Click here to switch to the map view.

The map label for this gene is hprK

Identifier: 116492244

GI number: 116492244

Start: 490029

End: 490967

Strand: Direct

Name: hprK

Synonym: PEPE_0441

Alternate gene names: 116492244

Gene position: 490029-490967 (Clockwise)

Preceding gene: 116492243

Following gene: 116492245

Centisome position: 26.74

GC content: 38.45

Gene sequence:

>939_bases
ATGGCCGATGGTGTTTCAGTATCTGAGTTAGTAGAAAAAATAAGATTAGATGTATTTTATGGCGATGAACTATTAGAACA
AAAAAAAGTTACAGTTAGTGATATTTCACGTCCAGGTTTAGAGTTAACCAATTACTTTAAATTTTATCCTCATGAACGAA
TTCAACTGTTTGGAGAAACAGAAATTTCGTACGCTAAGGATAGTATGACTAAAGATGAACGAACTAAGATTTATGATCGA
ATGGCGGACGTTGATACCCCAGCATTTGTGGTTTCGCGTGGTTTACCAATTCCTGAAGAATTGATCCAGGCCGCCAAAAA
TAATCAGGTTCCCATCTTAACGTCAACTTTACCAACCTCACGTCTGCTAAGTAACATGACCAACTTTTTAGAAGATCGGT
TGGCAGAACGTGATTCAATTCATGGTGAACTACTGGAAATTTATGGATTAGGGGTTTTAATTACGGGAGACTCTGGGATT
GGTAAAAGTGAAACGGCGTTGGACCTAATCAAACGCGGACATCGTCTGATTGCGGATGATCGGGTTGATATTTATCAACA
AGATGAACAAACCTTAATCGGGGAAGCTCCCCGCATTCTTCGTCATCTTTTGGAGATTCGAGGTGTTGGAATCATTGATG
TAATGAATTTATTTGGGGCGAGCGCGGTTAAAAATCACACGGAAATTAGTGTGATTGTTCATCTACAAAATTGGGATAAA
GATGCACATTTCGATCGTTTAGGTAACGGCGAACAAACACGACATTTCTTTGAATTAGATATTCCAAAGATTACCATCCC
AGTTCGTGTTGGACGAAACCTCGGTGATATTATCGAAGCCGCTACCATGAACTTTAGAGCTAAAAATATGGGATATGATG
CAACCAAAGTTTTTGATCGTAACTTAAATGAGTTGATCAAAGATAATTCCCAGAAATAG

Upstream 100 bases:

>100_bases
CATCCTTTGGAATGACGATGTTGATTTCGGTAATCTTATCCATTTGTAATACTATTATTTCGAACCACTTTACAAATCGT
TAGCGAAGGAGGCCCATTCA

Downstream 100 bases:

>100_bases
GAGTGGATTTTGTGAATTTAACGTTAGGAGCACTAAATCCAATTGCCTTTAATCTTGGTGGAATTCAAGTTCATTGGTAT
GGAATTATCATTGCGTCAGC

Product: Serine kinase of the HPr protein, regulates carbohydrate metabolism

Products: NA

Alternate protein names: HPrK/P; HPr(Ser) kinase/phosphorylase

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MADGVSVSELVEKIRLDVFYGDELLEQKKVTVSDISRPGLELTNYFKFYPHERIQLFGETEISYAKDSMTKDERTKIYDR
MADVDTPAFVVSRGLPIPEELIQAAKNNQVPILTSTLPTSRLLSNMTNFLEDRLAERDSIHGELLEIYGLGVLITGDSGI
GKSETALDLIKRGHRLIADDRVDIYQQDEQTLIGEAPRILRHLLEIRGVGIIDVMNLFGASAVKNHTEISVIVHLQNWDK
DAHFDRLGNGEQTRHFFELDIPKITIPVRVGRNLGDIIEAATMNFRAKNMGYDATKVFDRNLNELIKDNSQK

Sequences:

