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The map label for this gene is 116492691

Identifier: 116492691

GI number: 116492691

Start: 926405

End: 927388

Strand: Reverse

Name: 116492691

Synonym: PEPE_0926

Alternate gene names: NA

Gene position: 927388-926405 (Counterclockwise)

Preceding gene: 116492692

Following gene: 116492690

Centisome position: 50.61

GC content: 40.14

Gene sequence:

>984_bases
ATGAATGAAAAACATGGTTTTGCAAGAGCCCATACTAACATTGCATTACTTAAATATTGGGGTAAAATTAACTCGGATTT
AATTCTACCCGCTAATGACAGCATTTCTTTGACCCTCGACAAATTTTATACCGATACTGAGGTAACCTTTTCGGATGAAT
ACACTAGTAATCTTTTTTATCTAAATCATCAATTAATCGATGTTAAAAAGATGCAACGTATTAATCGCGTCCTAGAAGCG
GTTAAAAGTGAATTTGGTTATCAAGGTTTTGCTAAAATTGAATCTGAAAATCACGTTCCTACTGCCGCTGGCTTAGCCTC
CTCAGCTTCAGGCATGGCTGCTCTAGCCGGGGCCGCAGTGAGTGCTTTAGGTTCACATACTGATTTAACTAATCTCTCAC
GACTAGCACGTTTAGGCTCCGGTTCAGCTTCGCGCTCAGTTTTCGGCGGGATTGTGCATTGGCATCGCGGATATGATCAT
CAAAGTTCCTTTGCCGAACAAATTGTATCTGAAGACCAAATTGATTTAAATATGGTTACTATCGTCATTGATCGACGCCA
AAAGAAAGTTAAAAGTACGCTAGGAATGCAACATACCGCTAGTACTTCGCCTTTCTATCCTGCGTGGGTGGAAGCTACTA
ACCAAGCAATTCCAGAAATGATTAGTGCTGTACAAAACAATGATTTTACTAAAATTGGTGAATTGGCAGAACACAGTGCA
GCCATGATGCATGCAACGACTTTATCTTCTAAGCCTGCTTTTACCTATTTTGCACCTGAAACCATTCAAGCGATTAAGTT
GGTTGAACAACTGCGTGAAAGTGGAATTGAGTGTTACTACACCATTGATGCCGGACCCAACGTTAAAGTTCTGTGCCAAT
CTAAAAACATTACGCGGGTTAAGCGGTTCTTTGCCAGCTACTTTGATCAAGATCAATTAGTCGTGGCTAAGCCTGGTAGT
GGAATTAAATTTACTAAAAACTAA

Upstream 100 bases:

>100_bases
TCCTAACCTTCCAGCTGCTGAAAAAATTAGTCAGCAACTTACTGCTGGCGGAGCCACGGCCACTTGGATTGAAAAACTTT
AAAAGTAGGTTTCGATACGT

Downstream 100 bases:

>100_bases
GAGGAATTTTAAATTGATAACAGAAAAAGCTCCCGGAAAATTATATATTGCTGGTGAATATGCCATTGTCGAACCTGGCA
ATAATGCCGTGCTAGTGGCA

Product: diphosphomevalonate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase; GHMP Kinase Domain-Containing Protein; Phosphomevalonate Kinase; Ghmp Kinase

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MNEKHGFARAHTNIALLKYWGKINSDLILPANDSISLTLDKFYTDTEVTFSDEYTSNLFYLNHQLIDVKKMQRINRVLEA
VKSEFGYQGFAKIESENHVPTAAGLASSASGMAALAGAAVSALGSHTDLTNLSRLARLGSGSASRSVFGGIVHWHRGYDH
QSSFAEQIVSEDQIDLNMVTIVIDRRQKKVKSTLGMQHTASTSPFYPAWVEATNQAIPEMISAVQNNDFTKIGELAEHSA
AMMHATTLSSKPAFTYFAPETIQAIKLVEQLRESGIECYYTIDAGPNVKVLCQSKNITRVKRFFASYFDQDQLVVAKPGS
GIKFTKN

Sequences:

>Translated_327_residues
MNEKHGFARAHTNIALLKYWGKINSDLILPANDSISLTLDKFYTDTEVTFSDEYTSNLFYLNHQLIDVKKMQRINRVLEA
VKSEFGYQGFAKIESENHVPTAAGLASSASGMAALAGAAVSALGSHTDLTNLSRLARLGSGSASRSVFGGIVHWHRGYDH
QSSFAEQIVSEDQIDLNMVTIVIDRRQKKVKSTLGMQHTASTSPFYPAWVEATNQAIPEMISAVQNNDFTKIGELAEHSA
AMMHATTLSSKPAFTYFAPETIQAIKLVEQLRESGIECYYTIDAGPNVKVLCQSKNITRVKRFFASYFDQDQLVVAKPGS
GIKFTKN
>Mature_327_residues
MNEKHGFARAHTNIALLKYWGKINSDLILPANDSISLTLDKFYTDTEVTFSDEYTSNLFYLNHQLIDVKKMQRINRVLEA
VKSEFGYQGFAKIESENHVPTAAGLASSASGMAALAGAAVSALGSHTDLTNLSRLARLGSGSASRSVFGGIVHWHRGYDH
QSSFAEQIVSEDQIDLNMVTIVIDRRQKKVKSTLGMQHTASTSPFYPAWVEATNQAIPEMISAVQNNDFTKIGELAEHSA
AMMHATTLSSKPAFTYFAPETIQAIKLVEQLRESGIECYYTIDAGPNVKVLCQSKNITRVKRFFASYFDQDQLVVAKPGS
GIKFTKN

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=305, Percent_Identity=33.1147540983607, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17537201, Length=318, Percent_Identity=30.188679245283, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17537203, Length=179, Percent_Identity=32.4022346368715, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324371, Length=338, Percent_Identity=34.3195266272189, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28571205, Length=324, Percent_Identity=34.2592592592593, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 36084; Mature: 36084

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKHGFARAHTNIALLKYWGKINSDLILPANDSISLTLDKFYTDTEVTFSDEYTSNLFY
CCCCCCCHHHHCCEEEEEECCCCCCCEEEECCCCEEEEEEHEECCCEEEECCCCCCCEEE
LNHQLIDVKKMQRINRVLEAVKSEFGYQGFAKIESENHVPTAAGLASSASGMAALAGAAV
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHCCCCCHHHHHHHHH
SALGSHTDLTNLSRLARLGSGSASRSVFGGIVHWHRGYDHQSSFAEQIVSEDQIDLNMVT
HHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEE
IVIDRRQKKVKSTLGMQHTASTSPFYPAWVEATNQAIPEMISAVQNNDFTKIGELAEHSA
EEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AMMHATTLSSKPAFTYFAPETIQAIKLVEQLRESGIECYYTIDAGPNVKVLCQSKNITRV
HHHHHEECCCCCCEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHH
KRFFASYFDQDQLVVAKPGSGIKFTKN
HHHHHHHCCCCCEEEECCCCCCEECCC
>Mature Secondary Structure
MNEKHGFARAHTNIALLKYWGKINSDLILPANDSISLTLDKFYTDTEVTFSDEYTSNLFY
CCCCCCCHHHHCCEEEEEECCCCCCCEEEECCCCEEEEEEHEECCCEEEECCCCCCCEEE
LNHQLIDVKKMQRINRVLEAVKSEFGYQGFAKIESENHVPTAAGLASSASGMAALAGAAV
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHCCCCCHHHHHHHHH
SALGSHTDLTNLSRLARLGSGSASRSVFGGIVHWHRGYDHQSSFAEQIVSEDQIDLNMVT
HHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEE
IVIDRRQKKVKSTLGMQHTASTSPFYPAWVEATNQAIPEMISAVQNNDFTKIGELAEHSA
EEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AMMHATTLSSKPAFTYFAPETIQAIKLVEQLRESGIECYYTIDAGPNVKVLCQSKNITRV
HHHHHEECCCCCCEEEECHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCHHHH
KRFFASYFDQDQLVVAKPGSGIKFTKN
HHHHHHHCCCCCEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA