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The map label for this gene is pyrC

Identifier: 116492117

GI number: 116492117

Start: 357983

End: 359260

Strand: Direct

Name: pyrC

Synonym: PEPE_0314

Alternate gene names: 116492117

Gene position: 357983-359260 (Clockwise)

Preceding gene: 116492116

Following gene: 116492118

Centisome position: 19.54

GC content: 42.72

Gene sequence:

>1278_bases
ATGAAAGTTTTACTTAAAAATGCCCGAGTAATAAAAAGTCATCAAGTGCAAAAAACTGACGTCCTTGTGGAAAACGACCG
AATCACTCAAATTCAACCCGAAATTAACGTTGAAGCTGAACAAATCATCGATGTAAAAAATCAACTTTTAATGCCAGGAC
TGGTGGATATCCACGTTCATTTTAGAGACCCGGGCCAAACGGATAAAGAAGATGTAGTTAGTGGCAGTGCTGCAGCAGTT
AAAGGCGGATTTACGACAGTATTAACTATGCCTAACGTTGATCCTGTCCCTGATACACCCGAAAAAATGACAGCGATGGT
AAAACATAATCAAACTGCTGGTAGTCTTCATATCGGACAATACGGGTCCATTACTAAAAAACGGACAAGCGAAGAATTGG
TTGATTTTAAAGCTTTAAAAGAAGCTGGTGCGGTAGCTTTTAGTAACGATGGTAACGGCATTCAAACTGCCGAAACCATG
TATCAAGCAATGCTTCAAATTAAAGAAGTGGGGCTACCACTGGCTGCGCATGTAGAAGATGAATCGCTAATGCAACACGG
GGTGATGAATCAAGGAACGGTAGCCGAAAAATTGGGTTTACCAGGTATTTCAGAATTGGCAGAGACAGCTCAATTAGCAC
GGGACCTTGAAATTGCGCGTAATACAGGCGCTCATTATCACGTTTGTCATGTTTCAAAAGCTCGAAGTGTGGAATTAATT
CGCCGTGCTCAGCGAGACGGCGTCCATGTTACCGCAGAAGTCGCACCTCATCATTTATTTCTTGATGAAACGATGATTTC
GATGGATAACCCCATGATGAAGATGAATCCGCCACTACGAACCTTGGAAGATCGGCAGGCACTCTTAGGGGGGCTGCTAG
ATGGCACAATTGGTATGATTGCAACGGATCATGCTCCGCACACGGTGAAAGATAAGGCTGGATCGATGAAGACCGCCTCT
TTTGGAATTACAGGGTTAGAAACAGCTTTCCCACTACTCTACACTAAGCTGGTTAAACCGGGACTTTGCACGGTAGAACA
ACTAGTGGAATGGATGAGCATTCAACCAGCTGAAATTTTTAACCTCAAGGCAGCTGGGCAATTGGAAGTGGGAGATGTAG
CTGATTTAACGGTAATGAATGTTGAAGATGAATATGAAATTAAAGAAGCAGATTTTGCTTCAAAGGGAATCAATTCTCCG
TTTATTGGTCAAAAGGTTTATGGACAGACACAACTGACCATGGTTGCTGGAAAAATTGTATATCAACGGGAAGGGTAA

Upstream 100 bases:

>100_bases
CAAGAATTTTCAAGCAAATGACTAATGGTATGTACATGCGCATGGCAATTTTAACGGATGTATTAGAGGCCAAGGGATTG
ATTAAGGGAGGATTGCATTA

Downstream 100 bases:

>100_bases
TTTAAAATGAAACGTTATTTAATTTTGGAAGACGGTACTACATATGAAGGAAAGGCGATTGGAGCCAATCGTGAAAGTAT
TGGAGAGCTAGTTTTTAATA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKVLLKNARVIKSHQVQKTDVLVENDRITQIQPEINVEAEQIIDVKNQLLMPGLVDIHVHFRDPGQTDKEDVVSGSAAAV
KGGFTTVLTMPNVDPVPDTPEKMTAMVKHNQTAGSLHIGQYGSITKKRTSEELVDFKALKEAGAVAFSNDGNGIQTAETM
YQAMLQIKEVGLPLAAHVEDESLMQHGVMNQGTVAEKLGLPGISELAETAQLARDLEIARNTGAHYHVCHVSKARSVELI
RRAQRDGVHVTAEVAPHHLFLDETMISMDNPMMKMNPPLRTLEDRQALLGGLLDGTIGMIATDHAPHTVKDKAGSMKTAS
FGITGLETAFPLLYTKLVKPGLCTVEQLVEWMSIQPAEIFNLKAAGQLEVGDVADLTVMNVEDEYEIKEADFASKGINSP
FIGQKVYGQTQLTMVAGKIVYQREG

Sequences:

>Translated_425_residues
MKVLLKNARVIKSHQVQKTDVLVENDRITQIQPEINVEAEQIIDVKNQLLMPGLVDIHVHFRDPGQTDKEDVVSGSAAAV
KGGFTTVLTMPNVDPVPDTPEKMTAMVKHNQTAGSLHIGQYGSITKKRTSEELVDFKALKEAGAVAFSNDGNGIQTAETM
YQAMLQIKEVGLPLAAHVEDESLMQHGVMNQGTVAEKLGLPGISELAETAQLARDLEIARNTGAHYHVCHVSKARSVELI
RRAQRDGVHVTAEVAPHHLFLDETMISMDNPMMKMNPPLRTLEDRQALLGGLLDGTIGMIATDHAPHTVKDKAGSMKTAS
FGITGLETAFPLLYTKLVKPGLCTVEQLVEWMSIQPAEIFNLKAAGQLEVGDVADLTVMNVEDEYEIKEADFASKGINSP
FIGQKVYGQTQLTMVAGKIVYQREG
>Mature_425_residues
MKVLLKNARVIKSHQVQKTDVLVENDRITQIQPEINVEAEQIIDVKNQLLMPGLVDIHVHFRDPGQTDKEDVVSGSAAAV
KGGFTTVLTMPNVDPVPDTPEKMTAMVKHNQTAGSLHIGQYGSITKKRTSEELVDFKALKEAGAVAFSNDGNGIQTAETM
YQAMLQIKEVGLPLAAHVEDESLMQHGVMNQGTVAEKLGLPGISELAETAQLARDLEIARNTGAHYHVCHVSKARSVELI
RRAQRDGVHVTAEVAPHHLFLDETMISMDNPMMKMNPPLRTLEDRQALLGGLLDGTIGMIATDHAPHTVKDKAGSMKTAS
FGITGLETAFPLLYTKLVKPGLCTVEQLVEWMSIQPAEIFNLKAAGQLEVGDVADLTVMNVEDEYEIKEADFASKGINSP
FIGQKVYGQTQLTMVAGKIVYQREG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=375, Percent_Identity=30.1333333333333, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI19923821, Length=448, Percent_Identity=24.5535714285714, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4503377, Length=445, Percent_Identity=23.1460674157303, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4503379, Length=443, Percent_Identity=22.3476297968397, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4503375, Length=456, Percent_Identity=23.6842105263158, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI190194363, Length=407, Percent_Identity=25.5528255528256, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786722, Length=441, Percent_Identity=25.8503401360544, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI87082175, Length=448, Percent_Identity=24.3303571428571, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI193204318, Length=372, Percent_Identity=32.258064516129, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI86575075, Length=443, Percent_Identity=23.0248306997743, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=429, Percent_Identity=26.1072261072261, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24642586, Length=409, Percent_Identity=29.0953545232274, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI18859883, Length=426, Percent_Identity=24.6478873239437, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137462, Length=452, Percent_Identity=23.8938053097345, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_PEDPA (Q03HB2)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_803852.1
- ProteinModelPortal:   Q03HB2
- SMR:   Q03HB2
- STRING:   Q03HB2
- MEROPS:   M38.972
- GeneID:   4418490
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0314
- NMPDR:   fig|278197.10.peg.289
- eggNOG:   COG0044
- HOGENOM:   HBG724623
- OMA:   PRVAEES
- PhylomeDB:   Q03HB2
- BioCyc:   PPEN278197:PEPE_0314-MONOMER
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 46345; Mature: 46345

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLLKNARVIKSHQVQKTDVLVENDRITQIQPEINVEAEQIIDVKNQLLMPGLVDIHVH
CCEEECCCHHHHHCCCCHHEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEE
FRDPGQTDKEDVVSGSAAAVKGGFTTVLTMPNVDPVPDTPEKMTAMVKHNQTAGSLHIGQ
ECCCCCCCHHHHHCCCCCEECCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEECCC
YGSITKKRTSEELVDFKALKEAGAVAFSNDGNGIQTAETMYQAMLQIKEVGLPLAAHVED
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCH
ESLMQHGVMNQGTVAEKLGLPGISELAETAQLARDLEIARNTGAHYHVCHVSKARSVELI
HHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
RRAQRDGVHVTAEVAPHHLFLDETMISMDNPMMKMNPPLRTLEDRQALLGGLLDGTIGMI
HHHHHCCCEEEEECCCCEEEHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCEEEE
ATDHAPHTVKDKAGSMKTASFGITGLETAFPLLYTKLVKPGLCTVEQLVEWMSIQPAEIF
EECCCCCCHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHE
NLKAAGQLEVGDVADLTVMNVEDEYEIKEADFASKGINSPFIGQKVYGQTQLTMVAGKIV
EECCCCCEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHCCCEEEEEEEEEEE
YQREG
EEECC
>Mature Secondary Structure
MKVLLKNARVIKSHQVQKTDVLVENDRITQIQPEINVEAEQIIDVKNQLLMPGLVDIHVH
CCEEECCCHHHHHCCCCHHEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEE
FRDPGQTDKEDVVSGSAAAVKGGFTTVLTMPNVDPVPDTPEKMTAMVKHNQTAGSLHIGQ
ECCCCCCCHHHHHCCCCCEECCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEECCC
YGSITKKRTSEELVDFKALKEAGAVAFSNDGNGIQTAETMYQAMLQIKEVGLPLAAHVED
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCH
ESLMQHGVMNQGTVAEKLGLPGISELAETAQLARDLEIARNTGAHYHVCHVSKARSVELI
HHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHH
RRAQRDGVHVTAEVAPHHLFLDETMISMDNPMMKMNPPLRTLEDRQALLGGLLDGTIGMI
HHHHHCCCEEEEECCCCEEEHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCEEEE
ATDHAPHTVKDKAGSMKTASFGITGLETAFPLLYTKLVKPGLCTVEQLVEWMSIQPAEIF
EECCCCCCHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHE
NLKAAGQLEVGDVADLTVMNVEDEYEIKEADFASKGINSPFIGQKVYGQTQLTMVAGKIV
EECCCCCEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCHHCCCEEEEEEEEEEE
YQREG
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA