Click here to switch to the map view.

The map label for this gene is era

Identifier: 116492866

GI number: 116492866

Start: 1104603

End: 1105517

Strand: Reverse

Name: era

Synonym: PEPE_1104

Alternate gene names: 116492866

Gene position: 1105517-1104603 (Counterclockwise)

Preceding gene: 116492867

Following gene: 116492865

Centisome position: 60.33

GC content: 37.38

Gene sequence:

>915_bases
ATGGAAGAAAACAATCAAGCATTTCACTCAGGATTTGTTGCTATTGTAGGGCGTCCTAATGTAGGAAAATCAACATTTTT
AAACTACGTGATTGGTCAGAAAGTTGCTATTATGAGTAACGTTCCTCAAACAACTCGGAATAAAATCCAAGGAATCTATA
CGACTGATCGAGAACAAATTGTTTTTATTGATACGCCGGGTATCCATAAATCTCACAATAAATTGGGAGACTTTATGGTG
CAATCAGCGATGTCTTCATTAAATGAAGTAGATGCAATTATGTTTATGGTTAACGCTGACGAACCTCGAGGAGCTGGTGA
TAATTACATTATCGAACGGCTAAAGAAAATTACCGATCGACCAGTCTATCTTGTGATCAATAAAATCGATTTAGTGCACC
CGGACGAATTATTACCGATTGTTGATTCATATAAAGATGCTATGGATTGGACAGAAGTTTTCCCGATTTCGGCGCTTCAA
GGTAATAATATTAACGAATTGGTGACAACTTTAAGTCAGCACATGCCTGAAGGACCTAAGTATTATCCTGATGATCAGGT
TACTGATCATCCAGAACGCTTTGTTGTTTCAGAGTTAATTCGTGAAAAAGTACTCCAATTGACTCGTCAGGAAGTTCCAC
ATTCAGTTGCGGTGGTAATTGAAACGATGAAATCTAATGATGAGGGATTGGTTAACATTCAAGCAACGATTATTGTTGAC
CGTTCTTCACAAAAGGGAATTGTAATTGGTAAAGGCGGAAAAATGCTTAAAGAAATTGGTAGCCGTGCCCGTGTAGATAT
TGAACACTTACTAGGTAGCCGTGTTTATCTTGAACTATGGGTTAAAGTTTCTGAAGGTTGGCGTGATAAACAAGGAATTT
TGCAATCATTTGGTTACAAAAAGGATGAGTATTAA

Upstream 100 bases:

>100_bases
GCAGCTAGTGGTGTGCTTGTCACAGCGCTATTTGCGGCCATAATTGGGTTATTAATTTTTGGTAATAAGTTATTCTAAAT
TAAAGAAACGGATATAAAAT

Downstream 100 bases:

>100_bases
AAGTGAACACAGTCGCCAATGCTGATTTTAATGGCATTGTAATGTTTGAACGAAGCCATCGCGAAAATGATTTGTTAGTT
AAGTTTCTAACTAAAGAGCA

Product: GTPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MEENNQAFHSGFVAIVGRPNVGKSTFLNYVIGQKVAIMSNVPQTTRNKIQGIYTTDREQIVFIDTPGIHKSHNKLGDFMV
QSAMSSLNEVDAIMFMVNADEPRGAGDNYIIERLKKITDRPVYLVINKIDLVHPDELLPIVDSYKDAMDWTEVFPISALQ
GNNINELVTTLSQHMPEGPKYYPDDQVTDHPERFVVSELIREKVLQLTRQEVPHSVAVVIETMKSNDEGLVNIQATIIVD
RSSQKGIVIGKGGKMLKEIGSRARVDIEHLLGSRVYLELWVKVSEGWRDKQGILQSFGYKKDEY

Sequences:

