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The map label for this gene is pyc [H]

Identifier: 116492050

GI number: 116492050

Start: 291055

End: 294480

Strand: Direct

Name: pyc [H]

Synonym: PEPE_0246

Alternate gene names: 116492050

Gene position: 291055-294480 (Clockwise)

Preceding gene: 116492049

Following gene: 116492051

Centisome position: 15.88

GC content: 41.54

Gene sequence:

>3426_bases
ATGCACCGTATTTTAATTGCCAACCGAGGCGAAATTGCGACCCGAATTATTCGGGCAACGCATGAACTCGGAAAAACAGC
TGTAGCAATTTATGCTAAAGCGGATGAATTTTCTATGCATCGTTTTAAAGCAGATGAAGCTTACCAAGTTGGTGAAGATA
GTGATCCAATTGGAGCATATTTAAATATTGATGACATTATTCGTATTGCAAAAGAAAATAATATTGATGCAATTCACCCC
GGCTATGGATTTTTGTCGGAAAATGCTGTATTTGCGCGAGCAGTTGAAGCAGCTGGGATTAAGTTCATTGGACCTCGACC
CGAATTACTAGAAATGTTTGGTGATAAATTACAAGCTAAAAATGCAGCCATTAAGGCCGGTGTACCAACTATTCCGGGAA
CGGAAAAACCAGTTAAAGATGTCGATGACGCGCTAAATTTTGCAGAGCAATTTGGCTATCCTATATTTGTTAAGTCAGCG
GCAGGTGGCGGTGGAAAAGGGATGCGGATTGTACATCATCAACAAGAAATGCGCGAAGCATTTAAGATGGCTCAGTCAGA
AGCTTCTTCGTCTTTTGGTGACGATGAGATTTACCTAGAACGTTACTTAGTTGATCCGATCCATATTGAGGTTCAAGTAG
TCGCGGATGAACACGGTGAGATGGTTCATTTGTATGAACGAAATTCATCGATTCAGCGACGCCATCAAAAAATCATTGAA
TTTGCTCCAGCGGTGGGAATTTCTGCCACCGTCCGTGATCAAATAAGAAAAGCTGCTTTAAAATTATTGAAGTCGGTCGA
TTATAGTAACGCTGCAACCATTGAGTTTTTGGTAGAAGGTAATCAATTTTACTTTATGGAAGTGAACCCACGAATTCAGG
TTGAACATACAGTTACCGAAGAAGTCACGGGAATTGATATTGTGCAAACCCAAATTAAGGTTGCAGAAGGCCAAAGATTG
CACGAAGAAATCGGTGTTCCTCAACAAGCCCAAATTGAAGCTGTGGGAGTGGCAATTCAAGCTCGAATTACCACTGAAGA
TCCAATGAATAACTTTATTCCAGATGTCGGTAGAATCCAGACGTATCGTTCACCTGGTGGAACAGGTGTGAGATTGGATG
CTGGAAATGCCTTTGCTGGCGCCATTGTAACTCCGCATTATGATTCACTTCTGACCAAGGCGATTGTCCATGCGCCAACC
TTTGACGAAGCCTTGGTAAAGATGGATCGGGTGCTCAATGAATTTGTAATTGCTGGGGTTAAAACTAATATCCCATTTTT
AAAGAAATTAATTCATCATCCTATTTTTAGATCGGAATTAGCTCCGACAAACTTTGTGGATGAGACACCAGAACTCTTTG
ATTTAAAAGCTGAAACCCCGGTAGTTACTCAACTTTTGAGTTACATTGCTAATACTACCATCAATGGTTATCCAGGCTTA
GAAAAGCAGAATCCAGTAGTGTTAACTCGGCCAGTCCGTCCACATTTTGAAGCACAAGTACCGCATGAAAATGCGAAACA
GATCTTGGATAGTAAGGGACCTGATGCCATGATCAATTGGCTGTTAAAACAAAAGCAGGTCTTGCTAACCGATACGACCA
TGCGGGATGCCCACCAATCATTATTTGCTACGCGAATGCGGACCAAAGACATGGTAGAAATTGCCGATCAAGTCCAGAAA
GGTCTGCCTAACCTATTTTCAGCTGAAGTTTGGGGCGGTGCGACCTTTGATGTTGCTTATCGGTTCCTAGGTGAGGATCC
ATGGGTAAGACTCCAACAATTGCGGGCTAAAATGCCAAATACGATGCTCCAAATGCTTTTACGTGGGTCAAATGCAGTAG
GGTATCAAAATTATCCAGACAACGCCATTGACGAATTTATTCGATTGGCTGCCAAAAATGGAATTGATGTTTTCCGAATC
TTTGATTCCCTTAATTGGGTTCCACAGCTTGAAGAATCTATCCAACGGGTGCGTGATAATGGAAAAGTGGCTGAAGCAGC
CATGGCATATACTGGCGATATTTTAGATACTAATCGTACTAAATATAATTTGAAATATTATGTGGATTTGGCTCAAGAAC
TCCAAGCAGCAGGTGCTCATATTATTGGAATCAAAGATATGTCAGGAATTTTAAAACCACAAGCTGCTTATGCATTAATT
TCAGAGTTAAAAAATCATCTGGATGTGCCAATTCATTTGCATACGCACGATACTACAGGCAACGGCATTTTCTTATATTC
TGAAGCAATACGAGCTGGAGTTGATGTGGTCGACGTTGCCACTTCTGCGCTAGCGGGAACGACTTCTCAGCCTTCAATGC
AGTCTCTTTACTATGCGTTGTCTAATAACCAGCGTCAACCAGATTTAGACATTCAAAAAGCGGAAAAACTAGATGAATAT
TGGGCTGGAATTCGACCATATTACGAAGGATTTGGCACCCAATTAAATGGACCACAAACTGAAATTTATCGAATTGAAAT
GCCTGGTGGACAGTATACCAACCTGCGCCAGCAAGCTAATGCAGTTCATTTGGGTAAGCGTTGGGATGAGATTAAGGAAA
TGTACGCGACCGTCAATCAAATGTTTGGCGATATTCCAAAGGTTACGCCTTCTTCTAAAGTAGTTGGCGATATGGCACTA
TTCATGGTCCAAAATGATTTGACGCCTGAAATGGTAATGAACGATAAGGGACAATTAAGTTTTCCCGAATCAGTGGTAAA
CTTTTTCCGTGGTGATTTAGGACAACCGGCGGGTGGTTTTCCAAAACAGCTCCAAAAGATGATTCTAAAAGAGCAAGCCC
CATTGACAGTACGACCAGGAGCTTTAGCCGATCCAGTTGATTTTGATCAAGTTCGTAAACAGGCAACTAAGGTTTTAGGT
CACCAAGCAAGTGATGAAGAAGTTATGTCGTTTATTATGTATCCAGATGTGATGACCGAATACGTTCAACGTCAAAATGA
ATATGGTCCAGTACCATTATTAGATACTCCAATCTTTTTCCAAGGCATGCATATTGGTCAACGCATTGATTTACAATTGG
GACGCGGAAAATCGGTCATTATTGTCCTTCGAGAAATTAGTGAAGCAGATGAGGCGGGCCAAAGGTCACTTTTCTTTGAT
ATAAATGGACAAAGTGAAGAAGTGATTGTTTATGATGTTAATGCGCAGGTAACGAAAGCAAAGAAGATTAAAGCTGATCC
TACTAAAGCCGAACAGATTGGAGCTACTATGGCGGGTTCGGTCATTGAAGTTCAAGTAGAAGCGGGCCAAAAGGTCCAGC
AAGGTGATAACTTAATTGTCACTGAGGCGATGAAAATGGAGACCGCGTTAAGAGCACCTTTCGACGCGACCATTAAGAAG
ATTTATGCTACCCCTGAAATGCAAATCGAGACGGGAGATTTATTGATTGAACTAGAAAAGGAGTAA

Upstream 100 bases:

>100_bases
TTTTTTATTTAGCAAATTACACAACAAGACCCGTTTAATTTGATACAATGAACATTAAATATTGATTAAATCACGAACAA
TTTAATTAGGGAGGTCCACT

Downstream 100 bases:

>100_bases
TCTGATGGAATTTTCGAAGCGGGCTAATCAAGTTAGTCCATCAGCAACATTAGCAGTTTCAACTGAGGCAAAAAAAATGC
AGGCGGCCGGCATCGACGTT

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC [H]

Number of amino acids: Translated: 1141; Mature: 1141

Protein sequence:

>1141_residues
MHRILIANRGEIATRIIRATHELGKTAVAIYAKADEFSMHRFKADEAYQVGEDSDPIGAYLNIDDIIRIAKENNIDAIHP
GYGFLSENAVFARAVEAAGIKFIGPRPELLEMFGDKLQAKNAAIKAGVPTIPGTEKPVKDVDDALNFAEQFGYPIFVKSA
AGGGGKGMRIVHHQQEMREAFKMAQSEASSSFGDDEIYLERYLVDPIHIEVQVVADEHGEMVHLYERNSSIQRRHQKIIE
FAPAVGISATVRDQIRKAALKLLKSVDYSNAATIEFLVEGNQFYFMEVNPRIQVEHTVTEEVTGIDIVQTQIKVAEGQRL
HEEIGVPQQAQIEAVGVAIQARITTEDPMNNFIPDVGRIQTYRSPGGTGVRLDAGNAFAGAIVTPHYDSLLTKAIVHAPT
FDEALVKMDRVLNEFVIAGVKTNIPFLKKLIHHPIFRSELAPTNFVDETPELFDLKAETPVVTQLLSYIANTTINGYPGL
EKQNPVVLTRPVRPHFEAQVPHENAKQILDSKGPDAMINWLLKQKQVLLTDTTMRDAHQSLFATRMRTKDMVEIADQVQK
GLPNLFSAEVWGGATFDVAYRFLGEDPWVRLQQLRAKMPNTMLQMLLRGSNAVGYQNYPDNAIDEFIRLAAKNGIDVFRI
FDSLNWVPQLEESIQRVRDNGKVAEAAMAYTGDILDTNRTKYNLKYYVDLAQELQAAGAHIIGIKDMSGILKPQAAYALI
SELKNHLDVPIHLHTHDTTGNGIFLYSEAIRAGVDVVDVATSALAGTTSQPSMQSLYYALSNNQRQPDLDIQKAEKLDEY
WAGIRPYYEGFGTQLNGPQTEIYRIEMPGGQYTNLRQQANAVHLGKRWDEIKEMYATVNQMFGDIPKVTPSSKVVGDMAL
FMVQNDLTPEMVMNDKGQLSFPESVVNFFRGDLGQPAGGFPKQLQKMILKEQAPLTVRPGALADPVDFDQVRKQATKVLG
HQASDEEVMSFIMYPDVMTEYVQRQNEYGPVPLLDTPIFFQGMHIGQRIDLQLGRGKSVIIVLREISEADEAGQRSLFFD
INGQSEEVIVYDVNAQVTKAKKIKADPTKAEQIGATMAGSVIEVQVEAGQKVQQGDNLIVTEAMKMETALRAPFDATIKK
IYATPEMQIETGDLLIELEKE

Sequences:

>Translated_1141_residues
MHRILIANRGEIATRIIRATHELGKTAVAIYAKADEFSMHRFKADEAYQVGEDSDPIGAYLNIDDIIRIAKENNIDAIHP
GYGFLSENAVFARAVEAAGIKFIGPRPELLEMFGDKLQAKNAAIKAGVPTIPGTEKPVKDVDDALNFAEQFGYPIFVKSA
AGGGGKGMRIVHHQQEMREAFKMAQSEASSSFGDDEIYLERYLVDPIHIEVQVVADEHGEMVHLYERNSSIQRRHQKIIE
FAPAVGISATVRDQIRKAALKLLKSVDYSNAATIEFLVEGNQFYFMEVNPRIQVEHTVTEEVTGIDIVQTQIKVAEGQRL
HEEIGVPQQAQIEAVGVAIQARITTEDPMNNFIPDVGRIQTYRSPGGTGVRLDAGNAFAGAIVTPHYDSLLTKAIVHAPT
FDEALVKMDRVLNEFVIAGVKTNIPFLKKLIHHPIFRSELAPTNFVDETPELFDLKAETPVVTQLLSYIANTTINGYPGL
EKQNPVVLTRPVRPHFEAQVPHENAKQILDSKGPDAMINWLLKQKQVLLTDTTMRDAHQSLFATRMRTKDMVEIADQVQK
GLPNLFSAEVWGGATFDVAYRFLGEDPWVRLQQLRAKMPNTMLQMLLRGSNAVGYQNYPDNAIDEFIRLAAKNGIDVFRI
FDSLNWVPQLEESIQRVRDNGKVAEAAMAYTGDILDTNRTKYNLKYYVDLAQELQAAGAHIIGIKDMSGILKPQAAYALI
SELKNHLDVPIHLHTHDTTGNGIFLYSEAIRAGVDVVDVATSALAGTTSQPSMQSLYYALSNNQRQPDLDIQKAEKLDEY
WAGIRPYYEGFGTQLNGPQTEIYRIEMPGGQYTNLRQQANAVHLGKRWDEIKEMYATVNQMFGDIPKVTPSSKVVGDMAL
FMVQNDLTPEMVMNDKGQLSFPESVVNFFRGDLGQPAGGFPKQLQKMILKEQAPLTVRPGALADPVDFDQVRKQATKVLG
HQASDEEVMSFIMYPDVMTEYVQRQNEYGPVPLLDTPIFFQGMHIGQRIDLQLGRGKSVIIVLREISEADEAGQRSLFFD
INGQSEEVIVYDVNAQVTKAKKIKADPTKAEQIGATMAGSVIEVQVEAGQKVQQGDNLIVTEAMKMETALRAPFDATIKK
IYATPEMQIETGDLLIELEKE
>Mature_1141_residues
MHRILIANRGEIATRIIRATHELGKTAVAIYAKADEFSMHRFKADEAYQVGEDSDPIGAYLNIDDIIRIAKENNIDAIHP
GYGFLSENAVFARAVEAAGIKFIGPRPELLEMFGDKLQAKNAAIKAGVPTIPGTEKPVKDVDDALNFAEQFGYPIFVKSA
AGGGGKGMRIVHHQQEMREAFKMAQSEASSSFGDDEIYLERYLVDPIHIEVQVVADEHGEMVHLYERNSSIQRRHQKIIE
FAPAVGISATVRDQIRKAALKLLKSVDYSNAATIEFLVEGNQFYFMEVNPRIQVEHTVTEEVTGIDIVQTQIKVAEGQRL
HEEIGVPQQAQIEAVGVAIQARITTEDPMNNFIPDVGRIQTYRSPGGTGVRLDAGNAFAGAIVTPHYDSLLTKAIVHAPT
FDEALVKMDRVLNEFVIAGVKTNIPFLKKLIHHPIFRSELAPTNFVDETPELFDLKAETPVVTQLLSYIANTTINGYPGL
EKQNPVVLTRPVRPHFEAQVPHENAKQILDSKGPDAMINWLLKQKQVLLTDTTMRDAHQSLFATRMRTKDMVEIADQVQK
GLPNLFSAEVWGGATFDVAYRFLGEDPWVRLQQLRAKMPNTMLQMLLRGSNAVGYQNYPDNAIDEFIRLAAKNGIDVFRI
FDSLNWVPQLEESIQRVRDNGKVAEAAMAYTGDILDTNRTKYNLKYYVDLAQELQAAGAHIIGIKDMSGILKPQAAYALI
SELKNHLDVPIHLHTHDTTGNGIFLYSEAIRAGVDVVDVATSALAGTTSQPSMQSLYYALSNNQRQPDLDIQKAEKLDEY
WAGIRPYYEGFGTQLNGPQTEIYRIEMPGGQYTNLRQQANAVHLGKRWDEIKEMYATVNQMFGDIPKVTPSSKVVGDMAL
FMVQNDLTPEMVMNDKGQLSFPESVVNFFRGDLGQPAGGFPKQLQKMILKEQAPLTVRPGALADPVDFDQVRKQATKVLG
HQASDEEVMSFIMYPDVMTEYVQRQNEYGPVPLLDTPIFFQGMHIGQRIDLQLGRGKSVIIVLREISEADEAGQRSLFFD
INGQSEEVIVYDVNAQVTKAKKIKADPTKAEQIGATMAGSVIEVQVEAGQKVQQGDNLIVTEAMKMETALRAPFDATIKK
IYATPEMQIETGDLLIELEKE

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=1145, Percent_Identity=46.0262008733624, Blast_Score=1038, Evalue=0.0,
Organism=Homo sapiens, GI106049295, Length=1145, Percent_Identity=46.0262008733624, Blast_Score=1038, Evalue=0.0,
Organism=Homo sapiens, GI106049292, Length=1145, Percent_Identity=46.0262008733624, Blast_Score=1038, Evalue=0.0,
Organism=Homo sapiens, GI65506442, Length=455, Percent_Identity=42.8571428571429, Blast_Score=350, Evalue=5e-96,
Organism=Homo sapiens, GI189095269, Length=455, Percent_Identity=42.8571428571429, Blast_Score=350, Evalue=6e-96,
Organism=Homo sapiens, GI295821183, Length=455, Percent_Identity=42.8571428571429, Blast_Score=350, Evalue=6e-96,
Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=42.5055928411633, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI38679960, Length=503, Percent_Identity=30.6163021868787, Blast_Score=207, Evalue=4e-53,
Organism=Homo sapiens, GI38679977, Length=503, Percent_Identity=30.6163021868787, Blast_Score=207, Evalue=5e-53,
Organism=Homo sapiens, GI38679967, Length=503, Percent_Identity=30.6163021868787, Blast_Score=207, Evalue=5e-53,
Organism=Homo sapiens, GI38679974, Length=503, Percent_Identity=30.6163021868787, Blast_Score=207, Evalue=5e-53,
Organism=Homo sapiens, GI38679971, Length=503, Percent_Identity=30.6163021868787, Blast_Score=207, Evalue=5e-53,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=28.7128712871287, Blast_Score=192, Evalue=1e-48,
Organism=Escherichia coli, GI1789654, Length=425, Percent_Identity=44, Blast_Score=347, Evalue=2e-96,
Organism=Escherichia coli, GI1786216, Length=273, Percent_Identity=26.3736263736264, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562816, Length=1147, Percent_Identity=47.079337401918, Blast_Score=1052, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17567343, Length=463, Percent_Identity=41.036717062635, Blast_Score=340, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI71987519, Length=477, Percent_Identity=38.9937106918239, Blast_Score=314, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=28.9205702647658, Blast_Score=196, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=440, Percent_Identity=30.2272727272727, Blast_Score=184, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71997168, Length=440, Percent_Identity=30.2272727272727, Blast_Score=184, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1161, Percent_Identity=45.2196382428941, Blast_Score=1001, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1161, Percent_Identity=45.3057708871662, Blast_Score=986, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319685, Length=478, Percent_Identity=37.0292887029289, Blast_Score=309, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6323863, Length=436, Percent_Identity=30.045871559633, Blast_Score=194, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6324343, Length=518, Percent_Identity=28.1853281853282, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24652212, Length=1152, Percent_Identity=45.5729166666667, Blast_Score=1022, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652210, Length=1152, Percent_Identity=45.5729166666667, Blast_Score=1022, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652214, Length=1152, Percent_Identity=45.5729166666667, Blast_Score=1022, Evalue=0.0,
Organism=Drosophila melanogaster, GI19921944, Length=1152, Percent_Identity=45.5729166666667, Blast_Score=1022, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652216, Length=1152, Percent_Identity=45.5729166666667, Blast_Score=1022, Evalue=0.0,
Organism=Drosophila melanogaster, GI281363050, Length=1168, Percent_Identity=45.2054794520548, Blast_Score=1021, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652224, Length=1168, Percent_Identity=45.2054794520548, Blast_Score=1021, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652222, Length=1168, Percent_Identity=45.2054794520548, Blast_Score=1021, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652220, Length=1168, Percent_Identity=45.2054794520548, Blast_Score=1021, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652218, Length=1168, Percent_Identity=45.2054794520548, Blast_Score=1021, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651757, Length=451, Percent_Identity=41.4634146341463, Blast_Score=335, Evalue=9e-92,
Organism=Drosophila melanogaster, GI24651759, Length=414, Percent_Identity=40.8212560386473, Blast_Score=296, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24586458, Length=416, Percent_Identity=29.5673076923077, Blast_Score=176, Evalue=8e-44,
Organism=Drosophila melanogaster, GI161076407, Length=416, Percent_Identity=29.5673076923077, Blast_Score=176, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24586460, Length=416, Percent_Identity=29.5673076923077, Blast_Score=176, Evalue=9e-44,
Organism=Drosophila melanogaster, GI161076409, Length=416, Percent_Identity=29.5673076923077, Blast_Score=176, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 127040; Mature: 127040

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRILIANRGEIATRIIRATHELGKTAVAIYAKADEFSMHRFKADEAYQVGEDSDPIGAY
CCEEEEECCCHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCEEE
LNIDDIIRIAKENNIDAIHPGYGFLSENAVFARAVEAAGIKFIGPRPELLEMFGDKLQAK
ECHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHC
NAAIKAGVPTIPGTEKPVKDVDDALNFAEQFGYPIFVKSAAGGGGKGMRIVHHQQEMREA
CCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEHHHHHHHHH
FKMAQSEASSSFGDDEIYLERYLVDPIHIEVQVVADEHGEMVHLYERNSSIQRRHQKIIE
HHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
FAPAVGISATVRDQIRKAALKLLKSVDYSNAATIEFLVEGNQFYFMEVNPRIQVEHTVTE
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEEEEEHHH
EVTGIDIVQTQIKVAEGQRLHEEIGVPQQAQIEAVGVAIQARITTEDPMNNFIPDVGRIQ
HHCCCHHHHHHHHHHCCHHHHHHHCCCCHHCEEEEEEEEEEEECCCCCHHHHCCCCHHEE
TYRSPGGTGVRLDAGNAFAGAIVTPHYDSLLTKAIVHAPTFDEALVKMDRVLNEFVIAGV
EECCCCCCEEEEECCCCEECCEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
KTNIPFLKKLIHHPIFRSELAPTNFVDETPELFDLKAETPVVTQLLSYIANTTINGYPGL
CCCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCC
EKQNPVVLTRPVRPHFEAQVPHENAKQILDSKGPDAMINWLLKQKQVLLTDTTMRDAHQS
CCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEECCHHHHHHHH
LFATRMRTKDMVEIADQVQKGLPNLFSAEVWGGATFDVAYRFLGEDPWVRLQQLRAKMPN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCH
TMLQMLLRGSNAVGYQNYPDNAIDEFIRLAAKNGIDVFRIFDSLNWVPQLEESIQRVRDN
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHHHHHHHCC
GKVAEAAMAYTGDILDTNRTKYNLKYYVDLAQELQAAGAHIIGIKDMSGILKPQAAYALI
CCHHHHHHHHCCCCCCCCCCEEEEEEEEEHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHH
SELKNHLDVPIHLHTHDTTGNGIFLYSEAIRAGVDVVDVATSALAGTTSQPSMQSLYYAL
HHHHHHCCCEEEEEECCCCCCEEEEEEHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
SNNQRQPDLDIQKAEKLDEYWAGIRPYYEGFGTQLNGPQTEIYRIEMPGGQYTNLRQQAN
HCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHCC
AVHLGKRWDEIKEMYATVNQMFGDIPKVTPSSKVVGDMALFMVQNDLTPEMVMNDKGQLS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEHECCCCCHHHHCCCCCCCC
FPESVVNFFRGDLGQPAGGFPKQLQKMILKEQAPLTVRPGALADPVDFDQVRKQATKVLG
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHC
HQASDEEVMSFIMYPDVMTEYVQRQNEYGPVPLLDTPIFFQGMHIGQRIDLQLGRGKSVI
CCCCHHHHHHHHHCHHHHHHHHHHCCCCCCCCEECCCHHEECCCCCCEEEEEECCCCEEE
IVLREISEADEAGQRSLFFDINGQSEEVIVYDVNAQVTKAKKIKADPTKAEQIGATMAGS
EEEEHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEEHHHHCCCCCCHHHHHCHHHCCC
VIEVQVEAGQKVQQGDNLIVTEAMKMETALRAPFDATIKKIYATPEMQIETGDLLIELEK
EEEEEECCCCHHHCCCCEEEEHHHHHHHHHCCCHHHHHHHHHCCCCCEEECCCEEEEEEC
E
C
>Mature Secondary Structure
MHRILIANRGEIATRIIRATHELGKTAVAIYAKADEFSMHRFKADEAYQVGEDSDPIGAY
CCEEEEECCCHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCEEE
LNIDDIIRIAKENNIDAIHPGYGFLSENAVFARAVEAAGIKFIGPRPELLEMFGDKLQAK
ECHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHC
NAAIKAGVPTIPGTEKPVKDVDDALNFAEQFGYPIFVKSAAGGGGKGMRIVHHQQEMREA
CCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEHHHHHHHHH
FKMAQSEASSSFGDDEIYLERYLVDPIHIEVQVVADEHGEMVHLYERNSSIQRRHQKIIE
HHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
FAPAVGISATVRDQIRKAALKLLKSVDYSNAATIEFLVEGNQFYFMEVNPRIQVEHTVTE
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEEEEEHHH
EVTGIDIVQTQIKVAEGQRLHEEIGVPQQAQIEAVGVAIQARITTEDPMNNFIPDVGRIQ
HHCCCHHHHHHHHHHCCHHHHHHHCCCCHHCEEEEEEEEEEEECCCCCHHHHCCCCHHEE
TYRSPGGTGVRLDAGNAFAGAIVTPHYDSLLTKAIVHAPTFDEALVKMDRVLNEFVIAGV
EECCCCCCEEEEECCCCEECCEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
KTNIPFLKKLIHHPIFRSELAPTNFVDETPELFDLKAETPVVTQLLSYIANTTINGYPGL
CCCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCC
EKQNPVVLTRPVRPHFEAQVPHENAKQILDSKGPDAMINWLLKQKQVLLTDTTMRDAHQS
CCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHCCCEEEECCHHHHHHHH
LFATRMRTKDMVEIADQVQKGLPNLFSAEVWGGATFDVAYRFLGEDPWVRLQQLRAKMPN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCH
TMLQMLLRGSNAVGYQNYPDNAIDEFIRLAAKNGIDVFRIFDSLNWVPQLEESIQRVRDN
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHHHHHHHCC
GKVAEAAMAYTGDILDTNRTKYNLKYYVDLAQELQAAGAHIIGIKDMSGILKPQAAYALI
CCHHHHHHHHCCCCCCCCCCEEEEEEEEEHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHH
SELKNHLDVPIHLHTHDTTGNGIFLYSEAIRAGVDVVDVATSALAGTTSQPSMQSLYYAL
HHHHHHCCCEEEEEECCCCCCEEEEEEHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
SNNQRQPDLDIQKAEKLDEYWAGIRPYYEGFGTQLNGPQTEIYRIEMPGGQYTNLRQQAN
HCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHCC
AVHLGKRWDEIKEMYATVNQMFGDIPKVTPSSKVVGDMALFMVQNDLTPEMVMNDKGQLS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEHECCCCCHHHHCCCCCCCC
FPESVVNFFRGDLGQPAGGFPKQLQKMILKEQAPLTVRPGALADPVDFDQVRKQATKVLG
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHC
HQASDEEVMSFIMYPDVMTEYVQRQNEYGPVPLLDTPIFFQGMHIGQRIDLQLGRGKSVI
CCCCHHHHHHHHHCHHHHHHHHHHCCCCCCCCEECCCHHEECCCCCCEEEEEECCCCEEE
IVLREISEADEAGQRSLFFDINGQSEEVIVYDVNAQVTKAKKIKADPTKAEQIGATMAGS
EEEEHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCEEHHHHCCCCCCHHHHHCHHHCCC
VIEVQVEAGQKVQQGDNLIVTEAMKMETALRAPFDATIKKIYATPEMQIETGDLLIELEK
EEEEEECCCCHHHCCCCEEEEHHHHHHHHHCCCHHHHHHHHHCCCCCEEECCCEEEEEEC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]