Click here to switch to the map view.

The map label for this gene is nox [H]

Identifier: 116492089

GI number: 116492089

Start: 329881

End: 331221

Strand: Direct

Name: nox [H]

Synonym: PEPE_0285

Alternate gene names: 116492089

Gene position: 329881-331221 (Clockwise)

Preceding gene: 116492088

Following gene: 116492090

Centisome position: 18.0

GC content: 39.08

Gene sequence:

>1341_bases
ATGAAAATAGCAATTGTAGGTTGTACACATGCAGGTACCTTCTCAGCGCAACAAATTTTAACTGAGCACCCCGATTATGA
AGTAACGGTATACGAACGTAATAATAATTTGTCATTTTTATCTTGTGGAATCGCCCTTTGGGTAGGTAACCACGTTTCAG
ATCCTAATAAAATGTTCTATTCATCACCGGAGGCCCTAACTAAGTTGGGTGCTACTATGAATATGGAACATGATGTACTT
AGTATCGACCCCGATAATAAAACTTTAGAAGTAAAAGATTTAAAAACCGGTGAAATTAAAACAGATACTTACGATAAATT
GGTGGTAACTACTGGTTCAGCACCTATTATTCCTCCGATTGATGGAATCGATAATAAACGAGTTAAACTTTGCAAAAATT
GGGCTCATGCTGCGGAATTAAAACGAATTGATGATGACATTAACTCAGTAATTGTAATTGGTGCAGGTTATATTGGAGCG
GAACTTGCTGAACAATATGCCTTGACTGGCCGCGAAGTAACCTTGATTGATGGATTACCAAGTGTTTTAGCTAAGAATTT
TGATCCTGAAATCTCTGATCGAGTAGCTAAAGATTACACTGATCACGGAGTTAAATTGGCCATGAACGAAATGGTTCAAG
GATTTAGTGGTGATGATCAGATTACTGTAAAAACCGATAAAGGCAGTTACACGGCCGACTATGCTGTACTTTGCGTTGGT
TTCCGCCCACATACAGAATTATTGAAGGGCAAAGTGGATATGTTGAAGAACGGAGCAATTATTACTAATGAGTACATGCA
AACTTCGAACCTTGATATTTTTGCAGCAGGAGATTCATCCGTTGTTCATTACAATCCAACTGGAAAAGATGATTACATTC
CATTAGCAACTAATGCAGTTCGTCAAGGAATTTTGATTGGACATAACATTGAAAAACCAACGATGAAATATCTTGGTACA
CAAGCAAGCTCGGCAGTAGCACTCTTTGGTAAGACGATGGCAAGTTCAGGATTAACTGTTGGTGCGGCTAAAGCACGGGG
TGTAGAAGTAGACTCTGTAACCTTAGAACAAGACTACCGTCCCGAATTTATGCTTTCAACGACCCCAATCCTAATGCGGT
TAGTTTGGGACCCAGAAACACGAGTGGTTCTAGGTGGATCATTCTATAGCGAATATGACTGTGCTCAATCAGCTAATGTA
ATTTCATTAGCTATTCAAAATAAGATGACGATTGATGACTTATCCATGGTTGATATGTTCTTCCAACCTAACTACGACCA
ACCGTTAAATTATATTAATGCGTTAGCAATGACGGCGGTGGCCCAAGCGGATGCAAAATAA

Upstream 100 bases:

>100_bases
TTATTGTTTCATTTTTTTGTTCTAAAGGACCAGAGTTAAGTTGACAAAGCAATGAAAGCGCTTAATAATTAGATATAGAC
AAATAGGAGGTTAGTTAATT

Downstream 100 bases:

>100_bases
ATAATAAAATAGTTCAAAGAGGCGAAGGATGATGGCAAACAAAACCAAAGTTGCATTAGTAACGGGAGCAGGACAAGGAA
TTGGGGCAGCAATTGCGACC

Product: NAD(FAD)-dependent dehydrogenase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKIAIVGCTHAGTFSAQQILTEHPDYEVTVYERNNNLSFLSCGIALWVGNHVSDPNKMFYSSPEALTKLGATMNMEHDVL
SIDPDNKTLEVKDLKTGEIKTDTYDKLVVTTGSAPIIPPIDGIDNKRVKLCKNWAHAAELKRIDDDINSVIVIGAGYIGA
ELAEQYALTGREVTLIDGLPSVLAKNFDPEISDRVAKDYTDHGVKLAMNEMVQGFSGDDQITVKTDKGSYTADYAVLCVG
FRPHTELLKGKVDMLKNGAIITNEYMQTSNLDIFAAGDSSVVHYNPTGKDDYIPLATNAVRQGILIGHNIEKPTMKYLGT
QASSAVALFGKTMASSGLTVGAAKARGVEVDSVTLEQDYRPEFMLSTTPILMRLVWDPETRVVLGGSFYSEYDCAQSANV
ISLAIQNKMTIDDLSMVDMFFQPNYDQPLNYINALAMTAVAQADAK

Sequences:

>Translated_446_residues
MKIAIVGCTHAGTFSAQQILTEHPDYEVTVYERNNNLSFLSCGIALWVGNHVSDPNKMFYSSPEALTKLGATMNMEHDVL
SIDPDNKTLEVKDLKTGEIKTDTYDKLVVTTGSAPIIPPIDGIDNKRVKLCKNWAHAAELKRIDDDINSVIVIGAGYIGA
ELAEQYALTGREVTLIDGLPSVLAKNFDPEISDRVAKDYTDHGVKLAMNEMVQGFSGDDQITVKTDKGSYTADYAVLCVG
FRPHTELLKGKVDMLKNGAIITNEYMQTSNLDIFAAGDSSVVHYNPTGKDDYIPLATNAVRQGILIGHNIEKPTMKYLGT
QASSAVALFGKTMASSGLTVGAAKARGVEVDSVTLEQDYRPEFMLSTTPILMRLVWDPETRVVLGGSFYSEYDCAQSANV
ISLAIQNKMTIDDLSMVDMFFQPNYDQPLNYINALAMTAVAQADAK
>Mature_446_residues
MKIAIVGCTHAGTFSAQQILTEHPDYEVTVYERNNNLSFLSCGIALWVGNHVSDPNKMFYSSPEALTKLGATMNMEHDVL
SIDPDNKTLEVKDLKTGEIKTDTYDKLVVTTGSAPIIPPIDGIDNKRVKLCKNWAHAAELKRIDDDINSVIVIGAGYIGA
ELAEQYALTGREVTLIDGLPSVLAKNFDPEISDRVAKDYTDHGVKLAMNEMVQGFSGDDQITVKTDKGSYTADYAVLCVG
FRPHTELLKGKVDMLKNGAIITNEYMQTSNLDIFAAGDSSVVHYNPTGKDDYIPLATNAVRQGILIGHNIEKPTMKYLGT
QASSAVALFGKTMASSGLTVGAAKARGVEVDSVTLEQDYRPEFMLSTTPILMRLVWDPETRVVLGGSFYSEYDCAQSANV
ISLAIQNKMTIDDLSMVDMFFQPNYDQPLNYINALAMTAVAQADAK

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1789065, Length=183, Percent_Identity=32.7868852459016, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788892, Length=183, Percent_Identity=23.4972677595628, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32565766, Length=192, Percent_Identity=29.1666666666667, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 48680; Mature: 48680

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIVGCTHAGTFSAQQILTEHPDYEVTVYERNNNLSFLSCGIALWVGNHVSDPNKMFY
CEEEEEEECCCCCCHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEEEECCCCCCCHHEEE
SSPEALTKLGATMNMEHDVLSIDPDNKTLEVKDLKTGEIKTDTYDKLVVTTGSAPIIPPI
CCHHHHHHHCCCCCCCCCEEEECCCCCEEEEEECCCCCEECCCCCEEEEEECCCCCCCCC
DGIDNKRVKLCKNWAHAAELKRIDDDINSVIVIGAGYIGAELAEQYALTGREVTLIDGLP
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCH
SVLAKNFDPEISDRVAKDYTDHGVKLAMNEMVQGFSGDDQITVKTDKGSYTADYAVLCVG
HHHHCCCCCCHHHHHHHHHHCCCHHEEHHHHHCCCCCCCEEEEEECCCCCEECEEEEEEE
FRPHTELLKGKVDMLKNGAIITNEYMQTSNLDIFAAGDSSVVHYNPTGKDDYIPLATNAV
CCCHHHHHHCHHHHHHCCCEEEECCEECCCEEEEECCCCCEEEECCCCCCCEEECCHHHH
RQGILIGHNIEKPTMKYLGTQASSAVALFGKTMASSGLTVGAAKARGVEVDSVTLEQDYR
HCCEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCCEEEEEEEECCCCC
PEFMLSTTPILMRLVWDPETRVVLGGSFYSEYDCAQSANVISLAIQNKMTIDDLSMVDMF
CCEEEECCCEEEEEEECCCCCEEECCCCCCCHHHCCCCCEEEEEECCCCCCCHHHHHHHH
FQPNYDQPLNYINALAMTAVAQADAK
CCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIAIVGCTHAGTFSAQQILTEHPDYEVTVYERNNNLSFLSCGIALWVGNHVSDPNKMFY
CEEEEEEECCCCCCHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEEEECCCCCCCHHEEE
SSPEALTKLGATMNMEHDVLSIDPDNKTLEVKDLKTGEIKTDTYDKLVVTTGSAPIIPPI
CCHHHHHHHCCCCCCCCCEEEECCCCCEEEEEECCCCCEECCCCCEEEEEECCCCCCCCC
DGIDNKRVKLCKNWAHAAELKRIDDDINSVIVIGAGYIGAELAEQYALTGREVTLIDGLP
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCEEEEECCCH
SVLAKNFDPEISDRVAKDYTDHGVKLAMNEMVQGFSGDDQITVKTDKGSYTADYAVLCVG
HHHHCCCCCCHHHHHHHHHHCCCHHEEHHHHHCCCCCCCEEEEEECCCCCEECEEEEEEE
FRPHTELLKGKVDMLKNGAIITNEYMQTSNLDIFAAGDSSVVHYNPTGKDDYIPLATNAV
CCCHHHHHHCHHHHHHCCCEEEECCEECCCEEEEECCCCCEEEECCCCCCCEEECCHHHH
RQGILIGHNIEKPTMKYLGTQASSAVALFGKTMASSGLTVGAAKARGVEVDSVTLEQDYR
HCCEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCCEEEEEEEECCCCC
PEFMLSTTPILMRLVWDPETRVVLGGSFYSEYDCAQSANVISLAIQNKMTIDDLSMVDMF
CCEEEECCCEEEEEEECCCCCEEECCCCCCCHHHCCCCCEEEEEECCCCCCCHHHHHHHH
FQPNYDQPLNYINALAMTAVAQADAK
CCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]