>Translated_312_residues
MADGVSVSELVEKIRLDVFYGDELLEQKKVTVSDISRPGLELTNYFKFYPHERIQLFGETEISYAKDSMTKDERTKIYDR
MADVDTPAFVVSRGLPIPEELIQAAKNNQVPILTSTLPTSRLLSNMTNFLEDRLAERDSIHGELLEIYGLGVLITGDSGI
GKSETALDLIKRGHRLIADDRVDIYQQDEQTLIGEAPRILRHLLEIRGVGIIDVMNLFGASAVKNHTEISVIVHLQNWDK
DAHFDRLGNGEQTRHFFELDIPKITIPVRVGRNLGDIIEAATMNFRAKNMGYDATKVFDRNLNELIKDNSQK
>Mature_311_residues
ADGVSVSELVEKIRLDVFYGDELLEQKKVTVSDISRPGLELTNYFKFYPHERIQLFGETEISYAKDSMTKDERTKIYDRM
ADVDTPAFVVSRGLPIPEELIQAAKNNQVPILTSTLPTSRLLSNMTNFLEDRLAERDSIHGELLEIYGLGVLITGDSGIG
KSETALDLIKRGHRLIADDRVDIYQQDEQTLIGEAPRILRHLLEIRGVGIIDVMNLFGASAVKNHTEISVIVHLQNWDKD
AHFDRLGNGEQTRHFFELDIPKITIPVRVGRNLGDIIEAATMNFRAKNMGYDATKVFDRNLNELIKDNSQK

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRK_PEDPA (Q03GY5)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_803979.1
- ProteinModelPortal:   Q03GY5
- SMR:   Q03GY5
- STRING:   Q03GY5
- GeneID:   4418372
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0441
- NMPDR:   fig|278197.10.peg.409
- eggNOG:   COG1493
- HOGENOM:   HBG566466
- OMA:   IHGVLVD
- BioCyc:   PPEN278197:PEPE_0441-MONOMER
- HAMAP:   MF_01249
- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126
- TIGRFAMs:   TIGR00679

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N

EC number: NA

Molecular weight: Translated: 35311; Mature: 35180

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: ACT_SITE 141-141 ACT_SITE 162-162 ACT_SITE 180-180 ACT_SITE 246-246

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGVSVSELVEKIRLDVFYGDELLEQKKVTVSDISRPGLELTNYFKFYPHERIQLFGET
CCCCCCHHHHHHHHHHHHEECHHHHHHCCCHHHHCCCCCCHHHHHHHHCCCHHEEEECCC
EISYAKDSMTKDERTKIYDRMADVDTPAFVVSRGLPIPEELIQAAKNNQVPILTSTLPTS
HHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHCCCCCCEEECCCCHH
RLLSNMTNFLEDRLAERDSIHGELLEIYGLGVLITGDSGIGKSETALDLIKRGHRLIADD
HHHHHHHHHHHHHHHHHHCHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHCCCEEECCC
RVDIYQQDEQTLIGEAPRILRHLLEIRGVGIIDVMNLFGASAVKNHTEISVIVHLQNWDK
CCHHHHCCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
DAHFDRLGNGEQTRHFFELDIPKITIPVRVGRNLGDIIEAATMNFRAKNMGYDATKVFDR
CCCHHHCCCCCHHCEEEEECCCEEEEEEEECCCHHHHHHHHHCCCCHHCCCCHHHHHHHC
NLNELIKDNSQK
CHHHHHHCCCCC
>Mature Secondary Structure 
ADGVSVSELVEKIRLDVFYGDELLEQKKVTVSDISRPGLELTNYFKFYPHERIQLFGET
CCCCCHHHHHHHHHHHHEECHHHHHHCCCHHHHCCCCCCHHHHHHHHCCCHHEEEECCC
EISYAKDSMTKDERTKIYDRMADVDTPAFVVSRGLPIPEELIQAAKNNQVPILTSTLPTS
HHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHCCCCCCEEECCCCHH
RLLSNMTNFLEDRLAERDSIHGELLEIYGLGVLITGDSGIGKSETALDLIKRGHRLIADD
HHHHHHHHHHHHHHHHHHCHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHCCCEEECCC
RVDIYQQDEQTLIGEAPRILRHLLEIRGVGIIDVMNLFGASAVKNHTEISVIVHLQNWDK
CCHHHHCCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
DAHFDRLGNGEQTRHFFELDIPKITIPVRVGRNLGDIIEAATMNFRAKNMGYDATKVFDR
CCCHHHCCCCCHHCEEEEECCCEEEEEEEECCCHHHHHHHHHCCCCHHCCCCHHHHHHHC
NLNELIKDNSQK
CHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA