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The map label for this gene is pepO [H]

Identifier: 116492106

GI number: 116492106

Start: 346504

End: 348417

Strand: Direct

Name: pepO [H]

Synonym: PEPE_0302

Alternate gene names: 116492106

Gene position: 346504-348417 (Clockwise)

Preceding gene: 116492105

Following gene: 116492107

Centisome position: 18.91

GC content: 38.19

Gene sequence:

>1914_bases
ATGCCAAGTTCAATTAAAGACGATTTTTATGATGCAGTGAATGGTGAATGGCTAGCAACTGCAGAAATCCCCTCAGATCA
TTCATCAACGGGTGGGTTTATGGACCTAGTTGATGGCGTGGATGAAAATTTGATGAAGGATTTTGCAGAAATGCGTTCAG
GTGCCAAAGAACCTAATACGCCAGAATTAAAAGAATTTATCAAGTTTTATGAAATTGCAGCTGATTTCAAAAAACGGGAC
GAAGATGGAGTAAAACCACTTCTTCCGTACTTAAAACAAATTGAAGATTTAAAGAGTTGGGATGATGTAAATGCCAACTT
AAAAGAATTATTTTTTAATGGCGTAGAATTACCAGTAGATTTAGGTATTGAACCTGATTTAAAGGGTAATGGAGCAGATA
AACGCAATGTTTTATGGGCTGGTGGTGTAAGTTTAATCCTCCCAGATAAAACCTACTATGACCAAGATAATCCGTCTGGA
CCACAGTTGATGCAAGTCTTTACCCAAATGATGATGCAATTACTAACGAAGTTGGGTAAGTCTGAAGATGAAGCCCAAGC
TATAATTGATGGAGCTAAACGTTTCGATGCTAGTATTGCTCCTTTCCGTAAAAACTCTGAAGAACTTAGCGATGTAGCTA
AGCTTTATAATCCATGGGAGCTTGATCATTTCGCTGACATGGTTCAAGAGATTGATGTTAAAAAATTAGTCCAAGCATTG
ATTGGAACTGTTCCAGAAAAATTAATTATCACTGAACCTAAATTCTACGAAAACTTGCACCAAATTGTTAACGCCGATAC
ATTTGAAGATTATAAAAAATGGGCCTACGTTAACATGGTCCGCTCGTTGTCAGGCTATTTGAGTGAAGAATTCCGCCAAA
TTGGTGGCACTTTTGGGCGAGCATTATCAGGGCAACAAGAATCAATGCCACAAGAAAAGAGTGCATTTTACTTAGCACGT
CGCACGTTTAGCCAAGTCGTTGGTGAATACTATGGACATAAATATTTCGGGGAAACTGCTAAAAAAGATGTTCATGATAT
GGTGGTTTCGATGATTGATGTTTATGAAAAACGACTGGCAGAAAATACTTGGTTAGGGGATGCAACCCGTTCTAAAGCGA
TTACGAAGTTACGTTCGTTGAAGATTTTAGTAGGTTACCCAGATGAATTAAAAGCAGTTTATAAGAAGTTGAAAACTAAA
ACAGCCGCTGAGGGTGGAAGTTTAGTGGAAAACGTTCAAGAATTTTCACGAATTTTCTTAGAAGATCAACTTGCTAAGTA
TGGTAAGGAAGTCGACCGTAGTGAATGGCATATGAGTGCTGATACAGTAAATGCTTATTATTCACCAGAAGGCAACTTAA
TCTGTTTCCCAGCTGCTATTTTACAAGCACCATTTTACAGTTTAGAACAAACCGCTAGTCAAAATTATGGTGGAATTGGC
GCAGTAATGGCGCACGAAATTTCACATGCTTTTGATCCTAACGGAGCTTTATTTGATGAATTTGGTAACATGGACAATTG
GTGGACAGAAGATGATTTGAAACATTTCCACCAACTTTCAGAAGCAATGGTAAAAGAATTTGATGGAATTCCATTTGCGG
GTGGAAAAGTAAACGGTAAGTTGGTTGTTACCGAAAATGTTGCAGATGATGGTGGACTTAAAGCAGCGTTGGAAGCAGCT
AAGGCTACTAAAGATGCTAATCTAGAAGAATTTTTTACTAACTGGGCCACAATTTGGCGCACTAAGGCTACTAAACAACG
AGAAGAGTTGCTATTAGCAATTGATGTCCATGCTCCTGCAAAGTTACGGGCGAACGTCCAAGTAAAAAATTTTGAAGAAT
TTTATGAAACCTTTGATGTAAAAGAGGGCGATGGAATGTATCTTGCTCCCGAAAAACGAGTTCAAATTTGGTAA

Upstream 100 bases:

>100_bases
GAATTCCAAAGATATTGCTAAGTATATGCATGACGCGGTGTCATAGAAGTAGATAAGAGTATAATACAGAGTTAATAAAT
TTTGAAAGTGAGGAATTAGA

Downstream 100 bases:

>100_bases
AAAATCAAACTAAAAAGACGATTGCTAATTAGCAGTCGTCTTTTTTAGTTATTTCTAAAGTAAAATACGAACTATAAAAG
TTTAAATAATCAATTTATGG

Product: neutral endopeptidase

Products: NA

Alternate protein names: Endopeptidase O [H]

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MPSSIKDDFYDAVNGEWLATAEIPSDHSSTGGFMDLVDGVDENLMKDFAEMRSGAKEPNTPELKEFIKFYEIAADFKKRD
EDGVKPLLPYLKQIEDLKSWDDVNANLKELFFNGVELPVDLGIEPDLKGNGADKRNVLWAGGVSLILPDKTYYDQDNPSG
PQLMQVFTQMMMQLLTKLGKSEDEAQAIIDGAKRFDASIAPFRKNSEELSDVAKLYNPWELDHFADMVQEIDVKKLVQAL
IGTVPEKLIITEPKFYENLHQIVNADTFEDYKKWAYVNMVRSLSGYLSEEFRQIGGTFGRALSGQQESMPQEKSAFYLAR
RTFSQVVGEYYGHKYFGETAKKDVHDMVVSMIDVYEKRLAENTWLGDATRSKAITKLRSLKILVGYPDELKAVYKKLKTK
TAAEGGSLVENVQEFSRIFLEDQLAKYGKEVDRSEWHMSADTVNAYYSPEGNLICFPAAILQAPFYSLEQTASQNYGGIG
AVMAHEISHAFDPNGALFDEFGNMDNWWTEDDLKHFHQLSEAMVKEFDGIPFAGGKVNGKLVVTENVADDGGLKAALEAA
KATKDANLEEFFTNWATIWRTKATKQREELLLAIDVHAPAKLRANVQVKNFEEFYETFDVKEGDGMYLAPEKRVQIW

Sequences:

>Translated_637_residues
MPSSIKDDFYDAVNGEWLATAEIPSDHSSTGGFMDLVDGVDENLMKDFAEMRSGAKEPNTPELKEFIKFYEIAADFKKRD
EDGVKPLLPYLKQIEDLKSWDDVNANLKELFFNGVELPVDLGIEPDLKGNGADKRNVLWAGGVSLILPDKTYYDQDNPSG
PQLMQVFTQMMMQLLTKLGKSEDEAQAIIDGAKRFDASIAPFRKNSEELSDVAKLYNPWELDHFADMVQEIDVKKLVQAL
IGTVPEKLIITEPKFYENLHQIVNADTFEDYKKWAYVNMVRSLSGYLSEEFRQIGGTFGRALSGQQESMPQEKSAFYLAR
RTFSQVVGEYYGHKYFGETAKKDVHDMVVSMIDVYEKRLAENTWLGDATRSKAITKLRSLKILVGYPDELKAVYKKLKTK
TAAEGGSLVENVQEFSRIFLEDQLAKYGKEVDRSEWHMSADTVNAYYSPEGNLICFPAAILQAPFYSLEQTASQNYGGIG
AVMAHEISHAFDPNGALFDEFGNMDNWWTEDDLKHFHQLSEAMVKEFDGIPFAGGKVNGKLVVTENVADDGGLKAALEAA
KATKDANLEEFFTNWATIWRTKATKQREELLLAIDVHAPAKLRANVQVKNFEEFYETFDVKEGDGMYLAPEKRVQIW
>Mature_636_residues
PSSIKDDFYDAVNGEWLATAEIPSDHSSTGGFMDLVDGVDENLMKDFAEMRSGAKEPNTPELKEFIKFYEIAADFKKRDE
DGVKPLLPYLKQIEDLKSWDDVNANLKELFFNGVELPVDLGIEPDLKGNGADKRNVLWAGGVSLILPDKTYYDQDNPSGP
QLMQVFTQMMMQLLTKLGKSEDEAQAIIDGAKRFDASIAPFRKNSEELSDVAKLYNPWELDHFADMVQEIDVKKLVQALI
GTVPEKLIITEPKFYENLHQIVNADTFEDYKKWAYVNMVRSLSGYLSEEFRQIGGTFGRALSGQQESMPQEKSAFYLARR
TFSQVVGEYYGHKYFGETAKKDVHDMVVSMIDVYEKRLAENTWLGDATRSKAITKLRSLKILVGYPDELKAVYKKLKTKT
AAEGGSLVENVQEFSRIFLEDQLAKYGKEVDRSEWHMSADTVNAYYSPEGNLICFPAAILQAPFYSLEQTASQNYGGIGA
VMAHEISHAFDPNGALFDEFGNMDNWWTEDDLKHFHQLSEAMVKEFDGIPFAGGKVNGKLVVTENVADDGGLKAALEAAK
ATKDANLEEFFTNWATIWRTKATKQREELLLAIDVHAPAKLRANVQVKNFEEFYETFDVKEGDGMYLAPEKRVQIW

Specific function: Endopeptidase with broad substrate specificity for several oligopeptides [H]

COG id: COG3590

COG function: function code O; Predicted metalloendopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M13 family [H]

Homologues:

Organism=Homo sapiens, GI157426891, Length=665, Percent_Identity=26.3157894736842, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI164519138, Length=671, Percent_Identity=25.0372578241431, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI164519140, Length=671, Percent_Identity=25.0372578241431, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI4503443, Length=668, Percent_Identity=25.1497005988024, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI164519136, Length=668, Percent_Identity=25.1497005988024, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI239049391, Length=686, Percent_Identity=26.530612244898, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI116256333, Length=685, Percent_Identity=26.4233576642336, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI116256331, Length=685, Percent_Identity=26.4233576642336, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI116256329, Length=685, Percent_Identity=26.4233576642336, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI116256327, Length=685, Percent_Identity=26.4233576642336, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI82617560, Length=670, Percent_Identity=24.6268656716418, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI153945761, Length=670, Percent_Identity=24.6268656716418, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI153945836, Length=670, Percent_Identity=24.6268656716418, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI153945771, Length=670, Percent_Identity=24.6268656716418, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI90403592, Length=679, Percent_Identity=25.6259204712813, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI4557691, Length=518, Percent_Identity=22.3938223938224, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI86562497, Length=682, Percent_Identity=26.099706744868, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17533333, Length=674, Percent_Identity=25.0741839762611, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32563993, Length=593, Percent_Identity=26.3069139966273, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17564342, Length=511, Percent_Identity=25.0489236790607, Blast_Score=174, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71987442, Length=667, Percent_Identity=24.1379310344828, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25148650, Length=686, Percent_Identity=24.3440233236152, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17534401, Length=326, Percent_Identity=25.7668711656442, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71994787, Length=330, Percent_Identity=26.3636363636364, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17570047, Length=348, Percent_Identity=25, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17533319, Length=568, Percent_Identity=22.5352112676056, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71998977, Length=316, Percent_Identity=26.2658227848101, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71998975, Length=316, Percent_Identity=26.2658227848101, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71988640, Length=222, Percent_Identity=29.7297297297297, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17532485, Length=319, Percent_Identity=26.0188087774295, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI133931212, Length=470, Percent_Identity=22.3404255319149, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193204436, Length=318, Percent_Identity=21.0691823899371, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643425, Length=684, Percent_Identity=26.6081871345029, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI45551938, Length=547, Percent_Identity=27.0566727605119, Blast_Score=208, Evalue=9e-54,
Organism=Drosophila melanogaster, GI45550777, Length=547, Percent_Identity=27.0566727605119, Blast_Score=208, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24640050, Length=685, Percent_Identity=25.2554744525547, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24640052, Length=685, Percent_Identity=25.2554744525547, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI17737761, Length=679, Percent_Identity=25.3313696612666, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24650487, Length=405, Percent_Identity=24.9382716049383, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI221474862, Length=381, Percent_Identity=27.0341207349081, Blast_Score=129, Evalue=9e-30,
Organism=Drosophila melanogaster, GI281362760, Length=672, Percent_Identity=21.7261904761905, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24650889, Length=650, Percent_Identity=22, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24650765, Length=364, Percent_Identity=23.9010989010989, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24650885, Length=347, Percent_Identity=23.9193083573487, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355943, Length=338, Percent_Identity=23.3727810650888, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641622, Length=357, Percent_Identity=25.7703081232493, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24650883, Length=281, Percent_Identity=22.7758007117438, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000718
- InterPro:   IPR018497
- InterPro:   IPR008753 [H]

Pfam domain/function: PF01431 Peptidase_M13; PF05649 Peptidase_M13_N [H]

EC number: NA

Molecular weight: Translated: 71969; Mature: 71838

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSIKDDFYDAVNGEWLATAEIPSDHSSTGGFMDLVDGVDENLMKDFAEMRSGAKEPNT
CCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCC
PELKEFIKFYEIAADFKKRDEDGVKPLLPYLKQIEDLKSWDDVNANLKELFFNGVELPVD
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEE
LGIEPDLKGNGADKRNVLWAGGVSLILPDKTYYDQDNPSGPQLMQVFTQMMMQLLTKLGK
CCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
SEDEAQAIIDGAKRFDASIAPFRKNSEELSDVAKLYNPWELDHFADMVQEIDVKKLVQAL
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHH
IGTVPEKLIITEPKFYENLHQIVNADTFEDYKKWAYVNMVRSLSGYLSEEFRQIGGTFGR
HHCCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALSGQQESMPQEKSAFYLARRTFSQVVGEYYGHKYFGETAKKDVHDMVVSMIDVYEKRLA
HCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENTWLGDATRSKAITKLRSLKILVGYPDELKAVYKKLKTKTAAEGGSLVENVQEFSRIFL
HCCCCCCHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EDQLAKYGKEVDRSEWHMSADTVNAYYSPEGNLICFPAAILQAPFYSLEQTASQNYGGIG
HHHHHHHHHHHCHHHHHCCCCCEEEEECCCCCEEEECHHHHHCCHHHHHHHHCCCCCCHH
AVMAHEISHAFDPNGALFDEFGNMDNWWTEDDLKHFHQLSEAMVKEFDGIPFAGGKVNGK
HHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
LVVTENVADDGGLKAALEAAKATKDANLEEFFTNWATIWRTKATKQREELLLAIDVHAPA
EEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCC
KLRANVQVKNFEEFYETFDVKEGDGMYLAPEKRVQIW
HHCCCCEEHHHHHHHHHHCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure 
PSSIKDDFYDAVNGEWLATAEIPSDHSSTGGFMDLVDGVDENLMKDFAEMRSGAKEPNT
CCCCCHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCC
PELKEFIKFYEIAADFKKRDEDGVKPLLPYLKQIEDLKSWDDVNANLKELFFNGVELPVD
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEE
LGIEPDLKGNGADKRNVLWAGGVSLILPDKTYYDQDNPSGPQLMQVFTQMMMQLLTKLGK
CCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
SEDEAQAIIDGAKRFDASIAPFRKNSEELSDVAKLYNPWELDHFADMVQEIDVKKLVQAL
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHH
IGTVPEKLIITEPKFYENLHQIVNADTFEDYKKWAYVNMVRSLSGYLSEEFRQIGGTFGR
HHCCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALSGQQESMPQEKSAFYLARRTFSQVVGEYYGHKYFGETAKKDVHDMVVSMIDVYEKRLA
HCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENTWLGDATRSKAITKLRSLKILVGYPDELKAVYKKLKTKTAAEGGSLVENVQEFSRIFL
HCCCCCCHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EDQLAKYGKEVDRSEWHMSADTVNAYYSPEGNLICFPAAILQAPFYSLEQTASQNYGGIG
HHHHHHHHHHHCHHHHHCCCCCEEEEECCCCCEEEECHHHHHCCHHHHHHHHCCCCCCHH
AVMAHEISHAFDPNGALFDEFGNMDNWWTEDDLKHFHQLSEAMVKEFDGIPFAGGKVNGK
HHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
LVVTENVADDGGLKAALEAAKATKDANLEEFFTNWATIWRTKATKQREELLLAIDVHAPA
EEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCC
KLRANVQVKNFEEFYETFDVKEGDGMYLAPEKRVQIW
HHCCCCEEHHHHHHHHHHCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8244921; 11337471 [H]