Click here to switch to the map view.

The map label for this gene is mvk [H]

Identifier: 116492692

GI number: 116492692

Start: 927407

End: 928327

Strand: Reverse

Name: mvk [H]

Synonym: PEPE_0927

Alternate gene names: 116492692

Gene position: 928327-927407 (Counterclockwise)

Preceding gene: 116492696

Following gene: 116492691

Centisome position: 50.66

GC content: 38.76

Gene sequence:

>921_bases
GTGGAAGAAATTATAAAGAGTAGTAATTCAAAAATAATTTTAATTGGCGAACATAGCGTCGTCTATGGACAGCCTGCAAT
TGCATTACCAATCCGTAATGTTAAAACTACGGTTAAAATCCAACCAACTAATGGCGACATTCAAATCAAAAGTCGCTATT
TTAATGGGTCTCTAAAGGATATCCATAGTAATCTACTTGGTATTAAAAATCTAATTAAACAAACTTTAAACGAGCTTAAT
CGCCCCAATACTAATTTATTAATTACCATTGATAGTGATGTTCCAGCCGAACGCGGAATGGGCTCTTCAGCATCGACAGC
AGTTGCTCTAGTACGGGCCCTATACGCGTATTTTGAACATCCCTTAACGCGAACGACCCTTCTAAAAACTGTCGATATTT
CAGAAAAGATTATTCACGGAAAGCCTAGCGGGCTAGATTCTGCTACTGCAAGTGCTAATAATCCAATCTGGTTTAAAAAA
GATGGTACCATTAAGCCATTACCAATCAACGTCGACGCTTACCTCATAATTAGTGATTCGGGAATTAAGGGTAAAACGAG
TGAAGCAGTCGAAATCGTTAAAAATAAGCTTCGATTTGACTCTGACAGTAGACTTTTAATCGAAAAATTGGGAGAATTGA
CTAGTCAGACTGCGACTGTCCTCCGTCAAAATGATGTAAGTACGTTAGGGAAAATTTTAACTGAAGCACATACTAACTTA
CGTCAATTGGGAGTCAGTCACCCTGCTGTTGAAAAATTAATTAAAATTGCTAATGATTCAGGTGCGCTTGGCAGTAAATT
AACTGGCGGTGGTTTAGGAGGATGTGTGATTTCACTTGCTCCTAACCTTCCAGCTGCTGAAAAAATTAGTCAGCAACTTA
CTGCTGGCGGAGCCACGGCCACTTGGATTGAAAAACTTTAA

Upstream 100 bases:

>100_bases
GTTATCTACCTATTAATTTTACCAAATGTTTACCTTCTCTACATAGAACAATTGTTTTATTTAAGGTATCATTTAATTTG
GACCAAAAAGGAGTATCGTC

Downstream 100 bases:

>100_bases
AAGTAGGTTTCGATACGTATGAATGAAAAACATGGTTTTGCAAGAGCCCATACTAACATTGCATTACTTAAATATTGGGG
TAAAATTAACTCGGATTTAA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MEEIIKSSNSKIILIGEHSVVYGQPAIALPIRNVKTTVKIQPTNGDIQIKSRYFNGSLKDIHSNLLGIKNLIKQTLNELN
RPNTNLLITIDSDVPAERGMGSSASTAVALVRALYAYFEHPLTRTTLLKTVDISEKIIHGKPSGLDSATASANNPIWFKK
DGTIKPLPINVDAYLIISDSGIKGKTSEAVEIVKNKLRFDSDSRLLIEKLGELTSQTATVLRQNDVSTLGKILTEAHTNL
RQLGVSHPAVEKLIKIANDSGALGSKLTGGGLGGCVISLAPNLPAAEKISQQLTAGGATATWIEKL

Sequences:

>Translated_306_residues
MEEIIKSSNSKIILIGEHSVVYGQPAIALPIRNVKTTVKIQPTNGDIQIKSRYFNGSLKDIHSNLLGIKNLIKQTLNELN
RPNTNLLITIDSDVPAERGMGSSASTAVALVRALYAYFEHPLTRTTLLKTVDISEKIIHGKPSGLDSATASANNPIWFKK
DGTIKPLPINVDAYLIISDSGIKGKTSEAVEIVKNKLRFDSDSRLLIEKLGELTSQTATVLRQNDVSTLGKILTEAHTNL
RQLGVSHPAVEKLIKIANDSGALGSKLTGGGLGGCVISLAPNLPAAEKISQQLTAGGATATWIEKL
>Mature_306_residues
MEEIIKSSNSKIILIGEHSVVYGQPAIALPIRNVKTTVKIQPTNGDIQIKSRYFNGSLKDIHSNLLGIKNLIKQTLNELN
RPNTNLLITIDSDVPAERGMGSSASTAVALVRALYAYFEHPLTRTTLLKTVDISEKIIHGKPSGLDSATASANNPIWFKK
DGTIKPLPINVDAYLIISDSGIKGKTSEAVEIVKNKLRFDSDSRLLIEKLGELTSQTATVLRQNDVSTLGKILTEAHTNL
RQLGVSHPAVEKLIKIANDSGALGSKLTGGGLGGCVISLAPNLPAAEKISQQLTAGGATATWIEKL

Specific function: Galactose metabolism; first step. [C]

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI167001643, Length=364, Percent_Identity=25.2747252747253, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4557769, Length=364, Percent_Identity=25.2747252747253, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323864, Length=359, Percent_Identity=26.4623955431755, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI78707210, Length=365, Percent_Identity=25.4794520547945, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 32786; Mature: 32786

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEIIKSSNSKIILIGEHSVVYGQPAIALPIRNVKTTVKIQPTNGDIQIKSRYFNGSLKD
CCHHHCCCCCEEEEEECCEEEECCCEEEEEECCCEEEEEEEECCCCEEEEEEECCCCHHH
IHSNLLGIKNLIKQTLNELNRPNTNLLITIDSDVPAERGMGSSASTAVALVRALYAYFEH
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHC
PLTRTTLLKTVDISEKIIHGKPSGLDSATASANNPIWFKKDGTIKPLPINVDAYLIISDS
CCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCEEECCEEEEEEECC
GIKGKTSEAVEIVKNKLRFDSDSRLLIEKLGELTSQTATVLRQNDVSTLGKILTEAHTNL
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RQLGVSHPAVEKLIKIANDSGALGSKLTGGGLGGCVISLAPNLPAAEKISQQLTAGGATA
HHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHH
TWIEKL
HHHHCC
>Mature Secondary Structure
MEEIIKSSNSKIILIGEHSVVYGQPAIALPIRNVKTTVKIQPTNGDIQIKSRYFNGSLKD
CCHHHCCCCCEEEEEECCEEEECCCEEEEEECCCEEEEEEEECCCCEEEEEEECCCCHHH
IHSNLLGIKNLIKQTLNELNRPNTNLLITIDSDVPAERGMGSSASTAVALVRALYAYFEH
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHC
PLTRTTLLKTVDISEKIIHGKPSGLDSATASANNPIWFKKDGTIKPLPINVDAYLIISDS
CCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCEEECCEEEEEEECC
GIKGKTSEAVEIVKNKLRFDSDSRLLIEKLGELTSQTATVLRQNDVSTLGKILTEAHTNL
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
RQLGVSHPAVEKLIKIANDSGALGSKLTGGGLGGCVISLAPNLPAAEKISQQLTAGGATA
HHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCHH
TWIEKL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA