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The map label for this gene is pbuG [H]

Identifier: 116492107

GI number: 116492107

Start: 348602

End: 349909

Strand: Direct

Name: pbuG [H]

Synonym: PEPE_0303

Alternate gene names: 116492107

Gene position: 348602-349909 (Clockwise)

Preceding gene: 116492106

Following gene: 116492108

Centisome position: 19.02

GC content: 39.76

Gene sequence:

>1308_bases
TTGAAACAAATCGCTAAGTATTTTCAATTTGATAAATTGAAAACAAACTATAAAACAGAAATTATTGCTGGGATTACTAC
TTATATTTCAATGGTCTACATTATGTTCGTTAATCCGAACGTTTTAGGAGCATCTGGGATGGATAAGGGAGCGGTCTTCA
CCGCAACAGCATTGGCTAGTGCCATTGGTTGTTTCCTGATGGGGATTATCGCTAATTACCCAATTGCTTCAGCACCTGCT
TTAGGAATTAATGCATTCTTCGCTTATTCCGTGGTTATTGGGATGCATGTGCCTTGGCAAACGGCTTTGGCGGGCGTTTT
CGTAGCTTCCTTAATCTTTGTTTTAATCACCGTTTTTAAACTACGAGAATTAATTATTAATGCGATTCCAGTCGATTTGA
AGCATGCTATTTCTTCAGGAATTGGATTGTTCGTGGCTTTTCTAGGTTTGAGCCAAGGTGGAATTGTGGTTGCTAACAAA
TCTACGATGGTTGGATTAGGTTCATTCTTAGTTCCTTCCACATGGTTGACCGTCTTTGGGTTGGTTGTGACAATTTTCTT
GATGGTTCGCAAGGTGCCAGGGGCTATTTTCGTGGGAATGATTTTAACAACCGTCTTTGGTTTATTGACTGGTTTAATTC
ATGCACCAGCACACATTGTTTCAGCTGCACCAAGCTTGAAACCAACTTTCTTGACAGCTATTTCACATGTTGGGGATATT
AATACTCTCCAACTTTGGGTAGTAGTCTTGACTTTCTTGCTGGTAACGTTCTTTGATACAGCCGGCACATTGGTTGGTTT
GGCTACTCAAGCAGGATTTATGAAAGACAATAAGATGCCGCGCGTAGGGAAGGCATTGATGTCTGATTCAGCTTCAATGT
TGACTGGATCATTATTAGGTACTTCTCCAGTGGGGGCTTTCGTTGAGTCTTCAGCTGGGATTGCTGTAGGTGGACGTTCT
GGCTTTACTGTAGTTGTGACAGGAATTATGTTCCTATTAGGACTCTTCTTCTCACCATTGTTAACCGTCGTTACTTCACA
AGTTACCGCACCTGCATTAGTGATTGTGGGGGTATTAATGGCTCAACAAACTCGTGAAATTGCTTGGGATAAATTAGAAA
TTGCTATTCCAGCTTTCTTAATTATCATTGGAATGCCATTAACATATAGTATTTCAGATGGGATTGCATTAGGATTTATT
ACTTACCCCATTGCCATGATTGCTGCTAAACGTGGCAAAGAAGTTCATCCATTAATGTACGCACTATTCTTTGTATTTAT
TGGTTTTATTGCTATTTTAAATGCATAA

Upstream 100 bases:

>100_bases
AATAATCAATTTATGGCGTTCTTTACTTATATTTTAAATTAGTGTAGACTTTATTGGTGCTATTTTTGATTTAGATTCGA
ACTAAAAGGGAGAAATGATT

Downstream 100 bases:

>100_bases
GTATAAAGTTTGAAAATAATCATTTATAATAAGAGCTATGCTTTAAGGCAGTTGGATTAAAATAAAAATTCAACCCTTGG
ACATAGTTCTTTTTTTAATT

Product: xanthine/uracil/vitamin C permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKQIAKYFQFDKLKTNYKTEIIAGITTYISMVYIMFVNPNVLGASGMDKGAVFTATALASAIGCFLMGIIANYPIASAPA
LGINAFFAYSVVIGMHVPWQTALAGVFVASLIFVLITVFKLRELIINAIPVDLKHAISSGIGLFVAFLGLSQGGIVVANK
STMVGLGSFLVPSTWLTVFGLVVTIFLMVRKVPGAIFVGMILTTVFGLLTGLIHAPAHIVSAAPSLKPTFLTAISHVGDI
NTLQLWVVVLTFLLVTFFDTAGTLVGLATQAGFMKDNKMPRVGKALMSDSASMLTGSLLGTSPVGAFVESSAGIAVGGRS
GFTVVVTGIMFLLGLFFSPLLTVVTSQVTAPALVIVGVLMAQQTREIAWDKLEIAIPAFLIIIGMPLTYSISDGIALGFI
TYPIAMIAAKRGKEVHPLMYALFFVFIGFIAILNA

Sequences:

>Translated_435_residues
MKQIAKYFQFDKLKTNYKTEIIAGITTYISMVYIMFVNPNVLGASGMDKGAVFTATALASAIGCFLMGIIANYPIASAPA
LGINAFFAYSVVIGMHVPWQTALAGVFVASLIFVLITVFKLRELIINAIPVDLKHAISSGIGLFVAFLGLSQGGIVVANK
STMVGLGSFLVPSTWLTVFGLVVTIFLMVRKVPGAIFVGMILTTVFGLLTGLIHAPAHIVSAAPSLKPTFLTAISHVGDI
NTLQLWVVVLTFLLVTFFDTAGTLVGLATQAGFMKDNKMPRVGKALMSDSASMLTGSLLGTSPVGAFVESSAGIAVGGRS
GFTVVVTGIMFLLGLFFSPLLTVVTSQVTAPALVIVGVLMAQQTREIAWDKLEIAIPAFLIIIGMPLTYSISDGIALGFI
TYPIAMIAAKRGKEVHPLMYALFFVFIGFIAILNA
>Mature_435_residues
MKQIAKYFQFDKLKTNYKTEIIAGITTYISMVYIMFVNPNVLGASGMDKGAVFTATALASAIGCFLMGIIANYPIASAPA
LGINAFFAYSVVIGMHVPWQTALAGVFVASLIFVLITVFKLRELIINAIPVDLKHAISSGIGLFVAFLGLSQGGIVVANK
STMVGLGSFLVPSTWLTVFGLVVTIFLMVRKVPGAIFVGMILTTVFGLLTGLIHAPAHIVSAAPSLKPTFLTAISHVGDI
NTLQLWVVVLTFLLVTFFDTAGTLVGLATQAGFMKDNKMPRVGKALMSDSASMLTGSLLGTSPVGAFVESSAGIAVGGRS
GFTVVVTGIMFLLGLFFSPLLTVVTSQVTAPALVIVGVLMAQQTREIAWDKLEIAIPAFLIIIGMPLTYSISDGIALGFI
TYPIAMIAAKRGKEVHPLMYALFFVFIGFIAILNA

Specific function: Involved in the uptake of the purine bases hypoxanthine and guanine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082309, Length=417, Percent_Identity=41.4868105515587, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI1790150, Length=436, Percent_Identity=41.743119266055, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI48994909, Length=420, Percent_Identity=34.7619047619048, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1790499, Length=425, Percent_Identity=33.6470588235294, Blast_Score=201, Evalue=8e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45981; Mature: 45981

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQIAKYFQFDKLKTNYKTEIIAGITTYISMVYIMFVNPNVLGASGMDKGAVFTATALAS
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCEECCCCCCCCHHHHHHHHHH
AIGCFLMGIIANYPIASAPALGINAFFAYSVVIGMHVPWQTALAGVFVASLIFVLITVFK
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LRELIINAIPVDLKHAISSGIGLFVAFLGLSQGGIVVANKSTMVGLGSFLVPSTWLTVFG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
LVVTIFLMVRKVPGAIFVGMILTTVFGLLTGLIHAPAHIVSAAPSLKPTFLTAISHVGDI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
NTLQLWVVVLTFLLVTFFDTAGTLVGLATQAGFMKDNKMPRVGKALMSDSASMLTGSLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHCC
TSPVGAFVESSAGIAVGGRSGFTVVVTGIMFLLGLFFSPLLTVVTSQVTAPALVIVGVLM
CCCHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQQTREIAWDKLEIAIPAFLIIIGMPLTYSISDGIALGFITYPIAMIAAKRGKEVHPLMY
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ALFFVFIGFIAILNA
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQIAKYFQFDKLKTNYKTEIIAGITTYISMVYIMFVNPNVLGASGMDKGAVFTATALAS
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEECCCEECCCCCCCCHHHHHHHHHH
AIGCFLMGIIANYPIASAPALGINAFFAYSVVIGMHVPWQTALAGVFVASLIFVLITVFK
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LRELIINAIPVDLKHAISSGIGLFVAFLGLSQGGIVVANKSTMVGLGSFLVPSTWLTVFG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
LVVTIFLMVRKVPGAIFVGMILTTVFGLLTGLIHAPAHIVSAAPSLKPTFLTAISHVGDI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
NTLQLWVVVLTFLLVTFFDTAGTLVGLATQAGFMKDNKMPRVGKALMSDSASMLTGSLLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHCC
TSPVGAFVESSAGIAVGGRSGFTVVVTGIMFLLGLFFSPLLTVVTSQVTAPALVIVGVLM
CCCHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQQTREIAWDKLEIAIPAFLIIIGMPLTYSISDGIALGFITYPIAMIAAKRGKEVHPLMY
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
ALFFVFIGFIAILNA
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377; 11591660 [H]