>Translated_304_residues
MEENNQAFHSGFVAIVGRPNVGKSTFLNYVIGQKVAIMSNVPQTTRNKIQGIYTTDREQIVFIDTPGIHKSHNKLGDFMV
QSAMSSLNEVDAIMFMVNADEPRGAGDNYIIERLKKITDRPVYLVINKIDLVHPDELLPIVDSYKDAMDWTEVFPISALQ
GNNINELVTTLSQHMPEGPKYYPDDQVTDHPERFVVSELIREKVLQLTRQEVPHSVAVVIETMKSNDEGLVNIQATIIVD
RSSQKGIVIGKGGKMLKEIGSRARVDIEHLLGSRVYLELWVKVSEGWRDKQGILQSFGYKKDEY
>Mature_304_residues
MEENNQAFHSGFVAIVGRPNVGKSTFLNYVIGQKVAIMSNVPQTTRNKIQGIYTTDREQIVFIDTPGIHKSHNKLGDFMV
QSAMSSLNEVDAIMFMVNADEPRGAGDNYIIERLKKITDRPVYLVINKIDLVHPDELLPIVDSYKDAMDWTEVFPISALQ
GNNINELVTTLSQHMPEGPKYYPDDQVTDHPERFVVSELIREKVLQLTRQEVPHSVAVVIETMKSNDEGLVNIQATIIVD
RSSQKGIVIGKGGKMLKEIGSRARVDIEHLLGSRVYLELWVKVSEGWRDKQGILQSFGYKKDEY

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=334, Percent_Identity=25.1497005988024, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1788919, Length=296, Percent_Identity=39.8648648648649, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI87082120, Length=156, Percent_Identity=32.0512820512821, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI2367268, Length=168, Percent_Identity=26.1904761904762, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17532761, Length=141, Percent_Identity=29.0780141843972, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=235, Percent_Identity=22.5531914893617, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646434, Length=320, Percent_Identity=27.8125, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_PEDPA (Q03F63)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804601.1
- ProteinModelPortal:   Q03F63
- SMR:   Q03F63
- STRING:   Q03F63
- GeneID:   4417039
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1104
- NMPDR:   fig|278197.10.peg.968
- eggNOG:   COG1159
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- PhylomeDB:   Q03F63
- BioCyc:   PPEN278197:PEPE_1104-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34342; Mature: 34342

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEENNQAFHSGFVAIVGRPNVGKSTFLNYVIGQKVAIMSNVPQTTRNKIQGIYTTDREQI
CCCCCCHHHCCEEEEEECCCCCHHHHHHHHHCCHHEEHHCCCHHHHHHCCCEEECCCCEE
VFIDTPGIHKSHNKLGDFMVQSAMSSLNEVDAIMFMVNADEPRGAGDNYIIERLKKITDR
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHCCC
PVYLVINKIDLVHPDELLPIVDSYKDAMDWTEVFPISALQGNNINELVTTLSQHMPEGPK
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
YYPDDQVTDHPERFVVSELIREKVLQLTRQEVPHSVAVVIETMKSNDEGLVNIQATIIVD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEEEEE
RSSQKGIVIGKGGKMLKEIGSRARVDIEHLLGSRVYLELWVKVSEGWRDKQGILQSFGYK
CCCCCCEEEECCCHHHHHHCCCCCEEHHHHHCCCEEEEEEEEHHCCCCHHHHHHHHCCCC
KDEY
CCCC
>Mature Secondary Structure
MEENNQAFHSGFVAIVGRPNVGKSTFLNYVIGQKVAIMSNVPQTTRNKIQGIYTTDREQI
CCCCCCHHHCCEEEEEECCCCCHHHHHHHHHCCHHEEHHCCCHHHHHHCCCEEECCCCEE
VFIDTPGIHKSHNKLGDFMVQSAMSSLNEVDAIMFMVNADEPRGAGDNYIIERLKKITDR
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHCCC
PVYLVINKIDLVHPDELLPIVDSYKDAMDWTEVFPISALQGNNINELVTTLSQHMPEGPK
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
YYPDDQVTDHPERFVVSELIREKVLQLTRQEVPHSVAVVIETMKSNDEGLVNIQATIIVD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEEEEE
RSSQKGIVIGKGGKMLKEIGSRARVDIEHLLGSRVYLELWVKVSEGWRDKQGILQSFGYK
CCCCCCEEEECCCHHHHHHCCCCCEEHHHHHCCCEEEEEEEEHHCCCCHHHHHHHHCCCC
KDEY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA