Counterclockwise)

Preceding gene: 116516721

Following gene: 116515810

Centisome position: 51.72

GC content: 44.09

Gene sequence:

>465_bases
ATGCCTCAGTTAGCGACGATTTGTTACATTGATAATGGGAAAGAACTGCTCATGCTCCATCGTAATAAGAAACCCAATGA
TGTCCATGAAGGGAAATGGATTGGTGTGGGTGGTAAGCTAGAGAGAGGAGAGACGCCCCAGGAATGCGCGGTACGTGAAA
TCCTTGAAGAAACAGGGCTCAAAGCCAAGCCAGTTCTAAAAGGTGTCATCACTTTTCCTGAATTTACACCAGATTTAGAC
TGGTACACCTATGTTTTTAAGGTGACGGAGTTTGAGGGCGACTTGATTGACTGCAATGAGGGGATGCTAGAATGGGTTCC
CTATGATGAGGTTTTGAGCAAGCCGACCTGGGAAGGTGACCACACCTTTGTTGAGTGGCTTTTAGAGGATAAACCCTTCT
TTTCAGCCAAGTTTGTTTATGATGGGGATAAATTGTTGGATACCCAAGTTGATTTCTATGAATAA

Upstream 100 bases:

>100_bases
TTATAGAGGATTTTGGGGTTCCAAGCCTTTTTCCAAGGCCAATACATTCTTAAAAGAGACAGGACAAGAGCCAATCGATT
GGCTTAGATAAGGAGAAAAT

Downstream 100 bases:

>100_bases
AGGAGAAAGCAGATGCTACTAATCAAAAATGGTCGTGTAATGGATCCCAAGTCTGGTTTGGATCAAGTTTGTGATGTCTT
AGTTCAAGATGGGAAAATTA

Product: Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase)

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAVREILEETGLKAKPVLKGVITFPEFTPDLD
WYTYVFKVTEFEGDLIDCNEGMLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE

Sequences:

>Translated_154_residues
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAVREILEETGLKAKPVLKGVITFPEFTPDLD
WYTYVFKVTEFEGDLIDCNEGMLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
>Mature_153_residues
PQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAVREILEETGLKAKPVLKGVITFPEFTPDLDW
YTYVFKVTEFEGDLIDCNEGMLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 17870; Mature: 17739

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAVREILEETGL
CCCEEEEEEEECCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
KAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGMLEWVPYDEVLSKPTWEGD
CCCCHHEEEEECCCCCCCCCEEEEEEEEEECCCCEEECCCCEEEECCHHHHHCCCCCCCC
HTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
HHHHHHHHCCCCCEEEEEEECCCEEECCCCCCCC
>Mature Secondary Structure 
PQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAVREILEETGL
CCEEEEEEEECCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
KAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGMLEWVPYDEVLSKPTWEGD
CCCCHHEEEEECCCCCCCCCEEEEEEEEEECCCCEEECCCCEEEECCHHHHHCCCCCCCC
HTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
HHHHHHHHCCCCCEEEEEEECCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170394; 11463916; 8163538 [H]