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The map label for this gene is copB [H]

Identifier: 116493373

GI number: 116493373

Start: 1628411

End: 1630501

Strand: Reverse

Name: copB [H]

Synonym: PEPE_1645

Alternate gene names: 116493373

Gene position: 1630501-1628411 (Counterclockwise)

Preceding gene: 116493374

Following gene: 116493372

Centisome position: 88.98

GC content: 39.65

Gene sequence:

>2091_bases
ATGAATCATAAGCAAATGAATGAAGAGCACATGGACCATTCAAAAATGGATCATTCCCAGATGCATCATGAGATGAGTGG
ACATCAACATGACATGCACGATATGCATGACATGGGCGATGGACATATGATGCACATGGGGAATCTAAAACAATTATTTT
GGGTAAGCTTAATTGCTACTATTCCAATTCTATTATTATCGCCATTTATGGGAATGGATTTTAGAATTGGTGACTTGAAA
TTGCCGATTAGTTTTACCGGTTCTGATTATATTGTCTTAATCTTAGCAACCTTCTTATTCTTCTATGGGGGTAAGCCTTT
TTTGGCTGGGGCAGTCAGTGAGTTAAAATCAAAAGCACCCGCAATGATGACTTTAATTGCGATGGGAATTACCGTAGCAT
ACGGCTATTCGCTTTATGCATTTATAATGAATCAATGGATTAATCCTAGCGGTCATGTAATGGACTTCTTTTGGGAACTT
GCAACACTAATTGTAATTATGCTTCTAGGGCACTGGGTAGAAATGAATTCAGTGATGGCGGCAGGCTCTGCAGTTGAAAA
AATGGTCGCACTTTTACCTAGTCAAGCGCATGTTTTGCATGGAGATCATGTCATGGATATGGATTTGAGCGATGTTGAAG
TTGGCCAAACGGTCCGCGTACTTGCAGGAGAACAAATTCCAACTGATGGTGACGTAGTTTCAGGTTCAACTAAAGTAAAT
GAATCTTTAGTAACTGGTGAAGCACGTTTAATCGATAAAAAAGAAGGTAGTCAAGTAATTGGTGGAGCAGTTAACGGAGA
CGGAGTTATCGAAGTTAAGGTTACTGGAACTGGCGAAAGTGGCTATCTATCACAAGTAATGAAGTTAGTTAGTGACGCTC
AAAAATCTAAATCCAAAGCTGAAAGTTTGGCTGATAAAGTAGCTTCATGGTTATTCTATGCGGCTCTAATTGTTGGTGTG
ATTGCGTTTGTGGCTTGGTTACCACAAGGCTTGGATGTGGCATTTGAACGAATGGTGACGGTCTTTATTATTGCTTGTCC
GCATGCTTTAGGTCTAGCAATTCCATTAGTAGTTGCACGAAGTACCAGTATTGCGGCCACCAATGGTTTACTAGTTCGTA
ACCGTCAATCGATTGAAGAAGCTAAAAAAGTTAAATACGTCCTAATGGATAAAACTGGTACATTAACAGAAGGGAAATTC
ACGGTTAACGCAGTTAAGAGTTATGCTGACGATTTAAACCAAGATGATATTCTAGCACTGATGGCTAGCTTAGAAGACCA
TTCCGATCATCCTTTAGCAACTGGTATTAAAGCAGCAGCTAAAAAGCTGAAGCAAACAATTAAAACAGCTCATGATGTTT
CAGCCCAAAAAGGGATTGGTTTAACAGGTACAATCGAAGGTCAGAAGTATCAGATTGTGAACGCCTCTTATTTGAAACAA
AAAGAGATTAAGTTTGATACAAATGATTTTGAGAAATGGAGCACAGCTGGTAATTCAGTTTCATTCCTAGTAAGAGAAAA
TCAAGTTTTAGGTGGATTAGCTGAAGGTGACCAAATAAAGGAAAATGCAGTTTCCTTTATTAAAGAACTAAAGCAATTGG
GTTATATTCCGGTAATGTTGACGGGAGATAACCAACAAACAGCGCAAAAAATTGCGGCAAGCCTTCAAATTGATGAATGG
CATGGAGAATTATTACCAGAAGACAAACTAAAGGCACTTGAAAAATATCAAGAACAAGGAAAAGTAATTATGGTAGGAGA
CGGCATCAACGATGCGCCTAGCCTTGCTAAAGCAAACATTGGAATTGCCATTGGAGCCGGAACGGACGTTGCAATTGATT
CCGCTGATGTAGTCCTTGTGCACAGTGATCCAAGTGATATCTTGAACTTCTTGAAATTAGCTCAAGCAACCAATGCTAAA
ATGGTTCAAAACCTCTGGTGGGGAGCTGGATATAACTTATTTGCAATTCCACTAGCAGCTGGAATTTTGGCTCCGATTGG
ATTCGTCCTTAGTCCGGCAGTTGGAGCGGTGTTAATGTCACTTTCAACCGTTATTGTGGCATTGAACGCGTTGGCGTTAA
AGATTAAGTAA

Upstream 100 bases:

>100_bases
GGTAAGTTGGAGGAAAAGGCACAAACAGCACCGGATAAGGTGAGCTGTAATTGTTTGCCAGAAAACTGTGATATGGATTG
TAAGATGGAGGATATGTAAC

Downstream 100 bases:

>100_bases
AAATTTTTTTAGTAAAAGGCTTACATTCCATATTACGTGTAAACTAGGCGTTCTCTAGTATATAATTGGCATATAAAACC
AATGGGGGATTTGCCAATGA

Product: cation transport ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 696; Mature: 696

Protein sequence:

>696_residues
MNHKQMNEEHMDHSKMDHSQMHHEMSGHQHDMHDMHDMGDGHMMHMGNLKQLFWVSLIATIPILLLSPFMGMDFRIGDLK
LPISFTGSDYIVLILATFLFFYGGKPFLAGAVSELKSKAPAMMTLIAMGITVAYGYSLYAFIMNQWINPSGHVMDFFWEL
ATLIVIMLLGHWVEMNSVMAAGSAVEKMVALLPSQAHVLHGDHVMDMDLSDVEVGQTVRVLAGEQIPTDGDVVSGSTKVN
ESLVTGEARLIDKKEGSQVIGGAVNGDGVIEVKVTGTGESGYLSQVMKLVSDAQKSKSKAESLADKVASWLFYAALIVGV
IAFVAWLPQGLDVAFERMVTVFIIACPHALGLAIPLVVARSTSIAATNGLLVRNRQSIEEAKKVKYVLMDKTGTLTEGKF
TVNAVKSYADDLNQDDILALMASLEDHSDHPLATGIKAAAKKLKQTIKTAHDVSAQKGIGLTGTIEGQKYQIVNASYLKQ
KEIKFDTNDFEKWSTAGNSVSFLVRENQVLGGLAEGDQIKENAVSFIKELKQLGYIPVMLTGDNQQTAQKIAASLQIDEW
HGELLPEDKLKALEKYQEQGKVIMVGDGINDAPSLAKANIGIAIGAGTDVAIDSADVVLVHSDPSDILNFLKLAQATNAK
MVQNLWWGAGYNLFAIPLAAGILAPIGFVLSPAVGAVLMSLSTVIVALNALALKIK

Sequences:

>Translated_696_residues
MNHKQMNEEHMDHSKMDHSQMHHEMSGHQHDMHDMHDMGDGHMMHMGNLKQLFWVSLIATIPILLLSPFMGMDFRIGDLK
LPISFTGSDYIVLILATFLFFYGGKPFLAGAVSELKSKAPAMMTLIAMGITVAYGYSLYAFIMNQWINPSGHVMDFFWEL
ATLIVIMLLGHWVEMNSVMAAGSAVEKMVALLPSQAHVLHGDHVMDMDLSDVEVGQTVRVLAGEQIPTDGDVVSGSTKVN
ESLVTGEARLIDKKEGSQVIGGAVNGDGVIEVKVTGTGESGYLSQVMKLVSDAQKSKSKAESLADKVASWLFYAALIVGV
IAFVAWLPQGLDVAFERMVTVFIIACPHALGLAIPLVVARSTSIAATNGLLVRNRQSIEEAKKVKYVLMDKTGTLTEGKF
TVNAVKSYADDLNQDDILALMASLEDHSDHPLATGIKAAAKKLKQTIKTAHDVSAQKGIGLTGTIEGQKYQIVNASYLKQ
KEIKFDTNDFEKWSTAGNSVSFLVRENQVLGGLAEGDQIKENAVSFIKELKQLGYIPVMLTGDNQQTAQKIAASLQIDEW
HGELLPEDKLKALEKYQEQGKVIMVGDGINDAPSLAKANIGIAIGAGTDVAIDSADVVLVHSDPSDILNFLKLAQATNAK
MVQNLWWGAGYNLFAIPLAAGILAPIGFVLSPAVGAVLMSLSTVIVALNALALKIK
>Mature_696_residues
MNHKQMNEEHMDHSKMDHSQMHHEMSGHQHDMHDMHDMGDGHMMHMGNLKQLFWVSLIATIPILLLSPFMGMDFRIGDLK
LPISFTGSDYIVLILATFLFFYGGKPFLAGAVSELKSKAPAMMTLIAMGITVAYGYSLYAFIMNQWINPSGHVMDFFWEL
ATLIVIMLLGHWVEMNSVMAAGSAVEKMVALLPSQAHVLHGDHVMDMDLSDVEVGQTVRVLAGEQIPTDGDVVSGSTKVN
ESLVTGEARLIDKKEGSQVIGGAVNGDGVIEVKVTGTGESGYLSQVMKLVSDAQKSKSKAESLADKVASWLFYAALIVGV
IAFVAWLPQGLDVAFERMVTVFIIACPHALGLAIPLVVARSTSIAATNGLLVRNRQSIEEAKKVKYVLMDKTGTLTEGKF
TVNAVKSYADDLNQDDILALMASLEDHSDHPLATGIKAAAKKLKQTIKTAHDVSAQKGIGLTGTIEGQKYQIVNASYLKQ
KEIKFDTNDFEKWSTAGNSVSFLVRENQVLGGLAEGDQIKENAVSFIKELKQLGYIPVMLTGDNQQTAQKIAASLQIDEW
HGELLPEDKLKALEKYQEQGKVIMVGDGINDAPSLAKANIGIAIGAGTDVAIDSADVVLVHSDPSDILNFLKLAQATNAK
MVQNLWWGAGYNLFAIPLAAGILAPIGFVLSPAVGAVLMSLSTVIVALNALALKIK

Specific function: Involved in copper export. Can also export silver [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=755, Percent_Identity=31.523178807947, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI55743071, Length=713, Percent_Identity=31.2762973352034, Blast_Score=316, Evalue=5e-86,
Organism=Homo sapiens, GI55743073, Length=507, Percent_Identity=34.3195266272189, Blast_Score=258, Evalue=1e-68,
Organism=Escherichia coli, GI1786691, Length=664, Percent_Identity=33.2831325301205, Blast_Score=306, Evalue=4e-84,
Organism=Escherichia coli, GI1789879, Length=549, Percent_Identity=31.8761384335155, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1786914, Length=449, Percent_Identity=28.2850779510022, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17556548, Length=715, Percent_Identity=30.9090909090909, Blast_Score=287, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6320475, Length=641, Percent_Identity=28.7051482059282, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6319772, Length=699, Percent_Identity=29.8998569384835, Blast_Score=243, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6321430, Length=525, Percent_Identity=22.8571428571429, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325221, Length=551, Percent_Identity=23.049001814882, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321271, Length=588, Percent_Identity=22.2789115646259, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221329854, Length=388, Percent_Identity=30.9278350515464, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24668696, Length=276, Percent_Identity=24.6376811594203, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 75238; Mature: 75238

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHKQMNEEHMDHSKMDHSQMHHEMSGHQHDMHDMHDMGDGHMMHMGNLKQLFWVSLIAT
CCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHH
IPILLLSPFMGMDFRIGDLKLPISFTGSDYIVLILATFLFFYGGKPFLAGAVSELKSKAP
HHHHHHHHCCCCCEEECCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
AMMTLIAMGITVAYGYSLYAFIMNQWINPSGHVMDFFWELATLIVIMLLGHWVEMNSVMA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGSAVEKMVALLPSQAHVLHGDHVMDMDLSDVEVGQTVRVLAGEQIPTDGDVVSGSTKVN
HHHHHHHHHHHCCCCCEEECCCEEECCCCCCCCCCCEEEEHCCCCCCCCCCEECCCCCCC
ESLVTGEARLIDKKEGSQVIGGAVNGDGVIEVKVTGTGESGYLSQVMKLVSDAQKSKSKA
HHHHCCCHHEEECCCCCEEECEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
ESLADKVASWLFYAALIVGVIAFVAWLPQGLDVAFERMVTVFIIACPHALGLAIPLVVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
STSIAATNGLLVRNRQSIEEAKKVKYVLMDKTGTLTEGKFTVNAVKSYADDLNQDDILAL
CCCEEECCCEEEECHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHH
MASLEDHSDHPLATGIKAAAKKLKQTIKTAHDVSAQKGIGLTGTIEGQKYQIVNASYLKQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECHHHHHH
KEIKFDTNDFEKWSTAGNSVSFLVRENQVLGGLAEGDQIKENAVSFIKELKQLGYIPVML
HCCCCCCCHHHHHHCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
TGDNQQTAQKIAASLQIDEWHGELLPEDKLKALEKYQEQGKVIMVGDGINDAPSLAKANI
ECCCHHHHHHHHHHCEEEHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHCCC
GIAIGAGTDVAIDSADVVLVHSDPSDILNFLKLAQATNAKMVQNLWWGAGYNLFAIPLAA
CEEEECCCCEEECCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHH
GILAPIGFVLSPAVGAVLMSLSTVIVALNALALKIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
>Mature Secondary Structure
MNHKQMNEEHMDHSKMDHSQMHHEMSGHQHDMHDMHDMGDGHMMHMGNLKQLFWVSLIAT
CCCCCCCHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHH
IPILLLSPFMGMDFRIGDLKLPISFTGSDYIVLILATFLFFYGGKPFLAGAVSELKSKAP
HHHHHHHHCCCCCEEECCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCH
AMMTLIAMGITVAYGYSLYAFIMNQWINPSGHVMDFFWELATLIVIMLLGHWVEMNSVMA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGSAVEKMVALLPSQAHVLHGDHVMDMDLSDVEVGQTVRVLAGEQIPTDGDVVSGSTKVN
HHHHHHHHHHHCCCCCEEECCCEEECCCCCCCCCCCEEEEHCCCCCCCCCCEECCCCCCC
ESLVTGEARLIDKKEGSQVIGGAVNGDGVIEVKVTGTGESGYLSQVMKLVSDAQKSKSKA
HHHHCCCHHEEECCCCCEEECEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
ESLADKVASWLFYAALIVGVIAFVAWLPQGLDVAFERMVTVFIIACPHALGLAIPLVVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
STSIAATNGLLVRNRQSIEEAKKVKYVLMDKTGTLTEGKFTVNAVKSYADDLNQDDILAL
CCCEEECCCEEEECHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHH
MASLEDHSDHPLATGIKAAAKKLKQTIKTAHDVSAQKGIGLTGTIEGQKYQIVNASYLKQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECHHHHHH
KEIKFDTNDFEKWSTAGNSVSFLVRENQVLGGLAEGDQIKENAVSFIKELKQLGYIPVML
HCCCCCCCHHHHHHCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEE
TGDNQQTAQKIAASLQIDEWHGELLPEDKLKALEKYQEQGKVIMVGDGINDAPSLAKANI
ECCCHHHHHHHHHHCEEEHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHCCC
GIAIGAGTDVAIDSADVVLVHSDPSDILNFLKLAQATNAKMVQNLWWGAGYNLFAIPLAA
CEEEECCCCEEECCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHH
GILAPIGFVLSPAVGAVLMSLSTVIVALNALALKIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8048974; 2953719 [H]