| Definition | Lactobacillus casei ATCC 334, complete genome. |
|---|---|
| Accession | NC_008526 |
| Length | 2,895,264 |
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The map label for this gene is yxjF [H]
Identifier: 116494263
GI number: 116494263
Start: 718648
End: 719508
Strand: Direct
Name: yxjF [H]
Synonym: LSEI_0715
Alternate gene names: 116494263
Gene position: 718648-719508 (Clockwise)
Preceding gene: 116494260
Following gene: 116494264
Centisome position: 24.82
GC content: 47.5
Gene sequence:
>861_bases ATGAAGGATTTTAAGGACAAGGTCATGTTCATCACCGGGGCCGCCCACGGATTTGGTCGGGTCATTGCTGAAGAAGGGGC AAAACGGGGGATGAAGCTCGCCTTAGTCGATATCGACAAGCCGGCTTTGAATGAAACTTATCAAATCGTTGTGGCAACAG GGGCGGATGCTGTGATGATTCCGACTGATGTTACCAAAGAAGACGAAGTCAACGCAGCTATTGATCAGACACTTCAAACA TTTAAGCAAATCGATCTGCTGATCAATGATGCAGGGATTGCTTTGCCAGGACGTATGTGGGAATTACCAACCCGTGATTG GGAATGGATCATGCACGTCAATGTGATGAGTCAGGTTTATGCGATGAAGCGGATTATTCCAATTATGATGGCGCAAAAAA CGCACGGGGCGATTTTAAACGTCGCTTCGATCGCTGGCTTGGTCGATACCCCAGGCATGCCTGCGTATCACGCCAGCAAG TTTGCCAGCGTCGGTATGAGTGAAGCAACTGCTTATGATCTGCAGCGGGCCGGTGCTGATATTGAAATGCATGTGATGTG CCCAGGTTTTGTTCAGACGGATCTTTATCACACTGAAGAACATCGGCCAAAGCAATACAGCGATCCAAGTGATCCTTACT ATCAAAGCGAGGCTTTCCTGAAAGGTCAACAGTTTGCCAAATATGTGATCACCAACGGTATGCCACTTGATACGATTGCG GCGACGGTTTTCAAAGCACTTGAAGAAGATCAGTTCTACATTTTGACCCACCCACAGTTCAACCCATTGATTTTGGATCG GGTCAATCGGATCGTCAAAAATGGTGCACCAGATGTCCATGTGATGGATGGGATTATGTAG
Upstream 100 bases:
>100_bases TTTTGAAAGCGCTATCGTAAAGGCGTATTCGAAATTGTGAATAAGCACACACATGAATGACTGCGTGCGTGGATTCACGC CACATAGGAGGCAAGCAATT
Downstream 100 bases:
>100_bases TTAGTTACTTTCAATAACACGCGAATTAGCGCAGCAACCTGCATGTAAGGACCTTGGTCACAATGGTCAAAGTGCGACCA TCACCCCAAGGCCGCTTATA
Product: Short-chain alcohol dehydrogenase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 286; Mature: 286
Protein sequence:
>286_residues MKDFKDKVMFITGAAHGFGRVIAEEGAKRGMKLALVDIDKPALNETYQIVVATGADAVMIPTDVTKEDEVNAAIDQTLQT FKQIDLLINDAGIALPGRMWELPTRDWEWIMHVNVMSQVYAMKRIIPIMMAQKTHGAILNVASIAGLVDTPGMPAYHASK FASVGMSEATAYDLQRAGADIEMHVMCPGFVQTDLYHTEEHRPKQYSDPSDPYYQSEAFLKGQQFAKYVITNGMPLDTIA ATVFKALEEDQFYILTHPQFNPLILDRVNRIVKNGAPDVHVMDGIM
Sequences:
>Translated_286_residues MKDFKDKVMFITGAAHGFGRVIAEEGAKRGMKLALVDIDKPALNETYQIVVATGADAVMIPTDVTKEDEVNAAIDQTLQT FKQIDLLINDAGIALPGRMWELPTRDWEWIMHVNVMSQVYAMKRIIPIMMAQKTHGAILNVASIAGLVDTPGMPAYHASK FASVGMSEATAYDLQRAGADIEMHVMCPGFVQTDLYHTEEHRPKQYSDPSDPYYQSEAFLKGQQFAKYVITNGMPLDTIA ATVFKALEEDQFYILTHPQFNPLILDRVNRIVKNGAPDVHVMDGIM >Mature_286_residues MKDFKDKVMFITGAAHGFGRVIAEEGAKRGMKLALVDIDKPALNETYQIVVATGADAVMIPTDVTKEDEVNAAIDQTLQT FKQIDLLINDAGIALPGRMWELPTRDWEWIMHVNVMSQVYAMKRIIPIMMAQKTHGAILNVASIAGLVDTPGMPAYHASK FASVGMSEATAYDLQRAGADIEMHVMCPGFVQTDLYHTEEHRPKQYSDPSDPYYQSEAFLKGQQFAKYVITNGMPLDTIA ATVFKALEEDQFYILTHPQFNPLILDRVNRIVKNGAPDVHVMDGIM
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI210032110, Length=197, Percent_Identity=31.9796954314721, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI142976729, Length=195, Percent_Identity=31.7948717948718, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI40254992, Length=202, Percent_Identity=31.6831683168317, Blast_Score=99, Evalue=4e-21, Organism=Homo sapiens, GI40807363, Length=198, Percent_Identity=30.3030303030303, Blast_Score=98, Evalue=8e-21, Organism=Homo sapiens, GI31542939, Length=216, Percent_Identity=28.2407407407407, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI25282469, Length=249, Percent_Identity=27.710843373494, Blast_Score=92, Evalue=8e-19, Organism=Homo sapiens, GI310128830, Length=205, Percent_Identity=26.3414634146341, Blast_Score=88, Evalue=1e-17, Organism=Homo sapiens, GI310115468, Length=205, Percent_Identity=26.3414634146341, Blast_Score=88, Evalue=1e-17, Organism=Homo sapiens, GI20149619, Length=198, Percent_Identity=28.7878787878788, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI4758504, Length=251, Percent_Identity=27.0916334661355, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI4503817, Length=243, Percent_Identity=27.9835390946502, Blast_Score=79, Evalue=6e-15, Organism=Homo sapiens, GI15277342, Length=202, Percent_Identity=23.7623762376238, Blast_Score=78, Evalue=8e-15, Organism=Homo sapiens, GI66933014, Length=241, Percent_Identity=26.9709543568465, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI83715985, Length=186, Percent_Identity=29.5698924731183, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=29.3103448275862, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI7706318, Length=197, Percent_Identity=27.4111675126904, Blast_Score=75, Evalue=1e-13, Organism=Homo sapiens, GI150247226, Length=204, Percent_Identity=28.921568627451, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI109715829, Length=236, Percent_Identity=22.8813559322034, Blast_Score=71, Evalue=9e-13, Organism=Homo sapiens, GI5031737, Length=209, Percent_Identity=24.4019138755981, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI59889578, Length=195, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI33667109, Length=193, Percent_Identity=24.8704663212435, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=28.4974093264249, Blast_Score=97, Evalue=1e-21, Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=28.0769230769231, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI1789208, Length=202, Percent_Identity=26.7326732673267, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1788459, Length=257, Percent_Identity=24.9027237354086, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1790717, Length=189, Percent_Identity=25.9259259259259, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI87082160, Length=202, Percent_Identity=25.2475247524752, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1786812, Length=217, Percent_Identity=30.4147465437788, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI1787905, Length=188, Percent_Identity=28.1914893617021, Blast_Score=68, Evalue=8e-13, Organism=Escherichia coli, GI1789057, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=29.9492385786802, Blast_Score=105, Evalue=4e-23, Organism=Caenorhabditis elegans, GI193203115, Length=195, Percent_Identity=29.2307692307692, Blast_Score=104, Evalue=6e-23, Organism=Caenorhabditis elegans, GI193203117, Length=190, Percent_Identity=28.9473684210526, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI17538486, Length=257, Percent_Identity=29.9610894941634, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI71994604, Length=203, Percent_Identity=30.0492610837438, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=29.0566037735849, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17538182, Length=217, Percent_Identity=29.9539170506912, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=25, Blast_Score=88, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17562904, Length=201, Percent_Identity=32.3383084577114, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=25.7028112449799, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17551412, Length=224, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=26.8199233716475, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI193204405, Length=282, Percent_Identity=26.5957446808511, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17567345, Length=204, Percent_Identity=27.9411764705882, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI17562908, Length=201, Percent_Identity=29.8507462686567, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI17560332, Length=220, Percent_Identity=29.0909090909091, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17561402, Length=213, Percent_Identity=26.7605633802817, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17555706, Length=202, Percent_Identity=27.2277227722772, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=26.9961977186312, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17565030, Length=200, Percent_Identity=32.5, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17560676, Length=242, Percent_Identity=25.2066115702479, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17544670, Length=206, Percent_Identity=28.1553398058252, Blast_Score=71, Evalue=6e-13, Organism=Caenorhabditis elegans, GI17560150, Length=199, Percent_Identity=30.1507537688442, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17568967, Length=178, Percent_Identity=32.0224719101124, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=26.9961977186312, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI25147288, Length=188, Percent_Identity=22.8723404255319, Blast_Score=68, Evalue=5e-12, Organism=Saccharomyces cerevisiae, GI6323882, Length=216, Percent_Identity=29.1666666666667, Blast_Score=78, Evalue=1e-15, Organism=Saccharomyces cerevisiae, GI6322861, Length=192, Percent_Identity=29.6875, Blast_Score=72, Evalue=9e-14, Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=32.03125, Blast_Score=102, Evalue=2e-22, Organism=Drosophila melanogaster, GI28571526, Length=197, Percent_Identity=35.0253807106599, Blast_Score=101, Evalue=5e-22, Organism=Drosophila melanogaster, GI24581726, Length=198, Percent_Identity=29.7979797979798, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI23397609, Length=195, Percent_Identity=31.7948717948718, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI17737361, Length=223, Percent_Identity=29.1479820627803, Blast_Score=95, Evalue=7e-20, Organism=Drosophila melanogaster, GI221510726, Length=212, Percent_Identity=33.4905660377358, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI281364892, Length=177, Percent_Identity=31.638418079096, Blast_Score=87, Evalue=2e-17, Organism=Drosophila melanogaster, GI21355631, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=5e-16, Organism=Drosophila melanogaster, GI24644339, Length=198, Percent_Identity=28.2828282828283, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI24639444, Length=189, Percent_Identity=27.5132275132275, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI24640492, Length=204, Percent_Identity=24.5098039215686, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI28571387, Length=209, Percent_Identity=27.7511961722488, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI281364494, Length=213, Percent_Identity=27.2300469483568, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24644337, Length=251, Percent_Identity=28.6852589641434, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI24649181, Length=195, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24641232, Length=203, Percent_Identity=25.615763546798, Blast_Score=68, Evalue=5e-12, Organism=Drosophila melanogaster, GI21355319, Length=204, Percent_Identity=25.4901960784314, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI24648944, Length=196, Percent_Identity=26.0204081632653, Blast_Score=68, Evalue=8e-12, Organism=Drosophila melanogaster, GI21358495, Length=193, Percent_Identity=24.8704663212435, Blast_Score=67, Evalue=2e-11, Organism=Drosophila melanogaster, GI221331218, Length=269, Percent_Identity=24.1635687732342, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI24665243, Length=269, Percent_Identity=24.1635687732342, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI161076933, Length=187, Percent_Identity=28.3422459893048, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI24584748, Length=187, Percent_Identity=28.3422459893048, Blast_Score=65, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011294 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 31822; Mature: 31822
Theoretical pI: Translated: 5.14; Mature: 5.14
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 5.9 %Met (Translated Protein) 6.3 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 5.9 %Met (Mature Protein) 6.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKDFKDKVMFITGAAHGFGRVIAEEGAKRGMKLALVDIDKPALNETYQIVVATGADAVMI CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEECCCEEEE PTDVTKEDEVNAAIDQTLQTFKQIDLLINDAGIALPGRMWELPTRDWEWIMHVNVMSQVY CCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEECCCCEECCCCCCCEEEEEHHHHHHHH AMKRIIPIMMAQKTHGAILNVASIAGLVDTPGMPAYHASKFASVGMSEATAYDLQRAGAD HHHHHHHHHHHCCCCCHHEEHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCC IEMHVMCPGFVQTDLYHTEEHRPKQYSDPSDPYYQSEAFLKGQQFAKYVITNGMPLDTIA EEEEEECCCHHHHCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHH ATVFKALEEDQFYILTHPQFNPLILDRVNRIVKNGAPDVHVMDGIM HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCC >Mature Secondary Structure MKDFKDKVMFITGAAHGFGRVIAEEGAKRGMKLALVDIDKPALNETYQIVVATGADAVMI CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEEECCCEEEE PTDVTKEDEVNAAIDQTLQTFKQIDLLINDAGIALPGRMWELPTRDWEWIMHVNVMSQVY CCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCEECCCCEECCCCCCCEEEEEHHHHHHHH AMKRIIPIMMAQKTHGAILNVASIAGLVDTPGMPAYHASKFASVGMSEATAYDLQRAGAD HHHHHHHHHHHCCCCCHHEEHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCC IEMHVMCPGFVQTDLYHTEEHRPKQYSDPSDPYYQSEAFLKGQQFAKYVITNGMPLDTIA EEEEEECCCHHHHCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHH ATVFKALEEDQFYILTHPQFNPLILDRVNRIVKNGAPDVHVMDGIM HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8969509; 9384377 [H]