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The map label for this gene is prsA

Identifier: 116492445

GI number: 116492445

Start: 718456

End: 719343

Strand: Reverse

Name: prsA

Synonym: PEPE_0677

Alternate gene names: 116492445

Gene position: 719343-718456 (Counterclockwise)

Preceding gene: 116492446

Following gene: 116492435

Centisome position: 39.26

GC content: 35.47

Gene sequence:

>888_bases
ATGAAAAAAGTTTTAATTGGTTTTGCCAGTATTGCAATGGCATTTACCTTAGCAGCATGTGGAAATAAGACGGTTGCTAC
AACATCGGGTGGTAAAATCACTCAAGACGAATACTACAGCAGCTTGAAGAACACCACTAGTGGTAAGCAAGTTCTTCAAG
AAATGATCGTCAACAAAGTTTTAGAAAAACAATATGGTGATAAAGTTTCTAAAAAGACGGTTACTAAGCAATACAACTCA
TACAAGGATCAATATGGATCATCATTTAAGAGCATCCTTTCATCTAATGGTATGACAACTTCTTCTTTGAAGACTCAGAT
TCGTTCTAATCTGCTATTGAAAGAAGCCGTTAAAGCTAACGATAAGATTTCAAATGCAGACCTTAAGAAAGAATGGAAAT
CTTATGAACCAAAGGTTACAGTGGCTCAGATTTTAGTTTCTAAGAAATCAACTGCTGAAGATATTATCAAGAAGCTTAAC
GATGGTGGAGATTTCACTAAACTTGCTAAGCAATATTCAACTGATTCTTCAACTAAGAATAAGGGTGGTAAAATTGCTGC
CTTTGATGACACAAACTCAACACTGGACTCTTCTTTCAAGAAAGCTGCATTCAAGCTTGATGAAGGTAAATATACAACTA
CACCAGTTAAAACTGAATATGGTTACCAAGTGATTAAGATGATTAACAAACCATCTAAGGGTAAGATGTCTGACCATACT
AAAGAACTTAAAGAACGTATCTGGAATGCAGATATGAGCGATAGCACAACCTTACGTAGTGTAATCACTAAAGTTCTTAA
GAAGGGTAACGTAACTATTAAGGACAAAGACCTTAAGAACGTTCTTGACGATTACCTTGGTAGCTCTGCTAGCTCAAGTA
CTAAATAA

Upstream 100 bases:

>100_bases
CTTTTTCTAAAGATTAAAGTTGTTTTATTATCATCCATTTAGGTATGGTATGATAGGTTTTGTATTTAACAAATTAAATT
GTTAGGATGTGTAGATTGTA

Downstream 100 bases:

>100_bases
TGCTAAATAAAAAAGATGAACGATTTCTCGTTCATCTTTTTTATTTGCTTTCTGGTTTATAAAAATTACGTCCATCCATA
CCAAAAATTCGTTCACTGAA

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKKVLIGFASIAMAFTLAACGNKTVATTSGGKITQDEYYSSLKNTTSGKQVLQEMIVNKVLEKQYGDKVSKKTVTKQYNS
YKDQYGSSFKSILSSNGMTTSSLKTQIRSNLLLKEAVKANDKISNADLKKEWKSYEPKVTVAQILVSKKSTAEDIIKKLN
DGGDFTKLAKQYSTDSSTKNKGGKIAAFDDTNSTLDSSFKKAAFKLDEGKYTTTPVKTEYGYQVIKMINKPSKGKMSDHT
KELKERIWNADMSDSTTLRSVITKVLKKGNVTIKDKDLKNVLDDYLGSSASSSTK

Sequences:

>Translated_295_residues
MKKVLIGFASIAMAFTLAACGNKTVATTSGGKITQDEYYSSLKNTTSGKQVLQEMIVNKVLEKQYGDKVSKKTVTKQYNS
YKDQYGSSFKSILSSNGMTTSSLKTQIRSNLLLKEAVKANDKISNADLKKEWKSYEPKVTVAQILVSKKSTAEDIIKKLN
DGGDFTKLAKQYSTDSSTKNKGGKIAAFDDTNSTLDSSFKKAAFKLDEGKYTTTPVKTEYGYQVIKMINKPSKGKMSDHT
KELKERIWNADMSDSTTLRSVITKVLKKGNVTIKDKDLKNVLDDYLGSSASSSTK
>Mature_295_residues
MKKVLIGFASIAMAFTLAACGNKTVATTSGGKITQDEYYSSLKNTTSGKQVLQEMIVNKVLEKQYGDKVSKKTVTKQYNS
YKDQYGSSFKSILSSNGMTTSSLKTQIRSNLLLKEAVKANDKISNADLKKEWKSYEPKVTVAQILVSKKSTAEDIIKKLN
DGGDFTKLAKQYSTDSSTKNKGGKIAAFDDTNSTLDSSFKKAAFKLDEGKYTTTPVKTEYGYQVIKMINKPSKGKMSDHT
KELKERIWNADMSDSTTLRSVITKVLKKGNVTIKDKDLKNVLDDYLGSSASSSTK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRSA_PEDPA (Q03GD4)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804180.1
- ProteinModelPortal:   Q03GD4
- SMR:   Q03GD4
- STRING:   Q03GD4
- GeneID:   4418142
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0677
- NMPDR:   fig|278197.10.peg.602
- eggNOG:   COG0760
- HOGENOM:   HBG712792
- OMA:   NTYKKQY
- ProtClustDB:   PRK04405
- BioCyc:   PPEN278197:PEPE_0677-MONOMER
- HAMAP:   MF_01145
- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 32507; Mature: 32507

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2; PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLIGFASIAMAFTLAACGNKTVATTSGGKITQDEYYSSLKNTTSGKQVLQEMIVNKV
CCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
LEKQYGDKVSKKTVTKQYNSYKDQYGSSFKSILSSNGMTTSSLKTQIRSNLLLKEAVKAN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
DKISNADLKKEWKSYEPKVTVAQILVSKKSTAEDIIKKLNDGGDFTKLAKQYSTDSSTKN
CCCCCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
KGGKIAAFDDTNSTLDSSFKKAAFKLDEGKYTTTPVKTEYGYQVIKMINKPSKGKMSDHT
CCCEEEEECCCCHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCHHHH
KELKERIWNADMSDSTTLRSVITKVLKKGNVTIKDKDLKNVLDDYLGSSASSSTK
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKKVLIGFASIAMAFTLAACGNKTVATTSGGKITQDEYYSSLKNTTSGKQVLQEMIVNKV
CCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
LEKQYGDKVSKKTVTKQYNSYKDQYGSSFKSILSSNGMTTSSLKTQIRSNLLLKEAVKAN
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
DKISNADLKKEWKSYEPKVTVAQILVSKKSTAEDIIKKLNDGGDFTKLAKQYSTDSSTKN
CCCCCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
KGGKIAAFDDTNSTLDSSFKKAAFKLDEGKYTTTPVKTEYGYQVIKMINKPSKGKMSDHT
CCCEEEEECCCCHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCHHHH
KELKERIWNADMSDSTTLRSVITKVLKKGNVTIKDKDLKNVLDDYLGSSASSSTK
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA