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The map label for this gene is ndk [H]

Identifier: 116493372

GI number: 116493372

Start: 1627877

End: 1628314

Strand: Reverse

Name: ndk [H]

Synonym: PEPE_1644

Alternate gene names: 116493372

Gene position: 1628314-1627877 (Counterclockwise)

Preceding gene: 116493373

Following gene: 116493371

Centisome position: 88.86

GC content: 38.36

Gene sequence:

>438_bases
ATGAGTACAGAAAAATCACTAATTTTAGTTAAACCAGACGGAGTTCAATGTGGACATATCGGTCATGTGATTTCACGAAT
TGAAAATCGTCGTTATGAAATCAAAGCCTTAAAGATGGTAAACGCAACGGAAGAACAGTTACGTCAACATTACTCACAAT
TAGTAGATAAACCATATTACGCCGACATTGAAAAATTTATGACAAGTGGTCCAATTGTGGCCATTATTGCTGAAGGTAAT
GAAATTATCGACACCTTCCGTAAAATGGCTGGTCCAACTAATCCGAGTGAAGCAATGGCCGGAACGATTCGCGGTGACTT
TGCCAGAGCTTGGGGACCTGGTCCTATTAAGAATGTAGTTCATAGTTCAGATAGTGTAGAAAGCGCTGAAAAAGAAATTA
AGATTTGGTTCCCAGAAAGAATCAATACTGAAAACTAA

Upstream 100 bases:

>100_bases
GTAAAAATTTTTTTAGTAAAAGGCTTACATTCCATATTACGTGTAAACTAGGCGTTCTCTAGTATATAATTGGCATATAA
AACCAATGGGGGATTTGCCA

Downstream 100 bases:

>100_bases
ATCTACAATTATAGATAAAGACTTATGCAATGGACAATATCTTGTTCTTGGGTAAGTCTTTTTTTATTGAAAACATTTTC
TTGAGTAAAGTAATTGACAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MSTEKSLILVKPDGVQCGHIGHVISRIENRRYEIKALKMVNATEEQLRQHYSQLVDKPYYADIEKFMTSGPIVAIIAEGN
EIIDTFRKMAGPTNPSEAMAGTIRGDFARAWGPGPIKNVVHSSDSVESAEKEIKIWFPERINTEN

Sequences:

>Translated_145_residues
MSTEKSLILVKPDGVQCGHIGHVISRIENRRYEIKALKMVNATEEQLRQHYSQLVDKPYYADIEKFMTSGPIVAIIAEGN
EIIDTFRKMAGPTNPSEAMAGTIRGDFARAWGPGPIKNVVHSSDSVESAEKEIKIWFPERINTEN
>Mature_144_residues
STEKSLILVKPDGVQCGHIGHVISRIENRRYEIKALKMVNATEEQLRQHYSQLVDKPYYADIEKFMTSGPIVAIIAEGNE
IIDTFRKMAGPTNPSEAMAGTIRGDFARAWGPGPIKNVVHSSDSVESAEKEIKIWFPERINTEN

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI66392203, Length=141, Percent_Identity=46.0992907801418, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI66392227, Length=141, Percent_Identity=46.0992907801418, Blast_Score=139, Evalue=7e-34,
Organism=Homo sapiens, GI66392205, Length=141, Percent_Identity=46.0992907801418, Blast_Score=139, Evalue=7e-34,
Organism=Homo sapiens, GI4505409, Length=141, Percent_Identity=46.0992907801418, Blast_Score=139, Evalue=7e-34,
Organism=Homo sapiens, GI66392192, Length=141, Percent_Identity=46.0992907801418, Blast_Score=139, Evalue=7e-34,
Organism=Homo sapiens, GI38045913, Length=141, Percent_Identity=46.0992907801418, Blast_Score=139, Evalue=7e-34,
Organism=Homo sapiens, GI4557797, Length=141, Percent_Identity=46.0992907801418, Blast_Score=139, Evalue=9e-34,
Organism=Homo sapiens, GI37693993, Length=134, Percent_Identity=46.2686567164179, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=44.1176470588235, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=28.0575539568345, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=28.0575539568345, Blast_Score=70, Evalue=9e-13,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=38.8489208633094, Blast_Score=108, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17506807, Length=142, Percent_Identity=42.9577464788732, Blast_Score=126, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=45.9259259259259, Blast_Score=131, Evalue=5e-32,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=44.5255474452555, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 16257; Mature: 16126

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01307 MOTA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEKSLILVKPDGVQCGHIGHVISRIENRRYEIKALKMVNATEEQLRQHYSQLVDKPYY
CCCCCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCH
ADIEKFMTSGPIVAIIAEGNEIIDTFRKMAGPTNPSEAMAGTIRGDFARAWGPGPIKNVV
HHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCCCCHHHHHH
HSSDSVESAEKEIKIWFPERINTEN
CCCCCHHHHHHEEEEECCCCCCCCC
>Mature Secondary Structure 
STEKSLILVKPDGVQCGHIGHVISRIENRRYEIKALKMVNATEEQLRQHYSQLVDKPYY
CCCCCEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCH
ADIEKFMTSGPIVAIIAEGNEIIDTFRKMAGPTNPSEAMAGTIRGDFARAWGPGPIKNVV
HHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCCCCHHHHHH
HSSDSVESAEKEIKIWFPERINTEN
CCCCCHHHHHHEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]