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The map label for this gene is ifcA [H]

Identifier: 116492121

GI number: 116492121

Start: 364469

End: 365857

Strand: Direct

Name: ifcA [H]

Synonym: PEPE_0318

Alternate gene names: 116492121

Gene position: 364469-365857 (Clockwise)

Preceding gene: 116492120

Following gene: 116492122

Centisome position: 19.89

GC content: 41.76

Gene sequence:

>1389_bases
GTGACTGAACGAGTAGAATTTAAACCAACAAGTATTGATGATTTAAGTAGCCAATATGATGTAATTATTATCGGAGCTGG
GAGTACGGGTTTAACCAGTGCTCTAGAACTGACTGAGTTGGGCAAAAAAGTGGTTGTCCTAGAGAAGATGGAGAAGCCTG
GTGGAAACTCTATGCGGGCATCTTCAGGGATGAACGCCGCTGAAACAGCAATCCAAAGGCATGAAGGGATTATCGATAGT
TATGAATCCTTTTATGAAGATACATATAAAGGTGGCGGCAAACAAAATGATGTCGAAATGTTGAAATATTTTACAAGTCA
TGCGGATTCTGCCGTTGAGTGGTTAAAAGAACATGATGTTGTTTTAGATGAAATCACTTTGACCGGTGGAATGAGTGTGA
AGCGGGCCCATCGCCCTAGTAGCGCCCCTGCAATTGGTGGATATTTAATCCACCAACTACTAAATCAGTTAGCTGAAGAA
AAGGTTCCAGTAGTTTGTGGAGCAACGGTTAGGGAAATTGATTGTGGGGATAATCATCAATTTAAAGTTGATTTTGCCGA
CGCCCAAGGCTCAAACCATTTACTTAATAGTGCAGCAATCATTCTAGCCACGGGTGGTTTTGCTGCTAGTGATGCTTTAA
TTAAAAAATATCGTCCCGATCTCGTTCACTACAAGACAACTAATCACCCTGGGGCGACTGGCGATGGATTACAATTAGCG
GAGAATTTAGGTGCTCAATTGGTAGATATGGACCAAATTCAAGTTCATCCCACCGTTTACCAAGATGGAGACCATGCATT
CTTAATTGGTGAAATGGTACGTGGGGAAGGCGCAATTTTAGTTAATCAAAGTGGTCATCGCTTTGTAAACGAACTAGACA
CACGTAAAGTTGTAACGGATGCAATTAACGCTCAAACCCAACCAGATGCCTATCTGATATTTAATGCAGCGTTAGCTAAA
AGAGCCAGTGCGATTGGTTTTTACGATCACATCGGTCTAGTTCAACATGGTGATCATATTGATGAGTTAGCGAAGACTTT
GGGATTACCAGTTGCTAATCTAAAAGAAACGATGCAGCAGTGGAGTGATGTGGTTGCTAAGCGTAAGGATGAAGCATTCG
GAAGAACTATGGGTTTGGTTGATGGTTTTGAAGAAGGTCCTTATATGGCAATTCATATTGCACCAGCTATTCACTATACG
ATGGGCGGACTCAAAACGTCTGCTAAAGCCGAAGTTTTAGATAAAAAATTTAAACCCATCAAAGGGTTATATGCCGGTGG
GGAAGTTGCTGGTGGATTACATGGAAACAACCGTATCGGAGGTAACTCAATCGCCGAAACAGTGGTTTTTGGATTGCAAG
CTGCTCGCCAAGCATTCAAAAATTTATAA

Upstream 100 bases:

>100_bases
CTTGCCACGACATTATTCAAGGCTTAGTTCCAGCAATGGATCAATATCACTTTAACAACATTGCGGAGTTTAGCTCCGAG
AAATAAGCGGAGGTTTAGTA

Downstream 100 bases:

>100_bases
TAGATATTATGTACAAATATATATATAACCAAATTAAAGGTAAGATTTTGTTAAATGTTCCAATTGACAAGGTCTTGCCT
TTTTTAGACAATCAATATAA

Product: succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Products: NA

Alternate protein names: Fe(3+)-induced flavocytochrome C3; Ifc3; Iron(III)-induced flavocytochrome C3 [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTERVEFKPTSIDDLSSQYDVIIIGAGSTGLTSALELTELGKKVVVLEKMEKPGGNSMRASSGMNAAETAIQRHEGIIDS
YESFYEDTYKGGGKQNDVEMLKYFTSHADSAVEWLKEHDVVLDEITLTGGMSVKRAHRPSSAPAIGGYLIHQLLNQLAEE
KVPVVCGATVREIDCGDNHQFKVDFADAQGSNHLLNSAAIILATGGFAASDALIKKYRPDLVHYKTTNHPGATGDGLQLA
ENLGAQLVDMDQIQVHPTVYQDGDHAFLIGEMVRGEGAILVNQSGHRFVNELDTRKVVTDAINAQTQPDAYLIFNAALAK
RASAIGFYDHIGLVQHGDHIDELAKTLGLPVANLKETMQQWSDVVAKRKDEAFGRTMGLVDGFEEGPYMAIHIAPAIHYT
MGGLKTSAKAEVLDKKFKPIKGLYAGGEVAGGLHGNNRIGGNSIAETVVFGLQAARQAFKNL

Sequences:

>Translated_462_residues
MTERVEFKPTSIDDLSSQYDVIIIGAGSTGLTSALELTELGKKVVVLEKMEKPGGNSMRASSGMNAAETAIQRHEGIIDS
YESFYEDTYKGGGKQNDVEMLKYFTSHADSAVEWLKEHDVVLDEITLTGGMSVKRAHRPSSAPAIGGYLIHQLLNQLAEE
KVPVVCGATVREIDCGDNHQFKVDFADAQGSNHLLNSAAIILATGGFAASDALIKKYRPDLVHYKTTNHPGATGDGLQLA
ENLGAQLVDMDQIQVHPTVYQDGDHAFLIGEMVRGEGAILVNQSGHRFVNELDTRKVVTDAINAQTQPDAYLIFNAALAK
RASAIGFYDHIGLVQHGDHIDELAKTLGLPVANLKETMQQWSDVVAKRKDEAFGRTMGLVDGFEEGPYMAIHIAPAIHYT
MGGLKTSAKAEVLDKKFKPIKGLYAGGEVAGGLHGNNRIGGNSIAETVVFGLQAARQAFKNL
>Mature_461_residues
TERVEFKPTSIDDLSSQYDVIIIGAGSTGLTSALELTELGKKVVVLEKMEKPGGNSMRASSGMNAAETAIQRHEGIIDSY
ESFYEDTYKGGGKQNDVEMLKYFTSHADSAVEWLKEHDVVLDEITLTGGMSVKRAHRPSSAPAIGGYLIHQLLNQLAEEK
VPVVCGATVREIDCGDNHQFKVDFADAQGSNHLLNSAAIILATGGFAASDALIKKYRPDLVHYKTTNHPGATGDGLQLAE
NLGAQLVDMDQIQVHPTVYQDGDHAFLIGEMVRGEGAILVNQSGHRFVNELDTRKVVTDAINAQTQPDAYLIFNAALAKR
ASAIGFYDHIGLVQHGDHIDELAKTLGLPVANLKETMQQWSDVVAKRKDEAFGRTMGLVDGFEEGPYMAIHIAPAIHYTM
GGLKTSAKAEVLDKKFKPIKGLYAGGEVAGGLHGNNRIGGNSIAETVVFGLQAARQAFKNL

Specific function: Catalyzes unidirectional fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=478, Percent_Identity=25.7322175732218, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1786942, Length=471, Percent_Identity=25.6900212314225, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790597, Length=223, Percent_Identity=26.9058295964126, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71986328, Length=461, Percent_Identity=34.4902386117137, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17505833, Length=479, Percent_Identity=27.1398747390397, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550100, Length=468, Percent_Identity=27.991452991453, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320788, Length=460, Percent_Identity=39.1304347826087, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6322511, Length=471, Percent_Identity=33.3333333333333, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322416, Length=475, Percent_Identity=26.9473684210526, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322701, Length=459, Percent_Identity=26.797385620915, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17137288, Length=476, Percent_Identity=26.2605042016807, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24655642, Length=476, Percent_Identity=26.2605042016807, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24655647, Length=476, Percent_Identity=26.2605042016807, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24663005, Length=474, Percent_Identity=25.5274261603376, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR010960
- InterPro:   IPR011031 [H]

Pfam domain/function: PF00890 FAD_binding_2 [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 49858; Mature: 49727

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERVEFKPTSIDDLSSQYDVIIIGAGSTGLTSALELTELGKKVVVLEKMEKPGGNSMRA
CCCCEECCCCCHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEHHCCCCCCCCCC
SSGMNAAETAIQRHEGIIDSYESFYEDTYKGGGKQNDVEMLKYFTSHADSAVEWLKEHDV
CCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
VLDEITLTGGMSVKRAHRPSSAPAIGGYLIHQLLNQLAEEKVPVVCGATVREIDCGDNHQ
EEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCE
FKVDFADAQGSNHLLNSAAIILATGGFAASDALIKKYRPDLVHYKTTNHPGATGDGLQLA
EEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHH
ENLGAQLVDMDQIQVHPTVYQDGDHAFLIGEMVRGEGAILVNQSGHRFVNELDTRKVVTD
HHCCCEEEECCCEEECCEEEECCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHH
AINAQTQPDAYLIFNAALAKRASAIGFYDHIGLVQHGDHIDELAKTLGLPVANLKETMQQ
HHCCCCCCCEEEEEEHHHHHHHHHCCHHHHCCHHHCCCHHHHHHHHHCCCHHHHHHHHHH
WSDVVAKRKDEAFGRTMGLVDGFEEGPYMAIHIAPAIHYTMGGLKTSAKAEVLDKKFKPI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHCCCH
KGLYAGGEVAGGLHGNNRIGGNSIAETVVFGLQAARQAFKNL
HCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TERVEFKPTSIDDLSSQYDVIIIGAGSTGLTSALELTELGKKVVVLEKMEKPGGNSMRA
CCCEECCCCCHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEHHCCCCCCCCCC
SSGMNAAETAIQRHEGIIDSYESFYEDTYKGGGKQNDVEMLKYFTSHADSAVEWLKEHDV
CCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
VLDEITLTGGMSVKRAHRPSSAPAIGGYLIHQLLNQLAEEKVPVVCGATVREIDCGDNHQ
EEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCE
FKVDFADAQGSNHLLNSAAIILATGGFAASDALIKKYRPDLVHYKTTNHPGATGDGLQLA
EEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHH
ENLGAQLVDMDQIQVHPTVYQDGDHAFLIGEMVRGEGAILVNQSGHRFVNELDTRKVVTD
HHCCCEEEECCCEEECCEEEECCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHH
AINAQTQPDAYLIFNAALAKRASAIGFYDHIGLVQHGDHIDELAKTLGLPVANLKETMQQ
HHCCCCCCCEEEEEEHHHHHHHHHCCHHHHCCHHHCCCHHHHHHHHHCCCHHHHHHHHHH
WSDVVAKRKDEAFGRTMGLVDGFEEGPYMAIHIAPAIHYTMGGLKTSAKAEVLDKKFKPI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHCCCH
KGLYAGGEVAGGLHGNNRIGGNSIAETVVFGLQAARQAFKNL
HCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10455032; 10581549 [H]