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The map label for this gene is galM [H]

Identifier: 116494216

GI number: 116494216

Start: 672053

End: 673063

Strand: Direct

Name: galM [H]

Synonym: LSEI_0668

Alternate gene names: 116494216

Gene position: 672053-673063 (Clockwise)

Preceding gene: 116494215

Following gene: 116494217

Centisome position: 23.21

GC content: 48.66

Gene sequence:

>1011_bases
ATGGACGTTTCAGTTGAACCATACGGTCAGTATCAAGGCCACAATTTGTATGAGCTGACCTTGACCAATGATCAAGGCAT
GGTTGTGAAGTTGTTGAATTATGGTGCAACCTTGGAAAAAGTGTTGTTACCAGAAGCTGATGGCTTGCACAACATGATTC
TGTCGCTGCCAAGTCGGGAAGATTACGCAAAAGAGCGCAATTTTCTCGGCGGTACGGTCGGTCGAGTGGTCGGCCGGATT
CGTGGTCATGTTTGGCAGCATGGGGATGTGAAAATTGATCTGCCAATGAACGAAGGTAAGAATCACATTCACGGCGGGGA
TGACGGTCTGGATCGGCAAGTTTATAACTTCCGTATTGACCAGACAGCTACCACAGCTAGTGCTAGTTTTACCTTTGTTG
ATCCAGCAGGGCATAATGGCTATCCGGGCAACGTCAAGCTGCAAGTGACTTATACCTTGGAGAATACGAATACCTTGCAC
TATCGTCTGGATGCAGTTAGTGATGAAGAAACGCTCTTCAATCCAACTAACCATACCTATTTTGCGATTGACCAGCCAAA
CAAAATTGATGCCACCACGCTGACGATTCCAGCCGACGATTACAAACCGCTTGATGCAGACCATCTGCCAGATCAAGGCT
GGCAGCCAGTTGCTGGAACGGTCTTTGATTTTCGGCAAGGGCAAAAGCTTGGCGATGTCATTCACACTCGAGCAGCGCAA
ATCACTGCAGAACGGGGCATTAATCACCCATTCCTACTGAAACACGGTCAAACCCTCGCGGCCAAACTCCAGACTGACAA
ACATACTATGACCCTGGCAACCACTGCGCCGTCCGTCGTCGTATACACCGCCAACCACTTTGATGGTACCGGTATTCCTC
ACAACATTGATCAATTTGATGGCGTGGCTCTTGAATGCCAATTTGCTCCGGTCAGCGGCGATGATCTTTCGGCGATCACA
TTATTGCCGGGCGAACCATTTACGTTGGTGAATAGTTGGGCGTTTGAATAG

Upstream 100 bases:

>100_bases
CTCAAGTGCAATGACCAAAAGCGGGTCATCATACTTGAGGTCGGCTGATGCTTTGGTTTCTAACCGCGCTGGCTTACGCT
CGTTTATAAAGGAGGACAAG

Downstream 100 bases:

>100_bases
GCAGCTTAACTTTTTATTGCCTCGGGATGTTCTGAACGAACCTAATCTTTATAAAGAAAAAAGCCTTCCAAATCATTGGA
AGGCTTTTTTGACGCAACGA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MDVSVEPYGQYQGHNLYELTLTNDQGMVVKLLNYGATLEKVLLPEADGLHNMILSLPSREDYAKERNFLGGTVGRVVGRI
RGHVWQHGDVKIDLPMNEGKNHIHGGDDGLDRQVYNFRIDQTATTASASFTFVDPAGHNGYPGNVKLQVTYTLENTNTLH
YRLDAVSDEETLFNPTNHTYFAIDQPNKIDATTLTIPADDYKPLDADHLPDQGWQPVAGTVFDFRQGQKLGDVIHTRAAQ
ITAERGINHPFLLKHGQTLAAKLQTDKHTMTLATTAPSVVVYTANHFDGTGIPHNIDQFDGVALECQFAPVSGDDLSAIT
LLPGEPFTLVNSWAFE

Sequences:

>Translated_336_residues
MDVSVEPYGQYQGHNLYELTLTNDQGMVVKLLNYGATLEKVLLPEADGLHNMILSLPSREDYAKERNFLGGTVGRVVGRI
RGHVWQHGDVKIDLPMNEGKNHIHGGDDGLDRQVYNFRIDQTATTASASFTFVDPAGHNGYPGNVKLQVTYTLENTNTLH
YRLDAVSDEETLFNPTNHTYFAIDQPNKIDATTLTIPADDYKPLDADHLPDQGWQPVAGTVFDFRQGQKLGDVIHTRAAQ
ITAERGINHPFLLKHGQTLAAKLQTDKHTMTLATTAPSVVVYTANHFDGTGIPHNIDQFDGVALECQFAPVSGDDLSAIT
LLPGEPFTLVNSWAFE
>Mature_336_residues
MDVSVEPYGQYQGHNLYELTLTNDQGMVVKLLNYGATLEKVLLPEADGLHNMILSLPSREDYAKERNFLGGTVGRVVGRI
RGHVWQHGDVKIDLPMNEGKNHIHGGDDGLDRQVYNFRIDQTATTASASFTFVDPAGHNGYPGNVKLQVTYTLENTNTLH
YRLDAVSDEETLFNPTNHTYFAIDQPNKIDATTLTIPADDYKPLDADHLPDQGWQPVAGTVFDFRQGQKLGDVIHTRAAQ
ITAERGINHPFLLKHGQTLAAKLQTDKHTMTLATTAPSVVVYTANHFDGTGIPHNIDQFDGVALECQFAPVSGDDLSAIT
LLPGEPFTLVNSWAFE

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=315, Percent_Identity=29.5238095238095, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786971, Length=331, Percent_Identity=31.4199395770393, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17557428, Length=331, Percent_Identity=25.9818731117825, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115533334, Length=331, Percent_Identity=25.9818731117825, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24659048, Length=352, Percent_Identity=29.5454545454545, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24668278, Length=329, Percent_Identity=27.0516717325228, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24583720, Length=286, Percent_Identity=25.5244755244755, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24668282, Length=352, Percent_Identity=24.4318181818182, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24641876, Length=241, Percent_Identity=24.0663900414938, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37064; Mature: 37064

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVSVEPYGQYQGHNLYELTLTNDQGMVVKLLNYGATLEKVLLPEADGLHNMILSLPSRE
CCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHCCCCCCCHHHHHEECCCCH
DYAKERNFLGGTVGRVVGRIRGHVWQHGDVKIDLPMNEGKNHIHGGDDGLDRQVYNFRID
HHHHHHCCCCHHHHHHHHHHHHCEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEC
QTATTASASFTFVDPAGHNGYPGNVKLQVTYTLENTNTLHYRLDAVSDEETLFNPTNHTY
CCCCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCHHEECCCCCEE
FAIDQPNKIDATTLTIPADDYKPLDADHLPDQGWQPVAGTVFDFRQGQKLGDVIHTRAAQ
EEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCHHHHHHHHHHHH
ITAERGINHPFLLKHGQTLAAKLQTDKHTMTLATTAPSVVVYTANHFDGTGIPHNIDQFD
HHHHHCCCCCEEEECCCEEEEEEECCCEEEEEEECCCEEEEEEECCCCCCCCCCCCCCCC
GVALECQFAPVSGDDLSAITLLPGEPFTLVNSWAFE
CEEEEEEEECCCCCCCEEEEEECCCCEEEEECCCCC
>Mature Secondary Structure
MDVSVEPYGQYQGHNLYELTLTNDQGMVVKLLNYGATLEKVLLPEADGLHNMILSLPSRE
CCCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHHCCCCCCCHHHHHEECCCCH
DYAKERNFLGGTVGRVVGRIRGHVWQHGDVKIDLPMNEGKNHIHGGDDGLDRQVYNFRID
HHHHHHCCCCHHHHHHHHHHHHCEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEC
QTATTASASFTFVDPAGHNGYPGNVKLQVTYTLENTNTLHYRLDAVSDEETLFNPTNHTY
CCCCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEECCCCCHHEECCCCCEE
FAIDQPNKIDATTLTIPADDYKPLDADHLPDQGWQPVAGTVFDFRQGQKLGDVIHTRAAQ
EEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCHHHHHHHHHHHH
ITAERGINHPFLLKHGQTLAAKLQTDKHTMTLATTAPSVVVYTANHFDGTGIPHNIDQFD
HHHHHCCCCCEEEECCCEEEEEEECCCEEEEEEECCCEEEEEEECCCCCCCCCCCCCCCC
GVALECQFAPVSGDDLSAITLLPGEPFTLVNSWAFE
CEEEEEEEECCCCCCCEEEEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]