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The map label for this gene is nhaC [H]

Identifier: 116493564

GI number: 116493564

Start: 1821155

End: 1822522

Strand: Reverse

Name: nhaC [H]

Synonym: PEPE_1838

Alternate gene names: 116493564

Gene position: 1822522-1821155 (Counterclockwise)

Preceding gene: 116493565

Following gene: 116493560

Centisome position: 99.46

GC content: 38.52

Gene sequence:

>1368_bases
ATGAAAAAGGTTAGTATTTTAGAAACTAGCACGGTATTGGTTTTAATGTTAGTGATAATGGGGCTAGGAGTAATTAAATT
TAAATTATCTCCTCAAACGCCAGTATTGTTAGTTTTAGGTTTAATAACGATGTGGGCTAAGCTACGAGGTTTTGAATGGG
AAGATATCAATCAAGGAATTAAAAATGGAATTGAAACGGGGATTATCCCCATCTTTATTTTTATTTTAGTTGGGGCACTA
ATTAGTGTCTGGATTGCAGCCGGTATTATTCCGACGTTAATGGTAATTGGTTTTAAGTTGATAAATGTAGCATGGTTTGT
TCCTTCGGTATTTATCGTCTGTTCACTAGTCGGTACCGCTGTGGGTTCAGCATTTACGGTAATGTCAACGGTGGGAATAG
CATTTTTTGGTATGGGAGTCACCATGGGAGTCAATCCGGCCCTCGTAGCTGGAGCAATTATTTCTGGGGCAATTTTTGGT
GATAAGTGTTCGCCCCTTTCTGAATCAACTAATTTGTCGGCCGCAGTAGTAGACGCAGACCTATTTGATCATATTAAAAA
TCTAATGTGGTCAACAGTTCCAGCATTTGTGGGAGCTTTGATTTTATTTACGATAATGGGGATGGGCGAAGCTAAAAGTG
CAGACATGAGTAAGATTAACCAAACCGTGGCTATTTTAGAACAGCACTTCAACGTCAACTTCTGGGTTATTATTCCAATT
GCTTTAATGTTTATCTGCGCTTGGATGAGAGTACCTGCCGTTCCAACTCTATTTATTAATATCGGGGTTTCTGTAATATT
TGTTTTTATCGGCAATCCTCAGATTACAGTAACAAAAATTGCCTCAATTATTGAAAATGGATTTATTTCAAAGACTGGTA
ATATAGACGTTGATCAGCTATTAACTCGAGGTGGGATTGCTAGCATGATGGGGACCGTAGCTTTGATTGTTGTCACATTA
TCTTTGGGTGGTATTTTAGTACACTTAGGCTTAATTGAACAAATCATGGCACCAATCGCGCAACGTTTAAATAGCGATGG
GAAACTAATCTTAGCGGTAATTGCTAGTGCAATTGGAGTGAATTTATTCATCGGTGAACAATTCCTATCTGTCATCTTAC
CTGGGAAAGCATTTAAACCAACTTTTGAACGCTCAGGGCTAGCAAACGTCACACTAAGTCGTGCACTTGAAGATGGTGGA
ACAGTAATTAATTACATTGTGCCATGGGGGGTAGCAGGTACTTTCGCGGCCAATACTTTTCATGTAGCAACTTTAAGTTA
CCTACCATTCGTATTCTTTAGCTTGTTGTCTCCAGTATTCTCAATTTTAAGTGGTTTTACAGGAATCGGAATCAAACATC
GAAATTAA

Upstream 100 bases:

>100_bases
GGTTCTCTTAAGCTGGGTGGTACCACGGTCTCCATATCGTCCCTGTTGCATTTATGATGCAGCAGGGACATTTTTTTGGT
CAAAATAAGGGGGACTTGGA

Downstream 100 bases:

>100_bases
AAAACAGGTTACAAGAGGAGAATATTACTCCGATTGTAACCTGTTTTGAGGTTCAGTAAACCAAGCGACTAAATGGTCAC
TAATTGCTTTTGATCCTTCT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKKVSILETSTVLVLMLVIMGLGVIKFKLSPQTPVLLVLGLITMWAKLRGFEWEDINQGIKNGIETGIIPIFIFILVGAL
ISVWIAAGIIPTLMVIGFKLINVAWFVPSVFIVCSLVGTAVGSAFTVMSTVGIAFFGMGVTMGVNPALVAGAIISGAIFG
DKCSPLSESTNLSAAVVDADLFDHIKNLMWSTVPAFVGALILFTIMGMGEAKSADMSKINQTVAILEQHFNVNFWVIIPI
ALMFICAWMRVPAVPTLFINIGVSVIFVFIGNPQITVTKIASIIENGFISKTGNIDVDQLLTRGGIASMMGTVALIVVTL
SLGGILVHLGLIEQIMAPIAQRLNSDGKLILAVIASAIGVNLFIGEQFLSVILPGKAFKPTFERSGLANVTLSRALEDGG
TVINYIVPWGVAGTFAANTFHVATLSYLPFVFFSLLSPVFSILSGFTGIGIKHRN

Sequences:

>Translated_455_residues
MKKVSILETSTVLVLMLVIMGLGVIKFKLSPQTPVLLVLGLITMWAKLRGFEWEDINQGIKNGIETGIIPIFIFILVGAL
ISVWIAAGIIPTLMVIGFKLINVAWFVPSVFIVCSLVGTAVGSAFTVMSTVGIAFFGMGVTMGVNPALVAGAIISGAIFG
DKCSPLSESTNLSAAVVDADLFDHIKNLMWSTVPAFVGALILFTIMGMGEAKSADMSKINQTVAILEQHFNVNFWVIIPI
ALMFICAWMRVPAVPTLFINIGVSVIFVFIGNPQITVTKIASIIENGFISKTGNIDVDQLLTRGGIASMMGTVALIVVTL
SLGGILVHLGLIEQIMAPIAQRLNSDGKLILAVIASAIGVNLFIGEQFLSVILPGKAFKPTFERSGLANVTLSRALEDGG
TVINYIVPWGVAGTFAANTFHVATLSYLPFVFFSLLSPVFSILSGFTGIGIKHRN
>Mature_455_residues
MKKVSILETSTVLVLMLVIMGLGVIKFKLSPQTPVLLVLGLITMWAKLRGFEWEDINQGIKNGIETGIIPIFIFILVGAL
ISVWIAAGIIPTLMVIGFKLINVAWFVPSVFIVCSLVGTAVGSAFTVMSTVGIAFFGMGVTMGVNPALVAGAIISGAIFG
DKCSPLSESTNLSAAVVDADLFDHIKNLMWSTVPAFVGALILFTIMGMGEAKSADMSKINQTVAILEQHFNVNFWVIIPI
ALMFICAWMRVPAVPTLFINIGVSVIFVFIGNPQITVTKIASIIENGFISKTGNIDVDQLLTRGGIASMMGTVALIVVTL
SLGGILVHLGLIEQIMAPIAQRLNSDGKLILAVIASAIGVNLFIGEQFLSVILPGKAFKPTFERSGLANVTLSRALEDGG
TVINYIVPWGVAGTFAANTFHVATLSYLPFVFFSLLSPVFSILSGFTGIGIKHRN

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 48406; Mature: 48406

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVSILETSTVLVLMLVIMGLGVIKFKLSPQTPVLLVLGLITMWAKLRGFEWEDINQGI
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
KNGIETGIIPIFIFILVGALISVWIAAGIIPTLMVIGFKLINVAWFVPSVFIVCSLVGTA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGSAFTVMSTVGIAFFGMGVTMGVNPALVAGAIISGAIFGDKCSPLSESTNLSAAVVDAD
HHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEHHH
LFDHIKNLMWSTVPAFVGALILFTIMGMGEAKSADMSKINQTVAILEQHFNVNFWVIIPI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHH
ALMFICAWMRVPAVPTLFINIGVSVIFVFIGNPQITVTKIASIIENGFISKTGNIDVDQL
HHHHHHHHHHCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
LTRGGIASMMGTVALIVVTLSLGGILVHLGLIEQIMAPIAQRLNSDGKLILAVIASAIGV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
NLFIGEQFLSVILPGKAFKPTFERSGLANVTLSRALEDGGTVINYIVPWGVAGTFAANTF
HHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHCCCHH
HVATLSYLPFVFFSLLSPVFSILSGFTGIGIKHRN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKKVSILETSTVLVLMLVIMGLGVIKFKLSPQTPVLLVLGLITMWAKLRGFEWEDINQGI
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
KNGIETGIIPIFIFILVGALISVWIAAGIIPTLMVIGFKLINVAWFVPSVFIVCSLVGTA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGSAFTVMSTVGIAFFGMGVTMGVNPALVAGAIISGAIFGDKCSPLSESTNLSAAVVDAD
HHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEHHH
LFDHIKNLMWSTVPAFVGALILFTIMGMGEAKSADMSKINQTVAILEQHFNVNFWVIIPI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHHHH
ALMFICAWMRVPAVPTLFINIGVSVIFVFIGNPQITVTKIASIIENGFISKTGNIDVDQL
HHHHHHHHHHCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
LTRGGIASMMGTVALIVVTLSLGGILVHLGLIEQIMAPIAQRLNSDGKLILAVIASAIGV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
NLFIGEQFLSVILPGKAFKPTFERSGLANVTLSRALEDGGTVINYIVPWGVAGTFAANTF
HHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHCCCHH
HVATLSYLPFVFFSLLSPVFSILSGFTGIGIKHRN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]