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The map label for this gene is ciaH [H]

Identifier: 116494260

GI number: 116494260

Start: 715079

End: 716374

Strand: Direct

Name: ciaH [H]

Synonym: LSEI_0712

Alternate gene names: 116494260

Gene position: 715079-716374 (Clockwise)

Preceding gene: 116494259

Following gene: 116494263

Centisome position: 24.7

GC content: 46.76

Gene sequence:

>1296_bases
ATGAACGCAGAAAAAGGTATTAAACATCAGCAACGTCGCTTATTCATCGGGCAACTGTTGAGCTTTGCGGGCTTGTTTGT
GGTATTAGGTATCATTGTTTTTTTCTTATATGAGCGCTCAATTTATCAAGACATTGATCACACCTTAGAGCAGCAACAAG
CAATGATTCTTAATCCAAACGAAGAAACGACAAAGCTTGGTCCGCAGCAACCCGGTACGAGAGTCACTCACCCAGCACCT
TTCCGGACCAACATGGTGGTCTTTAACCAAAAAGGCCGCATCATTAATCAAGCCATGCTTGGTGAGCGGTTTTATGCTTA
CTTTAAAAATTTAAAACTGGATCGATCAGCGCAAAACAAGTTACAGACATTGACCACATCAACTGGAACATTCCGGACGC
TATTAATCAAAGCACCTAAATACAGCGCAGATCCTCAGTATGCCGGTCACTATGTGTTAATTTTGCAAAATACCGATGCA
CAGGAAGCAGCGATTCGATCATTTCGGCAGGTTCTGATTGTCACCATTATTCTTTTTTGGGCATTGGCACTCGGCTTGTC
ATACTGGTTGTCCACACGTGCTATGCGGCCAATTGTCCGGTCATGGCAGCGGCAACAGGACTTCGTTGCCGACGCAGCAC
ACGAGTTGCGGGCGCCACTTGCCGTGATTCAAAGCAAGCAGGAAGCCCTGCTGACGAAACCACAAGCGACCATCATTGAC
GAAAGTGAGGCAATTGCGACTTCGTTGGGTGAGACGAAACGCTTGCGTCAGCTGACCGATGATCTGCTAACAATTGCCAA
AGCCGATAGCAACACCATCGAAATTGAATTGGTTGATCAACCTTTTGAAAAGGCCTTTGAACCACAGCTGTCTTCTTATC
AAGATATTGCTGTCAGTCAGCAGAAGTCCTTCACAACAACGCTACCCAAGGCCGGTCATGCACTGTTTGACACGGCGAGG
ATGAAACAACTGTTAGTGATTTTACTGGACAATGCCTTTAAATATACACAGGCGGGTGATTCTATCTGGGTTGAAGTGAC
ACAGACACCACGTGATTGGCAGTTGCAGGTTGGCAATTCTGGGCCGAGTATTGCGGATGCTGATAAAGCTCGCGTTTTTG
AACGTTTTTATCGAGAAGATGCCTCGCGTAGTCGCCAAACAGGTGGTAGTGGACTTGGTTTAGCAATTGCTCGGTGGATT
GTGACCATGCATCACGGGCATATTGAAGTCAAGGATGTCCATCCTCATGGCGCACTTTTCATCGCGACCTTCCCAAATAA
GCCGCGTATGCGTTGA

Upstream 100 bases:

>100_bases
TGTCCAACTTGCGCAAAAAATTAAAACCGCTAAAAGTTGAGCATTGGATCAAAACGATTCGCAACGTTGGCTATATTTTT
CAGGAGCCGGAGGGCAGTGA

Downstream 100 bases:

>100_bases
TCAAACCAAAGAACATAAAAAAAGCCGCGTCAAAAATCAATTGTGATTTTTGACGCGGCTTTTCTGTTACGAGTTGTTAA
GAATGCACCGAGATTACGTT

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNAEKGIKHQQRRLFIGQLLSFAGLFVVLGIIVFFLYERSIYQDIDHTLEQQQAMILNPNEETTKLGPQQPGTRVTHPAP
FRTNMVVFNQKGRIINQAMLGERFYAYFKNLKLDRSAQNKLQTLTTSTGTFRTLLIKAPKYSADPQYAGHYVLILQNTDA
QEAAIRSFRQVLIVTIILFWALALGLSYWLSTRAMRPIVRSWQRQQDFVADAAHELRAPLAVIQSKQEALLTKPQATIID
ESEAIATSLGETKRLRQLTDDLLTIAKADSNTIEIELVDQPFEKAFEPQLSSYQDIAVSQQKSFTTTLPKAGHALFDTAR
MKQLLVILLDNAFKYTQAGDSIWVEVTQTPRDWQLQVGNSGPSIADADKARVFERFYREDASRSRQTGGSGLGLAIARWI
VTMHHGHIEVKDVHPHGALFIATFPNKPRMR

Sequences:

>Translated_431_residues
MNAEKGIKHQQRRLFIGQLLSFAGLFVVLGIIVFFLYERSIYQDIDHTLEQQQAMILNPNEETTKLGPQQPGTRVTHPAP
FRTNMVVFNQKGRIINQAMLGERFYAYFKNLKLDRSAQNKLQTLTTSTGTFRTLLIKAPKYSADPQYAGHYVLILQNTDA
QEAAIRSFRQVLIVTIILFWALALGLSYWLSTRAMRPIVRSWQRQQDFVADAAHELRAPLAVIQSKQEALLTKPQATIID
ESEAIATSLGETKRLRQLTDDLLTIAKADSNTIEIELVDQPFEKAFEPQLSSYQDIAVSQQKSFTTTLPKAGHALFDTAR
MKQLLVILLDNAFKYTQAGDSIWVEVTQTPRDWQLQVGNSGPSIADADKARVFERFYREDASRSRQTGGSGLGLAIARWI
VTMHHGHIEVKDVHPHGALFIATFPNKPRMR
>Mature_431_residues
MNAEKGIKHQQRRLFIGQLLSFAGLFVVLGIIVFFLYERSIYQDIDHTLEQQQAMILNPNEETTKLGPQQPGTRVTHPAP
FRTNMVVFNQKGRIINQAMLGERFYAYFKNLKLDRSAQNKLQTLTTSTGTFRTLLIKAPKYSADPQYAGHYVLILQNTDA
QEAAIRSFRQVLIVTIILFWALALGLSYWLSTRAMRPIVRSWQRQQDFVADAAHELRAPLAVIQSKQEALLTKPQATIID
ESEAIATSLGETKRLRQLTDDLLTIAKADSNTIEIELVDQPFEKAFEPQLSSYQDIAVSQQKSFTTTLPKAGHALFDTAR
MKQLLVILLDNAFKYTQAGDSIWVEVTQTPRDWQLQVGNSGPSIADADKARVFERFYREDASRSRQTGGSGLGLAIARWI
VTMHHGHIEVKDVHPHGALFIATFPNKPRMR

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=222, Percent_Identity=31.5315315315315, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=30.9734513274336, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786783, Length=229, Percent_Identity=31.4410480349345, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=29.7297297297297, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=232, Percent_Identity=25, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=27.5555555555556, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790346, Length=255, Percent_Identity=27.0588235294118, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=26.9911504424779, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789403, Length=241, Percent_Identity=29.4605809128631, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790861, Length=214, Percent_Identity=26.1682242990654, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=27.5423728813559, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=25.4310344827586, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=25.7383966244726, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1790551, Length=210, Percent_Identity=29.5238095238095, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=27.1551724137931, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=242, Percent_Identity=25.6198347107438, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48767; Mature: 48767

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAEKGIKHQQRRLFIGQLLSFAGLFVVLGIIVFFLYERSIYQDIDHTLEQQQAMILNPN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
EETTKLGPQQPGTRVTHPAPFRTNMVVFNQKGRIINQAMLGERFYAYFKNLKLDRSAQNK
CHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
LQTLTTSTGTFRTLLIKAPKYSADPQYAGHYVLILQNTDAQEAAIRSFRQVLIVTIILFW
HHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
ALALGLSYWLSTRAMRPIVRSWQRQQDFVADAAHELRAPLAVIQSKQEALLTKPQATIID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHEEC
ESEAIATSLGETKRLRQLTDDLLTIAKADSNTIEIELVDQPFEKAFEPQLSSYQDIAVSQ
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCHHHCCHHHHHHHC
QKSFTTTLPKAGHALFDTARMKQLLVILLDNAFKYTQAGDSIWVEVTQTPRDWQLQVGNS
CCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCCEEEECCC
GPSIADADKARVFERFYREDASRSRQTGGSGLGLAIARWIVTMHHGHIEVKDVHPHGALF
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCEEE
IATFPNKPRMR
EEECCCCCCCC
>Mature Secondary Structure
MNAEKGIKHQQRRLFIGQLLSFAGLFVVLGIIVFFLYERSIYQDIDHTLEQQQAMILNPN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
EETTKLGPQQPGTRVTHPAPFRTNMVVFNQKGRIINQAMLGERFYAYFKNLKLDRSAQNK
CHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
LQTLTTSTGTFRTLLIKAPKYSADPQYAGHYVLILQNTDAQEAAIRSFRQVLIVTIILFW
HHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
ALALGLSYWLSTRAMRPIVRSWQRQQDFVADAAHELRAPLAVIQSKQEALLTKPQATIID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHEEC
ESEAIATSLGETKRLRQLTDDLLTIAKADSNTIEIELVDQPFEKAFEPQLSSYQDIAVSQ
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCHHHCCHHHHHHHC
QKSFTTTLPKAGHALFDTARMKQLLVILLDNAFKYTQAGDSIWVEVTQTPRDWQLQVGNS
CCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCCEEEECCC
GPSIADADKARVFERFYREDASRSRQTGGSGLGLAIARWIVTMHHGHIEVKDVHPHGALF
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCEEE
IATFPNKPRMR
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]