Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 116492251

GI number: 116492251

Start: 497678

End: 499681

Strand: Direct

Name: uvrB [H]

Synonym: PEPE_0448

Alternate gene names: 116492251

Gene position: 497678-499681 (Clockwise)

Preceding gene: 116492250

Following gene: 116492252

Centisome position: 27.16

GC content: 39.62

Gene sequence:

>2004_bases
ATGATTAAACGTGAGAATGATCGTGAATTTGAATTGGTTTCTAAGTACCAACCAACGGGGGATCAGCCAACGGCGATCAA
CGAATTAGTTGACGGTATTAAAAGTGGCGAGAAAGAACAAATCCTGTTGGGTGCAACGGGTACCGGGAAAACTTTTACGA
TTTCTAACGTAATTCAAAAAGTGAATAAACCAACTTTAATTTTGTCACACAATAAAACTTTGGCGGGCCAATTATATGGC
GAGTTTAAACAGTTTTTCCCGAATAACGCGGTAGAATATTTTGTTAGTTATTATGATTATTATCAGCCTGAAGCATACGT
TCCATCTAGTGACACTTATATTGAAAAAGACTCATCAATCAATGATGAAATCGATGAGCTCCGCCATTCCGCTACTAGTT
CACTACTTGAACGCAATGATGTGATTGTGGTGGCTTCTGTTTCAAGTATCTTTGGTTTGGGTGATCCTCGAGAATACCAA
GATCAAGCCTTAACACTTCGAGTAGGGCAGGAGATTGATCGAAATAAGTTACTACGAGAATTAGTTGATATTCAGTACGA
CCGTAATGATATTGATTTCCAGCGTGGCCGTTTTCGGGTGCATGGCGATGTAGTTGAAATTTTTCCGGCTGCTAATGATG
CGCATTCCATTCGAGTAGAATTCTTTGGGGATGAAATTGATCGAATGCGTGAAATGGATGCCTTAACGGGAGAAATTATT
GGTGATCGAGATCATATTACAATTTTCCCAGCAACCCATTTTATGACTAACGAAGATCGAATGGAACATGCGATTAAGAA
CATTGAAGCGGAATTGAAGGACCGTTTGGAAGAATTAGATGGTGAGGGAAAACTCCTAGAAGCGCAACGTTTACGACAAA
GAACGACCTATGATATCGAGATGTTAAAAGAAATGGGATACACCAACGGGATTGAAAATTATTCCAGACATATGGATGGT
CGTAAACCAGGTGAAGCACCTTATACTTTACTAGATTTCTTCCCCGATGATTTTCTATTGGTCGTAGATGAATCCCACGT
AACTATGCCACAAGTACGCGGTATGTACAATGGGGATCGAGCTCGTAAGCAACAATTAGTAGATTACGGGTTTAGATTGC
CAAGTGCGTTGGATAACCGACCCCTTAAATTAGAAGAATTTGAAAAACATATTAACCAAGTGGTTTATATGTCAGCTACC
CCAGGTGATTATGAAAATGAACGAACTAATAACGTTGTTCAACAGATTATTCGACCAACTGGGTTATTGGATCCAATCAT
CGAAGTACGCCCAATCATGGGCCAAATGGATGATTTGCTAGGTGAAATTAATCAACGGATTGAAAAAGACGAGCGTGTAT
TTGTAACAACTTTGACGAAGAAGATGGCCGAAGATTTAACCGATTATCTGAAAGATATGGGAATTAAGGTTGCTTACTTG
CATAGTGATATTAAGACGCTGGAAAGAACCCGTATTATCCGTGATTTACGGGTAGGCAAGTATGATGTTTTAGTAGGAAT
CAATTTGCTTCGTGAAGGAATTGATGTTCCGGAAGTATCTTTAGTAGCGATTTTAGATGCCGACAAGGAAGGTTTCCTTC
GAAATACTCGTTCGATGATTCAGGTGGCTGGGCGTGCGGCACGTAATGAAAATGGACACGTTATTATGTATGCTGATCAT
ATGACTAAGTCCATGCAAGAAACCATTGATGAAACTGCACGACGTCGTACGATTCAAGAAGCATATAACCGTGAACATGG
AATTACTCCTCATACAATTAAAAAGGATATTCGTTCGTTGATTTCATCAACCAGTGATACTGAGGATAAAGGTAAAAAAG
ACGACTTCTTGGACGTTGATTTTGCCGACATGGATAGTAAGGATCAAAAAGAAATGATTGCAAACTTGGAAGATCAAATG
CGAGCGGCTGCTAAGAAGCTAGACTTCGAAAAAGCAGCTAACTTGCGAGATACCGTTTTAGAATTAAAAGCACAGATTGG
TTAG

Upstream 100 bases:

>100_bases
AGCTATGGTTAATTTCGAGTAAATATAATTTTAGGAAATGGCTGAGAACTGATCCTGATCGGTTCAATCTCAGTCATTTT
GTGTGAACGGAGGAAAACGA

Downstream 100 bases:

>100_bases
GAGGCCTCTTTTTTGGCAAATGATAAAATTGTTATCCACGGTGCACGAGCACATAATTTAAAGAATATTGATGTTACCAT
TCCACGCGATAAACTAGTGG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MIKRENDREFELVSKYQPTGDQPTAINELVDGIKSGEKEQILLGATGTGKTFTISNVIQKVNKPTLILSHNKTLAGQLYG
EFKQFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSINDEIDELRHSATSSLLERNDVIVVASVSSIFGLGDPREYQ
DQALTLRVGQEIDRNKLLRELVDIQYDRNDIDFQRGRFRVHGDVVEIFPAANDAHSIRVEFFGDEIDRMREMDALTGEII
GDRDHITIFPATHFMTNEDRMEHAIKNIEAELKDRLEELDGEGKLLEAQRLRQRTTYDIEMLKEMGYTNGIENYSRHMDG
RKPGEAPYTLLDFFPDDFLLVVDESHVTMPQVRGMYNGDRARKQQLVDYGFRLPSALDNRPLKLEEFEKHINQVVYMSAT
PGDYENERTNNVVQQIIRPTGLLDPIIEVRPIMGQMDDLLGEINQRIEKDERVFVTTLTKKMAEDLTDYLKDMGIKVAYL
HSDIKTLERTRIIRDLRVGKYDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNTRSMIQVAGRAARNENGHVIMYADH
MTKSMQETIDETARRRTIQEAYNREHGITPHTIKKDIRSLISSTSDTEDKGKKDDFLDVDFADMDSKDQKEMIANLEDQM
RAAAKKLDFEKAANLRDTVLELKAQIG

Sequences:

>Translated_667_residues
MIKRENDREFELVSKYQPTGDQPTAINELVDGIKSGEKEQILLGATGTGKTFTISNVIQKVNKPTLILSHNKTLAGQLYG
EFKQFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSINDEIDELRHSATSSLLERNDVIVVASVSSIFGLGDPREYQ
DQALTLRVGQEIDRNKLLRELVDIQYDRNDIDFQRGRFRVHGDVVEIFPAANDAHSIRVEFFGDEIDRMREMDALTGEII
GDRDHITIFPATHFMTNEDRMEHAIKNIEAELKDRLEELDGEGKLLEAQRLRQRTTYDIEMLKEMGYTNGIENYSRHMDG
RKPGEAPYTLLDFFPDDFLLVVDESHVTMPQVRGMYNGDRARKQQLVDYGFRLPSALDNRPLKLEEFEKHINQVVYMSAT
PGDYENERTNNVVQQIIRPTGLLDPIIEVRPIMGQMDDLLGEINQRIEKDERVFVTTLTKKMAEDLTDYLKDMGIKVAYL
HSDIKTLERTRIIRDLRVGKYDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNTRSMIQVAGRAARNENGHVIMYADH
MTKSMQETIDETARRRTIQEAYNREHGITPHTIKKDIRSLISSTSDTEDKGKKDDFLDVDFADMDSKDQKEMIANLEDQM
RAAAKKLDFEKAANLRDTVLELKAQIG
>Mature_667_residues
MIKRENDREFELVSKYQPTGDQPTAINELVDGIKSGEKEQILLGATGTGKTFTISNVIQKVNKPTLILSHNKTLAGQLYG
EFKQFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSINDEIDELRHSATSSLLERNDVIVVASVSSIFGLGDPREYQ
DQALTLRVGQEIDRNKLLRELVDIQYDRNDIDFQRGRFRVHGDVVEIFPAANDAHSIRVEFFGDEIDRMREMDALTGEII
GDRDHITIFPATHFMTNEDRMEHAIKNIEAELKDRLEELDGEGKLLEAQRLRQRTTYDIEMLKEMGYTNGIENYSRHMDG
RKPGEAPYTLLDFFPDDFLLVVDESHVTMPQVRGMYNGDRARKQQLVDYGFRLPSALDNRPLKLEEFEKHINQVVYMSAT
PGDYENERTNNVVQQIIRPTGLLDPIIEVRPIMGQMDDLLGEINQRIEKDERVFVTTLTKKMAEDLTDYLKDMGIKVAYL
HSDIKTLERTRIIRDLRVGKYDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNTRSMIQVAGRAARNENGHVIMYADH
MTKSMQETIDETARRRTIQEAYNREHGITPHTIKKDIRSLISSTSDTEDKGKKDDFLDVDFADMDSKDQKEMIANLEDQM
RAAAKKLDFEKAANLRDTVLELKAQIG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=58.1325301204819, Blast_Score=755, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76548; Mature: 76548

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRENDREFELVSKYQPTGDQPTAINELVDGIKSGEKEQILLGATGTGKTFTISNVIQK
CCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHH
VNKPTLILSHNKTLAGQLYGEFKQFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSI
CCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCC
NDEIDELRHSATSSLLERNDVIVVASVSSIFGLGDPREYQDQALTLRVGQEIDRNKLLRE
CHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCEEEEHHCCCCCHHHHHHH
LVDIQYDRNDIDFQRGRFRVHGDVVEIFPAANDAHSIRVEFFGDEIDRMREMDALTGEII
HHHCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHC
GDRDHITIFPATHFMTNEDRMEHAIKNIEAELKDRLEELDGEGKLLEAQRLRQRTTYDIE
CCCCCEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHH
MLKEMGYTNGIENYSRHMDGRKPGEAPYTLLDFFPDDFLLVVDESHVTMPQVRGMYNGDR
HHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCHHHHCCCCCCHH
ARKQQLVDYGFRLPSALDNRPLKLEEFEKHINQVVYMSATPGDYENERTNNVVQQIIRPT
HHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCC
GLLDPIIEVRPIMGQMDDLLGEINQRIEKDERVFVTTLTKKMAEDLTDYLKDMGIKVAYL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEE
HSDIKTLERTRIIRDLRVGKYDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNTRSMI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QVAGRAARNENGHVIMYADHMTKSMQETIDETARRRTIQEAYNREHGITPHTIKKDIRSL
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ISSTSDTEDKGKKDDFLDVDFADMDSKDQKEMIANLEDQMRAAAKKLDFEKAANLRDTVL
HCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHH
ELKAQIG
HHHHHCC
>Mature Secondary Structure
MIKRENDREFELVSKYQPTGDQPTAINELVDGIKSGEKEQILLGATGTGKTFTISNVIQK
CCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHH
VNKPTLILSHNKTLAGQLYGEFKQFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSI
CCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCC
NDEIDELRHSATSSLLERNDVIVVASVSSIFGLGDPREYQDQALTLRVGQEIDRNKLLRE
CHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCEEEEHHCCCCCHHHHHHH
LVDIQYDRNDIDFQRGRFRVHGDVVEIFPAANDAHSIRVEFFGDEIDRMREMDALTGEII
HHHCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHC
GDRDHITIFPATHFMTNEDRMEHAIKNIEAELKDRLEELDGEGKLLEAQRLRQRTTYDIE
CCCCCEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHH
MLKEMGYTNGIENYSRHMDGRKPGEAPYTLLDFFPDDFLLVVDESHVTMPQVRGMYNGDR
HHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCHHHHCCCCCCHH
ARKQQLVDYGFRLPSALDNRPLKLEEFEKHINQVVYMSATPGDYENERTNNVVQQIIRPT
HHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCC
GLLDPIIEVRPIMGQMDDLLGEINQRIEKDERVFVTTLTKKMAEDLTDYLKDMGIKVAYL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEE
HSDIKTLERTRIIRDLRVGKYDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNTRSMI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QVAGRAARNENGHVIMYADHMTKSMQETIDETARRRTIQEAYNREHGITPHTIKKDIRSL
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ISSTSDTEDKGKKDDFLDVDFADMDSKDQKEMIANLEDQMRAAAKKLDFEKAANLRDTVL
HCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHH
ELKAQIG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]