Click here to switch to the map view.

The map label for this gene is napA [H]

Identifier: 116494297

GI number: 116494297

Start: 750276

End: 751430

Strand: Direct

Name: napA [H]

Synonym: LSEI_0753

Alternate gene names: 116494297

Gene position: 750276-751430 (Clockwise)

Preceding gene: 116494296

Following gene: 116494298

Centisome position: 25.91

GC content: 47.71

Gene sequence:

>1155_bases
ATGCAGGACATTGGCAATTTGGCACTGATCTTAGTCACAACGCTGGTTTTAGCGCATTTAAGCCGATTGTTGAATATGCC
CGCTGTCATTGGGGAATTATTGGCTGGTATTTTGATTGGACCGGCGTTATTGGGCTGGTTGGCACCAAGTCACACGATTT
CATTATTTGCGGAGATTGGTGTCATTATTTTGATGTTTCTTGCTGGCTTGGAAAGTGACCTTGATTTATTAAAAAAATAC
TTCAAACCAGGCATGTTGGTCGCCATGATCGGCGTCATTGTACCGGTGGCTGTTGTGTTCGTTTTTGGACGCAGTTGGGG
CTTCAACATGACAAGCAGTCTATTCTTAGGCATTACCTTTGCCGCTACTTCTGTTTCGATCTCTGTTGAGGTTTTAAAAG
AGCTACATGCCCTAGAAGGTCGAAATGGTGCGACCATTCTCGGTGCGGCGGTGGTTGATGATATTCTCACTGTCCTCATT
TTAAGTTTCACGGTAGCAGTCCTTGGTGAGCAAAAGACCGCGAGTTTGCCTTTCTGGGTGCAAATCATTGAACAGTTGCT
CTACTTTGCCGGCATTTATTTGGTTGTCAGGTGGGCTGCGCCATACTTAATGGGTTTGGCAGAAAAAATGTTTCCGTCGT
TGGCTGTGACCATTATGTCTCTGCTCATTTGCCTCGGTATGGCCTATCTGGCTGATCTTGTGGGAATGTCCGCCGTTATC
GGCGCTTTCTTCGCTGGCGTGGCAGTAGGCCAGACACGTCATCGCCATGAAGTGGATGGTAGTTTGAGTGCGATTGGGTA
TGCCGTGTTTATTCCGGTGTTCTTTGTCAGCGTCGGCTTGAATATGCGATTTGATACCTTTGGCCGCGATCTAGGGTTTA
TTGCGATTTTGACCTTATTAGCCTTAGTCACAAAATGGGTCGGCTGTGGGGTTGGTGATCGTTTGGCCGGTGCGAGTTGG
CTACAGAGTAATGTCGTGGGTGCCGGCATGGTTTCCCGTGGCGAGATGGCATTGATTGTCGCCCAAATTGGGTTCGAGGC
CAAACTCATGGACGCTGAATATTACTCGGCGGTTATTGTTGTGATTGTCCTGACGACATTGATTGCCCCAATTATCTTGA
AAGATGCGCTACGGCGTGAACAGGAACCTGTATAA

Upstream 100 bases:

>100_bases
ATCGCGGCATTGTTTACATGGATGAACCGGTTCCTGAACGCAATGCTTATGAGGTTCGTTTGGCACACTAACAGAAAGAC
ACGAAATGGAGGAGATCGAC

Downstream 100 bases:

>100_bases
TAAAGATGCGCGTCTATTTAACGCGACATAAAGCCGAGCGTGCGTGCGAGTTCTTAAAAATGTGTTGACTGGGCAATCAT
TGCGGGACTGGCGGCCGCGT

Product: Kef-type K+ transport system, membrane component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MQDIGNLALILVTTLVLAHLSRLLNMPAVIGELLAGILIGPALLGWLAPSHTISLFAEIGVIILMFLAGLESDLDLLKKY
FKPGMLVAMIGVIVPVAVVFVFGRSWGFNMTSSLFLGITFAATSVSISVEVLKELHALEGRNGATILGAAVVDDILTVLI
LSFTVAVLGEQKTASLPFWVQIIEQLLYFAGIYLVVRWAAPYLMGLAEKMFPSLAVTIMSLLICLGMAYLADLVGMSAVI
GAFFAGVAVGQTRHRHEVDGSLSAIGYAVFIPVFFVSVGLNMRFDTFGRDLGFIAILTLLALVTKWVGCGVGDRLAGASW
LQSNVVGAGMVSRGEMALIVAQIGFEAKLMDAEYYSAVIVVIVLTTLIAPIILKDALRREQEPV

Sequences:

>Translated_384_residues
MQDIGNLALILVTTLVLAHLSRLLNMPAVIGELLAGILIGPALLGWLAPSHTISLFAEIGVIILMFLAGLESDLDLLKKY
FKPGMLVAMIGVIVPVAVVFVFGRSWGFNMTSSLFLGITFAATSVSISVEVLKELHALEGRNGATILGAAVVDDILTVLI
LSFTVAVLGEQKTASLPFWVQIIEQLLYFAGIYLVVRWAAPYLMGLAEKMFPSLAVTIMSLLICLGMAYLADLVGMSAVI
GAFFAGVAVGQTRHRHEVDGSLSAIGYAVFIPVFFVSVGLNMRFDTFGRDLGFIAILTLLALVTKWVGCGVGDRLAGASW
LQSNVVGAGMVSRGEMALIVAQIGFEAKLMDAEYYSAVIVVIVLTTLIAPIILKDALRREQEPV
>Mature_384_residues
MQDIGNLALILVTTLVLAHLSRLLNMPAVIGELLAGILIGPALLGWLAPSHTISLFAEIGVIILMFLAGLESDLDLLKKY
FKPGMLVAMIGVIVPVAVVFVFGRSWGFNMTSSLFLGITFAATSVSISVEVLKELHALEGRNGATILGAAVVDDILTVLI
LSFTVAVLGEQKTASLPFWVQIIEQLLYFAGIYLVVRWAAPYLMGLAEKMFPSLAVTIMSLLICLGMAYLADLVGMSAVI
GAFFAGVAVGQTRHRHEVDGSLSAIGYAVFIPVFFVSVGLNMRFDTFGRDLGFIAILTLLALVTKWVGCGVGDRLAGASW
LQSNVVGAGMVSRGEMALIVAQIGFEAKLMDAEYYSAVIVVIVLTTLIAPIILKDALRREQEPV

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=376, Percent_Identity=27.6595744680851, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789749, Length=361, Percent_Identity=24.6537396121884, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786232, Length=371, Percent_Identity=23.7196765498652, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322367, Length=414, Percent_Identity=24.3961352657005, Blast_Score=125, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 41033; Mature: 41033

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDIGNLALILVTTLVLAHLSRLLNMPAVIGELLAGILIGPALLGWLAPSHTISLFAEIG
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VIILMFLAGLESDLDLLKKYFKPGMLVAMIGVIVPVAVVFVFGRSWGFNMTSSLFLGITF
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AATSVSISVEVLKELHALEGRNGATILGAAVVDDILTVLILSFTVAVLGEQKTASLPFWV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
QIIEQLLYFAGIYLVVRWAAPYLMGLAEKMFPSLAVTIMSLLICLGMAYLADLVGMSAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAFFAGVAVGQTRHRHEVDGSLSAIGYAVFIPVFFVSVGLNMRFDTFGRDLGFIAILTLL
HHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHH
ALVTKWVGCGVGDRLAGASWLQSNVVGAGMVSRGEMALIVAQIGFEAKLMDAEYYSAVIV
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCCEEECHHHHHHHHH
VIVLTTLIAPIILKDALRREQEPV
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQDIGNLALILVTTLVLAHLSRLLNMPAVIGELLAGILIGPALLGWLAPSHTISLFAEIG
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VIILMFLAGLESDLDLLKKYFKPGMLVAMIGVIVPVAVVFVFGRSWGFNMTSSLFLGITF
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AATSVSISVEVLKELHALEGRNGATILGAAVVDDILTVLILSFTVAVLGEQKTASLPFWV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
QIIEQLLYFAGIYLVVRWAAPYLMGLAEKMFPSLAVTIMSLLICLGMAYLADLVGMSAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAFFAGVAVGQTRHRHEVDGSLSAIGYAVFIPVFFVSVGLNMRFDTFGRDLGFIAILTLL
HHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHH
ALVTKWVGCGVGDRLAGASWLQSNVVGAGMVSRGEMALIVAQIGFEAKLMDAEYYSAVIV
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHCCCCEEECHHHHHHHHH
VIVLTTLIAPIILKDALRREQEPV
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]